SCHIZOPHRENIA

This study tested whether a new daily pill called LB-102 could help reduce symptoms in adults hospitalized with a sudden worsening of schizophrenia. About 360 participants were randomly assigned to receive either the drug at different doses or a placebo (a pill with no medicine) …

This study tested whether a new daily pill called MK-8189 could safely reduce symptoms in adults experiencing a sudden worsening of schizophrenia. About 500 participants took either MK-8189, a placebo, or an existing antipsychotic for 6 weeks to compare their effects. The main go…

This study tested the long-term safety of cariprazine, a medication, in children and teenagers with schizophrenia, bipolar I disorder, or autism spectrum disorder. Over 300 participants took flexible doses of the medication for 52 weeks while researchers monitored for side effect…

This study aimed to understand the long-term safety and side effects of the medication brexpiprazole in teenagers (ages 13-17) with schizophrenia. Nearly 300 adolescents took a flexible dose of the drug for up to two years while researchers closely monitored their health. The mai…

This study tested a new medication called MP-214 for people with schizophrenia. It involved 38 participants and lasted 12 weeks. The main goals were to see how the drug moves through the body, check its safety, and measure if it helps control symptoms.

This study tested a long-acting, injectable version of the medication olanzapine (called TV-44749) for adults with schizophrenia. The goal was to see if a monthly injection could effectively control symptoms and was safe to use for up to a year. Researchers compared the injection…

This early-stage study tested a new, long-acting injection of the medication risperidone for schizophrenia. The goal was to see if a single shot given every three months is safe and how the body processes it. The study involved 58 adults with stable schizophrenia who were already…

This study tested whether a mindfulness and education program could help people with schizophrenia stick to their medication and improve their awareness. Forty stable outpatients were randomly assigned to either receive the special program or continue with their usual care. The g…

This study tested whether a medication called ITI-007 could help control symptoms in people experiencing a schizophrenia flare-up. Researchers compared the drug against a placebo in 450 adults with schizophrenia over 28 days. They measured changes in symptoms like hallucinations,…

This study tested whether delivering specialized early psychosis care via video calls (telehealth) works as well as standard in-clinic visits. It involved 74 young adults (ages 16-35) with recent-onset psychotic disorders. Over 12 months, researchers compared how often participan…

This study tested if adding a drug called memantine to a brain training program could help people with schizophrenia or schizoaffective disorder. Researchers wanted to see if this combination could improve thinking skills, reduce symptoms, and help with daily activities better th…

This study aimed to test the long-term safety and effectiveness of an investigational drug called MP-214 for people with schizophrenia. It involved 42 participants who were already taking one or more other antipsychotic medications. The main goal was to see how well patients tole…

This study tested whether a new oral medication called CPL500036 could help control symptoms during acute flare-ups of schizophrenia. For 28 days, 189 patients experiencing worsening symptoms received either one of two doses of the medication or a placebo pill. Researchers measur…

This study tested whether a new medication called CVL-231 (Emraclidine) could help control symptoms in people with schizophrenia who were experiencing a sudden worsening of psychosis. 385 participants received either one of two doses of the drug or a placebo for 6 weeks. Research…

This study tested a remote coaching program designed to help adults with schizophrenia who struggle to take their medication as prescribed. For 12 weeks, participants received either this special coaching or standard enhanced care. Researchers measured how well people attended th…

This study tested a new long-acting injectable form of the schizophrenia medication olanzapine against the standard oral pill. It involved 153 adults with stable schizophrenia to see how the body absorbs the medicine from each form and to check the safety of the injection. The go…

This large Phase 3 study tested whether a new medication called ITI-007 could help control symptoms in people experiencing a sudden worsening of schizophrenia. For 6 weeks, 696 adult patients received either ITI-007, an existing antipsychotic medication, or a placebo pill, with n…

This study compared a new tablet called VHX-896 to an existing drug, iloperidone, in people with schizophrenia or bipolar I disorder. The main goal was to see if the new tablet gets into the bloodstream the same way as the old one. Researchers also checked how safe and tolerable …

This study tested whether education groups led by fellow patients with schizophrenia could help others manage their condition better than groups led by professionals or standard care alone. It involved 342 Chinese adults with schizophrenia who were followed for two years. Researc…

This study aimed to see if a new drug called KarXT is safe and effective for long-term use in people with schizophrenia. Over 500 adults who were starting a new treatment took the drug for up to one year. Researchers closely monitored side effects and whether the drug helped cont…

