Schizophrenia treatment could go from daily pills to four shots a year

NCT ID NCT06276361

First seen Jun 26, 2026 ยท Last updated Jun 26, 2026

Summary

This early-phase study tested a new long-acting injection of the antipsychotic drug risperidone that would only need to be given once every three months. Fifty-eight adults with stable schizophrenia received a single shot at different doses to measure how the drug moves through the body and to check for safety issues. The goal is to see if this quarterly shot could eventually offer a more convenient option for people who currently take daily risperidone pills.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
risperidone (quarterly injection)
What this could lead to
If successful, this could lead to a once-every-three-months injection for schizophrenia, reducing the need for daily pills.
What could go wrong
This is a very early Phase 1 study with only 58 participants, focused on safety and drug levels, not on how well it controls symptoms. The injection may not work as well as daily medication, and side effects are still being evaluated.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Investigational Site

    Amman, Jordan

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