SCHIZOPHRENIA

This study will test the long-term safety and effectiveness of the medication ML-007C-MA in adults with schizophrenia. About 500 participants will take the medication for 52 weeks while researchers monitor side effects and how well it controls symptoms. The goal is to see if this…

This study is testing whether a structured education program helps hospitalized patients with conditions like schizophrenia or bipolar disorder take their psychiatric medications more consistently. Researchers will teach one group of patients about their illness, their medication…

This study is testing if switching stable schizophrenia patients from their daily oral medications to a monthly injection of paliperidone palmitate is effective. It will involve 120 adults whose symptoms are currently controlled with pills. Researchers will check if the injection…

This study is testing whether a new medication called LB-102 can help control symptoms during acute schizophrenia episodes. Researchers will compare two different doses of LB-102 against a placebo in 456 adults currently experiencing symptom worsening. The main goal is to see if …

This study is testing a 10-session group program designed to help Veterans with serious mental illnesses like schizophrenia or bipolar disorder work more effectively with their treatment teams. The goal is to help Veterans gain the skills and confidence to collaborate on their ow…

This study is testing an investigational drug called NBI-1117570 for adults who are hospitalized due to a severe worsening of schizophrenia symptoms. It will compare the drug to a placebo to see if it helps reduce symptoms and is safe. The goal is to find a new treatment option t…

This study is testing how well the medication paliperidone works for adults with schizophrenia in Bangladesh. Researchers will follow 505 participants for 12 weeks to see if their symptoms improve and monitor any side effects. The study also measures how the treatment affects peo…

This early-stage study aims to understand how a new long-acting injectable medication for schizophrenia moves through the body and how safe it is. It will involve 48 adults with stable schizophrenia who will receive a single injection. The main goal is to measure drug levels in t…

This small pilot study is testing if adding a drug called bromocriptine is safe and can help control blood sugar problems in people with schizophrenia. The blood sugar issues are a serious side effect of common antipsychotic medications and can lead to diabetes. The study will in…

This study is testing an investigational medicine, NBI-1117568, to see if it can help prevent the return of schizophrenia symptoms in adults whose condition is currently stable. About 560 participants will first take the study drug openly. Those who respond well will then be rand…

This study is testing a new extended-release tablet called LY03020 for adults experiencing an acute worsening of schizophrenia symptoms. It will compare the drug to a placebo (inactive pill) to see if it better reduces symptoms like hallucinations and delusions and is safe. The g…

This study is testing whether adding a smartphone app can improve a community-based support program for people living with schizophrenia in India. The research will involve 240 participants who have schizophrenia and a physical health risk, like high blood pressure. The goal is t…

This study is testing whether a new mobile phone app is practical and acceptable for helping people with schizophrenia or schizoaffective disorder take their medication as prescribed. The app will provide reminders, educational videos, and rewards to encourage adherence. Research…

This study tests whether a non-invasive magnetic brain stimulation technique can help reduce symptoms in people with schizophrenia who haven't gotten enough relief from standard medications. It will involve 36 adults aged 18-40 who have a history of childhood trauma and are still…

This study aims to check the long-term safety and side effects of a new medication called LB-102 for adults with stable schizophrenia. It will involve 900 participants who are not fully satisfied with their current antipsychotic medication and want to switch. The main goal is to …

This study is testing whether adding an investigational drug called brenipatide to standard schizophrenia medication is safe and more effective than standard care alone. It will involve 450 adults with schizophrenia who are already on stable medication. The main goal is to see if…

This study is testing whether aerobic exercise and a gentle, non-invasive brain stimulation technique (tDCS) can help improve memory, attention, and other thinking skills in people with schizophrenia that hasn't responded well to standard medications. 160 participants will be ran…

This study is testing if adding a dietary supplement called Pyrroloquinoline quinone (PQQ) to standard medication can help people with chronic schizophrenia. It will see if PQQ can reduce hard-to-treat symptoms like lack of motivation and improve problems with memory and thinking…

This study is testing a brief mobile phone app designed to help improve mood by addressing unhelpful thinking patterns. It will involve 100 people who either have schizophrenia or are at high risk for developing psychosis. The main goal is to see if the app is helpful and easy to…

This small, early-stage study is testing whether a drug normally used for constipation (prucalopride) can help improve thinking, memory, and problem-solving skills in people with schizophrenia. Thirty-four stable patients will take the drug for four weeks alongside their regular …

This study aims to understand the connections between mental health, emotional eating, sleep quality, and the risk of developing metabolic syndrome (a cluster of conditions like high blood pressure and blood sugar) in people with schizophrenia or bipolar disorder. Researchers wil…

This research aims to understand how cannabis use affects people living with schizophrenia. Researchers will follow 120 patients in their daily lives using smartphone surveys to track symptoms and cannabis use. The goal is to learn whether cannabis makes some symptoms worse while…

This study aims to understand the differences between psychosis caused by methamphetamine use and schizophrenia. Researchers will follow 200 adults in Egypt who have either condition, tracking their symptoms and recovery over three months. The goal is to see if these two types of…

This study aims to understand if a specific community support program, called the Clubhouse Model, helps improve thinking skills, daily functioning, and brain activity in adults with schizophrenia more than standard outpatient care. Researchers will compare 30 new Clubhouse membe…

This early-stage study aims to understand how the body absorbs, breaks down, and eliminates a potential new oral medication for schizophrenia. Eight healthy adult men will receive a single dose containing a tiny, safe amount of radioactive tracer to track the drug's path. The mai…

This study aims to understand how brain networks are involved in thinking problems that occur with schizophrenia, bipolar disorder, and major depression. Researchers will use brain scans and cognitive tests in 400 participants (including patients and healthy volunteers) to identi…