Gut hormone may control Post-Meal blood pressure drops
NCT ID NCT06934473
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looks at how a natural gut hormone called GIP affects blood pressure after a meal. Sixteen healthy adults will receive either a GIP-blocking drug, a GIP-activating drug, or a placebo during a tilt-table test. The goal is to see if blocking or boosting GIP changes how blood pressure responds after eating.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- GIP(3-30)NH2 (a blocker of the GIP hormone receptor) and GIP(1-42) (an activator of the GIP hormone receptor)
- What this could lead to
- If successful, this could clarify how the gut hormone GIP influences blood pressure after meals, potentially pointing toward new ways to manage dizziness or fainting.
- What could go wrong
- This is a very small, early-stage study in healthy volunteers, not patients. It is designed to understand basic biology, not to test a treatment. Results may not apply to people with blood pressure problems.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 16 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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May 2025
- Expected to finish
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Jan 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age 18-40 years 2. BMI between 18.5 and 29.9 kg/m2 (both included) 3. Informed consent Exclusion Criteria: 1. Allergy or intolerance to ingredients included in the mixed meal 2. History of Orthostatic Hypotension (OH) or Postural Orthostatic Tachycardia Syndrome (POTS) or other autonomic dysfunction at the discretion of the investigators 3. Anaemia (haemoglobin below normal range \<7.3 mmol/L for women and \<8.3 mmol/L for men) 4. Kidney disease (estimated glomerular filtration rate (eGFR) \<90 ml/min/1.73 m2) at screening 5. Known liver disease and/or elevated plasma alanine aminotransferase (ALT) \> three times the upper limit of normal at screening 6. Treatment with antihypertensives 7. Treatment with GLP-1RA (Glucagon-like Peptide-1 Receptor Agonist) 8. Treatment with SNRI (Serotonin and Noradrenalin Reuptake Inhibitor) or treatment within two weeks before the first experimental day 9. Any ongoing medication that the investigator evaluates would interfere with trial participation 10. Any physical or psychological condition that the investigator evaluates would interfere with trial participation, including any acute or chronic illnesses 11. Any concomitant disease or treatment that, at the discretion of the investigators, might jeopardize the participant's safety during the trial 12. Alcohol/drug abuse as per discretion of the investigators 13. Pregnancy or breastfeeding 14. Participation in any other clinical trial during the study period 15. Mental incapacity or language barriers that preclude adequate understanding or cooperation or unwillingness to comply with trial requirements or pr discretion of the investigator
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Center for Clinical Metabolic Research
NOT_YET_RECRUITINGCopenhagen, Hellerup, 2900, Denmark
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Center for Clinical Metabolic Research
RECRUITINGCopenhagen, Hellerup, 2900, Denmark