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Tiny particles in the blood may warn of dangerous pregnancy high blood pressure

NCT ID NCT07728656

Knowledge-focused Sponsor: Josip Juraj Strossmayer University of Osijek Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This study looks at whether tiny particles shed from blood vessels, called endothelial extracellular vesicles, can serve as early warning signs for hypertensive disorders of pregnancy, such as preeclampsia. Researchers will compare levels of these particles in pregnant women with and without high blood pressure and examine how they relate to blood vessel function. The goal is to find a non-invasive way to detect and monitor these conditions earlier, potentially improving outcomes for mothers and babies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a simple blood test to detect and monitor hypertensive disorders in pregnancy earlier and more accurately.
What could go wrong
This is an observational study, not a treatment trial. It may not find a clear link, and any future test would require much larger studies to confirm.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Sep 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will include pregnant women aged 18 years and older recruited from the outpatient clinics of the Department of Obstetrics and Gynecology, University Hospital Centre Osijek, Croatia. Participants will comprise normotensive pregnant women and women with newly diagnosed hypertensive disorders of pregnancy, including gestational hypertension and preeclampsia, diagnosed according to current international clinical guidelines.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Pregnant women aged ≥18 years. * Singleton pregnancy. * Ability to provide written informed consent. * Normotensive pregnancy or diagnosis of gestational hypertension or preeclampsia according to current clinical guidelines. * Ability to comply with study procedures. Exclusion Criteria: * Chronic hypertension diagnosed before pregnancy. * Multiple pregnancy. * Pre-existing diabetes mellitus. * Chronic kidney disease. * Autoimmune disease. * Known cardiovascular disease. * Active infection or inflammatory disease. * Malignancy. * Inability or unwillingness to provide informed consent.

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Conditions

The condition(s) this trial relates to.

hypertension, pregnancy-induced hypertensive disorder preeclampsia Toxemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gestational hypertension Hypertensive disorder of pregnancy Preeclampsia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faculty of Medicine Osijek

    RECRUITING

    Osijek, Croatia

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