No-Scalpel fix for swallowing disorder tracked in massive study

NCT ID NCT02770859

ENROLLING_BY_INVITATION Disease control Sponsor: Indiana University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is tracking 5,000 adults with achalasia, a condition where the esophagus fails to relax and push food into the stomach. All participants are treated with POEM, a procedure that uses an endoscope to cut the tight muscle without any incisions on the body. Researchers will measure symptom scores over time to see how well POEM controls the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: POEM (Per-Oral Endoscopic Myotomy) procedure
What this could lead to: If successful, this could confirm POEM as a reliable, minimally invasive option to control achalasia symptoms and improve swallowing.
What could go wrong: This is an observational registry, not a controlled trial, so results may not prove cause and effect. Risks of POEM include perforation, bleeding, or symptom recurrence.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

achalasia Esophageal Achalasia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACHALASIA

Contacts and locations

Locations

Indiana University Hospital

Indianapolis, Indiana, 46202-5121, United States

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