Last-Resort treatment opens for rare swallowing disorder

NCT ID NCT05095116

NO_LONGER_AVAILABLE Disease control Sponsor: Ellodi Pharmaceuticals, LP Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This program offers APT-1011, a fluticasone tablet that dissolves in the mouth, to patients aged 12 and older with eosinophilic esophagitis who cannot join other studies or have not responded to available treatments. The goal is to provide access until the drug is commercially available. It is an open-label, single-arm program, meaning everyone gets the drug and there is no comparison group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: fluticasone propionate orally disintegrating tablet
What this could lead to: If this works, it could provide a treatment option for people with eosinophilic esophagitis who have run out of other choices.
What could go wrong: This is an expanded access program, not a formal trial, so results are not designed to prove effectiveness. It is only for patients who cannot join other studies or have failed other treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

allergic disease digestive system disorder Eosinophilia eosinophilic esophagitis esophageal disorder esophagitis gastroenteritis hematologic disorder Hypersensitivity, Immediate immune system disorder leukocyte disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EOSINOPHILIC ESOPHAGITIS

Contacts and locations

Locations

Arkansas Gastroenterology

North Little Rock, Arkansas, 72117, United States
Bernstein Clinical Research Center, LLC

Cincinnati, Ohio, 45236, United States
Boston Specialists

Boston, Massachusetts, 02111, United States
Bozeman Health Clinical Research

Bozeman, Montana, 59715, United States
Carolina Research

Greenville, North Carolina, 27834, United States
Clinical Research Institute of Michigan LLC

Chesterfield, Michigan, 48047, United States
Clinical Research Professionals

Chesterfield, Missouri, 63005, United States
Clinical and Translational Research Center (CTRC)

Chapel Hill, North Carolina, 27599, United States
Del Sol Research Management LLC

Tucson, Arizona, 85715, United States
Endoscopic Research, Inc.

Orlando, Florida, 32803, United States
FOMAT Medical Research

Glendale, California, 91204, United States
GI Alliance

Garland, Texas, 75044, United States
Gastro Center of Maryland

Columbia, Maryland, 21045, United States
Gastro Health Research

Cincinnati, Ohio, 45219, United States
Great Lakes Gastroenterology

Mentor, Ohio, 44060, United States
Henry Ford Health System

Novi, Michigan, 48377, United States
MGG Group Co., Inc.

Chevy Chase, Maryland, 20815, United States
MNGI Digestive Health, P.A.

Minneapolis, Minnesota, 55413, United States
Medical Associates Research Group

San Diego, California, 92123, United States
Medical Research Center of Connecticut

Hamden, Connecticut, 06518-3694, United States
Minnesota Gastroenterology PA Plymouth Endoscopy Center Clinic

Plymouth, Minnesota, 55446, United States
Nature Coast Clinical Research

Inverness, Florida, 34452, United States
Northshore Gastroenterology Research LLC

Westlake, Ohio, 44145, United States
Nuvance Health Medical Practice Ct, Inc.

Danbury, Connecticut, 06810, United States
Peak Gastroenterology Associates

Colorado Springs, Colorado, 80907, United States
Rapid City Medical Center LLP

Rapid City, South Dakota, 57701, United States
Regional Gastroenterology Associates of Lancaster, Ltd.

Wyomissing, Pennsylvania, 19610, United States
Summit Clinical Research

Athens, Georgia, 30607, United States
United Medical Doctors

Murrieta, California, 92563, United States
University of Iowa Hospitals and Clinics

Iowa City, Iowa, 52242, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
Ventura County Gastroenterology Medical Group Camarillo

Camarillo, California, 93012, United States
Vital Prospects Clinical Research Institute, P.C.

Tulsa, Oklahoma, 74136, United States
West Michigan Clinical Research Center

Wyoming, Michigan, 49519, United States
Western States Clinical Research Inc

Wheat Ridge, Colorado, 80033, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.