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Can we stop early artery aging in kids with kidney disease?

NCT ID NCT07768865

Knowledge-focused Sponsor: King's College London Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 17, 2026 · Last updated Aug 18, 2026 · Updated 1 time

Summary

This study investigates why arteries stiffen and harden faster in children and young people with chronic kidney disease (CKD) and high blood pressure. Researchers will use non-invasive tests to compare arterial stiffness between those with CKD and matched controls, including healthy peers and those with high blood pressure alone. The goal is to understand whether the stiffness is due only to high blood pressure or also to other factors like nerve activity and metabolic changes. This could help find ways to prevent or treat arterial stiffness and protect future heart and kidney health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could identify ways to prevent or treat arterial stiffness in young people with kidney disease, potentially protecting their heart and kidney health in later life.
What could go wrong
This is an observational study, so it won't directly test a treatment. The findings may not lead to immediate clinical changes, and the results depend on the specific group of participants studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Children and young adults with chronic kidney disease and age-, sex- and gender-matched healthy controls and those with primary hypertension.

Ages

10 to 25 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: For CKD participants: * Aged 10-25 years at study entry. * Diagnosis of CKD confirmed on at least two GFR assessments 3-months apart; eGFR will be estimated using routine bedside formulae (modified Schwartz). Participants may include those on dialysis or those with a functioning kidney transplant. * Able to tolerate study investigations including 24-hour ABPM, echocardiogram, vascular assessments and MRI. For controls: * Aged 10-25 years at study entry * Having completed study measurements as part of other research being completed by the research group and having consented to their anonymised data being used in future research within the same research theme. Exclusion criteria (for all participants): * Heart abnormalities or pre-existing cardiac disease including congenital heart disease, previous cardiac surgery or heart failure. * Cardiac dysrhythmia. * Inability to tolerate the required study investigations (out of office BP monitoring, applanation tonometry, cardiac MRI).

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic kidney disease Hypertension

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Evelina London Children's Hospital and Guys and St Thomas' NHS Foundation Trust

    RECRUITING

    London, Greater London, SE1 7EH, United Kingdom

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