This study tested whether a personalized 'SOS Plan' could help people with schizophrenia avoid hospital stays. The plan was created by the patient, their doctor, and family members to outline what to do during a mental health crisis. Researchers compared 124 patients who used the…

This study tested whether a new monthly injection for schizophrenia works the same way in the body as an existing, approved injection. It involved 256 adults in China with stable schizophrenia who received either the new or the existing injection for several months. The main goal…

This study tested whether a medication called MP-214 could help control symptoms in people experiencing a schizophrenia flare-up. Researchers compared the drug against a placebo in 512 patients over 6 weeks to see if it reduced symptoms and was safe to use. The trial measured cha…

This study tested how well people with schizophrenia could switch from their current antipsychotic medication to a new drug called SEP-363856. 101 participants took the new drug for 8 weeks while researchers monitored how many stopped treatment due to side effects or lack of bene…

This study tested a new oral medication called MP-214 to see if it is safe and effective for people with schizophrenia. Thirty-four participants took one of three different doses of the pill daily for two weeks. The main goals were to check for side effects and to see how the dru…

This study tested whether a very low-carbohydrate, high-fat ketogenic diet could improve brain network stability in people with schizophrenia or bipolar disorder. Researchers enrolled 71 adults and compared those on the special diet for four weeks to those eating as usual. The go…

This study tested the long-term safety of an experimental schizophrenia medication called SEP-363856. It involved 75 people with schizophrenia who had already switched to this drug from their previous antipsychotic medication in an earlier trial. Researchers monitored participant…

This study tested if sending supportive text messages could help young people with psychosis get from the emergency room to their first follow-up appointment. Researchers enrolled 186 young adults (ages 16-29) to see if reminders and check-ins via text improved attendance at that…

This study observed how well a long-acting injectable medication called Risperidone ISM worked for adults hospitalized due to a schizophrenia relapse. Researchers followed 275 patients in psychiatric hospitals across Europe to see if the injection helped control symptoms, shorten…

This study tested a structured program designed to help people with schizophrenia or bipolar disorder learn skills to better manage their condition. It compared the program to regular care for about 200 adults in Denmark. The main goal was to see if the program improved participa…

This study aimed to see if a medication called MP-214 is safe and effective for long-term use in people with chronic schizophrenia or elderly patients with schizophrenia. It involved 125 participants who were either in the chronic phase of the illness or between 65 and 74 years o…

This study tested a new daily pill called Emraclidine (CVL-231) to see if it could help control symptoms in adults with schizophrenia who were having a severe and sudden worsening of their illness. About 391 participants were randomly assigned to receive one of two doses of the m…

This study tested a medication called KarXT for adults in China who were hospitalized due to a severe worsening of schizophrenia symptoms. For the first 5 weeks, some participants received the drug while others received a placebo, and neither they nor their doctors knew which. Th…

This study tested a new mobile phone app called iTEST. It was designed to help adults with schizophrenia or similar conditions improve their ability to accurately judge their own performance on tasks. The goal was to see if this improved self-awareness could lead to better daily …

This study tested if a very low dose of amphetamine could make computer-based brain training more effective for people with schizophrenia or schizoaffective disorder. 68 participants completed up to 30 hours of training, with half receiving the medication and half receiving a pla…

This small study tested whether adding structured supportive talk therapy to standard schizophrenia medication (risperidone) could improve thinking skills and reduce body inflammation better than medication alone. It involved 46 men with recent schizophrenia diagnoses over 6 week…

This study aimed to check the long-term safety and effectiveness of an investigational medication called MP-214 for people with schizophrenia. It included 254 patients who had already finished a related earlier study. The main goal was to monitor for any side effects and see how …

This study tested a family training program delivered by video call. It aimed to help family members support a relative who is experiencing early psychosis and using substances like alcohol or cannabis. The goal was to see if the program improved family wellbeing and helped the r…

This study tested whether higher doses of a long-acting injectable antipsychotic medication (risperidone) work better than standard doses for people with schizophrenia or schizoaffective disorder whose symptoms aren't well controlled. 160 participants who hadn't responded well to…

This study tested whether customizing a brain training program (called Cognitive Remediation) could improve thinking skills and daily function for people with schizophrenia or schizoaffective disorder. Researchers first tested participants' basic hearing processing and then assig…

