New combo therapy aims to fight tough esophageal cancer

NCT ID NCT04550260

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether adding the immunotherapy drug durvalumab to standard chemoradiation helps people with advanced esophageal cancer that cannot be removed by surgery. About 640 participants will receive either durvalumab or a placebo alongside their cancer treatment. The study measures how long the cancer stays under control and overall survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: durvalumab (an immunotherapy drug)
What this could lead to: If successful, this could provide a new treatment option that helps people with advanced esophageal cancer live longer without their cancer growing.
What could go wrong: This is a late-stage trial, but immunotherapy doesn't work for everyone and can cause serious side effects. The results may not apply to all patients with this cancer.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

esophageal squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESOPHAGEAL SQUAMOUS CELL CARCINOMA

Contacts and locations

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Locations

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Beijing, 100021, China
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Beijing, 100036, China
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Bengbu, 233004, China
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Changsha, 410013, China
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Changzhi, 46000, China
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Chengdu, 610042, China
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Chongqing, 400030, China
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Fuzhou, 350001, China
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Fuzhou, 350014, China
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Guangzhou, 510000, China
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Guangzhou, 510060, China
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Hangzhou, China
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Hefei, 230031, China
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Huai'an, 223300, China
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Jieyang, 522000, China
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Jinan, 250117, China
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Kunming, 650118, China
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Liangyugang, 222002, China
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Nantong, 226361, China
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Qingdao, 266042, China
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Quanzhou, 362000, China
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Shenzhen, 518116, China
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Tianjin, 300060, China
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Xi'an, 710061, China
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Xuzhou, 221000, China
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Yangzhou, 225001, China
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Zhengzhou, 450008, China
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Zhenjiang, 212002, China
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Besançon, 25030, France
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Lille, 59000, France
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Lyon, 69008, France
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Montpellier, 34070, France
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Reims, 51100, France
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Rouen, 76031, France
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Strasbourg, 67033, France
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Villejuif, 94805, France
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Bunkyō City, 113-8431, Japan
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Chūōku, 104-0045, Japan
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Hidaka-shi, 350-1298, Japan
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Hirakata-shi, 573-1191, Japan
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Hiroshima, 730-8518, Japan
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Kashiwa, 277-8577, Japan
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Kitaadachi-gun, 362-0806, Japan
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Kōtoku, 135-8550, Japan
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Kumamoto, 860-8556, Japan
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Maebashi, 371-8511, Japan
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Matsuyama, 791-0280, Japan
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Niigata, 951-8566, Japan
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Okayama, 700-8558, Japan
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Osaka, 541-8567, Japan
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Osaka, 545-8586, Japan
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Ota-shi, 373-8550, Japan
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Sendai, 980-8574, Japan
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Shinagawa-ku, 142-8666, Japan
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Yokohama, 232-0024, Japan
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Yokohama, 241-8515, Japan
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Chihuahua City, 31210, Mexico
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Cuernavaca, 62290, Mexico
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Mérida, 97134, Mexico
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Monterrey, 66220, Mexico
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Veracruz, 91851, Mexico
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Katowice, 40-074, Poland
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Krakow, 31-115, Poland
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Lodz, 90-513, Poland
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Siedlce, 08-110, Poland
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Warsaw, 02-034, Poland
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Chelyabinsk, 454087, Russia
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Krasnodar, 350040, Russia
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Moscow, 115478, Russia
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Obninsk, 249031, Russia
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Saint Petersburg, 197758, Russia
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Tyumen, 6250041, Russia
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Ufa, 450054, Russia
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Yekaterinburg, 620905, Russia
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Daegu, 41404, South Korea
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Seoul, 06273, South Korea
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Seoul, 06351, South Korea
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Seoul, 138-736, South Korea
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Suwon, 16247, South Korea
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Barcelona, 8035, Spain
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Córdoba, 14004, Spain
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Madrid, 28007, Spain
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Madrid, 28034, Spain
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Madrid, 28046, Spain
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Pamplona, 31008, Spain
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Santander, 39008, Spain
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Zaragoza, 50009, Spain
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Changhua, 50006, Taiwan
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Kaohsiung City, 80756, Taiwan
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Kaohsiung City, 82445, Taiwan
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Kaohsiung City, 83301, Taiwan
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Taichung, 40443, Taiwan
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Taichung, 407, Taiwan
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Tainan, 710, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 11217, Taiwan
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Taoyuan, 333, Taiwan
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Bangkok, 10210, Thailand
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Bangkok, 10300, Thailand
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Bangkok, 10330, Thailand
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Bangkok, 10400, Thailand
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Chanthaburi, 22000, Thailand
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Chiang Mai, 50200, Thailand
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Hat Yai, 90110, Thailand
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Khon Kaen, 40002, Thailand
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Ankara, 06800, Turkey (Türkiye)
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Diyarbakır, 21280, Turkey (Türkiye)
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Erzurum, 25240, Turkey (Türkiye)
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Goztepe Istanbul, Turkey (Türkiye)
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Izmir, 35575, Turkey (Türkiye)
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Van, 65080, Turkey (Türkiye)
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Hanoi, 100000, Vietnam
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Ho Chi Minh City, 700000, Vietnam
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Ho Chi Minh City, Vietnam
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Atlanta, Georgia, 30308, United States
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Louisville, Kentucky, 40217, United States
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Dallas, Texas, 75390, United States
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Fairfax, Virginia, 22031, United States
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Morgantown, West Virginia, 26506, United States
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Brussels, 1090, Belgium
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Charleroi, 6060, Belgium
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Liège, 4000, Belgium
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Namur, 5000, Belgium
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Barretos, 14784-400, Brazil
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Fortaleza, 60430-230, Brazil
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Porto Alegre, 90050-170, Brazil
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Porto Alegre, 91350-200, Brazil
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Rio de Janeiro, 20231-050, Brazil
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São José do Rio Preto, 15090-000, Brazil
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Vitória, 29043-260, Brazil
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Barrie, Ontario, L4M 6M2, Canada
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Greater Sudbury, Ontario, P3E 5J1, Canada
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Anyang, 455000, China

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