Salt switch could shield Moms-to-Be from dangerous pregnancy complication
NCT ID NCT07294807
First seen Jun 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time
Summary
This study tests whether using a low-sodium salt substitute instead of regular salt can lower blood pressure and prevent pregnancy-related high blood pressure disorders in women at high risk. About 3,200 pregnant women in China will be randomly assigned to use either the salt substitute or regular salt until delivery. The goal is to find a simple, safe, and affordable way to protect both mother and baby.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 3,200 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2026
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Singleton pregnancy with a viable fetus at ≤16 weeks of gestation. 2. Meets at least one of the following criteria (enrolled sequentially): 1. Systolic Blood Pressure (SBP) ≥130 mmHg and \<160 mmHg at enrollment, OR current monotherapy with antihypertensive medications such as labetalol or nifedipine (priority enrollment). 2. At least one of the following 4 items: advanced maternal age (≥35 years), pre-pregnancy obesity (BMI ≥28 kg/m²), history of preeclampsia, or pre-existing type 1 or type 2 diabetes. 3. At least two of the following 5 items: history of adverse pregnancy outcome (e.g., fetal death, placental abruption, fetal growth restriction), personal history of gestational hypertension or family history of preeclampsia (mother or sister), history of gestational diabetes, obstructive sleep apnea, or pre-pregnancy overweight (BMI 24-28 kg/m²). 3. Routinely eats at least two meals per day at home (including meals brought from home). 4. Able to attend regular antenatal check-ups and is expected to complete the study follow-up. 5. Provides written informed consent. - Exclusion Criteria: 1. SBP ≥160 mmHg or Diastolic Blood Pressure (DBP) ≥110 mmHg at enrollment. 2. Conditions or history associated with high uterine tension (e.g., polyhydramnios, macrosomia, hydatidiform mole); autoimmune diseases (e.g., systemic lupus erythematosus, antiphospholipid syndrome). 3. History of chronic kidney disease, OR any antenatal check-up with a confirmed estimated Glomerular Filtration Rate (eGFR) \<70 ml/min/1.73m², OR dipstick urine protein ≥2+. 4. Diagnosed hyperkalemia. 5. History of hypotension or syncope. 6. A household member who shares meals has a confirmed diagnosis of chronic kidney disease or hyperkalemia.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
102 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Affiliated Hospital of Hebei University
NOT_YET_RECRUITINGBaoding, Hebei, China
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Altay Prefecture People's Hospital
NOT_YET_RECRUITINGAltay, Xinjiang, China
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Army Specialty Medical Center (Daping Hospital)
RECRUITINGYuzhong, Chongqing Municipality, China
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Baoding Maternal and Child Health Hospital
RECRUITINGBaoding, Hebei, China
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Bayingolin Mongolian Autonomous Prefecture People's Hospital
NOT_YET_RECRUITINGKorla, Xinjiang, China
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Binzhou Medical University Hospital
WITHDRAWNBinzhou, Shandong, China
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Bortala Mongolian Autonomous Prefecture People's Hospital
NOT_YET_RECRUITINGBole, Xinjiang, China
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Cangzhou Central Hospital
NOT_YET_RECRUITINGCangzhou, Hebei, China
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Cangzhou Maternal and Child Health Hospital
NOT_YET_RECRUITINGCangzhou, Hebei, China
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Changji Hui Autonomous Prefecture People's Hospital
NOT_YET_RECRUITINGChangji, Xinjiang, China
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Changsha Hospital for Maternal and Child Health Care
NOT_YET_RECRUITINGChangsha, Hunan, China
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China Petroleum Central Hospital (Hebei)
RECRUITINGLangfang, Hebei, China
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Chongqing Bishan District Maternal and Child Health Care Hospital
NOT_YET_RECRUITINGBishan, Chongqing Municipality, China
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Chongqing Fuling District Maternal and Child Health Care Hospital
NOT_YET_RECRUITINGFuling, Chongqing Municipality, China
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Chongqing Hechuan District Maternal and Child Health Care Hospital
NOT_YET_RECRUITINGHechuan, Chongqing Municipality, China
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Chongqing Jiangjin District Maternal and Child Health Care Hospital
NOT_YET_RECRUITINGJiangjin, Chongqing Municipality, China
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Chongqing Maternal and Child Health Care Hospital
RECRUITINGYubei, Chongqing Municipality, China
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Chongqing Qianjiang District Maternal and Child Health Care Hospital
NOT_YET_RECRUITINGQianjiang, Chongqing Municipality, China
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Chongqing Qijiang District People's Hospital
NOT_YET_RECRUITINGGunan, Chongqing Municipality, China
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Chongqing Wanzhou District Maternal and Child Health Care Hospital
NOT_YET_RECRUITINGWanzhou, China
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Chongqing Wulong District Maternal and Child Health Care Hospital
RECRUITINGWulong, Chongqing Municipality, China
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Chongqing Wushan County People's Hospital
RECRUITINGWushan, Chongqing Municipality, China
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Chongqing Yongchuan District Maternal and Child Health Care Hospital
