New hope for heartburn sufferers: study tests combo therapy for NERD

NCT ID NCT07174882

Ongoing Disease control Sponsor: I.M. Sechenov First Moscow State Medical University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study is testing a new combination treatment for non-erosive reflux disease (NERD), a common form of GERD that causes heartburn and other symptoms. The treatment adds therapies to strengthen the esophagus's natural barrier on top of standard acid-reducing medication. Researchers will track symptom changes and measure improvements in the esophageal lining in 60 adults over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: complex therapy (acid-suppressive medication plus treatments to strengthen esophageal lining)
What this could lead to: If successful, this could point toward a more effective treatment for NERD, especially for patients who don't get relief from standard acid-blocking drugs.
What could go wrong: This is a small, early-stage study with only 60 participants, so results may not apply to everyone. The complex therapy may not prove better than standard care, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastroesophageal reflux disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTROESOPHAGEAL REFLUX DISEASE (GERD) NON-EROSIVE GASTRO-ESOPHAGEAL REFLUX DISEASE

Contacts and locations

Locations

V.Kh.Vasilenko Clinic of Propedeutics of Internal Diseases, Gastroenterology and Hepatology, I.M.Sechenov First Moscow State Medical University (Sechenov University). Gastroenterology department, outpatient clinic.

Moscow, 119991, Russia

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