Esophageal disorder

This study looks at whether adding two immunotherapy drugs, nivolumab and ipilimumab, to standard chemotherapy and radiation helps people with esophageal or gastroesophageal junction cancer before and after surgery. About 278 adults with stage II to IVA cancer will take part. The…

This phase 2 trial explores whether adding low-dose radiotherapy and an immunotherapy drug (retlirafusp alfa) to standard chemotherapy before surgery can improve outcomes for people with a type of esophageal cancer that has spread locally but can still be removed. The study enrol…

This study tests whether adding the drug cixutumumab to standard chemotherapy (paclitaxel) can help people with advanced esophageal or stomach-junction cancer live longer without their cancer growing. About 94 adults whose cancer has spread and who have already tried one treatmen…

This study tests whether combining new drugs with or without chemotherapy can safely control advanced stomach, GEJ, or esophageal cancer. About 332 adults with inoperable or metastatic disease will receive different treatment combinations. The goal is to find more effective optio…

This early-phase trial is testing an experimental drug called AB598, alone or with other cancer drugs, in 40 people with advanced solid tumors like lung, bladder, or breast cancer. The main goal is to check safety and find the right dose. It is not yet known if the drug helps shr…

This study tests dupilumab, an injectable drug already used for allergies, in 22 adults and teens with eosinophilic gastritis (stomach inflammation caused by too many white blood cells). The goal is to see if it reduces inflammation and improves symptoms over 6 months to a year. …

This study tests whether a new drug called zanidatamab, combined with chemotherapy and sometimes another drug (tislelizumab), works better than the current standard treatment for advanced HER2-positive stomach and esophageal cancers. About 920 adults whose cancer has spread or ca…

This study tests a once-daily pill called vonoprazan against a placebo in 80 adults with eosinophilic esophagitis (EoE), a condition that makes swallowing difficult. The main goal is to see if the drug reduces inflammation in the esophagus after 12 weeks. Researchers will also ch…

This early-phase trial tests whether giving chemoradiation plus the immunotherapy drug pembrolizumab, followed by pembrolizumab and lenvatinib before surgery, can kill more cancer cells in people with esophageal or gastroesophageal junction cancer that hasn't spread. The study in…

This phase II trial tests whether adding cabozantinib to the immunotherapy drug nivolumab can prevent mucosal melanoma from returning after surgery. About 101 patients with resected mucosal melanoma will receive either nivolumab alone or nivolumab plus cabozantinib. The study aim…

This early-phase trial tests whether adding a cancer-killing virus called OBP-301 to standard chemotherapy and radiation is safe for people with advanced esophageal or gastroesophageal cancer who cannot have surgery. The virus is designed to infect and destroy tumor cells. Sixtee…

This early-phase trial tests an experimental drug called IPH5301, which targets a protein called CD73 on cancer cells. The study involves 27 people with advanced solid tumors, including breast, lung, and pancreatic cancers. In the first part, IPH5301 is given alone to find a safe…

This early-stage trial tested a drug called adavosertib together with radiation therapy for people with advanced esophageal or stomach cancer that cannot be surgically removed. The goal was to find the safest dose and see how well the combination works. Only 4 people took part, s…

This early-phase trial investigates whether itraconazole, a common antifungal medication, can reduce the risk of cancer in people with high-risk Barrett's esophagus who have already undergone endoscopic ablation. Barrett's esophagus often returns after treatment, increasing the c…

This early-phase study tests the safety and best dose of a drug called veliparib when given with two chemotherapy drugs (carboplatin and paclitaxel) in people with advanced solid tumors that have spread or can't be removed. It includes patients who also have liver or kidney probl…

This phase 2 trial tests whether taking aspirin can prevent Barrett's esophagus from returning after it has been successfully removed with radiofrequency ablation. Researchers will measure levels of a protein linked to Barrett's in tissue samples from 21 participants over 12 mont…

This phase 2 trial is testing a combination of two immunotherapy drugs, nivolumab and ipilimumab, in 798 people with over 50 types of rare cancers. The goal is to see if these drugs can shrink tumors by helping the immune system attack cancer cells. Participants receive the drugs…

This phase III trial is testing whether adding radiotherapy to standard chemotherapy improves survival in patients with HER2 negative esophageal or gastric cancer that has spread to a few other spots in the body (oligometastatic). About 314 participants will receive either chemot…

This early-phase study tests a new drug, RO7247669, that targets two immune system checkpoints (PD-1 and LAG-3) to help the body fight cancer. About 170 adults with advanced solid tumors (including melanoma, lung cancer, and esophageal cancer) who have run out of standard options…

This study tests whether a minimally invasive procedure called Transoral Incisionless Fundoplication (TIF) can reduce acid reflux and prevent Barrett's esophagus from coming back after successful ablation. Barrett's esophagus is a precancerous condition where the lining of the es…

This phase 2 trial is testing whether adding the drug neratinib to a standard combination of chemotherapy, trastuzumab, and pembrolizumab can shrink tumors in people with HER2-positive gastroesophageal cancers. The study includes 8 participants and aims to measure how many respon…

This early-phase trial tests several new drug combinations in people with advanced solid tumors (like stomach, ovarian, or liver cancer) that have spread and stopped responding to standard treatments. The goal is to find the safest dose and see if the drugs can help control the c…

This early-phase study tests a new drug called RNDO-564, alone or with pembrolizumab, in adults with advanced solid tumors (like bladder, lung, or breast cancer) that have stopped responding to standard treatments. The main goals are to check safety, find the best dose, and see i…

This study tests a freezing device (CryoBalloon) to treat Barrett's esophagus that hasn't improved after multiple standard heat treatments. About 70 adults with precancerous changes in the esophagus will receive the freezing therapy. The goal is to safely remove all abnormal tiss…

This study tests a special vacuum device placed inside the esophagus right after cancer surgery to prevent dangerous leaks where the stomach is reconnected to the esophagus. About 44 adults having minimally invasive esophageal cancer surgery will receive this preventive treatment…

This study looks at whether removing four common foods (dairy, wheat, egg, soy) from the diet can help children with eosinophilic esophagitis (EoE). The goal is to reduce symptoms like vomiting and trouble swallowing, and to find which foods trigger the condition. About 64 childr…