This study tested whether adding a drug called valbenazine to a person's current antipsychotic medication could better control schizophrenia symptoms. It involved 442 adults whose symptoms weren't fully controlled by their existing medication. Participants were randomly assigned …

This study aimed to see if a new, experimental schizophrenia medication called SEP-363856 is safe for people to take for a full year. It compared the drug's long-term safety and side effects to an already-approved medication, quetiapine XR. The trial involved 305 clinically stabl…

This study tested whether a smartphone app designed specifically for people with serious mental illness could help them quit smoking better than standard advice. Over 300 participants with conditions like schizophrenia, bipolar disorder, or depression were randomly assigned to us…

This study tested whether using MRI scans to guide magnetic brain stimulation could reduce treatment-resistant hallucinations in people with schizophrenia. Researchers enrolled 85 participants who continued to experience hallucinations despite medication. They used a non-invasive…

This study tested whether group-based cognitive training helps people with schizophrenia manage daily life better. Researchers compared a special training program that teaches practical strategies to usual care in 218 patients. The goal was to see if this approach improves functi…

This study tested whether aerobic exercise or computer-based cognitive training is better at helping people with schizophrenia. It involved 58 adults with schizophrenia who were already receiving mental health services. Researchers compared how these two different activities affe…

This study tested whether a special group training program could help people with schizophrenia, major depression, or bipolar disorder. The program, called Metacognitive Training, taught participants new ways of thinking over eight sessions. Researchers measured changes in sympto…

This study tested whether a talk therapy program for chronic pain is practical and helpful for veterans who also have serious mental illnesses like schizophrenia or bipolar disorder. Researchers worked with 47 veterans to see if they could successfully participate in the therapy …

This study tested whether the drug valbenazine could improve daily life for people with tardive dyskinesia (TD), a condition causing uncontrollable movements often linked to certain mental health medications. For 24 weeks, 59 adults with TD and conditions like schizophrenia or bi…

This study tested two different ways to help community mental health clinics use a smartphone app called FOCUS with their patients who have schizophrenia. The goal was to see which method worked better for helping clinics support patients in using the app to manage symptoms like …

This study tested whether a gentle, non-invasive brain stimulation technique could reduce cravings in people struggling with both substance use and another mental health condition like ADHD or bipolar disorder. Researchers targeted a specific brain area linked to craving using a …

This study tested whether a medicine called iclepertin could improve thinking, learning, and memory in people with schizophrenia. About 620 adults with stable schizophrenia took either iclepertin or a placebo pill daily for 26 weeks, while continuing their regular medications. Do…

This study tested whether a daily pill called iclepertin could improve learning, memory, and thinking skills in adults with schizophrenia. Over 600 participants took either iclepertin or a placebo (a dummy pill) for 26 weeks while continuing their standard schizophrenia medicatio…

This study compared two different activity programs to see which might better help people with schizophrenia. Researchers tested whether regular physical exercise or training using virtual reality (VR) could improve physical abilities, thinking skills, and quality of life. The st…

This study tested whether participating in arts programs like dance, cinema, or theater could improve mental wellbeing and reduce symptoms of anxiety and depression. 382 participants aged 10-99 with various mental health conditions were randomly assigned to either start arts acti…

This study tested a medication called BXCL501 to see if it could safely and effectively calm episodes of agitation when used at home by adults with schizophrenia or bipolar disorder. In the second part of the trial, 452 participants used the medication as needed over 12 weeks at …

This study tested whether a special training program could help people with schizophrenia improve their social skills. About 51 participants were randomly assigned to either receive the training or be on a waitlist. The training focused on helping people better understand social …

This study tested whether a new medication called ITI-007 could reduce symptoms in people with schizophrenia who were experiencing a sudden worsening of their psychosis. 335 participants were randomly assigned to receive either one of two doses of ITI-007, a placebo (inactive pil…

This study tested whether a virtual reality (VR) program could help people with schizophrenia improve their social skills and daily functioning. Thirty-seven participants with stable symptoms watched 360-degree videos of real-life social situations during 12 weekly sessions. The …

This study tested whether using a smartphone app for a second 16-week period could continue to help people with schizophrenia manage certain hard-to-treat symptoms. The app was used alongside standard medication by 73 participants who had already tried it in a previous trial. Res…