NOT_YET_RECRUITINGYongchuan, Chongqing Municipality, China
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Chongqing Yubei District Maternal and Child Health Care Hospital
NOT_YET_RECRUITINGYubei, Chongqing Municipality, China
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Chongqing Yunyang County People's Hospital
RECRUITINGYunyang, Chongqing Municipality, China
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Dong'e County People's Hospital
NOT_YET_RECRUITINGDong’e, Shandong, China
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Dongying Second People's Hospital
WITHDRAWNDongying, Shandong, China
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Feicheng People's Hospital
RECRUITINGFeicheng, Shandong, China
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Gucheng County Hospital
RECRUITINGHengshui, Hebei, China
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Guyuan Maternal and Child Health Care Hospital
NOT_YET_RECRUITINGGuyuan, Ningxia, China
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Guyuan People's Hospital
NOT_YET_RECRUITINGGuyuan, Ningxia, China
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Hami Central Hospital
NOT_YET_RECRUITINGHami, Xinjiang, China
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Hebei Yanda Hospital
NOT_YET_RECRUITINGLangfang, Hebei, China
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Hengshui Fourth Hospital
WITHDRAWNHengshui, Hebei, China
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Hengshui Maternal and Child Health Care Hospital
RECRUITINGHengshui, Hebei, China
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Heze Municipal Hospital
NOT_YET_RECRUITINGHeze, Shandong, China
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Hotan Prefecture People's Hospital
NOT_YET_RECRUITINGHotan, Xinjiang, China
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Huanghua People's Hospital
RECRUITINGCangzhou, Hebei, China
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Huantai County Maternal and Child Health Hospital
NOT_YET_RECRUITINGZibo, Shandong, China
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Jinan Maternal and Child Health Care Hospital
NOT_YET_RECRUITINGJinan, Shandong, China
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Jining First People's Hospital
RECRUITINGJining, Shandong, China
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Karamay Central Hospital
NOT_YET_RECRUITINGKaramay, Xinjiang, China
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Kizilsu Kirgiz Autonomous Prefecture People's Hospital
NOT_YET_RECRUITINGArtux, Xinjiang, China
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Laizhou Maternal and Child Health Hospital
RECRUITINGLaizhou, Shandong, China
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Langfang People's Hospital
NOT_YET_RECRUITINGLangfang, Hebei, China
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Lanling County People's Hospital
WITHDRAWNLanling, Shandong, China
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Liaocheng People's Hospital
RECRUITINGLiaocheng, Shandong, China
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Lingwu People's Hospital
NOT_YET_RECRUITINGLingwu, Ningxia, China
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Linxi County People's Hospital
RECRUITINGXingtai, Hebei, China
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Linyi People's Hospital
RECRUITINGLinyi, Shandong, China
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Ningxia Hui Autonomous Region Hospital of Traditional Chinese Medicine
NOT_YET_RECRUITINGXixia, Ningxia, China
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Ningxia Hui Autonomous Region People's Hospital
RECRUITINGYinchuan, Ningxia, China
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Peking University First Hospital Ningxia Women and Children's Hospital
NOT_YET_RECRUITINGYinchuan, Ningxia, China
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People's Hospital of Xinjiang Uygur Autonomous Region
NOT_YET_RECRUITINGÜrümqi, Xinjiang, China
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Pingluo County People's Hospital
NOT_YET_RECRUITINGPingluo Chengguanzhen, Ningxia, China
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Qilu Hospital of Shandong University
NOT_YET_RECRUITINGJinan, Shandong, China
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Qilu Hospital of Shandong University (Dezhou Hospital)
NOT_YET_RECRUITINGDezhou, Shandong, China
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Qingdao Chengyang District People's Hospital
NOT_YET_RECRUITINGQingdao, Shandong, China
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Qingdao Women and Children's Hospital (Peking University People's Hospital Qingdao Branch)
NOT_YET_RECRUITINGQingdao, Shandong, China
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Qinhuangdao Changli County Maternal and Child Health Hospital
NOT_YET_RECRUITINGQinhuangdao, Hebei, China
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Qinhuangdao Maternal and Child Health Hospital
WITHDRAWNQinhuangdao, Hebei, China
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Qinhuangdao Qinglong County People's Hospital
NOT_YET_RECRUITINGQinhuangdao, Hebei, China
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Rizhao People's Hospital
NOT_YET_RECRUITINGRizhao, Shandong, China
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Rongcheng Maternal and Child Health Hospital
RECRUITINGYatou, Shandong, China
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Shandong Provincial Hospital
RECRUITINGJinan, Shandong, China
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Shandong Provincial Maternal and Child Health Care Hospital
NOT_YET_RECRUITINGJinan, Shandong, China
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Shijiazhuang Maternity & Child Healthcare Hospital
NOT_YET_RECRUITINGShijiazhuang, Hebei, China