This registry follows 500 adults who receive the LINX device, a ring of magnetic beads implanted around the esophagus to help keep stomach acid down. The goal is to check for safety issues like device movement, erosion, or swallowing problems over up to 10 years. Participants wil…

This study looks at whether simply removing cow's milk from the diet can control eosinophilic esophagitis (EoE) in children aged 1 to 18. EoE is a condition where the esophagus becomes inflamed, often causing trouble swallowing. The trial will check if this diet change leads to l…

This early-phase study tests a personalized cell therapy for people with certain cancers (bladder, melanoma, head/neck, ovarian, lung, esophageal, stomach, or sarcoma) whose tumors have a specific marker called MAGE-A4. The treatment involves taking a patient's own immune cells, …

This study tests whether a special immune-boosting diet given before surgery can lower the risk of complications like infections and digestive issues in people with esophageal cancer. About 244 participants who have had chemotherapy and radiation will receive either the special d…

This phase 3 study tests whether a new combination of two immunotherapy drugs (domvanalimab and zimberelimab) plus chemotherapy works better than the current standard (nivolumab plus chemotherapy) for people with advanced stomach, gastroesophageal junction, or esophageal cancer t…

This study tests whether a structured program of dietary changes, lifestyle adjustments, and nutrient correction can reduce reflux symptoms in patients who had POEM surgery for achalasia. Many patients develop GERD after POEM and rely on long-term acid-reducing medications. The t…

This treatment program tests a personalized cell therapy for people with advanced pancreatic or colorectal cancers that have a specific genetic mutation (KRAS G12D). Patients' own immune cells are collected, genetically engineered to recognize and attack the cancer, and then infu…

This study was designed to see if a new drug called linaprazan glurate could keep the esophagus healed in people with GERD-related erosive esophagitis, compared to an existing drug (lansoprazole). Participants would have taken daily pills for up to 52 weeks and had regular camera…

This early-stage trial tests two experimental mRNA therapies (mRNA-4106 and mRNA-4200) in 42 people with advanced solid tumors like melanoma, lung, or liver cancer. Some participants receive the mRNA therapy alone, others get it combined with the immunotherapy drug pembrolizumab.…

This study tests a device that freezes abnormal cells in the esophagus to treat Barrett's esophagus, a condition that can lead to cancer. About 62 adults with low- or high-grade dysplasia (precancerous changes) will receive the treatment. The goal is to see if the freezing balloo…

This study tests whether a PD-1 inhibitor (INCMGA00012) can help prevent esophageal cancer from returning after standard chemoradiation. About 110 adults with locally advanced esophageal squamous cell carcinoma who completed chemoradiation without progression will be randomly ass…

This study tests a treatment called photodynamic therapy (PDT) for people whose superficial esophageal cancer has come back or remained after standard treatments. Patients receive an injection of hematoporphyrin, a drug that makes cancer cells sensitive to light, then a laser is …

This phase 2 trial tests whether giving the immune checkpoint inhibitor IMC-001 before surgery can shrink tumors in people with resectable gastric, esophageal, or liver cancer. About 48 participants will receive two cycles of the drug, then undergo surgery. The main goal is to se…

This early-stage trial tests a new drug called LY4101174 in people with advanced solid tumors, including bladder, breast, and lung cancers. The drug is an antibody-drug conjugate designed to target and kill cancer cells. The study will check if the drug is safe, tolerable, and ef…

This phase 3 trial tests whether adding the immunotherapy drug durvalumab to standard chemoradiation helps people with advanced esophageal cancer that cannot be removed by surgery. About 640 participants will receive either durvalumab or a placebo alongside their cancer treatment…

This phase 2 trial is testing a five-drug combination for people with advanced esophageal, stomach, or gastroesophageal junction cancer that has worsened after initial treatment. The combination includes immune cells from healthy donors, two immunotherapy drugs, and two standard …

This phase 3 trial tests whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard chemoradiotherapy helps people with esophageal cancer live longer and delay recurrence. About 700 participants who cannot have surgery will receive either pembrolizumab or a placeb…

This early-stage study is testing whether a combination of endoscopic surgery, chemotherapy, radiation, and an immunotherapy drug (durvalumab) can safely treat early esophageal cancer without removing the esophagus. Eleven patients with stage T1b or T2 cancer who cannot or choose…

This study tests whether adding a pill called vactosertib to standard chemoradiotherapy can improve outcomes for people with esophageal cancer. Participants take vactosertib for two weeks before and after standard treatment, then undergo surgery. The goal is to see if the drug he…

This study is testing a new device called the Edwards EVOQUE system, which replaces the tricuspid valve using a thin tube (catheter) instead of open-heart surgery. The trial includes 228 people with moderate or severe tricuspid regurgitation who still have symptoms despite medica…

This study tests a new device called the Luso-Cor esophageal stent for closing leaks (fistulas) that can happen after weight-loss or cancer surgery on the stomach or esophagus. About 180 adults will be enrolled and their outcomes compared to those treated with standard stents or …

This study is testing whether adding two immunotherapy drugs (atezolizumab and tiragolumab) to standard chemotherapy before surgery can help control esophageal or gastroesophageal cancer. About 43 adults with stage II or III cancer will receive the drug combination, then undergo …

This study compares two treatments for eosinophilic esophagitis (EoE): swallowed budesonide (Eohilia) and injected dupilumab (Dupixent). Researchers want to see which one better improves esophageal diameter and reduces scarring after 12 weeks. The trial enrolls 60 adults with act…

This study tests whether beta-blockers, a type of blood pressure medicine, can reduce the risk of bleeding from small varices in people with cirrhosis and portal hypertension. About 763 adults with small varices will receive either beta-blockers or a placebo for up to 3 years. Th…

This early-phase trial is testing a new drug called NTX-1088, which targets a protein on cancer cells, either alone or combined with the immunotherapy pembrolizumab. The study involves 90 people with advanced solid tumors that have spread or cannot be removed. The main goals are …

This study looks at how well dupilumab, an already approved drug, works for people with severe eosinophilic esophagitis (EoE) that has caused narrowing of the esophagus. About 23 participants aged 16 and older will receive weekly injections of dupilumab for one year. The goal is …

