SCHIZOPHRENIA

This study aims to see if a new, generic version of a long-acting schizophrenia injection works the same in the body as the existing brand-name version. It will involve 260 adults in China with stable schizophrenia. Researchers will measure drug levels in the blood and track side…

This study is testing if a new combination medication (OLZ/SAM) causes less weight gain than the standard drug olanzapine in children and teenagers with schizophrenia or bipolar I disorder. About 220 participants, aged 10-17, will take either the new combination or standard olanz…

This early-stage study is testing a new long-acting injectable version of the medication KarXT for people with schizophrenia. Researchers will give 48 participants single injections at different dose levels to check how safe the treatment is and how long the drug stays in the bod…

This study is testing whether a drug that targets a specific brain receptor works better for men or women to help control the 'negative symptoms' of schizophrenia, like lack of motivation and social withdrawal. 90 participants with stable schizophrenia will take the experimental …

This study is testing a new type of medication for schizophrenia in people who refuse or cannot tolerate standard antipsychotic drugs due to poor response or severe side effects. The 6-week trial will compare the new drug to a placebo in 80 participants to see if it improves symp…

This study is testing whether a weekly injection called tirzepatide, currently used for diabetes and weight loss, can help reduce heavy alcohol use in people who also have schizophrenia. About 108 participants will receive either the real drug or a placebo (dummy injection) for 2…

This study is testing whether an investigational medicine called NBI-1117568 can help reduce the severe symptoms of schizophrenia in adults who need to be hospitalized. Researchers will compare the drug to a placebo (an inactive substance) over 5 weeks. The goal is to see if the …

This study is testing the long-term safety of an investigational medication called NBI-1117568 for adults with schizophrenia. The trial will enroll 800 participants worldwide to monitor side effects and how well people tolerate the drug over an extended period. This is an open-la…

This study is testing whether adding an anti-inflammatory drug to an existing brain-targeting medication can help people with severe schizophrenia that hasn't responded to standard treatments. The trial will involve 80 participants who will continue their current medication while…

This study is testing whether an experimental medication called GXV813 can safely reduce symptoms in adults hospitalized for an acute schizophrenia episode. Researchers will compare GXV813 against a placebo in 142 participants over 6 weeks, measuring changes in symptoms like hall…

This study aims to see if a specific brain activity pattern, called Biotype-1, can predict which people with schizophrenia, schizoaffective disorder, or bipolar disorder with psychosis will respond exceptionally well to the medication clozapine. About 320 participants will be ran…

This study is testing if a non-invasive brain stimulation technique can reduce cravings for cannabis in people with schizophrenia. Researchers believe the brains of people with schizophrenia may be wired differently, making them more vulnerable to cannabis use. They will use targ…

This study is testing two different schedules for starting the antipsychotic medication olanzapine in people with schizophrenia. It aims to find out which schedule is safer and works better at controlling symptoms. The trial will involve 120 participants and carefully measure bot…

This study is testing whether an investigational medicine called NBI-1117568 can help reduce symptoms in adults with schizophrenia who need to be hospitalized. Researchers will compare the medicine against a placebo (inactive treatment) in 284 participants worldwide. The main goa…

This study aims to understand the long-term safety of KarXT for teenagers with schizophrenia and children with autism-related irritability. It follows 400 young participants who have already completed earlier studies with these medications. Researchers will monitor side effects a…

This study is testing whether a long-acting injection of the medication iloperidone can help prevent symptom flare-ups in people with schizophrenia. It will compare the injection to a placebo (a dummy shot) in 400 adults who are already stable on treatment. The main goal is to se…

This study is testing whether adding five extra support elements to standard early psychosis care helps young adults stay engaged in treatment. The enhanced program includes peer support, family therapy, digital outreach, care coordination, and cognitive training. Researchers wil…

This study aims to check the long-term safety of adding a new drug called KarXT to the current antipsychotic medications of adults with schizophrenia. It will follow about 280 people for one year to see how well they tolerate the combined treatment. The goal is to see if this add…

This study is testing whether Magnetic Seizure Therapy (MST) can work as well as electroconvulsive therapy (ECT) for people with schizophrenia who haven't responded to standard medications. Researchers will compare the two treatments in 80 participants who have tried at least two…

This study is testing if the medication clozapine is better than standard antipsychotic treatment at preventing violent acts in people with schizophrenia or schizoaffective disorder. It will involve 280 adults who have a recent history of violence. Participants will be randomly a…

This study is testing whether the medication KarXT can help control symptoms of schizophrenia in teenagers aged 13-17. Researchers will measure how well it reduces symptoms like hallucinations, delusions, and social withdrawal compared to a placebo. The trial involves 166 partici…

