Could an allergy drug tame rare stomach inflammation?

NCT ID NCT05831176

Ongoing Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study tests dupilumab, an injectable drug already used for allergies, in 22 adults and teens with eosinophilic gastritis (stomach inflammation caused by too many white blood cells). The goal is to see if it reduces inflammation and improves symptoms over 6 months to a year. It's an early, open-label trial, so results are promising but not yet proven.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

dupilumab (Dupixent)

What this could lead to

If successful, this could point toward a new treatment option for eosinophilic gastritis, a rare stomach condition with limited therapies.

What could go wrong

This is a small, early-phase trial with only 22 participants and no placebo group, so results may not apply broadly. Side effects and long-term benefits are still unknown.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

duodenitis Eosinophilic enteropathy eosinophilic esophagitis eosinophilic gastritis eosinophilic gastroenteritis eosinophilic gastrointestinal disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EOSINOPHILIC DUODENITIS (EOD) EOSINOPHILIC GASTRITIS (EOG) EOSINOPHILIC GASTROENTERITIS EOSINOPHILIC GASTROINTESTINAL DISEASE (EGID)

Contacts and locations

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Locations

AOOR Villa Sofia/Cervello

Palermo, Sicily, 90146, Italy
Advanced Research Institute

Reno, Nevada, 89511, United States
Allergy, Asthma and Clinical Research Center

Oklahoma City, Oklahoma, 73120, United States
Azienda Ospedaliero Universitaria Pisana

Pisa, 56124, Italy
Beth Israel Deaconess Medical Center (BIDMC) Harvard Medical School

Boston, Massachusetts, 02215, United States
Charlotte Gastroenterology & Hepatology, PLLC

Charlotte, North Carolina, 28207, United States
Connecticut Clinical Research Institute

Bristol, Connecticut, 06010, United States
Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
Duke University

Durham, North Carolina, 27710, United States
ESI Medical Research, PLLC

Kinston, North Carolina, 28513, United States
Encore Borland-Groover Clinical Research

Jacksonville, Florida, 32256, United States
Fondazione Serena Onlus - Azienda Ospedaliera Niguarda Ca' Granda - Centro Clinico Nemo (Neuro Muscular Omnicentre)

Milan, 20162, Italy
Froedtert Hospital

Milwaukee, Wisconsin, 53226, United States
GastroIntestinal BioSciences

Los Angeles, California, 90067, United States
Humanitas Research Hospital

Rozzano, Milan, 20089, Italy
Hyogo Prefectural Harima-Himeji General Medical Center

Himeji, Hyōgo, 670-8560, Japan
Icahn School of Medicine at Mount Sinai (ISMMS) - The Mount Sinai Hospital (MSH)

New York, New York, 10029, United States
Iizuka Hospital

Iizuka, Fukuoka, 820-8505, Japan
Kawasaki Medical School Hospital

Kurashiki, Okayama-ken, 701-0192, Japan
Kobe University Graduate School of Medicine

Kobe, Hyōgo, 650-0017, Japan
Kure Kyosai Hospital

Kure, Hiroshima, 737-8505, Japan
MNGI Digestive Health P.A.

Plymouth, Minnesota, 55446, United States
Mayo Clinic Hospital Rochester

Rochester, Minnesota, 55905, United States
Northwell Health

Great Neck, New York, 11021, United States
Northwestern University

Chicago, Illinois, 60611, United States
Ogaki Municipal Hospital

Ōgaki, Gifu, 503-8502, Japan
Ohio State University Medical Center

Columbus, Ohio, 43210, United States
Om Research LLC

Apple Valley, California, 92307, United States
Om Research LLC

Lancaster, California, 93534, United States
Ospedale S Giovanni Calibita Fatebenefratelli Isola Tiberina

Roma, 00186, Italy
Phoenix Childrens Hospital

Phoenix, Arizona, 85016, United States
Scripps Clinic

La Jolla, California, 92037, United States
Seattle Children's Home Health Company

Seattle, Washington, 98105, United States
Stollery Children's Hospital - University of Alberta

Edmonton, Alberta, T6G 1C9, Canada
TDDC dba GI Alliance Research

Mansfield, Texas, 76063, United States
The Oregon Clinic - Gastroenterology East

Portland, Oregon, 97220, United States
Toranomon Hospital

Minato-ku, Tokyo, 105-8470, Japan
U.O. Di Ematologia-Azienda Policlinico Consorziale, Ospedaliero-Universitaria, Ospedale

Bari, 70124, Italy
UConn Health

Farmington, Connecticut, 06030, United States
Ucsf Medical Center (Benioff Childrens Hospital)

San Francisco, California, 94158, United States
United Medical Doctors

Murrieta, California, 92563, United States
University Of Kansas

Kansas City, Kansas, 66103, United States
University of California - Los Angeles (UCLA)

Los Angeles, California, 90024, United States
University of Cincinnati Medical Center-Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
University of Colorado Anschutz Health Science Building (AHSB) CU Research Pharmacy

Aurora, Colorado, 80045, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27599, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Rome - Pediatric Gastroenterology and Liver Unit

Rome, 00161, Italy
University of Southern California Keck School of Medicine

Los Angeles, California, 90033, United States
University of Utah

Salt Lake City, Utah, 84132, United States
Yamagata University Hospital

Yamagata, 990-9585, Japan
Yokohama City University Hospital

Yokohama, Kanagawa, 236-0004, Japan