This phase II trial tests whether adding an immunotherapy drug (sintilimab) and immune-supporting agents to a medium-dose chemo-radiation regimen can improve outcomes for people with advanced esophageal cancer. About 50 participants will receive the combination, along with probio…

This study tests a new medicine called raludotatug deruxtecan in about 160 adults with advanced gastrointestinal cancers (pancreatic, bile duct, gallbladder, colorectal, stomach, or gastroesophageal junction). The drug is designed to attach to cancer cells and deliver a treatment…

This study tests a new drug called cadonilimab, combined with chemotherapy and radiation, for people with advanced esophageal cancer that cannot be removed by surgery. The goal is to see if this combination can better control the cancer and prevent it from coming back. About 46 p…

This study tests an experimental drug called tezepelumab in people aged 12 to 80 with eosinophilic esophagitis, a condition where white blood cells build up in the esophagus, causing trouble swallowing. Participants receive either the drug or a placebo as a shot under the skin. T…

This study examines whether placing a feeding tube before chemotherapy helps prevent muscle loss in people with advanced esophageal cancer. About 60 adults receiving treatment with a goal to cure will be followed. Researchers will compare muscle mass at diagnosis, before surgery,…

This study is for people with HER2-positive esophageal or gastroesophageal junction cancer who have already completed chemoradiation and surgery. The goal is to see if adding a year of treatment with trastuzumab deruxtecan (Enhertu) plus nivolumab is safe and helps prevent the ca…

This phase 3 study tests two doses of Nexium (esomeprazole) in 53 children aged 1 to 11 years who have erosive esophagitis, a condition where stomach acid damages the esophagus. The goal is to see which dose better maintains healing after an initial 8-week treatment period. Child…

This phase 3 trial tests a new drug called BL-B01D1 against standard chemotherapy for people with advanced esophageal cancer that has worsened after initial treatment. About 497 participants will receive either the new drug or one of several chemotherapies. The goal is to see if …

This early-phase trial tests a new drug called ALK-N001 in people with advanced solid tumors, including esophageal, lung, and stomach cancers. The main goals are to check safety, find the right dose, and see how the drug moves through the body. Only 16 participants were enrolled,…

This study tests whether adding tiragolumab to atezolizumab can help control esophageal cancer that hasn't grown after standard chemoradiotherapy. About 760 adults with inoperable esophageal squamous cell carcinoma will receive either the drug combination, atezolizumab alone, or …

This study looks at whether adding a small bypass (gastroenteroanastomosis) to the standard sleeve gastrectomy can prevent or reduce acid reflux in people with obesity. Sixty patients will be split into two groups: one gets the added bypass, the other does not. Researchers will c…

This pilot study tests whether giving a combination of two immunotherapy drugs (nivolumab and ipilimumab) along with chemotherapy and radiation therapy before surgery can help treat stomach cancer that can be surgically removed. The study includes 32 participants and primarily lo…

This early-phase trial tests a freezing treatment called cryotherapy, given before and during standard chemoradiation, for people with locally advanced esophageal cancer. The main goal is to find the safest number of cryotherapy sessions. Researchers will also check if the freezi…

This study compares two radiation methods—proton beam therapy and standard intensity-modulated radiation therapy—for people with esophageal cancer. Both are given alongside chemotherapy. The goal is to see if the newer proton therapy is safer and more effective at controlling the…

This study tests a new device called the Edwards EVOQUE eos mitral valve replacement system. It is for people with a leaky mitral valve who are too high-risk for open-heart surgery. The study will check if the device is safe and works well by looking at complications, heart funct…

This study tests a new drug called futibatinib combined with standard immunotherapy and chemotherapy in people with advanced esophageal or pancreatic cancer. The goal is to see if the combination can shrink tumors and control the disease. About 53 adults who have not had prior tr…

This study tests whether adding the immunotherapy drug toripalimab to standard chemotherapy before and after surgery helps people with a certain type of advanced esophageal cancer. About 663 participants will receive either toripalimab plus chemo or a placebo plus chemo. The goal…

This early-phase trial tests a new drug called AI-061, which combines two immune-boosting antibodies (anti-PD-1 and anti-CTLA-4) into one treatment. The study will enroll 18 adults with advanced solid tumors that have spread or cannot be removed. The main goals are to find a safe…

This phase 2 trial tests different chemotherapy combinations for people with advanced stomach or esophageal cancer that has spread or cannot be removed. The study compares a new liposomal form of irinotecan plus other drugs against standard treatments to see which works best at s…

This early-stage trial tests a personalized cell therapy called ADP-A2M4CD8 in people with certain cancers that have a specific marker (MAGE-A4). The therapy uses a patient's own immune cells, modified to better attack tumors, and is given alone or with standard immunotherapy dru…

This early-phase trial tests two experimental vaccines (ChAdOx1 and MVA) designed to help the immune system target cancer proteins MAGE-A3 and NY-ESO-1. About 15 adults with advanced non-small cell lung cancer or squamous esophageal cancer will receive the vaccines alongside thei…

This early-phase trial tests whether combining two drugs—camrelizumab (an immunotherapy) and palbociclib (a targeted therapy)—is safe and feasible when given before surgery for esophageal cancer. Six adults with resectable esophageal squamous cell carcinoma will receive the drugs…

This study looks at whether giving pantoprazole (a stomach acid reducer) after endoscopic treatment for enlarged veins in the esophagus or stomach can lower the chance of bleeding in people with liver cirrhosis. About 208 adults will take part. The goal is to see if short-term us…

This pilot trial tests whether using a patient's genetic profile to determine the dose of irinotecan (a chemotherapy drug) can improve outcomes for people with advanced stomach or esophageal cancer. The study combines chemotherapy before and after surgery, with the goal of increa…

This study looks at whether adding a special balloon-based internal radiation treatment after standard chemoradiation can lower the chance of the tumor coming back in people with esophageal cancer who chose not to have surgery. About 18 adults aged 20-85 with stage I-III esophage…

This study tests whether giving immunotherapy drugs (nivolumab alone or with relatlimab) before standard chemoradiation is safe and feasible for people with operable stage II/III esophageal or gastroesophageal junction cancer. About 32 adults will receive the drugs, then chemorad…

This early-stage study tests a new drug called DS-1055a in about 40 adults with advanced solid tumors (like head and neck, stomach, or lung cancer) that have come back or spread and no longer respond to standard treatments. The main goal is to check the drug's safety and find the…