This study tested whether a 4-week virtual reality (VR) brain training program could improve thinking skills and daily functioning in people with stable depression, bipolar disorder, or schizophrenia. 62 participants were randomly assigned to receive either the active VR cognitiv…

This study tested whether adding a behavioral skills training program to standard job support helps people with schizophrenia work longer. All 107 participants were on medication (risperidone or olanzapine) and received help finding a job. Researchers then compared those who got …

This study tested whether light therapy (photoneuromodulation) could help reduce the negative symptoms of schizophrenia in people who hadn't responded well to other treatments. Thirty participants received either real or fake light therapy sessions in a carefully controlled cross…

This study looked at what happens when people with schizophrenia or bipolar disorder stop taking a short-term medication for agitation. Researchers gave 29 adults the drug Igalmi as needed for 7 days to calm agitation episodes, then monitored them for 3 days after stopping. The m…

This study tested whether watching a video of themselves recorded during a difficult period could help people with schizophrenia or schizoaffective disorder better recognize and understand their illness. Sixty patients were randomly assigned to either watch their own video after …

This study tested whether a non-invasive brain stimulation technique called tDCS could help reduce persistent symptoms in people with schizophrenia who were already taking medication. 141 participants received either real or fake (sham) stimulation sessions over 5 days to see if …

This study tested whether two prescription smartphone apps could help reduce the 'negative symptoms' of schizophrenia, like low motivation and lack of pleasure. It involved 464 adults and late teens who were already on stable medication. The apps were used alongside standard care…

This study tested whether two types of non-invasive magnetic brain stimulation could reduce nicotine craving. It compared the effects in 90 participants: people with schizophrenia who smoke and people without psychosis who smoke. The main goal was to see if stimulating specific b…

This study tested whether a special program of educational and motivational talks could help people with schizophrenia better understand their condition and feel more hopeful. 44 participants were split into two groups: one received the new talk sessions, while the other continue…

This study tested whether two types of gentle, non-invasive electrical brain stimulation could improve thinking skills like memory and problem-solving in people with schizophrenia. Thirty-six adults with schizophrenia received different stimulation types in a random order to see …

This study tested whether a medicine called Iclepertin could help improve common thinking and memory problems in people with schizophrenia, like trouble remembering things or paying attention. Over 600 adults with stable schizophrenia took either Iclepertin or a placebo pill dail…

This study tested whether special computer exercises could help improve vision problems common in people with schizophrenia. Researchers worked with 79 adults who have schizophrenia or schizoaffective disorder, having them complete visual training tasks targeting contrast sensiti…

This study tested whether luteolin, a natural compound found in foods like celery and chamomile tea, could help improve symptoms and thinking problems in people with schizophrenia. For 12 weeks, 85 participants with schizophrenia or schizoaffective disorder took either luteolin c…

This study tested a new training program called Collaborative Decision Skills Training (CDST) for veterans with conditions like schizophrenia or severe depression. The goal was to teach veterans skills to help them work more closely with their doctors on treatment plans. Research…

This study tested whether two types of visual brain training could improve thinking skills in young adults with early psychosis. Researchers enrolled 152 people aged 18-30, including those with conditions like schizophrenia and those without any psychiatric diagnosis. The study w…

This small study aimed to understand how a non-invasive brain stimulation technique (TMS) affects brain activity in people with schizophrenia. Ten participants received both real and fake (sham) TMS sessions while researchers measured their brain signals. The goal was to gather i…

This study explored whether a training program on an iPad could help young people who have a close family member with schizophrenia improve their ability to recognize emotions in others. Researchers tested 82 participants aged 15-35, comparing a special emotion recognition traini…

This study tested a new AI-powered computer program called CBTpro, designed to help therapists learn and practice a specific talk therapy for people with psychosis. The tool listens to therapists practice with simulated patients and gives them feedback to improve their skills. Re…

This study aimed to understand how computer-based brain training affects thinking skills and brain activity in people with early psychosis. It involved 100 participants, including people with conditions like schizophrenia and healthy volunteers, who completed about 10 hours of tr…

This large, completed study aimed to understand the genetic and brain function factors behind schizophrenia and related disorders. Researchers compared patients, their siblings, and healthy volunteers to identify genes that might increase risk and affect thinking skills. The goal…

This small pilot study tested a new phone system called 'My Coach Connect' to see if it could help communication between patients and their mental health providers. Patients with conditions like depression or schizophrenia called in twice a week for four months to leave voice mes…

