Kidney disorder

This study tested a plant-based tablet called PH3 in 100 adults with diabetic nephropathy (kidney damage from diabetes). The goal was to see if PH3 can safely reduce protein in the urine, a sign of kidney stress, over 24 weeks. Researchers also looked at the best dose to use in f…

Researchers are testing whether a combination of mycophenolate mofetil and steroids works better than cyclosporine at reducing protein in the urine of people with focal segmental glomerulosclerosis (FSGS), a rare kidney disease. The trial enrolls people aged 2 to 40 with biopsy-c…

This study tests whether people with chronic kidney disease can safely eat potassium-rich fruits and vegetables instead of following the usual low-potassium diet. Thirty participants will receive home-delivered groceries with either high- or low-potassium produce in a random orde…

Researchers at Tanta University are comparing melatonin with folic acid in adults who have type 2 diabetes and early kidney damage. All 75 participants receive standard diabetes care, with one group adding melatonin (3 mg daily) and another adding folic acid (400 µg daily). The s…

Researchers are testing an experimental immunotherapy called GNR-051 in adults with advanced lung cancer, kidney cancer, or melanoma that has returned or not responded to other treatments. The Phase 1 trial aims to find the highest dose people can tolerate and to track side effec…

This study tests whether a new drug called vicadrostat, combined with the existing drug empagliflozin, can help people with chronic kidney disease (CKD) that is getting worse. About 492 adults with CKD will be randomly assigned to start both drugs together or one after the other …

Researchers are testing whether a ketone supplement drink can reduce protein in the urine and improve kidney function in people with chronic kidney disease or polycystic kidney disease. The study includes 45 participants who receive either the ketone drink or a placebo for four w…

This trial tests an experimental oral drug called EVER001 in people with primary membranous nephropathy, a kidney disease where the immune system damages the kidney's filtering units, causing protein to leak into urine. The study aims to see if EVER001 can reduce proteinuria and …

Researchers are testing whether finerenone, semaglutide, or the two together can lower albuminuria, a marker of kidney damage, in adults with chronic kidney disease. About 41 participants receive each treatment in turn, with urine protein measured throughout. The trial also check…

This early-phase trial tests a new drug called AI-061, which combines two immune-boosting antibodies (anti-PD-1 and anti-CTLA-4) into one treatment. The study will enroll 18 adults with advanced solid tumors that have spread or cannot be removed. The main goals are to find a safe…

This trial tests whether a steroid-free immunosuppression regimen can prevent rejection after a first kidney transplant. Participants receive rabbit anti-T-lymphocyte serum, mycophenolate mofetil, and cyclosporine, with one group also getting standard steroids for six months and …

Critically ill adults with acute kidney injury or end-stage kidney disease often need continuous renal replacement therapy, a slow form of dialysis that runs for hours or days. Blood tends to clot in the dialysis circuit, so doctors add a blood thinner. This study tests whether r…

This Phase 2 trial tests whether tirzepatide, a drug already used for diabetes and weight loss, can improve kidney health in 140 people with obesity and chronic kidney disease (with or without type 2 diabetes). Researchers will use MRI scans to measure changes in kidney fat and b…

This study followed 591 adults with eosinophilic granulomatosis with polyangiitis (EGPA) across Europe to see how well mepolizumab 300mg every 4 weeks works over the long term in everyday medical practice. Researchers looked at disease control, lung function, and safety by review…

This study tested a new device that uses focused ultrasound (histotripsy) to break apart solid kidney tumors without making any cuts. Twenty adults with small, non-spreading kidney tumors were treated. The main goals were to see if the device could fully cover the tumor and if th…

People on long-term dialysis can build up protein-bound toxins like indoxyl sulfate and p-cresyl sulfate that standard dialysis clears poorly. This study at one center in Shanghai tests whether adding a pHA130 hemoperfusion cartridge to regular dialysis or hemodiafiltration lower…

This early-stage trial tests a new daily pill, IPG11406, in 36 adults with lupus nephritis—a kidney complication of lupus. The study checks if the drug is safe and whether it can reduce protein in the urine and improve kidney function. It is too soon to know if it works, but the …

This phase 2 trial tests whether a daily capsule containing fucoidan, fucoxanthin, L-carnitine, and zinc can reduce protein leakage in the urine, a key sign of kidney damage, in people with diabetic kidney disease. About 63 participants will be randomly assigned to receive the su…

This study tests a new pill, vadadustat, taken three times a week, against the usual injected medicine for anemia in people with kidney failure who are on dialysis. About 350 adults will take part to see if the pill can safely keep their red blood cell levels in a healthy range. …

This trial tests whether a device that electrically stimulates the diaphragm during breathing, combined with inspiratory muscle training, can improve diaphragm function and clinical outcomes in people with moderate COPD. Participants aged 40 to 70 with stable COPD will receive ei…

This trial tests whether giving diuretics based on bioimpedance analysis, a body scan that measures fluid levels, can slow heart failure progression in people who have no visible signs of congestion. Participants are adults with heart failure and a reduced ejection fraction, but …