This study tests an experimental drug called NSI-8226 (solrikitug) in adults with eosinophilic esophagitis, a condition that causes trouble swallowing due to inflamed esophagus. About 184 participants will receive either the drug or a placebo to see if it reduces inflammation and…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy and radiation can help people with a certain type of esophageal cancer. The trial involves 42 adults whose cancer has not spread far but is locally advanced. The main goal is to see if t…

This study looks at 70 people with liver cancer who had bleeding from enlarged veins in the esophagus. It compares two procedures—an ultrasound-guided injection of a glue-like substance versus a banding technique—to see which better prevents future bleeding. The goal is to find t…

This study looks at whether children with eosinophilic esophagitis (EoE) can safely cut their steroid dose in half and still stay in remission. The 50 participants have already achieved remission on a full dose of topical steroids like fluticasone or budesonide. Researchers will …

This early-phase trial tests a new type of cell therapy for children and young adults with solid tumors that have come back or not responded to standard treatments. The therapy uses a patient's own immune cells, which are trained in the lab to recognize and attack multiple cancer…

This study tests whether avatrombopag, a pill that boosts platelet production, can help people with gastrointestinal cancer who develop low platelets from chemotherapy. About 60 participants will receive either avatrombopag or a placebo. The goal is to see if the drug can raise p…

This study tests an experimental drug, YL201, in about 990 people with advanced solid tumors like lung, prostate, and liver cancers. The goal is to check safety and see if tumors shrink. It is an early-stage trial, so the drug is not yet proven to work.

This study looks at whether ablation therapy (using heat or light to destroy abnormal cells) can control Barrett's esophagus, a condition that can lead to esophageal cancer. About 600 adults with high-grade dysplasia or early cancer will be treated and followed to see if the abno…

This phase 1/2 trial tests a vaccine made from two viruses designed to target and kill cancer cells that have a specific protein called MAGE-A3. The viruses are given to 56 people with advanced solid tumours that have not responded to other treatments. The goal is to see if the v…

This early-stage study tests a new drug called E7389 liposomal formulation in people with advanced solid tumors that have not responded to standard treatments. The main goal is to find the safest dose and check for side effects. The study also looks at how the drug works in speci…

This phase 3 trial compares a new drug, MK-2870, against standard treatments for people with advanced stomach, gastroesophageal junction, or esophageal cancer that has spread and not responded to prior therapies. About 450 participants will be randomly assigned to receive either …

This phase 2 trial tests a combination of two chemotherapy drugs (carboplatin and nab-paclitaxel) plus an immunotherapy drug (durvalumab) given before surgery for people with locally advanced head and neck cancer. The goal is to shrink or eliminate the tumor so that radiation—whi…

This study tests an experimental oral drug called Q702 combined with the immunotherapy pembrolizumab (Keytruda) in people with advanced esophageal, stomach, liver, or cervical cancer that has worsened after prior treatment. The goal is to see if the combination is safe and can sh…

This study is testing a drug called tucatinib combined with other cancer medicines (trastuzumab, chemotherapy, and pembrolizumab) in people with HER2-positive cancers of the digestive system. The main goals are to find safe doses and see what side effects occur. About 40 adults w…

This study tests a new way for cancer doctors and primary care doctors to work together to help cancer survivors manage other health problems like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers and at least one of these conditions will …

This early-stage trial aimed to test a new drug called S095033 combined with the chemotherapy paclitaxel in people with advanced or metastatic esophageal squamous cell carcinoma. The goal was to check safety, tolerability, and signs of tumor shrinkage. However, the study was with…

This early-phase study tests an experimental drug called MCLA-129, a bispecific antibody that targets two cancer-related proteins (EGFR and c-MET). It is for people with advanced non-small cell lung cancer, gastric cancer, esophageal cancer, head and neck cancer, or colorectal ca…

This study is tracking 5,000 adults with achalasia, a condition where the esophagus fails to relax and push food into the stomach. All participants are treated with POEM, a procedure that uses an endoscope to cut the tight muscle without any incisions on the body. Researchers wil…

This study tracks the safety and effectiveness of a procedure called TIF 2.0, which tightens the valve between the stomach and esophagus without any cuts. About 500 adults with acid reflux or throat reflux will be followed to see if their symptoms improve and if they can reduce o…

This study tests a new drug combination (E7389 liposomal formulation plus nivolumab) in 125 people with advanced solid tumors that have not responded to standard treatments. The goal is to find the safest dose and see if the combination can shrink tumors. The study is for people …

This study tests a combination of two drugs, abemaciclib and ramucirumab, in people with advanced esophageal or gastroesophageal junction cancer that has spread. The goal is to see if this treatment is safe and can help control tumor growth. About 8 participants are enrolled, and…

This study tests a new treatment plan for people with advanced esophageal cancer that cannot be surgically removed. Participants first receive immunotherapy plus chemotherapy, followed by chemoradiation. The goal is to see if this approach improves survival and controls the disea…

This phase 2 trial tests whether combining two immune-boosting drugs (ipromlimab and tuvonralimab) with standard chemotherapy before surgery can help shrink tumors in people with locally advanced esophageal cancer. The study involves 62 participants and is currently active but no…

This study looks at whether a blood test that finds tiny traces of cancer DNA (called ctDNA-MRD) can help doctors decide who needs more treatment after standard chemoradiation for advanced esophageal cancer. About 65 people with unresectable cancer will get extra immunotherapy an…

This study tests whether carvedilol, a newer blood pressure drug, works better than the standard drug propranolol for preventing another bleeding episode in people with liver cirrhosis who have already had variceal bleeding. Both drugs are given alongside a procedure to tie off s…

This study tests whether injecting platelet-rich plasma (PRP) during hiatal hernia repair can lower the chance of the hernia coming back. About 150 adults with large hiatal hernias will be randomly assigned to get either standard surgery with mesh or surgery plus PRP. The main go…

This early-phase trial tests an investigational drug called ABBV-400 in about 300 adults with advanced solid tumors, including liver, pancreatic, breast, and ovarian cancers. The study aims to see if the drug can shrink tumors and to check for side effects. Participants receive A…

