Common antifungal drug may help prevent esophageal cancer recurrence
NCT ID NCT05609253
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial investigates whether itraconazole, a common antifungal medication, can reduce the risk of cancer in people with high-risk Barrett's esophagus who have already undergone endoscopic ablation. Barrett's esophagus often returns after treatment, increasing the chance of esophageal cancer. The study will measure drug levels in blood and tissue, and check for side effects, in 10 participants.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Itraconazole
What this could lead to
If it works, this could point toward a way to prevent Barrett's esophagus from coming back after treatment, lowering the risk of esophageal cancer.
What could go wrong
This is a very early, small study (10 people) focused on drug levels and safety, not yet on preventing recurrence. Itraconazole also has side effects and may not prove effective in larger trials.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Kansas Medical Center
Kansas City, Kansas, 66160, United States