This study tested a new dialysis filter called ELISIO-HX in 22 adults with kidney failure. Participants used the new filter three times a week for 12 weeks. The goal was to see if it safely maintained albumin levels while improving removal of certain waste products. The trial is …

This trial tests an experimental drug called SNS-101, which targets a protein called VISTA that may help tumors evade the immune system. Researchers give SNS-101 alone or with another immunotherapy, cemiplimab, to adults with advanced solid tumors that have not responded to stand…

This trial tests whether combining the immunotherapy drug atezolizumab with precise, high-dose radiation (SABR) can better control metastatic cancers, including colorectal, lung, kidney, and sarcoma. The idea is that radiation may make tumors more visible to the immune system, wh…

This study tests a new medicine, crovalimab, for paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disease that destroys red blood cells. It involves healthy volunteers and people with PNH to check safety and how well the drug works. The goal is to control the disease, not …

This study looked at whether taking kefir peptides for three months could help people with stage 3 or 4 chronic kidney disease. Researchers measured kidney function, protein in urine, and signs of inflammation. The goal was to see if this supplement could support disease control,…

This trial tests whether stereotactic ablative body radiation (SAbR), a precise form of high-dose radiation, can delay the need for systemic therapy in people with oligometastatic renal cell carcinoma, meaning kidney cancer that has spread to a few limited sites. Researchers will…

This study tested whether the diabetes drug pioglitazone, weight loss, or both can help prevent uric acid kidney stones in overweight people. Twenty-nine participants were randomly assigned to one of three groups for 24 weeks. The main goal was to see if these interventions could…

This trial tests whether performing surgery within 72 hours of birth improves outcomes for female newborns with bladder exstrophy, a rare birth defect where the bladder develops outside the body. Half the participants receive surgery within 72 hours, while the other half wait unt…

This study tested two flavors of a high-energy, low-protein drink called Renalive® LP in 74 adults with chronic kidney disease stages 3b-5. Participants drank the formula as a meal replacement or supplement for 4 weeks. The goal was to see if the drink was suitable and helped mai…

This phase 2 trial is testing whether adding precise, high-dose radiation (SBRT) to standard immunotherapy (ipilimumab and nivolumab) can help people with metastatic kidney cancer live longer without their disease getting worse. About 66 participants with intermediate or poor-ris…

This study looks at whether deep cleaning for gum disease can improve kidney health in people with uncontrolled type 2 diabetes. 46 adults with both conditions will either get gum treatment right away or after a delay. Researchers will measure kidney markers like creatinine and u…

This trial asks whether an intravenous (IV) injection of vitamin B12 works better than oral tablets to correct B12 deficiency in adults on long-term hemodialysis. Participants receive either a weekly IV dose after dialysis or oral tablets three times a day for four weeks. Researc…

This phase 3 trial is comparing a combination of two drugs—nivolumab (an immunotherapy) and cabozantinib (a targeted therapy)—against the current standard drug sunitinib in people with advanced or metastatic kidney cancer who have not yet received systemic treatment. The main goa…

This early-stage trial is testing an experimental drug called INZ-701 in adults with end-stage kidney disease who are on hemodialysis and have low levels of a natural substance called pyrophosphate, which helps prevent calcium buildup in blood vessels. The study aims to see if we…

This trial tests whether levosimendan, a drug used to support the heart, can also improve kidney function in adults with acute kidney injury in intensive care. Participants receive either levosimendan or a placebo, and their kidney function is measured daily. The goal is to see i…

This trial tests whether hydroxychloroquine, an anti-inflammatory drug, can reduce cardiovascular disease risk in people with chronic kidney disease (CKD). Participants with moderate-to-severe CKD will receive either hydroxychloroquine or a placebo for 18 months. Researchers will…

This trial tests whether sacubitril/valsartan, a newer heart failure medication, is safer and more effective for the kidneys than ramipril, an older ACE inhibitor, in people hospitalized with acute decompensated heart failure who also have chronic kidney disease. About 515 partic…

This trial tests whether spironolactone, a pill already used to protect the heart in other patients, can reduce heart failure and heart-related deaths in people on dialysis. Participants take either spironolactone or a placebo daily. The study aims to see if this treatment is bot…

This trial tests whether obinutuzumab, a next-generation antibody, can help people with membranous nephropathy—a kidney disease that causes protein leakage and swelling—who haven't responded well to the standard drug rituximab or who can't take it due to allergic reactions. About…

This trial tests whether lanthanum carbonate, a drug typically used to bind phosphate, can also reduce oxalate levels in urine. People with secondary hyperoxaluria and a history of kidney stones take the drug with meals for 28 days, with the dose increasing after two weeks. The g…

This trial tests two different concentrations of citrate solution used to prevent blood clotting during continuous kidney replacement therapy in critically ill patients with acute kidney injury. The goal is to see which concentration leads to fewer metabolic complications, such a…

