New hope for swallowing: drug targets esophagus scarring in EoE
NCT ID NCT06101095
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a medication called dupilumab in 69 adults with eosinophilic esophagitis, a condition that makes swallowing difficult due to inflammation and scarring in the esophagus. Participants receive either dupilumab or a placebo for 24 weeks, then everyone gets dupilumab for another 104 weeks. The goal is to see if the drug improves how well the esophagus can stretch and function, helping people eat more easily.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Borland Groover Clinic- Site Number : 8400016
Jacksonville, Florida, 32256, United States
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Cleveland Clinic - Cleveland- Site Number : 8400009
Cleveland, Ohio, 44195, United States
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Clinica de Alergia Martti Antila- Site Number : 0760001
Sorocaba, São Paulo, 18040-425, Brazil
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Clínica Loema - Unidade I- Site Number : 0760007
Campinas, São Paulo, 13010-001, Brazil
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GI Alliance - Glenview- Site Number : 8400012
Glenview, Illinois, 60026, United States
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GI Alliance - Mansfield- Site Number : 8400017
Mansfield, Texas, 76063, United States
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Hospital Alemao Oswaldo Cruz - São Paulo- Site Number : 0760003
São Paulo, 01323-020, Brazil
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Hospital São Lucas da PUCRS - Porto Alegre - Avenida Ipiranga- Site Number : 0760006
Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
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Illinois Gastroenterology Group- Site Number : 8400004
Gurnee, Illinois, 60031, United States
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Investigational Site Number : 1240002
Montreal, Quebec, H4A 3T2, Canada
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Investigational Site Number : 1240004
Vancouver, British Columbia, V6Z 2K5, Canada
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Investigational Site Number : 1240006
Vancouver, British Columbia, V5Z 1M9, Canada
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Investigational Site Number : 3760002
Haifa, 3109601, Israel
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Investigational Site Number : 3760003
Tel Aviv, 6423906, Israel
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Investigational Site Number : 3760004
Jerusalem, 9112001, Israel
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Investigational Site Number : 3760005
Jerusalem, 9103102, Israel
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Investigational Site Number : 3760006
Haifa, 3104802, Israel
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Investigational Site Number : 7560001
Wetzikon, 8620, Switzerland
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Investigational Site Number : 7560002
Zurich, 8091, Switzerland
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Itaigara Memorial - Hospital Dia- Site Number : 0760005
Salvador, Estado de Bahia, 41825-010, Brazil
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Mayo Clinic Hospital Rochester- Site Number : 8400008
Rochester, Minnesota, 55905, United States
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Northwestern University- Site Number : 8400003
Chicago, Illinois, 60611, United States
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Penn Medicine: University of Pennsylvania Health System- Site Number : 8400010
Philadelphia, Pennsylvania, 19104, United States
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Private Practice - Dr. Martin Yudovich- Site Number : 8400015
Houston, Texas, 77087, United States
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Treasure Valley Medical Research- Site Number : 8400018
Boise, Idaho, 83706, United States
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United Gastroenterologists - Murrieta- Site Number : 8400001
Murrieta, California, 92563, United States
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University of California San Francisco - Parnassus Heights- Site Number : 8400020
San Francisco, California, 94143, United States
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University of Iowa- Site Number : 8400006
Iowa City, Iowa, 52242, United States
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University of Massachusetts Chan Medical School- Site Number : 8400019
Worcester, Massachusetts, 01655, United States
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University of North Carolina at Chapel Hill- Site Number : 8400007
Chapel Hill, North Carolina, 27514, United States