New combo therapy aims to wipe out esophageal cancer before surgery
NCT ID NCT04028167
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing a two-step treatment for esophageal cancer. First, patients receive a chemotherapy combination called FLOT, followed by chemoradiation (chemo plus radiation). After that, they have surgery to remove the tumor. The goal is to see if this approach leads to a complete disappearance of cancer in the removed tissue. The study involves 40 adults with resectable cancer of the esophagus or gastroesophageal junction.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- FLOT chemotherapy (docetaxel, oxaliplatin, leucovorin, 5-FU) followed by chemoradiation with carboplatin and paclitaxel
- What this could lead to
- If successful, this treatment sequence could increase the number of patients whose cancer disappears completely before surgery, potentially improving long-term survival.
- What could go wrong
- This is a small, early-phase trial with only 40 participants, so results may not apply broadly. Chemotherapy and radiation have significant side effects, and the regimen may not improve outcomes over standard care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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UCHealth Northern Colorado - Greeley Hospital
Greeley, Colorado, 80634, United States
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UCHealth Northern Colorado - Harmony Campus
Fort Collins, Colorado, 80528, United States
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UCHealth Northern Colorado - Poudre Valley Hospital
Fort Collins, Colorado, 80524, United States
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UCHealth Northern Colorado Medical Center of the Rockies
Loveland, Colorado, 80538, United States
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UCHealth Southern Colorado - Memorial Hospital Central
Colorado Springs, Colorado, 80909, United States
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UCHealth Southern Colorado - Memorial Hospital North
Colorado Springs, Colorado, 80920, United States
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University of Colorado Hospital
Aurora, Colorado, 80045, United States
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