This study checked whether eating a meal changes how the body absorbs a new, once-weekly version of the schizophrenia medication brexpiprazole. It involved 59 adults with stable schizophrenia who took the drug once while fasting and once after a high-fat meal. The main goal was t…

This study tested if a new generic version of the schizophrenia drug Brexpiprazole works the same way in the body as the established brand-name version. It involved 36 healthy adults who each took both pills at different times. Researchers measured drug levels in the blood to see…

This study aimed to understand why some people with schizophrenia or bipolar disorder feel their own actions are controlled by an outside force. Researchers compared healthy volunteers with patients who had these conditions. They tested how people process the sensory results of t…

This study aimed to understand how a brain chemical called KYNA affects thinking and memory in people with schizophrenia. Researchers gave 88 participants a dietary supplement (tryptophan) to increase KYNA, and then tested if another supplement (NAC) could block its effects. They…

This study aimed to understand the dental health of adults with schizophrenia in a specific region of France. Researchers examined the teeth of 110 participants, took a blood sample from some to check vitamin C levels, and asked questions about their dental hygiene and eating hab…

This study aimed to understand how the brain processes information in people with early psychosis. Researchers measured brain activity in 277 participants, including those with and without a diagnosis, while they played computer games. The goal was to see if differences in brain …

This study tested whether a learning method called 'retrieval practice' works for people with schizophrenia. Researchers compared 40 people (some with schizophrenia, some without) to see if practicing recalling word pairs from memory helps long-term learning more than just re-stu…

This early study tested how a potential schizophrenia medication (SEP-380135) might interact with other drugs in the body. Researchers gave the drug to 12 healthy adults to measure how their bodies processed it and check for safety issues. The goal was to understand potential dru…

This study aimed to see if a simple brain wave test could help match Veterans with mental health conditions to the right type of brain training. Researchers enrolled 100 Veterans from VA programs to measure their brain activity and see how it related to their thinking skills and …

This study aimed to create and validate a questionnaire to understand how people with schizophrenia perceive their own oral health. Researchers asked 59 adults with long-term schizophrenia to complete several surveys about their mouth, memory, mood, and quality of life. The goal …

This study tested a smartphone app designed to help veterans with serious mental health conditions track their own well-being. The app passively collects data on phone use, movement, and sleep patterns, which may act as warning signs for worsening symptoms. Researchers aimed to s…

This study aimed to understand how people with schizophrenia organize memories of personal events in time. 80 participants, including patients and healthy volunteers, took a one-hour walk wearing an automatic camera. Later, researchers tested their ability to put photos from the …

This early-stage study aimed to understand how a drug called lumateperone is processed by the body and to check its safety in teenagers with schizophrenia or schizoaffective disorder. It involved 26 participants aged 13 to 17 who were stable in their condition. The main goal was …

This study used special brain scans (PET scans) to measure dopamine activity and blood flow in the brains of healthy volunteers, people with Parkinson's disease, and people with schizophrenia. Researchers compared these measurements across groups to better understand how dopamine…

This study aimed to understand the biological basis of schizophrenia by seeing how the illness itself affects the brain, separate from the effects of medication. Researchers temporarily stopped antipsychotic drugs for 648 participants with schizophrenia in a closely monitored hos…

This study used advanced brain imaging (PET scans) to see how the frontal lobe works during thinking tasks. It compared healthy volunteers to people with conditions like schizophrenia and Parkinson's disease to understand brain function differences. The goal was to gather knowled…

This study aimed to understand if and how two common schizophrenia medications (risperidone and aripiprazole) affect the tiny power plants inside our cells, called mitochondria. Researchers compared 60 patients with schizophrenia, measuring markers of mitochondrial function, symp…

This study aimed to better understand brain disorders like schizophrenia by comparing detailed brain scans of patients to those of healthy volunteers. Researchers used advanced MRI and MEG imaging technology to look for differences in brain structure, chemistry, and activity. The…

This study aimed to understand why people with schizophrenia often use cannabis. Researchers tested if low doses of cannabis or a cannabis-like medicine (dronabinol) could help regulate the brain's reward system in people with both schizophrenia and cannabis use disorder. They us…

This study aimed to better understand how brain chemistry differs in people with schizophrenia. Researchers used special brain scans (PET and MRI) to measure dopamine receptors in 283 participants, including healthy volunteers and people with schizophrenia. The goal was to gather…