SCHIZOPHRENIA

This study looks at whether combining medication with one-on-one cognitive behavioral therapy helps people with mental health disorders like anxiety, depression, bipolar disorder, and schizophrenia. 107 adults aged 18-65 with an IQ of 80 or higher took part. The goal is to see if…

This study tests whether a combination of two drugs, dasatinib and quercetin, can safely slow accelerated aging in 40 older adults with treatment-resistant depression or schizophrenia. Participants must be 50 or older and have age-related health conditions. The main goal is to se…

This program tracks 4,000 people with schizophrenia who receive the injectable medication Zyprexa Relprevv. The goal is to better understand and reduce the risk of a rare but serious side effect called post-injection delirium/sedation syndrome (PDSS). Researchers will monitor eac…

This study tests whether giving time- and event-based cues (like alarms or daily routines) can help people with schizophrenia or schizoaffective disorder remember to take their medication. 104 adults aged 18-60 with these conditions will be split into two groups: one gets the cue…

This study looks at whether D-serine, a natural brain chemical, can help people with schizophrenia or schizoaffective disorder learn and remember better. About 60 adults aged 18-50 will take D-serine for 16 weeks while doing a special auditory training program. The goal is to see…

This study looks at the long-term safety of a drug called OLZ/SAM in teenagers with schizophrenia or bipolar I disorder. About 236 teens who finished a previous study can join. Researchers will track side effects over time to see if the drug is safe for ongoing use.

This study tests whether adding cannabidiol (CBD) to standard antipsychotic medication can help people with early schizophrenia manage their symptoms better and with fewer side effects. About 180 participants will receive either CBD or a placebo alongside their usual treatment fo…

This study aimed to see if a lifestyle program called Lifestyle MIND could help people with serious mental illness manage or prevent type 2 diabetes. Participants would have been randomly assigned to join the program right away or wait. The study was withdrawn before any particip…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce negative symptoms of schizophrenia, such as lack of motivation, social withdrawal, and flat emotions. About 62 adults with schizophrenia and persistent negative symptoms will receive either…

This study aimed to see if a sublingual film of dexmedetomidine (BXCL501) could quickly reduce agitation in adults with bipolar disorder or schizophrenia visiting the emergency department. It was a single-arm pilot study, but it was withdrawn before enrolling any participants. No…

This study tests a 6-week in-person program for primary caregivers of people with schizophrenia. The program teaches coping skills and provides support to reduce caregiver stress, improve mental well-being, and boost self-confidence. About 66 caregivers will participate to see if…

This study tests whether berberine, a natural compound, can safely improve negative symptoms of schizophrenia—like lack of motivation and emotion—that current medications often miss. About 120 adults with schizophrenia will receive berberine or a placebo for a set time. Researche…

This study aimed to see if a type of brain stimulation called intermittent theta burst stimulation could reduce symptoms of schizophrenia in people who still had symptoms despite medication. It planned to compare real stimulation to a placebo in about 40 adults aged 18 to 40. How…

This study tests a smartphone app called CT-155 for people with schizophrenia who have negative symptoms (like lack of motivation or pleasure). About 262 adults will use the app for 16 weeks, with an option to continue for another 16 weeks, while continuing their usual treatment.…

This study tests whether adding mindfulness-based therapy (MBT) to usual care helps adults with serious mental illness (like schizophrenia, bipolar disorder, or major depression) feel better and function better. Researchers will enroll 160 patients from a community mental health …

This study tests two types of talk therapy—Cognitive Enhancement Therapy and Enriched Supportive Therapy—to see if they can reduce persistent negative symptoms in people with schizophrenia. Negative symptoms include things like lack of motivation, reduced emotional expression, an…

This study tests a therapy called imagery rescripting in 8 people with early psychosis. The goal is to see if it helps change negative core beliefs, improve wellbeing, and boost self-esteem. Participants receive 4-6 therapy sessions over a few weeks and are followed for 3 more we…

