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Simple cuff therapy may sharpen brain blood flow in seniors

NCT ID NCT07179887

Knowledge-focused Sponsor: University of Nottingham Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether using a blood pressure cuff to create short periods of reduced blood flow in the arm can improve how the brain regulates its own blood supply. 45 healthy adults aged 65-85 will either do the therapy daily, three times a week, or a sham version for 6 weeks. Researchers will measure brain blood flow and other vascular health markers before and after.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Remote Ischaemic Conditioning (blood pressure cuff inflation cycles)
What this could lead to
If it works, this could point toward a simple, non-drug way to improve brain blood flow regulation in older adults.
What could go wrong
This is a small early study in healthy people, not patients. It only measures biomarkers, not health outcomes, so benefits are uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 to 85 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study * Participant aged 65 - 85 * Participant is able to perform RIC independently at home Exclusion Criteria: * Active cardiovascular or cerebrovascular disease (acute event within the last 12 months) * Atrial fibrillation or other significant arrhythmias * Peripheral Vascular Disease * Haemostatic disorders * Soft tissue injury or fracture to the upper limb * Pregnant or breast feeding * History or current psychiatric illness * History or current neurological condition (e.g. epilepsy) * Inability to identify temporal window for transcranial doppler ultrasound at screening visit * Any condition or presentation under current investigation that is deemed by the study clinician to exclude the participant from the study. * Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance

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Conditions

The condition(s) this trial relates to.

hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Blood pressure Cerebral autoregulation Dynamic cerebral autoregulation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • School of Medicine, University of Nottingham, Royal Derby Hospital Centre

    RECRUITING

    Derby, Derbyshire, DE22 3DT, United Kingdom

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