Major trial tests new shot for debilitating swallowing disease

NCT ID NCT05583227

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This study is testing whether a medication called tezepelumab, given as an injection, can help control eosinophilic esophagitis (EoE), a chronic condition that causes painful swallowing and inflammation in the food pipe. About 368 adults and adolescents with EoE will receive either the real medication or a placebo injection for 52 weeks to see if it reduces inflammation and improves swallowing symptoms. The goal is to see if this treatment can provide long-term control of the disease for people who continue to have symptoms despite current standard care.

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Contacts and locations

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Locations

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Phoenix, Arizona, 85016, United States
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Little Rock, Arkansas, 72202, United States
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Los Angeles, California, 90033, United States
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Aurora, Colorado, 80045, United States
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Inverness, Florida, 34452, United States
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Jacksonville, Florida, 32256, United States
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Saint Augustine, Florida, 32086, United States
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Normal, Illinois, 61761, United States
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Iowa City, Iowa, 52242, United States
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Topeka, Kansas, 66606, United States
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White Marsh, Maryland, 21162, United States
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Boston, Massachusetts, 02111, United States
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Chesterfield, Michigan, 48047, United States
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Lincoln, Nebraska, 68503, United States
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Ocean City, New Jersey, 07712, United States
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Brooklyn, New York, 11235, United States
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Chapel Hill, North Carolina, 27599, United States
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Cincinnati, Ohio, 45229, United States
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Philadelphia, Pennsylvania, 19104, United States
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Smithfield, Pennsylvania, 15478, United States
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Nashville, Tennessee, 37232, United States
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Houston, Texas, 77030, United States
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Salt Lake City, Utah, 84107, United States
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Salt Lake City, Utah, 84132, United States
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Elizabeth Vale, 5112, Australia
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Kogarah, 2217, Australia
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South Brisbane, QL 4101, Australia
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Woolloongabba, 4102, Australia
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Vienna, 1090, Austria
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Wels, 4600, Austria
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Bruges, 8310, Belgium
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Edegem, 2650, Belgium
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Ghent, 9000, Belgium
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Leuven, 3000, Belgium
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Botucatu, 18618-687, Brazil
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Brasília, 71681-603, Brazil
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Caxias do Sul, 95070-560, Brazil
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Curitiba, 80250-060, Brazil
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Curitiba, 80440-220, Brazil
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Porto Alegre, 90035-903, Brazil
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São José do Rio Preto, 15090-000, Brazil
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São Paulo, 05.403-010, Brazil
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Hamilton, Ontario, L8S 1G5, Canada
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London, Ontario, N6A 5W9, Canada
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Niagara Falls, Ontario, L2H 1H5, Canada
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Ottawa, Ontario, K1G 6C6, Canada
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Windsor, Ontario, N8X 2G1, Canada
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Beijing, 100020, China
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Beijing, 100050, China
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Guangzhou, 510080, China
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Hangzhou, 310052, China
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Nanjing, 2100008, China
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Shanghai, 200000, China
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Shenyang, 110004, China
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Tianjin, 300050, China
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Wuhan, 430022, China
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Brno, 625 00, Czechia
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Hradec Králové, 500 12, Czechia
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Prague, 190 00, Czechia
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Aalborg, 9000, Denmark
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Køge, 4600, Denmark
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Odense, 5000, Denmark
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Helsinki, 00290, Finland
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München, 81675, Germany
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Athens, 11521, Greece
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Athens, 11527, GR, Greece
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Athens, 11527, Greece
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Athens, 12462, Greece
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Thessaloniki, 56429, Greece
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Holon, 58100, Israel
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Jerusalem, 91120, Israel
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Petah Tikva, 4920235, Israel
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Petah Tikva, 4941492, Israel
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Tel Aviv, 62748, Israel
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Tel Aviv, 6423906, Israel
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Tel Litwinsky, 52620, Israel
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Bologna, 40138, Italy
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Milan, 20162, Italy
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Naples, 80131, Italy
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Padua, 35128, Italy
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Pisa, 56124, Italy
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Roma, 00161, Italy
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Roma, 00168, Italy
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Rozzano, 20089, Italy
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Verona, 37134, Italy
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Akita, 010-8543, Japan
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Fukuoka, 812-8582, Japan
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Himeji, 670-8560, Japan
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Hiroshima, 734-8551, Japan
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Isehara-shi, 259-1193, Japan
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Kawasaki-shi, 211-0063, Japan
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Kitakyushu-shi, 802-0077, Japan
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Maebashi, 371-8511, Japan
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Minatoku, 108-8329, Japan
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Osaka, 545-8586, Japan
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Shinjuku-ku, 160-8582, Japan
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Shinjuku-ku, 162-8655, Japan
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Yamagata, 990-9585, Japan
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Amsterdam, 1081 HV, Netherlands
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Nijmegen, 6525 GA, Netherlands
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Rotterdam, 3015 GD, Netherlands
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Christchurch, 8011, New Zealand
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Hamilton, 3204, New Zealand
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Newtown, 6021, New Zealand
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Otahuhu, 2025, New Zealand
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Ålesund, 6026, Norway
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Lørenskog, 1478, Norway
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Lørenskog, N-1478, Norway
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Oslo, 0450, Norway
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Tromsø, N-9038, Norway
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Košice, 04013, Slovakia
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Barcelona, 08035, Spain
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Barcelona, 08036, Spain
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Madrid, 28006, Spain
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Madrid, 28007, Spain
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Madrid, 28031, Spain
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Pamplona, 31008, Spain
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Seville, 41009, Spain
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Seville, 41013, Spain
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Tomelloso, 13700, Spain
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Stockholm, 171 76, Sweden
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Trollhättan, 461 73, Sweden
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Uppsala, 751 85, Sweden
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London, SW17 0QT, United Kingdom
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London, WC1N 3JH, United Kingdom

Conditions

Explore the condition pages connected to this study.

EOSINOPHILIC ESOPHAGITIS