Sleep apnea study tests CPAP plus sleep meds for better blood pressure control

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age between 18 and 70 years old; 2. Diagnosed with obstructive sleep apnea (OSA) through overnight polysomnography (PSG), as follows: (1) AHI ≥ 5 times/hour and one of the following conditions is met: (1) The patient complains of daytime sleepiness, lack of sleepiness during sleep, fatigue or insomnia; (2) Waking up due to breathlessness or wheezing; (3) The bed partner or other witnesses report that the patient has habitual snoring, breathing interruptions or both during sleep. Or (2) AHI ≥ 15 times/hour. 3. Satisfy any of the following blood pressure conditions: (1) Office blood pressure 120-139/80-89 mmHg, with ≤ 2 cardiovascular risk factors; (2) Newly diagnosed blood pressure 140-159/90-99 mmHg and without cardiovascular risk factors; (3) Currently taking stable types and doses of antihypertensive drugs, but the office blood pressure has not reached the normal blood pressure standard (120/80 mmHg) with a low-risk level of cardiovascular risk for patients with hypertension; (4) Any non-cardiovascular risk level high-risk patient who voluntarily requests three-month CPAP treatment and accepts follow-up; 4. Able to tolerate 24-hour ambulatory blood pressure monitoring and continuous blood pressure monitoring; Exclusion Criteria: 1. Previously diagnosed with OSA and currently undergoing OSA treatment (such as CPAP, orthodontic devices, surgery, etc.); 2. Secondary hypertension caused by other reasons other than OSA, such as renal artery stenosis, kidney disease, Cushing's syndrome, primary aldosteronism; 3. Unstable condition (having experienced cardiovascular events or major surgeries in the past 3 months, severe sleepiness (ESS ≥ 16 points), or cognitive impairment that makes it impossible to cooperate, active mental illness or drug/alcohol abuse); 4. Rheumatic immune diseases and malignant tumors; 5. Large artery diseases (such as giant cell arteritis, arterial dissection, aneurysm, etc.); 6. Diseases that cannot accurately measure blood pressure (such as atrial fibrillation, upper limb vascular diseases); 7. Early-onset familial hypertension; 8. Any prescription or over-the-counter sleep aid (benzodiazepines, non-benzodiazepines, melatonin receptor agonists, trazodone, sedative antipsychotic/antidepressants containing sedative components, OTC containing sedative components) within 4 weeks before enrollment; 9. Allergic or contraindicated to the potential study drugs (trazodone, zopiclone); 10. Pregnant, lactating, or planning to become pregnant; 11. Frequent night shift work (≥ 3 nights/week) or circadian rhythm disorder (diagnosed by a doctor); 12. Participating in other interventional clinical trials.