This study tests adding two drugs, nivolumab and cetuximab, to standard chemoradiation for people with a type of esophageal cancer that hasn't spread far. The goal is to see if this combination can make tumors disappear before surgery. The study involves 12 adults who haven't had…

This phase 2 trial is testing a two-step treatment for esophageal cancer. First, patients receive a chemotherapy combination called FLOT, followed by chemoradiation (chemo plus radiation). After that, they have surgery to remove the tumor. The goal is to see if this approach lead…

This early-phase trial tests a new approach for people with locally advanced esophageal cancer. Before surgery, patients receive proton beam radiotherapy along with two chemotherapy drugs (carboplatin and paclitaxel). The main goal is to find the safest dose and see how well pati…

This study tests whether giving immunotherapy before surgery can help people with MSI/dMMR tumors. The goal is to shrink or eliminate the tumor before it is removed, potentially improving survival. The trial includes adults with localized, resectable cancers such as colorectal, g…

This phase II trial tests whether adding two targeted drugs (nimotuzumab and camrelizumab) to standard chemotherapy before surgery can improve outcomes for people with locally advanced esophageal cancer. About 48 participants will be randomly assigned to receive the combination o…

This phase 3 trial tests whether adding immunotherapy (sintilimab) and chemotherapy before standard chemoradiotherapy helps people with inoperable esophageal cancer live longer and reduces the chance of the cancer coming back. About 242 adults aged 18-75 with stage 2-4 esophageal…

This study tests a medication called dupilumab in 69 adults with eosinophilic esophagitis, a condition that makes swallowing difficult due to inflammation and scarring in the esophagus. Participants receive either dupilumab or a placebo for 24 weeks, then everyone gets dupilumab …

This study tests whether adding lenvatinib to pembrolizumab and chemotherapy helps people with metastatic esophageal cancer live longer. About 864 participants receive either the new three-drug combo or standard care. The goal is to improve overall survival, but this is not a cur…

This early-phase trial is testing a new treatment called LB1908, which uses a patient's own immune cells (T-cells) that have been modified in the lab to recognize and attack cancer cells that have a protein called claudin 18.2 on their surface. The study includes up to 56 adults …

This early-phase trial is testing a personalized vaccine made from a patient's own tumor proteins. The goal is to see if it's safe and can help prevent esophageal cancer from coming back after surgery and standard therapy. 27 patients who have completed initial treatments will re…

This study tests whether adding the drug serplulimab to standard chemotherapy before surgery can help people with a certain type of esophageal cancer. The goal is to shrink tumors more effectively and lower the chance of cancer coming back. About 48 adults with stage II to IVA es…

This early-phase trial tests a personalized cell therapy called TBI-1301 for people with advanced solid tumors that express a protein called NY-ESO-1. Patients' own T cells are collected, genetically modified in a lab to better recognize and attack cancer cells, and then infused …

This early-phase trial is testing a combination of two immunotherapy drugs, naptumomab estafenatox and durvalumab, in 120 people with advanced or metastatic solid tumors like pancreatic, ovarian, and lung cancer. The main goal is to find a safe dose and see how the body reacts. R…

This phase 2 study tests whether adding the immunotherapy drug tislelizumab to chemotherapy after standard chemoradiation can improve outcomes for people with locally advanced esophageal cancer who are at high risk. About 80 participants will receive the combination before surger…

This early-phase study tests whether combining the immunotherapy drug camrelizumab with standard radiation before surgery can help shrink tumors in people with esophageal cancer. About 25 patients will receive the combination, then undergo surgery 4-8 weeks later. Researchers wil…

This phase 2 trial tests whether adding the drug apatinib to standard chemotherapy and radiation helps people with advanced esophageal cancer that cannot be removed by surgery. About 170 participants will receive either the standard treatment or the standard treatment plus apatin…

This study tests a drug called sacituzumab govitecan in 53 adults with advanced solid tumors that have not responded to standard treatments. The main goal is to see if the drug can shrink tumors. Researchers will also track how long any response lasts and how well the drug contro…

This study tests a new drug called BT8009, alone or with another drug (pembrolizumab), in people with advanced solid tumors like bladder, breast, lung, or ovarian cancer. The drug targets a protein called Nectin-4 found on some cancer cells. The trial aims to find safe doses and …

This early-phase study tests whether giving healthy donor NK cells along with two medicines (vactosertib and IL-2) is safe and helps the cells stay active in people with advanced colorectal, stomach, esophageal, or blood cancers. The NK cells are meant to attack cancer, but the b…

This early-phase trial tests a new antibody drug called IMT-009, given alone or with the cancer pill fruquintinib, in about 67 people with advanced solid tumors or lymphomas that have stopped responding to standard treatments. The main goals are to find a safe dose, understand si…

This study looks at whether a special drink made with easily digested protein and MCT oil can help improve malnutrition in cancer patients who are having radiotherapy. The study will follow 132 adults with head and neck, lung, rectal, or esophageal cancer for 12 weeks. Researcher…

This program offers APT-1011, a fluticasone tablet that dissolves in the mouth, to patients aged 12 and older with eosinophilic esophagitis who cannot join other studies or have not responded to available treatments. The goal is to provide access until the drug is commercially av…

This study tests a combination of two drugs, SI-B001 and irinotecan, in people with advanced esophageal cancer that has come back or spread. The goal is to see if the combo can shrink tumors and control the disease. About 22 adults who have already tried standard treatments are t…

This study is testing a new combination treatment for non-erosive reflux disease (NERD), a common form of GERD that causes heartburn and other symptoms. The treatment adds therapies to strengthen the esophagus's natural barrier on top of standard acid-reducing medication. Researc…

This small study tests an endoscopic procedure that uses band ligation to tighten the lower esophagus and upper stomach, aiming to reduce acid reflux in people who had gastric sleeve surgery. Twelve participants will undergo the procedure and be monitored for six months to see if…

This early study tests a small, permanent device called the Omega-Cuff in 8 adults with GERD. Placed around the weak esophageal sphincter during keyhole surgery, it aims to block acid from backing up while allowing food to pass normally. Researchers will check safety, acid levels…

This phase II trial is testing whether giving a chemotherapy combination called mFOLFOX6 before the usual chemoradiation and surgery can help prevent esophageal cancer from returning. The study involves 40 adults with locally advanced esophageal cancer that can be surgically remo…