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Shizuishan First People's Hospital
NOT_YET_RECRUITINGShizuishan, Ningxia, China
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Taian Central Hospital
NOT_YET_RECRUITINGTaian, Shandong, China
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The Affiliated Hospital of Jining Medical University
NOT_YET_RECRUITINGJining, Shandong, China
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The First Affiliated Hospital of Army Medical University (Xinan Hospital)
NOT_YET_RECRUITINGShapingba, Chongqing Municipality, China
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The First Affiliated Hospital of Chongqing Medical University
RECRUITINGYuzhong, Chongqing Municipality, China
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The First Affiliated Hospital of Shandong First Medical University (Qianfoshan Hospital)
NOT_YET_RECRUITINGJinan, Shandong, China
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The First Affiliated Hospital of Shihezi University
RECRUITINGShihezi, Xinjiang, China
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The First Affiliated Hospital of Xinjiang Medical University
NOT_YET_RECRUITINGÜrümqi, Xinjiang, China
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The First Affiliated Hospital of Xinjiang Medical University (Changji Branch)
NOT_YET_RECRUITINGChangji, Xinjiang, China
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The First People's Hospital of Aksu Prefecture
NOT_YET_RECRUITINGAksu, Xinjiang, China
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The First People's Hospital of Changde
RECRUITINGChangde, Hunan, China
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The First People's Hospital of Kashi
NOT_YET_RECRUITINGKashgar, Xinjiang, China
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The Second Affiliated Hospital of Army Medical University (Xinqiao Hospital)
WITHDRAWNShapingba, Chongqing Municipality, China
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The Second Affiliated Hospital of Chongqing Medical University
NOT_YET_RECRUITINGYuzhong, Chongqing Municipality, China
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The Second Hospital of Shandong University
RECRUITINGJinan, Shandong, China
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The Second Jinan Maternal and Child Health Care Hospital
RECRUITINGJinan, Shandong, China
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The Second People's Hospital of Kashi Prefecture
NOT_YET_RECRUITINGKashgar, Xinjiang, China
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Tongxin County People's Hospital
RECRUITINGYuhai, Ningxia, China
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Turpan Gaochang District People's Hospital
RECRUITINGTurpan, Xinjiang, China
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Turpan People's Hospital
NOT_YET_RECRUITINGTurpan, Xinjiang, China
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University Town Hospital of Chongqing Medical University
NOT_YET_RECRUITINGShapingba, Chongqing Municipality, China
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Urumqi First People's Hospital (Railway Bureau Campus)
NOT_YET_RECRUITINGÜrümqi, Xinjiang, China
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Urumqi Maternal and Child Health Care Hospital (Urumqi You'ai Hospital)
WITHDRAWNÜrümqi, Xinjiang, China
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Weifang Maternal and Child Health Hospital
NOT_YET_RECRUITINGWeifang, Shandong, China
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Weihai Maternal and Child Health Hospital
RECRUITINGWeihai, Shandong, China
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Weixian County People's Hospital
NOT_YET_RECRUITINGXingtai, Hebei, China
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Wuzhong People's Hospital
NOT_YET_RECRUITINGWuzhong, Ningxia, China
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Xiangya Hospital of Central South University
NOT_YET_RECRUITINGChangsha, Hunan, China
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Xingtai People's Hospital
NOT_YET_RECRUITINGXingtai, Hebei, China
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Xinjiang Military Region General Hospital
NOT_YET_RECRUITINGÜrümqi, Xingjiang, China
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Xinle City Hospital
NOT_YET_RECRUITINGShijiazhuang, Hebei, China
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Yantai Yeda Hospital
WITHDRAWNYantai, Shandong, China
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Yantai Yuhuangding Hospital
RECRUITINGYantai, Shandong, China
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Yili Prefecture Friendship Hospital
NOT_YET_RECRUITINGYining, Xinjiang, China
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Yinchuan First People's Hospital
RECRUITINGYinchuan, Ningxia, China
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Yinchuan Maternal and Child Health Care Hospital
NOT_YET_RECRUITINGYinchuan, Ningxia, China
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Yixian Maternal and Child Health Hospital
NOT_YET_RECRUITINGBaoding, Hebei, China
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Zaozhuang Maternal and Child Health Hospital
NOT_YET_RECRUITINGZaozhuang, Shandong, China
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Zhongning County People's Hospital
NOT_YET_RECRUITINGZhongwei, Ningxia, China
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Zhongwei People's Hospital
RECRUITINGZhongwei, Ningxia, China
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Zibo Maternal and Child Health Hospital
RECRUITINGZibo, Shandong, China
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Zoucheng People's Hospital
RECRUITINGZoucheng, Shandong, China
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Zouping People's Hospital
RECRUITINGZouping, Shandong, China
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