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Grape powder shows promise for gut and heart health in new study

NCT ID NCT06544954

Disease control Sponsor: University of California, Davis Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether eating grape powder daily for 3 weeks can improve gut health, reduce inflammation, and improve blood vessel function in 40 overweight adults aged 45-70. Participants will drink grape or placebo powder twice a day and provide blood and stool samples. The goal is to see if grapes can act as a prebiotic to support heart and metabolic health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
freeze-dried grape powder
What this could lead to
If it works, this could point toward a simple dietary supplement to improve heart and gut health in overweight adults.
What could go wrong
This is a small, early-stage trial with only 40 people over 3 weeks. Results may not apply to everyone, and the effect may be small or not last.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * post-menopausal women (cessation of menstruation for minimum two years) * overweight and obese (BMI between 25-35 kg/m2) * stable treatment for type 2 diabetes or metabolic syndrome * ability to understand the intervention concept and written consent to participate * willingness to accept randomization, undergo testing and intervention procedures, and deliver stool and blood samples Exclusion Criteria: * menopausal hormone replacement therapy started within less than 6 months * antibiotics, prebiotics within last 3 months * antidiabetic treatment involving insulin (for type 1 diabetes) * vegetarian/vegan and not able to follow modified diet * any serious medical condition including but not limited to coronary artery disease, uncontrolled hypertension, stroke, congestive heart failure, insulin-dependent diabetes, liver disease, active cancer and anemia * psychiatric disease that interferes with the understanding and implementation of the intervention * history of eating disorders such as bulimia nervosa, anorexia nervosa, severe binge eating disorder in the last 5 years * history of substance abuse or alcohol abuse * involvement in a weight loss intervention program (including anti-obesity medication) within last 3 months or have had bariatric surgery * current smokers (within last 180 days) * use of dietary supplements containing polyphenols in the past 1 month * strenuous exercise greater than 10 hours per week

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Conditions

The condition(s) this trial relates to.

Dysbiosis hypertensive disorder Inflammation inflammatory disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Arterial stiffness Blood pressure Dysbiosis Inflammation Permeability; increased

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ragle Human Nutrition Center

    RECRUITING

    Davis, California, 95616, United States

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