This early-stage study is testing a new extended-release pill called LY03020 to see if it's safe and how it moves through the body. It will involve 40 Chinese adults, including both healthy volunteers and people with stable schizophrenia. Researchers will give different doses to …

This study is testing whether adding a second brain-targeting drug to an experimental treatment works better for schizophrenia that hasn't responded well to standard medications. It will involve 90 adults whose schizophrenia symptoms persist despite trying at least two different …

This is an early-stage study to check the safety and how the body processes a new potential schizophrenia medication called VV119. It will first test the drug in healthy adults, then in a small group of patients with schizophrenia to see if it is safe and how it affects their sym…

This study is testing a medication called valbenazine for people with tardive dyskinesia (TD), which causes uncontrollable movements. It is for adults with TD who still have symptoms while taking a similar medication or after stopping one. The main goal is to see if switching to …

This study aims to see how safe and effective a new investigational drug called SEP-363856 is when taken for a full year by adults with stable schizophrenia. It will involve about 100 participants who will take the medication daily. The main goal is to monitor for any side effect…

This study is testing a new oral drug called emraclidine for adults with schizophrenia. The main goals are to see if it is safe, how the body processes it, and if it helps reduce symptoms. About 268 participants will be randomly assigned to receive either the new drug or a placeb…

This study aims to check the long-term safety of the schizophrenia medication KarXT, specifically looking at how it might affect bladder function. It will follow 60 adults with stable schizophrenia for 12 months while they take the drug. The main goal is to see if KarXT causes an…

This study is testing whether a medication called KarXT can help control symptoms in Japanese adults experiencing acute schizophrenia episodes. The trial has two parts: first, 250 participants will receive either KarXT or a placebo for 5 weeks, followed by a year-long extension w…

This study is exploring whether a non-invasive brain stimulation technique can improve thinking problems and mood in people with several brain-based conditions. Researchers will use a magnetic coil placed on the head to stimulate a part of the brain called the cerebellum in 200 p…

This study is testing two types of magnetic brain stimulation to help people with schizophrenia quit smoking. Researchers believe the high smoking rates in this group may be due to overlapping brain circuits for addiction and schizophrenia. They will measure changes in brain acti…

This study is testing whether a new medication called SEP-363856 (Ulotaront) can reduce symptoms in people experiencing an acute schizophrenia episode. Researchers will compare the drug against a placebo in 522 hospitalized participants over 6 weeks. The main goal is to see if th…

This study is testing if a medication called cariprazine can help control symptoms of schizophrenia in teenagers aged 13 to 17. Over 330 participants will be randomly assigned to receive either the real medication or a placebo (a pill with no medicine) for 6 weeks. Researchers wi…

This study is testing a special training program designed to help adults with schizophrenia or schizoaffective disorder improve their thinking skills, like memory and problem-solving. Participants will use computer exercises and attend group therapy sessions to learn strategies f…

This study is testing whether a computer-based brain training program can help people in forensic mental health care. The training aims to improve thinking skills like planning and problem-solving, which are often impaired. Researchers hope better thinking skills will lead to few…

This study is testing a new monthly injection of a medication called cariprazine for people with schizophrenia, bipolar disorder, or major depression. It aims to see if the injection is safe, how the body processes it, and if it helps control symptoms. The study will enroll 24 ad…

This study is testing an investigational oral medication called ML-007C-MA for adults hospitalized due to a sudden, severe worsening of schizophrenia symptoms (acute psychosis). The goal is to see if it is better than a placebo at reducing overall schizophrenia symptoms, as measu…

This study is observing adults with schizophrenia who are switching to a newer medication called KarXT. It aims to see how well the drug works and what side effects people experience in real-world settings, outside of a controlled clinical trial. Researchers will follow 1500 part…

This study is testing if adding the diabetes medication metformin can help people with schizophrenia who need cholesterol-lowering statins. Statins can raise blood sugar and diabetes risk, which is a particular concern for this group. Researchers will give 400 participants either…

This study is testing if a prebiotic fiber supplement can help people with schizophrenia or schizoaffective disorder. Researchers think the supplement might reduce harmful inflammation in the body and brain, which could improve thinking skills and other symptoms. For 12 weeks, 60…

This study is testing whether adding ongoing electroconvulsive therapy (ECT) to standard medication can help prevent relapse in people with severe schizophrenia who haven't responded to other treatments. Researchers will compare patients receiving maintenance ECT plus clozapine a…

This study is testing whether a new smartphone app called Kiso Mind is practical and helpful for people living with schizophrenia or schizoaffective disorder. About 60 participants will either use the app alongside their usual care or receive only their usual care for 12 weeks. R…