This study looked at 159 people with granulomatosis with polyangiitis (GPA), a rare disease that causes inflammation of blood vessels. Participants were randomly assigned to either stay on a low 5 mg daily dose of prednisone or slowly stop it over six months. The goal was to see …

This trial tests whether giving a single dose of cyclosporine A to deceased organ donors before their kidneys are removed can reduce the chance of delayed graft function in recipients. Delayed graft function means the kidney does not start working right away, often requiring dial…

This trial tests whether a combination of everolimus and low-dose tacrolimus is better than the standard tacrolimus plus mycophenolate mofetil at preventing serious long-term complications in children who have had a heart transplant. The study will follow 211 participants from 25…

This study tested a single intravenous dose of TIN816, an enzyme that breaks down ATP to reduce inflammation, in 316 ICU patients with sepsis-related acute kidney injury. The goal was to see if it improves kidney function over 8 days and reduces major kidney problems by day 90. T…

This pilot trial tests whether a single infusion of pegloticase, a drug that breaks down uric acid, can improve markers of heart and kidney health in young men aged 18–25 with youth-onset type 2 diabetes. High uric acid is common in this group and linked to later complications. T…

This trial compares two immunosuppressive regimens in CMV-positive kidney transplant recipients. One group receives everolimus with a reduced dose of cyclosporine A, while the other gets standard mycophenolic acid with full-dose cyclosporine. The goal is to see whether the everol…

This study tests whether two drugs, daratumumab and belatacept, can lower the immune system's sensitivity in kidney transplant candidates who are very hard to match. About 19 highly sensitized patients will receive the treatment to see if it reduces their antibody levels or allow…

This study tested whether adding the drug atrasentan to standard care (including SGLT2 inhibitors) can reduce protein in the urine of people with IgA nephropathy, a kidney disease. 54 adults with biopsy-confirmed IgA nephropathy participated. The main goal was to see if atrasenta…

This study tests whether a peer coaching program delivered by phone and text can help adolescents and young adults (ages 16–22) with chronic conditions like sickle cell disease, diabetes, or cystic fibrosis improve their self-management skills. Participants are paired with a trai…

This study tests a support program for people with type 2 diabetes and chronic kidney failure who struggle to take their medications regularly. Participants receive an electronic pill bottle that tracks when they open it, plus short motivational interviews with a pharmacist. The …

This study tests whether starting haemodialysis with fewer sessions per week (twice instead of the standard three times) can help preserve patients' remaining natural kidney function. New dialysis patients who still have some kidney function are randomly assigned to either standa…

This study compared two types of IV fluids given to kidney transplant patients during their first week after surgery. The goal was to see which fluid better prevents electrolyte imbalances and helps the new kidney work well. About 159 adult patients who received a kidney from a l…

This study investigates whether taking two medications—finerenone and empagliflozin—together can better slow kidney function decline in people with chronic kidney disease and type 2 diabetes compared to taking either drug alone. Participants are randomly assigned to receive the c…

This phase 3 trial investigates whether the drug tolvaptan can safely and effectively correct low sodium levels in patients with hyponatremia, a condition where the body's sodium-water balance is off. The study enrolls adults with mild to moderate hyponatremia who are either euvo…

This phase 2 trial tests felzartamab (MOR202), an antibody that targets CD38 on plasma cells, in people with membranous nephropathy who did not improve with rituximab or similar therapies. The goal is to reduce protein leakage in urine and achieve remission of nephrotic syndrome.…

This study looks at whether canagliflozin, a drug used for diabetes, can safely reduce protein in the urine (a sign of kidney damage) in people with advanced chronic kidney disease (CKD), including those on dialysis. About 35 adults with CKD stage 4 or 5 will take the drug for up…

This study tests two strategies in low-income seniors with chronic conditions like heart disease, diabetes, or kidney disease. One group gets free preventive medications (no copayment), and another receives personalized education on medication use and lifestyle. The goal is to se…

This study tests a new drug called pegilodecakin, a lab-made version of a natural immune protein (interleukin-10), in people with advanced solid tumors such as melanoma, lung, breast, prostate, ovarian, kidney, colorectal, and pancreatic cancers. The drug is given as a daily shot…

This study tests whether a 3-month community program combining nutrition education, cooking classes, and exercise can improve health outcomes for people with Cardiovascular Kidney Metabolic (CKM) syndrome—a cluster of conditions including diabetes, high blood pressure, high chole…

This study tested a personalized way to dose the blood thinner enoxaparin in 50 children after kidney transplant. The goal was to prevent dangerous blood clots in the new kidney while avoiding excessive bleeding. Doctors used a computer model (Bayesian approach) to adjust doses b…

This trial tests a new cell therapy called TX200-TR101 in people who receive a kidney from a living donor. The therapy is made from the patient's own immune cells, which are genetically modified to help the body accept the donated kidney instead of rejecting it. The study focuses…

This study tests whether a secure website with educational sessions, goal-setting, and tracking tools can help survivors of several cancers (including breast, prostate, colorectal, and others) improve their diet, increase physical activity, and manage weight. Participants are age…

