Study reveals which salty sauces are worst for your heart
NCT ID NCT07397754
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how different salty condiments, like soy sauce or fish sauce, affect blood pressure and blood vessel health shortly after eating. Researchers want to create a system to rank these condiments based on heart risks. The study involves 32 adults aged 50 to 75 with slightly high blood pressure. Participants will eat meals with various condiments and have their blood pressure and blood vessel function measured.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 32 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2025
- Expected to finish
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Sep 2026
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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50 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. ≥ 50, \< 75 years old 2. Male or postmenopausal female (self-reported) 3. ≥ 50 kg body weight 4. Systolic blood pressure (≥ 130, \< 160 mmHg) or diastolic blood pressure (≥ 85, \< 100 mmHg) 5. Willing and able to follow intervention protocol 6. Ability to identify basic tastes (determined by taste discrimination test) 7. English speaking Exclusion Criteria: 1. Prescribed and taking medication which may affect study outcomes (i.e. for blood pressure management, blood thinning etc.) in consultation with study physician (Prof Melvin Leow) and PI(Dr Darel Toh) 2. Type 1 or type 2 diabetes mellitus (i.e. fasting blood glucose ≥ 7.0 mmol/L or HbA1c ≥ 6.5 %) 3. Taking dietary supplements which may affect study outcomes one month prior to their first visit in consultation with study physician, PI and study team 4. Obesity (BMI ≥ 27.5 kg/m2) 5. History or known present diagnosis of hematological (G6PD and coagulation disorders), hepatic (hepatitis B and C), renal, gastrointestional or other relevant disease / disorders which may affect the outcomes of interest in consultation with study physician, PI and study team 6. History of arteriovenous shunt or mastectomy 7. Women who are pregnant, lactating or planning pregnancy 8. History or present diagnosis of HIV and/or tuberculosis 9. History of severe vasovagal syncope (blackouts or near faints) following blood draw 10. Drug abuse within last 5 years 11. Excessive alcoholic beverage consumption \> 2 servings per day (1 serving defined as 360 mL beer, 150 mL wine or 45 mL distilled spirits) 12. Smoking (cigarette, e-cigarette, cigar, pipe, vape) 13. Engaging in habitual vigorous physical activity (as defined by physical activity questionnaire-PAR) 14. Allergic or intolerance to intervention foods. 15. Dislike or unwilling to consume intervention foods 16. Photophobic (sensitivity to intense lights and colours), particularly to intense red lights 17. Has sinus problems problems that affect taste and smell 18. Involvement in other clinical studies that may influence the outcome of the study 19. An ASTAR Staff. 20. A study team member or their immediate family member
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Clinical Nutrition Research Centre
RECRUITINGSingapore, 117599, Singapore
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