Shocking news: TENS therapy plus exercise may tame stubborn high blood pressure
NCT ID NCT07383220
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether combining transcutaneous electrical nerve stimulation (TENS) with isometric exercise can improve blood pressure in people with resistant hypertension. Resistant hypertension means blood pressure stays high despite taking three or more medications. The trial will include 50 men and women aged 50-60. One group will receive TENS and exercise plus their usual medication, while the other group gets standard physical therapy and medication. The goal is to see if the combination can reduce blood pressure and improve heart health.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Transcutaneous Electrical Nerve Stimulation (TENS) and isometric exercise
- What this could lead to
- If it works, this could offer a drug-free way to help control blood pressure in people with resistant hypertension.
- What could go wrong
- This is a small, early-stage trial with only 50 people. The results may not apply to everyone, and the benefits might be modest or not last long.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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50 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age between 50 and 60 years. Both sexes were included Patients had been diagnosed with hypertension for at least 5 years. Patients had resistant hypertension according to (Whelton et al 2018), defined as: * Systolic blood pressure (SBP) ≥140 mmHg and/or diastolic blood pressure (DBP) ≥90 mmHg despite the use of three or more antihypertensive medications of different classes, including a diuretic, * or controlled blood pressure (\<140/90 mmHg) while on four or more antihypertensive medications. Body Mass Index (BMI) 25: 34.9 kg/m² Increased waist circumference, defined as: * Greater than 102 cm for males. * Greater than 88 cm for females. Exclusion Criteria: * Secondary hypertension due to identifiable causes (e.g., renal artery stenosis, primary aldosteronism, pheochromocytoma). * History of major cardiovascular events in the last 6 months (e.g., myocardial infarction, stroke, or heart failure exacerbation). * Severe musculoskeletal or neurological disorders that impair the ability to perform isometric exercise safely (e.g., recent joint replacement, severe osteoarthritis, stroke with residual motor deficit). * Contraindications to the use of Transcutaneous Electrical Nerve Stimulation (TENS): Implanted electronic devices: pacemakers, cardioverter defibrillators. Uncontrolled arrhythmias. Sever skin condition: open wounds, rashes, burns, eczema. Peripheral neuropathy or sensory loss. -Known cognitive impairment or psychiatric conditions that would limit the ability to follow instructions or provide informed consent.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Out Clinics of Port Said Hospitals
RECRUITINGPort Said, Port Said Governorate, 42515, Egypt
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