This study is testing if metformin, a common diabetes medication, can improve thinking, memory, and brain function in people with schizophrenia. It will involve 120 participants who will take either metformin or a placebo pill for 24 weeks. Researchers will use brain scans and co…

This study is testing a new virtual reality (VR) training program designed to help people with schizophrenia improve their job interview skills and problem-solving abilities. Researchers will recruit 40 participants to complete the VR training and measure changes in their intervi…

This study is testing whether a specific type of talk therapy, called Cognitive Behavioral Therapy for Chronic Pain (CBT-CP), can help veterans who have both serious mental illness and chronic back pain. Researchers will compare the therapy to a general health education program i…

This study is testing if adding a repurposed allergy/asthma drug called cromoglicate to standard antipsychotic medication can help reduce symptoms in adults with schizophrenia or schizoaffective disorder. It will enroll 160 outpatients who are still experiencing significant sympt…

This study is testing whether a personalized, non-invasive brain stimulation technique can help reduce symptoms for people with schizophrenia. Forty participants will receive two weeks of daily stimulation while continuing their regular medications, aiming to see if it improves s…

This study is testing a 12-week group program designed to help young adults with conditions like schizophrenia, bipolar disorder, or major depression improve their skills for romantic relationships. The program focuses on communication, emotional understanding, and building healt…

This study is testing whether a program called 'Taking Action,' led by trained peers, can help college students with serious mental illnesses like depression, bipolar disorder, or schizophrenia. About 300 students will be randomly assigned to either try the five-session program o…

This study is testing whether a year-long yoga-based exercise program can help veterans with serious mental health conditions function better in their daily lives. Researchers will compare the yoga program to a general wellness program to see which helps more with social activiti…

This study is testing whether magnetic stimulation of the brain can improve thinking skills and brain function in people with schizophrenia. 40 participants will receive either real or fake magnetic stimulation five days a week for four weeks. Researchers will use brain scans and…

This small pilot study is testing whether breathing slightly enriched oxygen at night can help young people experiencing their first episode of psychosis. For 4 weeks, participants will use a nasal tube connected to a machine that delivers either regular room air or air with extr…

This early-stage study is checking if MDMA (commonly known as ecstasy) is safe for people with schizophrenia. It aims to see if low doses worsen psychotic symptoms like hallucinations or delusions. The goal is to eventually use the drug's known social-bonding effects to treat sev…

This study is testing two different talk therapies to see if they can help reduce persistent negative symptoms in people with schizophrenia. Negative symptoms include things like low motivation, reduced emotional expression, and social withdrawal. The study will enroll 90 stable …

This study is testing if safely stopping certain medications that are no longer needed can help improve thinking skills, quality of life, and daily functioning for adults aged 40-70 with schizophrenia. About 105 participants will be randomly assigned to either continue their curr…

This study is testing whether a special brain scan can help people with schizophrenia learn to control the brain activity linked to hearing voices. It involves 104 adults with schizophrenia whose hallucinations haven't improved with medication. Participants will receive either re…

This study is testing a new group therapy called Motivation Skills Training (MST) for adults with schizophrenia or schizoaffective disorder. It aims to help participants understand and manage their motivation to improve daily functioning and reach personal goals. The therapy is c…

This study is testing whether a gentle, non-invasive form of electrical brain stimulation can help improve thinking, memory, and attention in people with schizophrenia. Researchers will compare the effects of this stimulation against a sham (fake) treatment in 100 participants. T…

This study is testing whether a new skin patch called ALTO-101 can help improve thinking and memory problems in people with schizophrenia. Researchers will measure changes in brain wave activity and thinking tests in about 82 participants. The study compares the active patch to a…

This study is testing whether a non-invasive brain stimulation technique can improve thinking skills like memory and focus in people with schizophrenia or schizoaffective disorder who are already taking the medication clozapine. Researchers will use magnetic pulses directed at th…

This study is testing a computer-based brain training program for veterans with serious mental illnesses like schizophrenia, bipolar disorder, or PTSD. The goal is to see if this training can improve thinking skills, reduce symptoms, and help with daily life activities. Researche…

This study is testing a new social skills training program designed to help Veterans with serious mental health conditions. The program teaches skills for understanding social cues and navigating work relationships, aiming to improve job success and quality of life. Researchers a…

This study is testing whether a non-invasive brain stimulation technique can help reduce the 'negative symptoms' of schizophrenia, like social withdrawal and lack of motivation. Forty patients will be randomly assigned to receive either real or sham magnetic stimulation to a spec…

This research study is exploring whether a mild, painless electrical current applied to the forehead (called tDCS) can improve thinking, memory, and attention problems in people with schizophrenia. It will compare different ways of delivering the stimulation and measure brain act…

