New pill aims to ease schizophrenia psychosis
NCT ID NCT05227703
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested two doses of a new drug called emraclidine (CVL-231) in 391 adults with schizophrenia who were having a sudden worsening of psychotic symptoms. Participants took the drug or a placebo daily for 6 weeks. The main goal was to see if the drug reduced symptoms like hallucinations and delusions better than a placebo.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Emraclidine (CVL-231)
- What this could lead to
- If it works, this could point toward a new treatment option for acute psychotic episodes in schizophrenia.
- What could go wrong
- This is a Phase 2 trial, so results are still early. The drug may not prove effective or could have side effects. It is not a cure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Atlanta, Georgia
Atlanta, Georgia, 30331-2012, United States
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Austin, Texas
Austin, Texas, 78754-5122, United States
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Bellflower, California
Bellflower, California, 90706-7079, United States
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Bentonville, Arkansas
Bentonville, Arkansas, 72712-3873, United States
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Berlin, New Jersey
Berlin, New Jersey, 08009, United States
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Budapest, Budapest
Budapest, 1083, Hungary
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Burgas, Burgas
Burgas, 8000, Bulgaria
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Charlotte, North Carolina
Charlotte, North Carolina, 28211-4849, United States
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Chicago, Illinois
Chicago, Illinois, 60640-5017, United States
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Chicago, Illinois
Chicago, Illinois, 60641, United States
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Győr, Győr-Moson-Sopron
Győr, Győr-Moson-Sopron, 9024, Hungary
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Homestead, Florida
Homestead, Florida, 33032-8187, United States
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Kalocsa, Bács-Kiskun
Kalocsa, Bács-Kiskun county, 6300, Hungary
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La Habra, California
La Habra, California, 90631-3842, United States
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Marlton, New Jersey
Marlton, New Jersey, 08053, United States
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Miami Lakes, Florida
Miami Lakes, Florida, 33016-1553, United States
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Miami Springs, Florida
Miami Springs, Florida, 33166-7225, United States
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Miami, Florida
Miami, Florida, 33122-1335, United States
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New Haven, Connecticut
New Haven, Connecticut, 06519-1109, United States
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Pleven, Pleven
Pleven, 5800, Bulgaria
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San Diego, California
San Diego, California, 92103-2209, United States
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Savannah, Georgia
Savannah, Georgia, 31405-5701, United States
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Sherman Oaks, California
Sherman Oaks, California, 91403-1747, United States
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Sofia, Sofia
Sofia, 1282, Bulgaria
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Sofia, Sofia-Grad
Sofia, Sofia-Grad, 1431, Bulgaria
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Torrance, California
Torrance, California, 90504-4432, United States
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