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Tiny nerve study could unlock secrets of blood pressure

NCT ID NCT03513770

Knowledge-focused Sponsor: Milton S. Hershey Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This early-stage study looks at how the body's nervous system controls blood pressure when veins are stretched. Researchers will use a blood pressure cuff to temporarily block blood flow in the arm and measure nerve activity in the leg, along with vein size using an MRI. They will also test whether a common painkiller (ketorolac) changes these responses. The study involves 18 healthy adults aged 21-35 and aims to better understand basic body functions, not to treat any disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ketorolac tromethamine (an intravenous NSAID)
What this could lead to
If successful, this study could help scientists better understand how blood pressure is regulated, potentially pointing toward new treatments for conditions like fainting or low blood pressure.
What could go wrong
This is a very small, early-phase study with only 18 healthy volunteers, so results may not apply to patients with medical conditions. The intervention is short-term and not intended to treat any disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 18 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2019

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 35 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Are capable of giving informed consent * Are any race or ethnicity * Are fluent in written and spoken English * Have a satisfactory history and physical exam to meet inclusion/exclusion criteria * Are free of acute or chronic medical conditions * Are 21 - 35 years of age (inclusive) * Weigh over 50 kg Exclusion Criteria * Are less than 21 or over 35 years of age * Are Pregnant or nursing women * Are prisoners or institutionalized individuals or unable to consent * Any chronic diseases (hypertension, heart, lung, neuromuscular disease, kidney disease, diabetes or cancer). * Are taking medications that may affect their cardiovascular or nervous system * Has taken an NSAID within 48 hours of any visit (visit will need to be rescheduled) * Has never taken NSAIDs and therefore would not know if they are allergic to it * Have a supine BP \>140/90 mmHg * Have known allergy to ibuprofen-like drugs (NSAIDS) or aspirin * Have history of asthma or nasal polyps * Have history of GI bleeding or ulcers * Subjects with ferromagnetic metal implants * Subjects who are claustrophobic

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Conditions

The condition(s) this trial relates to.

hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Blood pressure Venous distension reflex

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Penn State Milton S. Hershey Medical Center

    RECRUITING

    Hershey, Pennsylvania, 17033, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.