SCHIZOPHRENIA

This study tests whether a digital platform called mindLAMP can improve the effectiveness of a community-based program for people with schizophrenia in India. The program trains primary care workers to provide psychosocial support and connect patients to specialists. The trial wi…

This study tests the long-term safety of a new medication, LB-102, in 900 adults with stable schizophrenia. Participants will take the drug for 52 weeks while doctors monitor side effects and overall health. The goal is to see if LB-102 is safe for ongoing use to control schizoph…

This study looks at whether switching from daily oral antipsychotic pills to a monthly injection of paliperidone palmitate can better control schizophrenia symptoms and improve social functioning. About 120 adults with stable schizophrenia will take part. The goal is to see if th…

This study tests a personalized program combining lifestyle changes (exercise, diet, sleep, social activities), a weight-loss medication (semaglutide) for those who are overweight, and optional brain stimulation for depression. The goal is to improve mental functioning in 140 adu…

This study compares a generic version of aripiprazole injection (400 mg) to the brand-name drug Abilify Maintena® in people with stable schizophrenia. About 116 participants will receive five shots of each drug, one month apart, to see if the generic works the same in the body. T…

This study will test the safety and effectiveness of an extended-release medication called paliperidone in 505 adults with schizophrenia in Bangladesh. Participants will take the medication for 12 weeks, and researchers will track changes in symptoms and side effects. The goal is…

This small pilot study will test the safety and tolerability of bromocriptine, a drug used for other conditions, in 15 adults with schizophrenia who also have prediabetes (higher than normal blood sugar). The goal is to see if bromocriptine can help prevent or delay type 2 diabet…

This study is testing a new long-acting injectable medicine called AX251 in 48 adults with stable schizophrenia. The goal is to see how the drug moves through the body and whether it is safe. Participants receive a single shot and are monitored for side effects and drug levels ov…

This study tests whether aerobic exercise, alone or with a gentle brain stimulation technique called tDCS, can improve memory and attention in people with treatment-resistant schizophrenia. About 160 adults will take part in a 6-week program. The goal is to find a safe, drug-free…

This study tests an experimental drug called LY03020 in 160 adults with schizophrenia who are having acute psychotic symptoms. Participants will receive either the drug or a placebo for a fixed period, and researchers will measure changes in symptom severity using a standard rati…

This study tests whether a supplement called pyrroloquinoline quinone (PQQ) can help reduce negative symptoms (like lack of motivation) and improve thinking skills in people with chronic schizophrenia. About 70 adults aged 18 to 50 will receive either PQQ or a placebo for several…

This pilot study tests whether prucalopride, a drug used for constipation, can improve cognitive functions like memory and attention in people with schizophrenia. 34 clinically stable adults will take the drug for 4 weeks alongside their usual antipsychotic medication. Researcher…

This study tests a brief mobile app designed to reduce negative thinking and improve mood. Researchers will enroll 100 adults with schizophrenia or at clinical high risk for psychosis. Participants use the app and report changes in defeatist beliefs and negative symptoms. The goa…

This study tests a shared decision-making tool for antipsychotic medications in 120 people aged 18-30 with early psychosis. The goal is to see if the tool helps patients feel more involved in their treatment choices and improves their commitment to therapy. Participants will use …

This study will test a new mobile mental health app designed to help people with schizophrenia or schizoaffective disorder take their medication as prescribed. Researchers want to see if the app is easy to use and acceptable to patients. Fifty adults aged 18-60 who are in remissi…

This study looks at how cannabis use changes both positive symptoms (like hallucinations) and negative symptoms (like lack of motivation) in people with schizophrenia. Researchers will track 120 participants in their daily lives using mobile phone surveys and thinking tasks. The …

This study will compare 200 adults with psychosis to see if their condition is caused by methamphetamine use or by schizophrenia. Researchers will track symptoms, treatment response, and recovery over three months. The goal is to better understand the differences between these tw…

This study looks at how brain networks relate to thinking and memory problems in people with schizophrenia, bipolar disorder, or major depression. Researchers will use brain scans and cognitive tests to build models that could help diagnose these conditions and predict treatment …

This study looks at how the Clubhouse model—a structured, supportive community for people with mental illness—affects thinking skills, daily life, and brain activity in adults with schizophrenia or related conditions. Researchers will compare Clubhouse members to those receiving …

This study tests a new way to monitor muscle activity during electroconvulsive therapy (ECT) for people with depression, bipolar disorder, or schizophrenia. It compares a standard arm tourniquet method with a newer, potentially less painful approach. The goal is to see if the new…

This early-stage trial will give 8 healthy men a single radioactive-labeled dose of an experimental schizophrenia drug to see how it is absorbed, broken down, and eliminated. Participants must be in good health and have regular bowel movements. The study does not aim to treat any…

This study looks at how emotional eating (eating in response to feelings, not hunger) and sleep quality are linked to metabolic syndrome risk in 78 adults with schizophrenia or bipolar disorder. Researchers will measure mental state, eating habits, sleep, and metabolic risk to fi…

This study tests whether a structured medication education program helps psychiatric inpatients with schizophrenia, bipolar disorder, or psychotic depression take their medications as prescribed and manage side effects. Researchers will enroll 64 adults in a psychiatric clinic an…

This study tests a group program to help veterans with serious mental illness feel more comfortable and confident working with their doctors and therapists. About 119 veterans from three VA centers will take part. The goal is to see if the program improves teamwork between vetera…