New drug combo KarXT tested for Long-Term safety in schizophrenia

NCT ID NCT05304767

Completed Disease control Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This study looks at the long-term safety of an investigational drug called KarXT when added to current antipsychotic medications for people with schizophrenia. About 280 adults who completed a previous KarXT study will take the drug for up to 52 weeks. Researchers will track side effects to see if KarXT is safe for extended use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: KarXT (a combination of xanomeline and trospium chloride)
What this could lead to: If successful, this could show that KarXT is safe to use long-term alongside standard antipsychotics, potentially offering a new option for people with schizophrenia who don't fully respond to current treatments.
What could go wrong: This is an open-label extension study, meaning everyone knows they are getting the drug, which can bias results. It focuses on safety, not effectiveness, and the 52-week duration may not capture very rare or long-term side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCHIZOPHRENIA

Contacts and locations

Locations

Local Institution - 101

Bellevue, Washington, 98007, United States
Local Institution - 103

Irving, Texas, 75062-2757, United States
Local Institution - 104

New York, New York, 10017, United States
Local Institution - 105

Lauderhill, Florida, 33319-4985, United States
Local Institution - 108

Rochester, New York, 14623, United States
Local Institution - 109

Torrance, California, 90504, United States
Local Institution - 110

Cerritos, California, 90703, United States
Local Institution - 111

Atlanta, Georgia, 30328, United States
Local Institution - 112

Little Rock, Arkansas, 72211, United States
Local Institution - 113

Staten Island, New York, 10314-1607, United States
Local Institution - 126

Lafayette, California, 94549, United States
Local Institution - 127

Garden Grove, California, 92845, United States
Local Institution - 128

Austin, Texas, 78754, United States
Local Institution - 129

St Louis, Missouri, 63128, United States
Local Institution - 130

Bellflower, California, 90706, United States
Local Institution - 131

Lemon Grove, California, 91945-2956, United States
Local Institution - 133

Hialeah, Florida, 33016-1814, United States
Local Institution - 136

Atlanta, Georgia, 30303-3031, United States
Local Institution - 138

Decatur, Georgia, 30030, United States
Local Institution - 140

Rutland, Vermont, 05701, United States
Local Institution - 144

Riverside, California, 92506, United States
Local Institution - 145

Miami, Florida, 33122-1335, United States
Local Institution - 146

Anaheim, California, 92805, United States
Local Institution - 148

Las Vegas, Nevada, 89102, United States
Local Institution - 150

Orange, California, 92868, United States
Local Institution - 151

Chicago, Illinois, 60640, United States
Local Institution - 152

La Habra, California, 90631-3842, United States
Local Institution - 153

Miami Lakes, Florida, 33016, United States
Local Institution - 155

Tampa, Florida, 33629, United States
Local Institution - 156

Pembroke Pines, Florida, 33025, United States
Local Institution - 157

New York, New York, 10036, United States
Local Institution - 159

Richmond, Texas, 77407, United States
Local Institution - 160

New York, New York, 10035, United States
Local Institution - 161

Phoenix, Arizona, 85012, United States
Local Institution - 163

Independence, Ohio, 44131, United States
Local Institution - 164

Stanford, California, 94305, United States
Local Institution - 166

Gaithersburg, Maryland, 20877, United States
Local Institution - 167

Culver City, California, 90230, United States
Local Institution - 169

Marietta, Georgia, 30060, United States
Local Institution - 170

Pico Rivera, California, 90660, United States
Local Institution - 171

Miami, Florida, 33166, United States
Local Institution - 172

Richardson, Texas, 75080, United States
Local Institution - 173

Miami Lakes, Florida, 33014, United States
Local Institution - 174

Omaha, Nebraska, 68144, United States
Local Institution - 175

Little Rock, Arkansas, 72204, United States
Local Institution - 176

Hickory, North Carolina, 28601, United States
Local Institution - 178

St Louis, Missouri, 63141, United States
Local Institution - 179

Eugene, Oregon, 97403, United States
Local Institution - 180

Houston, Texas, 77074, United States
Local Institution - 181

Oceanside, California, 92056, United States
Local Institution - 182

Hialeah, Florida, 33012, United States
Local Institution - 186

Coral Gables, Florida, 33134, United States
Local Institution - 187

Boston, Massachusetts, 02118, United States
Local Institution - 188

Berlin, New Jersey, 08009, United States
Local Institution - 190

Fort Worth, Texas, 76104, United States
Local Institution - 192

Atlanta, Georgia, 30331, United States
Local Institution - 250

Toyoake-shi, Aichi-ken, 470-1168, Japan
Local Institution - 253

Meguro-ku, Tokyo, 1540012, Japan
Local Institution - 254

Karatsu-shi, Saga-ken, 847-0031, Japan
Local Institution - 255

Fukuoka, Fukuoka, 819-0037, Japan
Local Institution - 256

Shinjuku-ku, Tokyo-To, 162-0843, Japan
Local Institution - 257

Shirakawa-shi, Fukushima, 961-0021, Japan
Local Institution - 301

Pleven, 5800, Bulgaria
Local Institution - 302

Kazanlak, Stara Zagora, 6100, Bulgaria
Local Institution - 303

Sofia, 1680, Bulgaria
Local Institution - 304

Novi Iskar, 1282, Bulgaria
Local Institution - 305

Sofia, 1113, Bulgaria
Local Institution - 306

Sofia, Sofia-Grad, 1202, Bulgaria
Local Institution - 307

Sofia, 1510, Bulgaria
Local Institution - 308

Varna, 9020, Bulgaria
Local Institution - 309

Sofia, Sofia-Grad, 1463, Bulgaria
Local Institution - 310

Vratsa, 3000, Bulgaria
Local Institution - 311

Dupnitsa, 2600, Bulgaria
Local Institution - 312

Sliven, 8800, Bulgaria
Local Institution - 313

Razgrad, 7200, Bulgaria
Local Institution - 314

Plovdiv, 4002, Bulgaria
Local Institution - 315

Pleven, 5800, Bulgaria
Local Institution - 316

Kardzhali, 6600, Bulgaria
Local Institution - 317

Targovishte, 7700, Bulgaria
Local Institution - 318

Cherven Bryag, 5980, Bulgaria
Local Institution - 319

Sofia, 1408, Bulgaria
Local Institution - 321

Plovdiv, 4004, Bulgaria
Local Institution - 401

Kragujevac, 34 000, Serbia
Local Institution - 402

Belgrade, 11000, Serbia
Local Institution - 403

Belgrade, 101421, Serbia
Local Institution - 404

Kovin, 306041, Serbia
Local Institution - 405

Belgrade, 11000, Serbia
Local Institution - 406

Kragujevac, 34 000, Serbia
Local Institution - 407

Kragujevac, 34 000, Serbia
Local Institution - 408

Kragujevac, 34 000, Serbia
Local Institution - 410

Novi Kneževac, 23330, Serbia
Local Institution - 411

Gornja Toponica, 705631, Serbia
Local Institution - 414

Kovin, 26220, Serbia
Sangenjaya Neurology- Psychosomatic Clinic

Setagaya-ku, Tokyo, 1540004, Japan

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