New hope for schizophrenia: KarXT shows promise in phase 3 trial

NCT ID NCT05919823

First seen Nov 21, 2025 · Last updated May 11, 2026 · Updated 16 times

Summary

This study tested a new drug called KarXT in 202 Chinese adults hospitalized with schizophrenia. For 5 weeks, some received KarXT and others a placebo to see if the drug reduces symptoms like hallucinations and social withdrawal. After that, everyone could take KarXT for 12 more weeks to check long-term safety and effects.

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Contacts and locations

Locations

  • Anhui Mental Health Center

    Hefei, Anhui, 230022, China

  • Beijing Anding Hospital Capital Medical University

    Beijing, Beijing Municipality, 100035, China

  • Beijing HuiLongGuan Hospital

    Changping, Beijing Municipality, 100096, China

  • Chongqing 11th People's Hospital

    Chongqing, Chongqing Municipality, 400047, China

  • Chongqing Mental Health Center

    Jiangbei, Chongqing Municipality, 401147, China

  • Daqing City Third Hospital

    Daqing, Heilongjiang, 163161, China

  • Guangyuan Mental Health Center

    Guangyuan, Sichuan, 628033, China

  • Hangzhou Seventh People's Hospital

    Hangzhou, Zhejiang, 310013, China

  • HuZhou Third Municipal Hospital

    Huzhou, Zhejiang, 313028, China

  • Jiangxi Mental Health Center

    Nanchang, Jiangxi, 330027, China

  • Mental Health Center of Xi'an City

    Xi'an, Shaanxi, 710061, China

  • Ningbo Kangning Hospital

    Ningbo, Zhejiang, 315002, China

  • Peking University Sixth Hospital

    Beijing, Beijing Municipality, 100083, China

  • Renmin Hospital of Wuhan University

    Wuhan, Hubei, 430064, China

  • Shandong Daizhuang Hospital

    Jining, Shandong, 272009, China

  • Shandong Mental Health Center

    Jinan, Shandong, 250014, China

  • Shanghai Mental Health Center

    Shanghai, Shanghai Municipality, 200032, China

  • The Affiliated Brain Hospital of Guangzhou Medical University

    Guanzhou, Guangdong, 510370, China

  • The First Affiliated Hospital of Wenzhou Medical University

    Wenzhou, Zhejiang, 325015, China

  • The Fourth People's Hospital of Chengdu

    Chengdu, Sichuan, 610036, China

  • The Second Xiangya Hospital of Central South University

    Changsha, Hunan, 410011, China

  • The Sixth People's Hosptial of Hebei Province

    Baoding, Hebei, 071051, China

  • Tianjin Anding Hospital

    Tianjin, Tianjin Municipality, 300382, China

  • Urumqi Fourth People's Hospital

    Ürümqi, Xinjiang, 830002, China

  • Wuhan Mental Health Center

    Wuhan, Hubei, 430000, China

  • Wuhu Hospital of Beijing Anding Hospital

    Wuhu, Anhui, 241000, China

  • Wuxi Mental Health Center

    Wuxi, Jiangsu, 214151, China

  • Zhumadian Second People's Hospital

    Zhumadian, Henan, 463001, China

Conditions

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