This study tests adding the immunotherapy drug durvalumab to standard chemoradiation for people with esophageal or gastroesophageal junction cancer. About 64 participants will receive the combination to see if it is safe and effective. The goal is to improve cancer control withou…

This Phase 2 trial tests whether adding an experimental immunotherapy drug (SHR-8068) to a standard immunotherapy (adebrelimab) plus chemotherapy can shrink tumors better than standard treatment alone in people with advanced stomach or esophageal cancer. About 153 participants wi…

This phase 1 trial is testing a new imaging tracer called 68Ga-FAPI-46 to see where it collects in normal and cancerous tissues. About 30 people with various solid tumors or blood cancers will receive the tracer and then undergo a PET/CT scan. The goal is to understand how the tr…

This study is testing a new, less invasive device that measures the health of the esophagus in people with acid reflux (GERD). Researchers will compare two versions of the device in 75 patients undergoing routine endoscopy. The goal is to see if this technology can diagnose GERD …

This study tests two AI models that analyze endoscopy and CT images to diagnose esophageal cancer and predict how deep the tumor has grown. The goal is to help doctors decide if a patient can be treated with a less invasive endoscopic procedure or needs more aggressive therapy. T…

This study looks at whether artificial intelligence can accurately determine the depth of early esophageal cancer from endoscopic images. Researchers will review past records and images from 890 patients who had their tumors removed. The goal is to see if AI can help doctors deci…

This study tests a new, less invasive device called the Esophageal String Test (EST) to diagnose and monitor a rare condition called eosinophilic esophagitis (EoE). Instead of using a scope with a biopsy, patients swallow a small string that collects samples from the esophagus. T…

This study is testing a simple, less invasive way to detect Barrett's esophagus and esophageal cancer using a sponge on a string. Participants swallow the sponge, which collects cells from the esophagus. Researchers will analyze these cells to develop a lab test that can spot ear…

This study tests a new magnetic tracer, FerroTrace, to find sentinel lymph nodes in people with stomach or esophageal cancer. About 60 participants will receive the tracer before standard treatment, and doctors will compare its accuracy to current methods. The goal is to see if t…

This study tests a device called Endosign, which is a sponge on a string that patients swallow to collect cells from the esophagus. The goal is to see if this simple, non-sedation method can provide good enough samples to replace regular endoscopies for monitoring Barrett's esoph…

This study looks at whether a simple, swallowable device can help screen for esophageal cancer in rural Oregon, where getting a traditional endoscopy is hard. About 110 adults with chronic heartburn and other risk factors will try the device at their local clinic. Researchers wan…

This study tests whether a 4-week course of vonoprazan, a stronger acid blocker, can help identify which patients with persistent heartburn actually have acid reflux. About 100 adults with symptoms that don't improve on standard treatment will take the drug and complete symptom q…

This study is testing a new, less invasive way to screen for Barrett's esophagus, a condition that can lead to esophageal cancer. Participants swallow a small capsule attached to a thin string, which takes pictures of the esophagus. The goal is to see if this method is comfortabl…

This study tests a special imaging capsule (OFDI) that patients swallow to take detailed pictures of the esophagus. The goal is to see if it can accurately detect Barrett's esophagus, a condition that can lead to cancer. Researchers will compare the capsule's images with standard…

This study looks at whether feeding preterm babies (weighing less than 3.3 pounds) through a tube placed past the stomach can prevent small amounts of stomach fluid from getting into their lungs. The goal is to reduce lung inflammation. About 46 babies on breathing machines will …

This study tests whether using telemedicine and remote monitoring can help people with advanced digestive cancers manage chemotherapy side effects at home, reducing the need for emergency room visits and hospital stays. About 750 patients and their caregivers will receive enhance…

This study looks at whether speech therapy can reduce air-related symptoms like belching and bloating in people with GERD. Researchers will compare symptoms before and after therapy in 100 adults. The goal is to see if speech therapy can help patients avoid antireflux surgery, wh…

This study looks at three ways to manage pain during and after laparoscopic Nissen fundoplication (a surgery for acid reflux). About 63 adults will receive either a spinal injection of morphine, a spinal injection of fentanyl, or morphine through an IV. Researchers will measure t…

This study looks at whether combining Botox injections with a balloon dilation of the esophagus works better than Botox alone for people with achalasia, a rare swallowing disorder. The trial enrolls 50 adults who are not healthy enough for more invasive treatments. Participants a…

This study tests whether a daily medicine called dexlansoprazole can safely reduce symptoms of gastroesophageal reflux disease (GERD) in children aged 2 to 11 years who have heartburn but no damage to their esophagus. About 71 children will take the medicine or a placebo for 12 w…

This early-phase trial tests a treatment called vascular-targeted photodynamic therapy (VTP) for people with advanced esophageal or stomach cancer who have moderate to severe trouble swallowing. The treatment uses a light-sensitive drug (WST-11) and a laser delivered through a th…

This early-phase study tests an oral drug called ropidoxuridine (IPdR) in people with advanced gastrointestinal cancers that cannot be cured. The goal is to find the safest dose and see if it can make radiation therapy more effective at shrinking tumors. Nineteen participants wit…

This study tests an 8-week program of nutrition advice, exercise, and psychological support for people with pancreatic or esophageal cancer before they have surgery. The goal is to see if patients can complete the program and if it helps them prepare for surgery. Only 9 patients …

This study looks at whether proton beam therapy, a precise form of radiation, causes fewer severe side effects than standard radiation for people with esophageal cancer. About 22 patients with stage II or III esophageal cancer will receive proton therapy and report their symptoms…

This Phase 2 trial tests whether a prebiotic syrup called MHS-1031 (PIMO) can increase heartburn-free days when added to standard proton pump inhibitor (PPI) therapy for people with GERD. About 247 adults who still have heartburn despite taking PPIs will receive either the syrup …

This study tests whether drinking cola can help relieve sudden food blockages in the esophagus for people with esophageal cancer. Fifty participants will be randomly assigned to drink cola or receive standard care, and researchers will check if the blockage clears within 24 hours…

This study planned to test a laparoscopic-guided nerve block (TAP block) to reduce opioid painkiller use after weight-loss or anti-reflux stomach surgeries. It compared two numbing medicines, Bupivacaine HCL and Exparel. However, the trial was withdrawn before enrolling any parti…