This study tests a behavioral therapy designed to reduce violent behavior in young adults (ages 16-30) who have early psychosis, including schizophrenia. The therapy is offered through early psychosis clinics. The main goal is to see if the therapy is acceptable and practical for…

This small pilot study tests whether adding EEG biofeedback (brain training) to virtual reality therapy can help people with schizophrenia better tolerate and reduce distressing auditory hallucinations. Thirty adults with schizophrenia who hear voices will receive either VR thera…

This study tests whether a mild electrical current applied to the scalp (tDCS) before computer-based thinking exercises can improve memory, attention, and planning in people with schizophrenia. 120 adults aged 18-65 will be randomly assigned to receive either real or fake stimula…

This study tests an experimental drug called SPG302 in 32 adults with schizophrenia to see if it can reduce symptoms like hallucinations and disorganized thinking. Participants take the drug or a placebo for a set time, and researchers measure changes in symptom severity, brain a…

This study tests whether a ketogenic diet (low-carb, high-fat) can reduce symptoms in people with schizophrenia or schizoaffective disorder. Fifty adults aged 18-64 will be randomly assigned to either the ketogenic diet or a control diet for several weeks. Researchers will measur…

This study tests whether an accelerated schedule of transcranial magnetic stimulation (TMS) is safe and tolerable for people with psychotic disorders like schizophrenia. Twenty adults aged 18-65 will receive the treatment and be monitored for side effects. The goal is to see if t…

This study is testing whether adding a brain skills training program, called cognitive remediation, to standard early psychosis care helps young adults function better in daily life. The research involves about 117 young people in New York who have recently experienced their firs…

This study explores whether playing soft sounds during sleep can help normalize brain activity and improve memory in people with schizophrenia. Researchers will compare sleep and memory performance in 70 participants (healthy adults and schizophrenia patients) during two naps—one…

This study looks at health records and insurance claims from nearly 7,000 adults in the US who take KarXT for schizophrenia. Researchers want to understand who gets the drug, how it's used, and how often people need hospital visits. The goal is to see how the medication works in …

This study looks at how taking a new extended-release tablet (LY03020) with or without food changes the way the body absorbs the drug. The medicine is being developed for schizophrenia and psychosis in Alzheimer's disease. Sixteen healthy adults will take the drug twice—once afte…

This study was designed to observe how medication affects people with schizophrenia who have committed violent crimes. It planned to track changes in symptoms and aggressive behavior over time. However, the study was withdrawn before enrolling any participants, so no results are …

This study looks at how certain brain chemicals (from the tryptophan-kynurenine pathway) are linked to thinking and memory problems in people with early schizophrenia. Researchers will measure these chemicals in blood and assess cognitive function in 200 participants. The goal is…

This study looks at how a non-invasive brain stimulation technique called paired associative stimulation (PAS) affects working memory in people with schizophrenia. Researchers will use brain scans (EEG) and memory tasks to measure changes over one week. The goal is to understand …

This study aimed to see if a gentle brain stimulation technique called tDCS could help with negative symptoms of schizophrenia, like lack of motivation or emotion. Researchers planned to use brain scans and electrical recordings to understand how it works. However, the study was …

This study follows 400 people with schizophrenia who took part in an earlier clinical trial. Researchers want to see how their health and daily lives change over 3 to 10 years. The goal is to learn what early factors predict hospital stays and social functioning. No new treatment…

This study tests whether a non-invasive brain stimulation technique called cTBS can change brain activity and improve thinking in people with schizophrenia or schizoaffective disorder. Researchers will give 40 participants (including some healthy volunteers) a series of magnetic …

This study tests a new program that combines executive function training (like memory and planning exercises) with cognitive-behavioral social skills training for adults aged 60 and older with schizophrenia or schizoaffective disorder. The goal is to see if the combined approach …

This study uses MRI scans to look at the brains of children and adults with conditions like ADHD, schizophrenia, and autism, as well as healthy volunteers. The goal is to compare brain structure and function across different ages, genders, and diagnoses. Over 4,000 participants h…