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Swallow a string, skip the scope: new test for esophagitis

NCT ID NCT02008903

Diagnosis Sponsor: University of Colorado, Denver Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new, less invasive device called the Esophageal String Test (EST) to diagnose and monitor a rare condition called eosinophilic esophagitis (EoE). Instead of using a scope with a biopsy, patients swallow a small string that collects samples from the esophagus. The goal is to see if the string test can accurately measure inflammation and help doctors track treatment without needing repeated endoscopies. About 440 people with suspected or known EoE are taking part.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 440 people

The number the study aims to enrol. It can still change while the study runs.

Start date

Jan 2009

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Any pediatric or adult patient undergoing a clinically indicated endoscopy with biopsy at a participating site may be recruited. (initial cohort)

Ages

7 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients undergoing esophagogastroduodenoscopy (EGD) at Children's Hospital Colorado, or * Patients from a participating site in whom an inflammatory GI disease is suspected. * Patients with symptoms of: 1. abdominal pain, 2. vomiting, 3. growth delay, or 4. malabsorption for which an etiology has not been determined. * Patients with chronic eosinophilic esophagitis (EoE) in whom symptoms suggest ongoing inflammation. Exclusion Criteria: * Patients suffering from bleeding diathesis, or any other comorbid condition which their doctor feels may put them at additional risk. * Patients with a family history of connective tissue disease. * Patients undergoing a therapeutic endoscopy (such as dilatation, sclerotherapy, variceal banding). * Patients with a history of: 1. esophageal stricture, or 2. surgery such as fundoplication, or 3. allergy to gelatin, or 4. inability to swallow pills.

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Conditions

The condition(s) this trial relates to.

eosinophilic esophagitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Eosinophilic esophagitis

Contacts and locations

Locations

  • Children's Hospital Colorado

    Aurora, Colorado, 80045, United States

  • Indiana University

    Indianapolis, Indiana, 46202, United States

  • Lurie Children's Hospital

    Chicago, Illinois, 60611, United States

  • Northwestern University

    Chicago, Illinois, 60601, United States

  • OSF St Francis Medical Center

    Peoria, Illinois, 61603, United States

  • University of Colorado Hospital

    Aurora, Colorado, 80045, United States

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