This trial tests whether repeatedly adding sterile fluid into the womb can help fetuses with severe kidney failure grow enough lungs to survive after birth. Pregnant women with early pregnancy kidney failure can choose to receive the infusions or just be monitored. Babies who sur…

This study tested whether adding balcinrenone to the standard drug dapagliflozin helps people with chronic kidney disease more than dapagliflozin alone. 324 adults with kidney disease and protein in their urine took either a combination pill or dapagliflozin alone for 12 weeks. R…

This study looks at whether a new method of measuring parathyroid hormone (PTH) can help doctors better manage calcium and phosphate levels in people on hemodialysis. About 80 patients with end-stage kidney disease will be randomly assigned to have their PTH measured either with …

This large phase 3 trial tested whether taking sorafenib or sunitinib after kidney cancer surgery could prevent the cancer from coming back. Nearly 2000 patients participated. Unfortunately, neither drug improved disease-free survival compared to a placebo, and they caused side e…

This completed Phase 4 trial tested two drugs—dapagliflozin and spironolactone—alone and together in 12 adults with Alport syndrome, a genetic kidney disease. The goal was to see if these drugs could lower protein levels in urine, a key sign of kidney damage. Participants took ea…

This study tested whether taking two doses of sodium bicarbonate (baking soda) over 24 hours could reduce uric acid crystals in the urine of adults with type 1 diabetes. Uric acid crystals can harm the kidneys, so lowering them might help prevent diabetic kidney disease. The tria…

This study tested whether quickly alerting a kidney specialist team when hospitalized patients show signs of severe kidney disease could improve survival. Over 1,100 patients in France were included. The team of a nephrologist and pharmacist would help manage care during the hosp…

This study compares two dialysis filters, SOLACEA-H and HYDROLINK-NVU, to see if SOLACEA-H can allow dialysis sessions with less or no blood thinner (heparin). The trial involves 20 adults who have been on dialysis for at least 3 months and are medically stable. Each participant …

This study tested whether giving sodium bicarbonate (a common substance that neutralizes acid) to critically ill patients with severe metabolic acidosis and moderate-to-severe acute kidney injury could improve survival at 90 days. The trial enrolled 640 adults in the ICU who had …

This study tested two different combinations of immunosuppressant drugs in 88 adults who received a new kidney. The goal was to see which plan better protects kidney function over the short term. All participants took lifelong anti-rejection medication, so this is about managing …

This study looked at whether giving kidney transplant patients a lower dose of the drug cyclosporine could protect their kidney function over time. 208 patients who were at least one year post-transplant and on stable medications took part. The goal was to balance preventing orga…

This early-stage trial tested a drug called itolizumab (EQ001) in 52 adults with lupus, some of whom also had active kidney inflammation. The main goal was to check safety and find the right dose. Researchers also looked at how the drug behaves in the body and how it affects immu…

This study tested whether a probiotic supplement could change gut bacteria and reduce harmful antibodies that damage kidneys in IgA nephropathy. 18 adults with the disease took probiotics for 3 months. Researchers measured changes in antibody levels and kidney function to see if …

This study tested eculizumab in 25 adults with PNH in China who had not previously taken complement inhibitors. Participants received infusions over 62 weeks. The main goal was to see if the drug reduced LDH levels, a marker of disease activity. Results showed a decrease in LDH, …

This study tested a special stent called MEMOKATH 051 in 13 adults with long-term ureter blockages who usually need a standard double J stent. The goal was to see how long the new stent lasts and how well it is tolerated over 3 years. Participants had the new stent placed during …

This early-phase study tested a daily combination of two oral drugs, axitinib and everolimus, in 19 people with advanced solid tumors, particularly kidney cancer. The main goal was to find the safest dose by monitoring side effects in the first month. Researchers also tracked how…

This study tested whether using sevoflurane gas for anesthesia during kidney transplant surgery helps the new kidney recover faster than standard propofol anesthesia. 120 adults receiving a kidney transplant were randomly assigned to one of the two anesthetics. Researchers tracke…

This study compared two types of dialysis in 415 older adults (ages 65-90) with chronic kidney failure: online hemodiafiltration and conventional hemodialysis. The goal was to see which method is better tolerated and whether it reduces heart problems and other complications. Pati…

This study looked at 38 kidney transplant patients who had CMV infection. Researchers wanted to see if measuring a type of immune cell (γδ T cells) could help decide who needs extra medication to prevent the virus from coming back. The goal is to avoid unnecessary drugs while sti…

This study tested a new way to monitor kidney oxygen levels during liver surgery to try to prevent acute kidney injury (AKI). 80 adults having liver surgery were randomly assigned to either standard care or extra monitoring that triggered a step-by-step treatment plan if oxygen l…

This study tested whether adding regional citrate anticoagulation (RCA) to standard heparin can reduce clotting in continuous kidney dialysis circuits for patients on ECMO. Eighteen ICU adults with ARDS and acute kidney injury were enrolled. Each patient received alternating peri…

