New hope for advanced stomach cancer? trial tests combo therapies

NCT ID NCT05329766

First seen Oct 31, 2025 · Last updated May 13, 2026 · Updated 23 times

Summary

This phase 2 trial tests the safety and effectiveness of new drug combinations, with or without chemotherapy, in people with advanced stomach, GEJ, or esophageal cancer that cannot be removed by surgery or has spread. About 332 participants will receive treatments including FOLFOX chemotherapy. The goal is to see if these combos shrink tumors and improve survival, while monitoring side effects.

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Contacts and locations

Locations

  • Research Site

    Phoenix, Arizona, 85054, United States

  • Research Site

    Los Angeles, California, 90033, United States

  • Research Site

    Santa Monica, California, 90024, United States

  • Research Site

    Derby, Connecticut, 06418, United States

  • Research Site

    Fort Myers, Florida, 33901, United States

  • Research Site

    Jacksonville, Florida, 32224, United States

  • Research Site

    St. Petersburg, Florida, 33705, United States

  • Research Site

    Boston, Massachusetts, 02109, United States

  • Research Site

    New York, New York, 10021-0005, United States

  • Research Site

    New York, New York, 10032, United States

  • Research Site

    Durham, North Carolina, 27710, United States

  • Research Site

    Columbus, Ohio, 43219, United States

  • Research Site

    Oklahoma City, Oklahoma, 73104, United States

  • Research Site

    Nashville, Tennessee, 37203, United States

  • Research Site

    Nashville, Tennessee, 37232, United States

  • Research Site

    Fairfax, Virginia, 22031, United States

  • Research Site

    Toronto, Canada

  • Research Site

    Las Condes, Chile

  • Research Site

    Recoleta, Chile

  • Research Site

    Santiago, Chile

  • Research Site

    Talca, Chile

  • Research Site

    Bordeaux, France

  • Research Site

    Brest, France

  • Research Site

    Caen, France

  • Research Site

    Lille, France

  • Research Site

    Lyon, France

  • Research Site

    Marseille, France

  • Research Site

    Montpellier, France

  • Research Site

    Plérin, France

  • Research Site

    Poitiers, France

  • Research Site

    Rouen, France

  • Research Site

    Toulouse, France

  • Research Site

    Villejuif, France

  • Research Site

    Belgrade, Serbia

  • Research Site

    Kamenitz, Serbia

  • Research Site

    Kragujevac, Serbia

  • Research Site

    Busan, South Korea

  • Research Site

    Daegu, South Korea

  • Research Site

    Hwasun, South Korea

  • Research Site

    Seongnam-si, South Korea

  • Research Site

    Seoul, South Korea

  • Research Site

    Suwon, South Korea

Conditions

Explore the condition pages connected to this study.