This study looks at ways to prevent and reduce radiation esophagitis—painful inflammation of the swallowing tube—in 142 cancer patients receiving chest radiation. Researchers will test a two-step consent process and measure whether the approach cuts the need for strong painkiller…

This program allows people aged 12 and older with severe stomach or gut problems, like gastroparesis, to try domperidone when standard treatments have failed. The goal is to ease symptoms such as nausea, vomiting, and severe indigestion. The drug is not FDA-approved but is availa…

This study tests whether the Gracie Diet can reduce symptoms of gastroesophageal reflux disease (GERD) in adults who want to stop taking standard acid-reducing drugs. About 30 participants will stop their medication and follow the diet for 8 weeks. Researchers will track symptom …

This study looks at whether a yoga program can improve physical performance, quality of life, and reduce symptoms for cancer patients undergoing radiation therapy and their partners. About 600 patients with lung, head and neck, or esophageal cancer, along with their partners, wil…

This study looks at two ways to remove small throat patches (inlet patches) that can cause discomfort in people with GERD. About 72 participants will receive either argon plasma or radiofrequency ablation. The goal is to see which method patients find more comfortable and which w…

This study looks at two different procedures to help children aged 1 to 10 years who have trouble swallowing due to a laryngeal cleft (a gap in the airway). One procedure injects a gel to build up the airway wall, the other uses stitches to close the gap. The goal is to see which…

This phase II trial, called MATCH, is testing whether treating cancer based on the genetic makeup of a patient's tumor works better than standard treatments. Over 6,400 adults with advanced solid tumors, lymphomas, or multiple myeloma that have not responded to prior therapy are …

This study collects blood and tissue samples from 1,000 adults with Barrett's esophagus or esophageal cancer during their routine endoscopy. The goal is to build a biorepository that links clinical data with specimens, enabling future research into these conditions. Participants …

This study looks at how the immunotherapy drug nivolumab is used in routine care for adults with advanced cancers of the esophagus, gastroesophageal junction, or stomach. Researchers will analyze data from a Dutch cancer registry to see how long people live after starting nivolum…

This study aims to find early DNA changes in blood and esophageal tissue that could signal a higher risk of developing esophageal cancer. Researchers are studying 600 people with gastroesophageal reflux, Barrett's esophagus, or esophageal cancer who are already scheduled for an u…

This study follows 250 obese adults who are having a weight-loss procedure—either surgery or an endoscopic stomach reduction. The goal is to see how often acid reflux (GERD) develops afterward, including silent reflux with no symptoms. By tracking symptoms and using tests, resear…

This study is testing whether an artificial intelligence (AI) model can help doctors better detect, diagnose, and treat esophageal cancer. Researchers will feed de-identified data from 12,000 patients receiving routine care into the AI and compare its recommendations to standard …

This study looks at how frailty—a state of weakness and reduced physical function—affects the risk of severe side effects from chemotherapy in people aged 70 and older with cancer. Researchers will assess 160 patients using various tests for frailty, muscle loss, and overall heal…

This study gathers information from 300 children with eosinophilic esophagitis (EoE), a chronic allergic condition that inflames the esophagus. Researchers aim to better understand what causes EoE, how it relates to other allergies, and which treatments work best. No new treatmen…

This study aims to find non-invasive markers in blood and urine that can show whether inflammation is present in the esophagus of children with eosinophilic esophagitis (EoE). Researchers will compare these markers with tissue samples from biopsies to see if they can reliably det…

This study is looking for biological markers (biomarkers) that might predict how well patients with certain types of squamous cell carcinoma respond to a type of immunotherapy called PD-1 inhibitors. Researchers will analyze blood and tumor tissue samples from 800 patients, both …

This study looks at genetic changes in people with H. pylori infection or stomach cancer to understand how the infection can lead to cancer. Researchers will analyze tissue samples from 110 adults undergoing endoscopy. The goal is to find early warning signs and possible ways to …

This study is testing whether a special PET scan using a tracer called 68Ga-PSMA can identify patients with advanced upper digestive tract cancers (like stomach or esophageal cancer) who might be eligible for a type of targeted radiation therapy called endoradiotherapy. The resea…

This study is testing whether a special PET scan called 18F-FSPG can help doctors see how well chemotherapy and radiation are working in people with esophageal cancer. Nine adults with untreated, locally advanced esophageal cancer will get the scan before and during treatment. Th…

This study collects tissue and blood samples from 1,600 people with various advanced cancers, along with their medical information, over the course of their treatment. Researchers will store these samples and data in a biobank for current and future studies. The goal is to better…

This study is for people with gastrointestinal cancer that has spread to the lining of the abdomen. Researchers will collect tumor tissue and blood samples to create a custom blood test that looks for cancer DNA. The goal is to see if this test can help doctors monitor the cancer…

This study looks at tissue samples from 30 people with esophageal squamous cell carcinoma to see how far the cancer spreads beyond what the surgeon can see. Researchers want to find patterns of hidden tumor growth to help guide future surgeries. Participants have already had thei…

This study looks at 200 male FDNY rescue workers who were exposed to dust and toxins after the World Trade Center attacks. Many developed acid reflux, which can lead to Barrett's esophagus and even cancer. Researchers will use simple, noninvasive tests like saliva samples and que…

This study aimed to compare swallowing function in patients who had esophageal cancer surgery (Ivor Lewis esophagectomy) and either did or did not develop a leak at the surgical connection. Researchers planned to use three questionnaires to measure swallowing difficulties. Howeve…

This study is a registry that will review medical records of 1,000 patients treated for benign or malignant gastrointestinal diseases between 2005 and 2030. Researchers will look at survival, symptoms like heartburn and swallowing trouble, and quality of life. The goal is to lear…

This study follows 2,500 people with gastroesophageal reflux disease (GERD) to compare how well medications and surgery work over time. Researchers will track quality of life, heartburn symptoms, and patient satisfaction. The goal is to identify who benefits most from each treatm…

This study reviewed medical records of 500 adults with esophageal cancer treated between 2017 and 2024. Researchers analyzed patient details, lab results, tumor information, and treatments to find factors that influence survival. No new treatments were tested; the goal was to lea…