This study tested an experimental drug, ziltivekimab, in 36 adults with advanced chronic kidney disease (not on dialysis) to see if it can safely reduce inflammation and related heart risks. Participants received either a low dose, a high dose, or a placebo injection every 4 week…

This study tested a drug called imlifidase in 113 highly sensitized kidney patients who had a positive crossmatch against a deceased donor. The drug was given before transplant to reduce the risk of rejection. The main goal was to see how many patients still had a working kidney …

This study tested a device called Break Wave™ that uses focused ultrasound waves to break kidney stones into tiny pieces that can pass naturally. 64 adults with upper urinary tract stones (4-10 mm) received the treatment. The goal was to see if the device is safe and effective at…

This study tested a device that uses ultrasound to calm overactive nerves in the kidneys, which can drive high blood pressure. Researchers enrolled 44 people with stage 3 chronic kidney disease and uncontrolled hypertension. Half received the real procedure, half a sham, to see i…

This phase 3 trial tested a drug called imlifidase in 64 highly sensitized kidney transplant patients who had almost no chance of finding a compatible donor. The drug breaks down harmful antibodies, allowing a transplant from a donor that would normally be rejected. The study mea…

This study tested whether a drug called Lokelma (SZC) can help people with both chronic kidney disease and heart failure safely reach higher doses of life-saving heart medications (RAAS inhibitors) without dangerous potassium spikes. 112 adults with stable kidney disease and hear…

This study looked at whether a 12-week program of exercise, a protein-controlled diet, and education could improve health in people with early-stage kidney disease (stages G1 and G2). Fifteen participants completed the program. Researchers measured changes in cholesterol, muscle …

This study tested a new tool called the CVAC System, a steerable catheter that helps remove kidney stones during a procedure called ureteroscopy. Thirty adults with kidney stones took part. The main goal was to see how safe the device is and how well it clears stones, measured by…

This Phase 2 trial tested a drug called felzartamab in 54 adults with IgA nephropathy, a kidney disease that can lead to kidney failure. The drug targets immune cells to reduce protein leakage in urine, a sign of kidney damage. The study compared felzartamab to a placebo to see i…

This study tested whether a form of vitamin B6 called pyridoxamine can improve the health of small blood vessels in people with type 2 diabetes. The researchers gave 40 participants either pyridoxamine or a placebo for a period, then switched treatments to compare effects. They m…

This study tested whether a 6-month program of plant-based diet, home exercise, medication management, and behavioral counseling could improve physical function in 42 adults with stage 3-4 chronic kidney disease. Participants were randomly assigned to the lifestyle program or usu…

This study tested a new treatment for people with advanced clear cell kidney cancer that had spread and stopped responding to standard therapies. Six adults received four injections of a radioactive drug (177Lu-PSMA-1) that targets cancer cells. The goal was to check safety and s…

This study tested whether baricitinib, a drug used for arthritis, can safely reduce high protein levels in the urine of African American adults with a specific genetic form of kidney disease (APOL1). Eight participants took the drug to see if it lowered their urine protein and pr…

This phase 2 study tested a drug called pegcetacoplan in 13 kidney transplant patients whose original kidney disease (C3G or IC-MPGN) had come back. The goal was to see if the drug could reduce signs of disease activity in the kidney. The study was small and early-stage, so resul…

This Phase 3 trial tested whether sparsentan, a drug that blocks two pathways involved in kidney damage, can better protect kidney function than the standard treatment irbesartan in people with focal segmental glomerulosclerosis (FSGS). The study enrolled 371 adults and children …

This study tested whether methylene blue, a dye that affects blood vessel function, can prevent dangerous drops in blood pressure during kidney dialysis. It involved 261 critically ill adults with acute kidney injury who needed dialysis. The goal was to see if the treatment could…

This early-phase study tested two immunotherapy drugs (spartalizumab and canakinumab) given before surgery to 17 people with localized clear cell kidney cancer. The main goal was to see if this approach was safe and did not delay surgery. The study also looked at how the drugs af…

This study tests whether taking a daily alpha lipoic acid supplement can reduce the return of cystine kidney stones in people with cystinuria. Half of the 50 participants will take 1200 mg of the supplement daily for three years, and the other half will take a placebo. The main g…

This study tested a special dialysis fluid called icodextrin in 439 adults with chronic kidney failure who use peritoneal dialysis at home. The goal was to see if it works better than standard glucose solutions for overnight exchanges and to check for side effects. Researchers tr…

This study looked at how a tacrolimus tablet (TacroBell) works in people who received a kidney transplant. The goal was to measure drug levels in the blood and see how well patients tolerated it. 128 adults who were getting a kidney from a deceased or living donor took part. The …

This study tested a drug called patiromer in 262 Chinese adults with chronic kidney disease and high potassium levels. Participants took patiromer for 4 weeks, then some switched to placebo for 8 weeks to see if potassium stayed controlled. The goal was to manage potassium safely…

This study followed 27 HIV-positive people with kidney failure who received a kidney transplant. All were on a three-drug HIV treatment including Raltegravir. The goal was to see how many had graft rejection within 6 months, using blood tests and kidney biopsies.

