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New pill aims to calm schizophrenia symptoms fast

NCT ID NCT05278156

Completed Symptom relief Sponsor: Celon Pharma SA Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested a new drug called CPL500036 in 189 people having a sudden worsening of schizophrenia symptoms. Participants took either a low dose, high dose, or placebo for 28 days. The main goal was to see if the drug reduces symptoms like hallucinations and delusions better than a placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

CPL500036 (PDE10A inhibitor)

What this could lead to

If it works, this could point toward a new treatment option for acute schizophrenia symptoms.

What could go wrong

This is an early Phase 2 trial with only 189 people, so results may not apply broadly. The drug may not work better than placebo.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCHIZOPHRENIA

Contacts and locations

Locations

  • Bács-Kiskun County Teaching Hospital Kalocsa Holy Cross Hospital

    Kalocsa, H-6300, Hungary

  • Communal non- commercial enterprise of Lviv Regional Council "Lviv Regional Clinical Psychiatric Hospital",

    Lviv, 79021, Ukraine

  • Communal non-commercial enterprise of the Kyiv Regional Council "Regional Psychiatric-Narcological Medical Association", women's department No. 2, men's department No. 10.

    Kyiv, 08631, Ukraine

  • Communal non-commercial enterprise of the Lviv Regional Council "Lviv Regional Clinical Psychoneurological Dispensary",

    Lviv, 79017, Ukraine

  • Communal non-profit enterprise "Clinical Hospital "PSYCHIATRY"" of the executive body of the Kyiv City Council (Kyiv City State Administration), Center for Primary Psychotic Episode and Modern Treatment Methods.

    Kyiv, 04080, Ukraine

  • Department of Psychiatry and Psychotheraapy of Semmelweis University

    Budapest, H-1083, Hungary

  • Department of Psychiatry, Mental hygiene and Addictology of Petz Aladár County Teaching Hospital

    Győr, H-9024, Hungary

  • Ivano-Frankivsk National Medical University, Department of Psychiatry, Narcology and Medical Psychology

    Ivano-Frankivsk, 76014, Ukraine

  • Psychiatry Department of Tolna County Balassa Janos Hospital

    Szekszárd, H-7100, Hungary

  • Samodzielny Publiczny Psychiatryczny Zakład Opieki Zdrowotnej

    Choroszcz, 16-070, Poland

  • Semmelweis University, Faculty of Medicine, Department of Psychiatry and Psychotherapy

    Budapest, H-1085, Hungary

  • Ternopil National Medical University named after I.Y. Gorbachevskiy of the Ministry of Health of Ukraine, Department of Psychiatry, Narcology and Medical Psychology

    Ternopil, 46001, Ukraine

  • Uniwersytecki Szpital Kliniczny

    Bialystok, 15-272, Poland

  • Vinnytsia National Medical University named after M.I. Pirogov, Department of Psychiatry, Narcology and Psychotherapy with a course of postgraduate education

    Vinnytsia, 21018, Ukraine

  • Wojewódzki Szpital dla Nerwowo i Psychicznie Chorych

    Bolesławiec, 59-700, Poland

  • Wojewódzki Szpital dla Psychicznie i Nerwowo Chorych

    Gmina Świecie, 86-100, Poland