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Could water pills be the key to protecting kidneys and hearts?

NCT ID NCT05732727

Disease control Sponsor: University Hospital, Tours Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 04, 2026 · Updated 3 times

Summary

This phase 3 trial is testing whether a blood pressure treatment plan that focuses on diuretics (water pills) works better than usual care for people with moderate to severe chronic kidney disease and uncontrolled high blood pressure. The study will include 720 participants and track outcomes like kidney failure, heart problems, and death. The goal is to see if this approach can reduce serious complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
diuretics (water pills)
What this could lead to
If successful, this could provide a clearer, more effective treatment plan for controlling blood pressure in people with chronic kidney disease, potentially reducing the risk of kidney failure, heart problems, and death.
What could go wrong
This is a large phase 3 trial, but it is still testing a specific treatment algorithm. The results may not apply to all patients, and there is always a chance the diuretic-based approach is no better than standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 720 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2023

Expected to finish

Mar 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female \>=18 years with a clinical frailty score ≤5 for patient aged over 80 * Advanced or moderate chronic kidney disease (eGFR 15 to 44.9 mL/min/1.73m² using CKD-EPI formula) * Arterial hypertension treated with at least one blood pressure lowering drug therapy among blockers of the renin-angiotensin system (ACEi or ARB), at the maximal posology tolerated by the patients stable since at least one month. Other blood pressure lowering drug therapies are tolerated in combination with or in the event of intolerance to ACE inhibitors or ARBs. * Uncontrolled office BP * Uncontrolled office BP (\>140 and/or 90 mmHg) confirmed by home blood pressure monitoring (\>135 and/or 85 mmHg) or Day-time Ambulatory Blood Pressure Monitoring * Participant covered by or entitled to social security * Written informed consent obtained from the participant Exclusion Criteria: * Patient following any measures of legal presentation * Pregnant or breastfeeding woman * woman of childbearing without a highly effective contraceptive measure (combined or progestogen-only hormonal contraception associated with inhibition of ovulation, intrauterine device or intrauterine hormone-releasing system) * Clinical signs of hypovolemia * Symptomatic orthostatic hypotension * Hyponatremia (\<130 mmol/L) * Dyskalemia (\<3,5 mmol/L or \>5,5 mmol/L) * Major adverse cardiovascular event during the last three months: myocardial infarction, heart failure hospitalization, stroke * Current medical history of cancer requiring chemotherapy * Solid organ transplantation * Two or more diuretic agents (loop diuretic, thiazides and thiazide-like diuretics) * Mineralocorticoid receptor antagonists * Autosomal dominant polycystic kidney disease treated with Tolvaptan * Contraindication to diuretics involved in the algorithm * Severe heart failure (NYHA III\_IV) * Cirrhosis Child B-C

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic kidney disease (CKD) Uncontrolled hypertension

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    37 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AUB Santé foundation, Brest

    RECRUITING

    Brest, 29200, France

  • AUB Santé foundation, Lorient

    RECRUITING

    Lorient, 56100, France

  • Department of Nephrology, Bichat Hospital, AP-HP

    RECRUITING

    Paris, 75018, France

  • Department of Nephrology, Departemental Hospital of Vendée

    RECRUITING

    La Roche-sur-Yon, 85925, France

  • Department of Nephrology, European Hospital Georges Pompidou, AP-HP

    ACTIVE_NOT_RECRUITING

    Paris, 75015, France

  • Department of Nephrology, Hospital of Chalon-sur-Saône

    RECRUITING

    Chalon-sur-Saône, France

  • Department of Nephrology, Hospital of Chartres

    RECRUITING

    Chartres, 28630, France

  • Department of Nephrology, Hospital of Colmar

    RECRUITING

    Colmar, 68024, France

  • Department of Nephrology, Hospital of Haguenau

    RECRUITING

    Haguenau, 67500, France

  • Department of Nephrology, Hospital of Le Puy en Velay

    RECRUITING

    Le Puy-en-Velay, 43012, France

  • Department of Nephrology, Hospital of Orléans

    RECRUITING

    Orléans, 45067, France

  • Department of Nephrology, Hospital of Perpignan

    RECRUITING

    Perpignan, 66046, France

  • Department of Nephrology, Hospital of Roubaix

    RECRUITING

    Roubaix, 59100, France

  • Department of Nephrology, Hospital of Saint Malo

    RECRUITING

    St-Malo, 35400, France

  • Department of Nephrology, Hospital of Strasbourg

    RECRUITING

    Strasbourg, 67000, France

  • Department of Nephrology, Hospital of Valenciennes

    RECRUITING

    Valenciennes, 59322, France

  • Department of Nephrology, Necker Hospital, AP-HP

    RECRUITING

    Paris, 75015, France

  • Department of Nephrology, Regional Hospital of Metz

    RECRUITING

    Metz, 57085, France

  • Department of Nephrology, Régional Hospital of Mulhouse

    RECRUITING

    Mulhouse, 68100, France

  • Department of Nephrology, Tenon Hospital, AP-HP

    ACTIVE_NOT_RECRUITING

    Paris, 75020, France

  • Department of Nephrology, University Hospital of Angers

    RECRUITING

    Angers, 49933, France

  • Department of Nephrology, University Hospital of Bordeaux

    RECRUITING

    Bordeaux, 33000, France

  • Department of Nephrology, University Hospital of Brest

    RECRUITING

    Brest, 29200, France

  • Department of Nephrology, University Hospital of Clermont-Ferrand

    RECRUITING

    Clermont-Ferrand, 63001, France

  • Department of Nephrology, University Hospital of Grenoble

    RECRUITING

    Grenoble, 38043, France

  • Department of Nephrology, University Hospital of Lille

    RECRUITING

    Lille, 59000, France

  • Department of Nephrology, University Hospital of Limoges

    RECRUITING

    Limoges, 87042, France

  • Department of Nephrology, University Hospital of Lyon

    RECRUITING

    Lyon, 69003, France

  • Department of Nephrology, University Hospital of Marseille

    RECRUITING

    Marseille, 13005, France

  • Department of Nephrology, University Hospital of Nancy

    RECRUITING

    Vandœuvre-lès-Nancy, 54511, France

  • Department of Nephrology, University Hospital of Nantes

    RECRUITING

    Nantes, 44093, France

  • Department of Nephrology, University Hospital of Nîmes

    RECRUITING

    Nîmes, 30029, France

  • Department of Nephrology, University Hospital of Reims

    RECRUITING

    Reims, 51092, France

  • Department of Nephrology, University Hospital of Rennes

    RECRUITING

    Rennes, 35033, France

  • Department of Nephrology, University Hospital of Rouen

    RECRUITING

    Rouen, 76230, France

  • Department of Nephrology, University Hospital of Saint Etienne

    RECRUITING

    Saint-Etienne, 42270, France

  • Department of Nephrology, University Hospital of Tours

    RECRUITING

    Tours, 37044, France

  • ECHO Santé Association, Le Mans

    RECRUITING

    Le Mans, 72100, France

  • ECHO Santé Association, Nantes

    RECRUITING

    Nantes, 44402, France

  • ECHO Santé Association, Saint Herblain

    ACTIVE_NOT_RECRUITING

    Saint-Herblain, 44819, France

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