This study looked at whether dapagliflozin, a diabetes drug, can reduce protein in the urine (proteinuria) in people who have had a kidney transplant and have chronic kidney disease. Researchers followed 55 patients for 6 months to see if the drug lowered protein levels and prote…

This study looked at how safe and effective the drug Cabozantinib is for people aged 70 and older with advanced kidney cancer. Researchers tracked side effects and tumor response in 100 participants. The goal was to see if this treatment works well in older patients who have alre…

This Phase 3 trial tested whether lanreotide, a drug that blocks certain growth hormones, can slow the loss of kidney function in people with autosomal dominant polycystic kidney disease (ADPKD). The study included 159 adults with moderate kidney decline. Participants received ei…

This study tested two different drug combinations (Simulect or ATG, plus standard medications) in 60 kidney transplant patients at high risk of rejection. The goal was to see which approach better prevents treatment failure, including rejection, graft loss, or death, within 6 mon…

This study tested whether a new training package called TEACH-PD could lower infection rates in patients starting peritoneal dialysis (PD). Over 1,400 adults from multiple countries were randomly assigned to receive either the TEACH-PD training or standard PD training. The resear…

This study tested whether measuring drug levels in the blood can help doctors adjust doses of two common kidney cancer medications, sunitinib and pazopanib. The goal was to see if this personalized approach reduces side effects and keeps the cancer from growing longer than the st…

This study tested whether an educational worksheet plus health coaching could help people with chronic kidney disease improve their blood pressure. 320 adults with moderate to severe kidney disease and uncontrolled high blood pressure took part. The goal was to see if the coachin…

This study looked at 45 adults on hemodialysis who had a blocked superior vena cava (SVC), a large vein in the chest. Doctors used surgery or a tube-like device to reopen the vein and relieve symptoms. The goal was to improve blood flow and quality of life for these patients.

This pilot study tested whether using central blood pressure (measured near the heart) instead of the usual arm cuff leads to better outcomes in 116 people with advanced chronic kidney disease. Participants were randomly assigned to either a central BP target or a standard arm BP…

This study tested an oral antibiotic (tebipenem pivoxil hydrobromide) against a standard IV antibiotic in 1,690 hospitalized adults with complicated urinary tract infections or kidney infections. The goal was to see if the oral pill works as well as the IV treatment in curing the…

This study looked at whether using a very small amount of contrast dye (less than 15 ml) is safe and works for opening blocked leg arteries in 18 patients with both severe leg ischemia and kidney impairment. The goal was to save the leg while protecting the kidneys. Results focus…

This study tested whether an extended-release version of the diuretic torsemide helps heart failure patients get rid of more salt after lunch compared to the standard immediate-release version. Twenty adults with stable heart failure took both forms in a random order, and researc…

This pilot study tested a combined bone marrow and kidney transplant from a partially matched family donor in 10 people with both a blood disorder and chronic kidney disease. The goal was to treat both conditions at once and possibly reduce the need for lifelong anti-rejection dr…

This study tested the drug dapagliflozin (a diabetes medicine) against a placebo in 220 people on dialysis for kidney failure, with or without diabetes. The goal was to see if the drug could improve heart structure and be safe. Participants took the drug or placebo for a period, …

This study tested whether hydroxychloroquine, a drug used for malaria and autoimmune conditions, can safely reduce blood and protein in the urine of children with X-linked Alport syndrome, a genetic kidney disease. Fifty children aged 3 to 18 with stable kidney function took the …

This study tested a robot-assisted system called MONARCH to remove kidney stones through a small incision in the back. Fifteen adults with stones larger than 1 cm took part. The goal was to see if the robot could safely complete the procedure and clear the stones. Results showed …

This study tested whether people with type 2 diabetes and kidney damage can safely participate in a clinical trial from home. Twelve participants took the drug empagliflozin, and depending on their response, some added or switched to finerenone. The goal was to see if remote data…

This early-stage study tested a new approach to help kidney transplant recipients stop taking anti-rejection drugs. Eight adults received donor stem cells along with a special mix of medications to see if their bodies would accept the new kidney without needing lifelong drugs. Th…

This study looked at whether community health workers (CHWs) can help low-income, mostly minority adults better manage chronic diseases like diabetes, high blood pressure, and obesity. Over 10 months, 202 participants either received CHW support plus standard care or just standar…

This study tested a digital program called DDEP, delivered through the LINE messaging app, to help people with chronic kidney disease (CKD) and their care partners make healthy lifestyle changes. Over six months, 208 participants either received the DDEP plus usual care or usual …

This study tested whether citrate or heparin is better for keeping dialysis catheters working longer in ICU patients with sudden kidney failure. 405 adults were randomly assigned to receive either citrate or heparin as a catheter lock solution. The goal was to see which solution …

