SCHIZOPHRENIA

This study is testing whether a combination of two drugs, dasatinib and quercetin, can slow down accelerated aging in older adults with schizophrenia or treatment-resistant depression. The drugs are taken for just eight days over a month, alongside lifestyle coaching. Researchers…

This study is testing how well a combination of medication and a specific type of talk therapy (cognitive behavioral therapy) helps people with various mental health conditions. It involves 107 adults with diagnoses like anxiety, depression, PTSD, bipolar disorder, or schizophren…

This study follows children and teenagers with schizophrenia or bipolar I disorder who are already taking OLZ/SAM medication to check for long-term safety. Researchers want to see if side effects develop when patients take this drug combination for an extended period. The study i…

This study aimed to understand which medications work best for people with schizophrenia who committed violent crimes during psychotic episodes. Researchers planned to observe adults with schizophrenia in forensic treatment to see how different antipsychotic medications affected …

This study is testing whether daily phone reminders can help people with schizophrenia remember to take their medication. Researchers are comparing two groups of about 100 participants: one receives the reminders, and the other receives standard care. The goal is to see if the re…

This study is testing whether adding cannabidiol (CBD), a non-psychoactive compound from cannabis, to standard antipsychotic medication helps people with schizophrenia stay on treatment longer and improves their symptoms. It will involve 180 people who have been diagnosed within …

This program aims to make a long-acting injectable medication for schizophrenia safer by closely monitoring patients for a rare but serious side effect. It enrolls all patients who receive the medication, Zyprexa Relprevv, to track their health and ensure they are observed in a c…

This study is testing whether combining two types of therapy can help older adults with schizophrenia improve their daily functioning. The program blends cognitive-behavioral social skills training with computerized brain exercises designed to boost thinking skills. Researchers a…

This study is testing whether a one-day schedule of non-invasive brain stimulation can improve thinking and memory problems in people with schizophrenia. Researchers will deliver magnetic pulses to a specific brain network involved in attention and compare effects in 40 people wi…

This study is testing whether a special diet can help control symptoms of schizophrenia. Fifty adults with schizophrenia or schizoaffective disorder will follow either a ketogenic diet (very low in carbs, high in fat) or a standard diet for comparison. Researchers will measure ch…

This study aims to find out if long-acting injectable medications help people with schizophrenia stay on treatment better than daily oral pills. It follows 400 patients who were in a previous study, tracking them for 19 months to see which treatment leads to fewer hospital stays …

This study is testing whether adding a brain skills training program, called cognitive remediation, to standard early psychosis care helps young adults function better in work, school, and social life. It will compare two ways of delivering the training: fully in-person with a cl…

This study aimed to test whether a 10-week lifestyle program called Lifestyle MIND could help people with serious mental illness (like schizophrenia or bipolar disorder) better manage their type 2 diabetes. Researchers planned to compare a group that started the program immediate…

This study is testing whether a gentle, non-invasive brain stimulation technique can make computer-based thinking-skills training more effective for adults with schizophrenia. Researchers will compare two groups: one gets real stimulation before training, and the other gets a fak…

This study is testing whether an experimental medication called SPG302 can help control symptoms and improve brain function in adults with schizophrenia. Thirty-two participants will take either SPG302 or a placebo pill daily for six weeks while researchers measure changes in sym…

This study aimed to test a medication called BXCL501, a small dissolving film placed under the tongue, for quickly calming severe agitation in adults with bipolar disorder or schizophrenia arriving at the emergency department. The goal was to see how well and safely it worked in …

This study is testing a 6-week individual support program for the primary family caregivers of people with schizophrenia. The program provides education and teaches coping skills to help caregivers manage stress and feel more confident. Researchers want to see if this reduces the…

This study is testing a smartphone app called CT-155, designed to help adults with schizophrenia manage their 'negative symptoms,' like lack of motivation and reduced pleasure. Participants use the app for 16 weeks alongside their regular treatment, and researchers measure change…

This study is testing whether a non-invasive brain stimulation technique can help reduce the 'negative symptoms' of schizophrenia, such as low motivation, social withdrawal, and reduced emotional expression. Researchers are comparing two different stimulation methods against a pl…

This study is testing a therapy called imagery rescripting to see if it can help people with early psychosis. Eight participants will receive the therapy, which involves working with a practitioner to change distressing mental images. The main goal is to see if this improves thei…

This small pilot study is testing a new behavioral therapy program designed to help reduce violent behavior in young adults (ages 16-30) who are in the early stages of a psychotic disorder. The main goal is to see if the therapy is practical and acceptable for both patients and t…

This study is testing whether berberine, a natural compound, can help improve the 'negative symptoms' of schizophrenia like lack of motivation and emotional flatness. About 120 patients already on stable medication will take either berberine or a placebo for 12 weeks. Researchers…

This small pilot study is testing a new therapy that combines virtual reality (VR) with real-time brainwave feedback to help people with schizophrenia manage distressing auditory hallucinations (hearing voices). Researchers want to see if this combined approach is practical, acce…

This study is testing whether mindfulness-based therapy can help people with serious mental illnesses like schizophrenia, depression, and bipolar disorder. Researchers are working with 160 patients at community mental health centers to see if adding mindfulness therapy to regular…

This study is testing whether a non-invasive brain stimulation technique called theta-burst TMS can help improve the negative and cognitive symptoms of schizophrenia. Researchers are enrolling 90 adults with schizophrenia to see if the treatment safely improves social skills, mem…

This study aims to see if questionnaires filled out by patients and their close contacts (like family members) during episodes of severe agitation match up with ratings from doctors. It involves about 30 adults with schizophrenia or bipolar disorder and their chosen informant. Th…

This study aims to understand how brain development differs in people with childhood-onset conditions like ADHD, schizophrenia, and autism. Researchers are using MRI scans to take detailed pictures of the brain's structure and function in over 4,000 participants, including health…

This early-stage study aims to understand how eating food affects the way the body absorbs and processes a new extended-release medication (LY03020) being developed for schizophrenia and Alzheimer's disease psychosis. It involves 16 healthy adult volunteers who will take a single…

This study aims to understand why people with schizophrenia often have trouble with thinking, memory, and attention, even when their other symptoms are treated. Researchers will measure specific chemicals in the blood of 200 participants (100 with first-episode schizophrenia and …