This observational study follows 138 people who had surgery for esophageal cancer. Researchers use a saliva test called PEPTEST to measure reflux before and after surgery. The goal is to understand how often reflux happens and what factors, like surgical technique or lifestyle, m…

This study observes 208 adults in France with advanced or metastatic stomach, esophageal, or gastroesophageal junction cancer who are receiving nivolumab combined with chemotherapy as their first treatment. Researchers will track how long patients live and how their disease progr…

This pilot study is looking at whether dental erosion (loss of tooth enamel) could be a non-invasive biomarker for esophagogastric cancer and other cancers. Researchers will survey 174 participants (cancer patients and healthy volunteers) about diet, habits, and GERD symptoms, an…

This study looks at how common anesthetics change the way the esophagus moves during a special imaging procedure called FLIP. Researchers will measure muscle flexibility and contraction in 30 adults with swallowing problems like achalasia. The goal is to better understand how ane…

This study reviews medical records from 230 adults with stomach or esophagus cancer that spread to the brain. Researchers want to see which local treatments (like surgery or radiation) worked best and how long patients lived. The goal is to gather information to help doctors make…

This study is testing whether doing a special PET scan during radiation treatment can help doctors adjust the plan to better target tumors and spare healthy tissue. It involves 90 adults with cervical, vulvar, esophageal, or anal cancer. The goal is to see if this approach improv…

This study is not testing a new treatment. Instead, it follows 500 people who already had a procedure called TIF (transoral incisionless fundoplication) for acid reflux. Researchers will collect data from medical records to see how symptoms and quality of life change over time. T…

This study explores whether a special PET/MRI scan can predict how well esophageal cancer responds to chemotherapy and radiation given before surgery. Researchers will scan 121 patients during treatment and compare the images with the actual tumor response seen after surgery. The…

This study follows 200 patients who had minimally invasive surgery for conditions like achalasia, GERD, or hiatal hernia. Each year, patients fill out questionnaires about their symptoms and quality of life, and doctors review their medical records. The goal is to understand how …

This observational study collects blood and tumor tissue samples from people with gastroesophageal cancer to study genetic changes that may cause resistance to immunotherapy. It does not involve any treatment or experimental drugs. The goal is to identify new targets for future i…

This study collects leftover tissue, blood, and other fluid samples from 6,000 people with benign or malignant tumors of the soft tissue, gastrointestinal tract, or abdomen. Researchers will use these samples in lab studies to better understand the causes, prevention, diagnosis, …

This research study looks at how certain cancers (head and neck, esophagus, and anal canal) change at the genetic and immune level when patients receive chemotherapy or immunotherapy. About 39 people with advanced cancer will provide blood samples and tumor tissue over time. The …

This study examines tissue samples from 25 people with Barrett's esophagus (a condition where the lining of the food pipe changes) to find cell and gene changes linked to the disease. Participants provide a small tissue sample during a routine endoscopy. The goal is to better und…

This study looks for early signs of heart damage in people getting radiation therapy for lung or esophageal cancer. Researchers use heart scans and blood tests to see if changes happen during or shortly after treatment. The goal is to find patients at risk and help make future ca…

This study is creating a large registry of 2,000 people with gastroesophageal reflux disease (GERD) and related conditions like Barrett's esophagus. Researchers will collect data from medical records and questionnaires over 5 years to better understand the disease and its treatme…

This study tracks 500 adults with conditions like acid reflux, achalasia, or complications after weight-loss surgery. Participants choose either a newer endoscopic procedure (done through a scope) or standard surgery. Researchers will compare how well each approach controls sympt…

This study collects blood, urine, and tissue samples from 500 obese adults to help researchers understand why people gain weight, lose weight, or regain weight after treatment. Participants must be over 18 with a BMI of 30 or higher. The samples will be stored for up to 10 years …

This study follows 500 adults with Barrett's esophagus for 3 years using a tethered capsule endomicroscopy device—a pill-sized camera that patients swallow. The goal is to track how the condition changes over time without needing sedation or a traditional endoscopy. Researchers h…

This study aimed to test a special camera capsule that takes detailed images of the esophagus to diagnose eosinophilic esophagitis and Barrett esophagus. It planned to compare the capsule's images with standard biopsy results. However, the study was withdrawn before any participa…

This study tests a new, swallowable camera capsule that takes detailed images of the esophagus. It includes people with eosinophilic esophagitis and healthy volunteers. The goal is to see if the capsule works well and is comfortable to use.

This study follows 100 adults with Barrett's esophagus, a condition where the lining of the food pipe changes, to see how it naturally progresses. Participants swallow a small camera in a capsule that takes pictures of the esophagus during routine check-ups. The goal is to learn …

This study aimed to develop better diagnostic tests and a device (external pressure on the throat) for patients with pharyngeal reflux, where stomach contents reach the throat. It planned to include adults with GERD and throat symptoms. However, the study was withdrawn before enr…

This study looks back at 100 newborns who had a flexible bronchoscopy (a thin, flexible tube with a camera) to diagnose breathing problems in the neonatal intensive care unit over the past 10 years. Researchers want to see how often this procedure helped doctors find the exact ca…

This study was designed to check if swallowed corticosteroids, used to treat eosinophilic esophagitis (EoE) in children aged 5-12, affect bone density and growth over one year. It planned to compare these children to healthy age-matched controls. However, the study was withdrawn …

This study follows 75 people who had either sleeve gastrectomy or gastric bypass for severe obesity. Researchers track acid reflux symptoms, esophageal damage, and other measures for 8 years using tests like endoscopy and pH monitoring. No new treatments are given—it's purely obs…

This research study aims to understand why some people develop food allergies and others outgrow them. Researchers at Children's Hospital of Philadelphia will collect blood samples from 5,300 people (ages 1 month to 65 years) with and without food allergies to study immune cells …

This study surveys over 3,700 medical students and interns across the Middle East to find out how many have gastroesophageal reflux disease (GERD). It also looks at how eating habits, stress, anxiety, and depression relate to GERD and how the condition affects their quality of li…

This study followed 64 adults who had laparoscopic sleeve gastrectomy (a common weight-loss surgery) to see how acid reflux symptoms changed. Researchers compared those who had reflux before surgery with those who did not. They used a standard questionnaire to measure heartburn a…