This study tested a drug called vonafexor in 26 people with Alport syndrome, a genetic condition that damages kidneys. The goal was to see if the drug is safe and if it can help protect kidney function. Participants took increasing doses over 24 weeks. The study is now complete, …

This small completed study looked at a blood filtering procedure called double-filtration plasmapheresis (DFPP) in 5 kidney dialysis patients with very high levels of lipoprotein(a), a fatty substance linked to heart disease and blood clots. The goal was to see if DFPP could lowe…

This study looked at whether a 12-week course of dapagliflozin can improve blood vessel function in people with chronic kidney disease. 32 participants took the drug, and researchers measured changes in artery health using ultrasound. The goal was to see if the drug could help co…

This completed study looked at the safety and effectiveness of FASENRA (benralizumab) in 51 Korean adults with severe eosinophilic asthma or eosinophilic granulomatosis with polyangiitis (EGPA). Researchers tracked side effects and how well the drug controlled symptoms during rou…

This study tested a drug called pegcetacoplan in 124 adults and teens with two rare kidney diseases (C3G and IC-MPGN). The goal was to see if the drug could reduce protein in the urine, a sign of kidney damage. Participants received either the drug or a placebo twice a week for 2…

This early-phase trial tested a combination of two drugs—pembrolizumab (an immunotherapy) and nintedanib (a drug that blocks blood vessel growth)—in 196 adults with advanced solid tumors that had worsened after standard treatment. The main goal was to find the safest dose of nint…

This study tested whether the drug rituximab can help people with a rare disease called eosinophilic granulomatosis with polyangiitis (EGPA) achieve remission better than standard treatments. 107 adults with active EGPA were randomly assigned to receive either rituximab or conven…

This study tested a new drug called FR104 in 10 people who received a kidney transplant. The goal was to see if the drug is safe and helps prevent the body from rejecting the new kidney. Researchers monitored side effects and kidney function over time.

This study tested an oral medication called iptacopan in 52 adults with Paroxysmal Nocturnal Hemoglobinuria (PNH) who were already stable on standard infusion treatments. Participants switched from their usual therapy to iptacopan pills taken twice daily. The main goal was to see…

This study looked at whether weight-loss surgery (vertical sleeve gastrectomy) can improve kidney, heart, and pancreas function in teens aged 12-21 with type 2 diabetes and obesity. Researchers measured blood flow to the kidneys, kidney filtering ability, and insulin production b…

This study tested a special device called the Amplifi Vein Dilation System in 19 adults with end-stage kidney disease who needed a vein connection (fistula) for dialysis. The goal was to see if the device could safely widen the vein and help the fistula mature faster. The study m…

This study looked at whether taking L-carnitine or Coenzyme Q10 supplements could lower oxidative stress (a type of cell damage) in adults with end-stage kidney disease who are on regular hemodialysis. Fifty-two participants took one of the supplements or a placebo for 12 weeks, …

This study tested a new drug called KBP-5074 in 162 people with moderate-to-severe chronic kidney disease whose blood pressure was still high despite treatment. Participants took either a low or high dose of the drug or a placebo daily for 84 days. The main goal was to see if the…

This study tested a drug called ziltivekimab in 264 people with advanced chronic kidney disease and high inflammation. Participants received monthly injections of either a placebo or one of three doses of ziltivekimab for six months. The goal was to see if the drug could safely l…

This study tested whether a special material made from a child's own blood, called platelet-rich fibrin (PRF), can reduce complications after surgery for a rare bladder condition called bladder exstrophy. Twenty children having their first bladder repair surgery were split into t…

This study looked at 78 people with advanced kidney failure who needed a surgery to create an arteriovenous fistula (a connection between an artery and vein) for dialysis. The goal was to see if using a nerve block (axillary block) instead of local anesthesia could reduce early p…

This study tested whether drinking an extra 1.5 liters of water daily for a year could lower blood sugar in adults with signs of dehydration and high blood glucose. Nearly 800 participants were split into two groups: one received lifestyle advice plus extra water, the other only …

This study tested whether a daily probiotic drink could slow the buildup of calcium in blood vessels (vascular calcification) in 84 adults with advanced chronic kidney disease. Participants took either the probiotic or a placebo for 6 months, and researchers tracked changes in ki…

This study tested a combination of two drugs, pembrolizumab and lenvatinib, in 160 people with a rare type of advanced kidney cancer (non-clear cell renal cell carcinoma) that had not been treated before. The goal was to see if the drugs could shrink tumors. The study found that …

This study looked at 201 Canadian patients with ANCA-associated vasculitis to see if cheaper biosimilar versions of rituximab work as well as the original drug. Researchers compared disease control, side effects, and how long it took to get insurance approval for treatment. The g…

This study tested a new device called the FLEX System that creates a connection between an artery and a vein (AV fistula) using a tube inserted through the skin, instead of surgery. The goal was to see if this method is safe and works well for people with chronic kidney disease w…