This study aims to understand if a non-invasive magnetic brain stimulation technique can change how quickly people with psychotic disorders think and solve problems. Participants with schizophrenia, bipolar disorder, or schizoaffective disorder will perform thinking tasks and hav…

This study aims to understand how stimulating different parts of the brain with magnetic pulses affects symptoms of several mental health conditions. Researchers will enroll 180 adults with depression, anxiety, OCD, or schizophrenia to receive non-invasive brain stimulation at ra…

This study aims to identify patients experiencing their first psychotic episode who are unlikely to respond to standard treatments. Researchers will use brain imaging scans from 80 participants to find markers that predict poor treatment response at three months. The goal is to h…

This study aims to understand how brain energy use and chemicals differ in people with schizophrenia compared to healthy volunteers. Researchers will use advanced brain scans to measure glucose usage, lactate levels, and glutamate activity in 75 participants. The goal is to gathe…

This French research study aims to understand how people with schizophrenia or bipolar disorder experience the flow of time differently. Researchers will use virtual reality games and brain wave recordings (EEG) to measure time perception in 120 participants, including patients a…

This study aims to understand how pregnancy and breastfeeding affect long-acting injectable antipsychotic medications used for conditions like schizophrenia. Researchers will measure drug levels in the blood of pregnant and breastfeeding women, and also check how much of the medi…

This study is investigating whether a non-invasive brain stimulation technique can improve brain activity and working memory in people recently diagnosed with schizophrenia. Researchers will use magnetic pulses on the forehead to stimulate the brain while measuring electrical act…

This study aims to understand why people with first-time schizophrenia often have trouble with thinking and memory. Researchers will compare 200 new patients with 100 healthy volunteers, tracking changes in their blood, brain scans, and thinking tests over 12 weeks. The goal is t…

This study aims to understand how attention and thinking strategies affect decision-making in people with schizophrenia or schizoaffective disorder. Researchers will compare brain activity during gambling tasks and track real-world choices through daily surveys. The goal is to le…

This study aims to understand how the brain creates auditory hallucinations (hearing voices) in people with schizophrenia. Researchers will use MRI brain scans to compare brain activity and connections in 40 participants—some who experience these voices and some who do not. The g…

This is a small, early-stage research study to see if a type of magnetic brain stimulation is safe and can change brain activity in people with schizophrenia. Researchers will give 34 participants either real or fake stimulation for five days and measure changes in their brain si…

This study aims to understand how the brain makes predictions about sensory information and how this process might be different in people with schizophrenia. Researchers will use a visual illusion task where participants watch moving squares to measure these prediction mechanisms…

This study aims to create a detailed map of thinking problems in people with various brain and mental health conditions, such as schizophrenia, depression, and bipolar disorder. Researchers will compare 600 patients to healthy volunteers using computer-based thinking tests and op…

This is a basic research study to understand how a deep brain area helps people think flexibly and switch between tasks. Healthy participants will play thinking games while having a high-resolution brain scan. The goal is to learn how the brain organizes thoughts, which may help …

This study aims to understand the early stages of psychotic disorders like schizophrenia and bipolar disorder. Researchers will collect information from 320 people recently diagnosed, including brain scans, eye movement tests, and genetic samples, to see if these biological marke…

This study aims to understand if a mild, non-invasive brain stimulation technique can improve thinking skills like memory, focus, and decision-making. It will involve 600 people with conditions such as depression, ADHD, bipolar disorder, or a history of brain injury, as well as h…

This study aims to understand the brain circuits involved in hallucinations experienced by people with schizophrenia. Researchers will use a non-invasive magnetic stimulation technique (TMS) and brain scans (MRI) on 68 participants to measure how specific brain connections change…

This study aims to better understand psychosis in children and adolescents by observing them over time. Researchers will collect detailed information on symptoms, development, brain scans, and genetics from about 200 young people in France. The main goal is to see if different pa…

This study aims to find objective biological markers in the brain to help diagnose and track treatment for severe mental disorders like depression, schizophrenia, and bipolar disorder. Researchers will use a powerful 7T MRI scanner and vision tests to compare brain chemistry and …

This study aims to find biological markers that can predict which patients with hard-to-treat schizophrenia will benefit from the medication clozapine. Researchers will examine 200 patients before and after 12 weeks of clozapine treatment, looking at immune markers in blood and s…

This study aims to understand how a non-invasive brain stimulation treatment (tDCS) might work for schizophrenia. Researchers will use advanced brain scans to measure changes in the brain's connections before and after a 2-week treatment period. The study is enrolling 20 adults w…

This study aims to understand how satisfied adults with schizophrenia are with a new medication called KarXT (xanomeline and trospium chloride) in their daily lives. It will follow 300 participants in the U.S. who are starting this treatment, asking them about their medication pr…