This study looked at whether continuing a drug called sodium zirconium cyclosilicate (Lokelma) after hospital discharge helps people with chronic kidney disease maintain normal potassium levels. 186 hospitalized patients were randomly assigned to either continue the drug or recei…

This study tested whether giving a stronger pneumococcal vaccine schedule (either two doses close together or a single larger dose) followed by a standard booster could improve immune protection in 96 adults with ANCA-associated vasculitis who are also receiving rituximab therapy…

This study tested whether adding sparsentan to a standard SGLT2 inhibitor can better protect kidneys in people with IgA nephropathy, a disease that can lead to kidney failure. 48 adults who were already on stable doses of both a blood pressure drug and an SGLT2 inhibitor took spa…

This study tested a method to carefully remove extra fluid from critically ill patients with kidney failure who are on continuous dialysis. The goal was to keep their fluid levels balanced without causing dangerous drops in blood pressure. Researchers used advanced heart monitori…

This study looked at whether giving rituximab for 46 months instead of the usual 18 months can better prevent relapses of ANCA-associated vasculitis, a rare autoimmune disease that causes blood vessel inflammation. 97 patients who were already in remission after initial rituximab…

This study tested whether adding early steroids or SGLT2 inhibitors to standard blood pressure medication can better protect kidney function in people with IgA nephropathy who have severe kidney damage. 62 adults with active disease were randomly assigned to receive either the co…

Researchers are studying whether features from pretreatment 18F-FDG PET/CT scans can predict how well people with metastatic kidney cancer respond to first-line targeted therapy plus immunotherapy. The study reviews medical records and imaging data from 228 patients treated at a …

Researchers at Assiut University are investigating whether the ratio of two blood proteins, fibrinogen and albumin, is linked to diabetic kidney disease in people with type 2 diabetes. The study compares 50 patients who have both type 2 diabetes and kidney disease with 50 patient…

This study evaluates a portable digital test called KF4+ that measures urea and potassium from a tiny drop of capillary blood, like a finger prick. The trial involves 55 adults with end-stage kidney disease who are on dialysis. The goal is to see if the KF4+ results match standar…

This completed study tested whether a special type of MRI (multiparametric MRI) can accurately tell the difference between benign and malignant small kidney tumors. About 387 adults with small solid kidney masses (1.5-4 cm) were scanned before surgery or biopsy. The goal was to s…

This study tested whether a urine test measuring two proteins (TIMP2 and IGFBP7) can tell which septic shock patients will recover normal kidney function within 72 hours. Researchers analyzed data from 77 patients in French ICUs. The goal is to help doctors decide who needs aggre…

This study tested a new urine test (RENISCHEM L-FABP) to see if it can predict acute kidney injury within 2 days after heart or blood vessel procedures that use contrast dye. Researchers measured a kidney stress marker in 382 adults at higher risk. The goal was to validate the te…

This study is testing a portable, non-invasive breath analyzer that measures tiny particles in exhaled breath to screen for conditions like type 2 diabetes, liver disease, kidney disease, and lung disease. Researchers will enroll healthy volunteers and people with known diagnoses…

This study tested whether the Nephrocheck™ device can predict if early acute kidney injury will reverse within 72 hours in patients with septic shock. Researchers enrolled 184 adults in the ICU and measured the device's accuracy. The goal is to help doctors decide who might recov…

This study tested a short questionnaire called SCORED to see if it can accurately identify adults in Asia who are at risk for chronic kidney disease (CKD). Over 1,400 people took part across multiple hospitals. Researchers measured how well the questionnaire predicted kidney prob…

This study looked at whether a special light-based monitor (near-infrared spectroscopy) placed on the skin can help predict kidney injury after heart surgery. Researchers measured oxygen levels in the kidneys of 113 adults during surgery and checked if low levels were linked to l…

This study tested a new ultrasound technique called URM to look at tiny blood vessels in the kidneys of 150 people with kidney failure. The goal was to see if this method can help doctors better assess kidney function, stage the disease, and monitor treatment. The researchers com…

This study tested whether advanced ultrasound techniques can predict if an arteriovenous fistula (AVF) will work for dialysis in people with end-stage kidney disease. Researchers measured artery stiffness and blood flow in 76 patients before and after AVF surgery. The goal was to…

This study tested whether a fast removal of 250 ml of fluid during dialysis can predict which ICU patients with acute kidney injury are at risk of unstable blood pressure. Twenty adults on mechanical ventilation and continuous dialysis underwent two different speeds of fluid remo…

This study aims to create a better way to detect acute kidney injury early after heart surgery. Researchers will combine blood and urine tests with patient information to build a scoring system. The goal is to identify high-risk patients quickly so doctors can take steps to prote…

This study tested a new wearable patch that collects sweat to measure sodium and creatinine levels, which are important for monitoring kidney health and dehydration. Five adults with kidney disease wore the patch while their sweat was analyzed using a special light-based techniqu…

This study tested a new radioactive imaging agent, 68Ga-OncoCAIX, in 20 people with a type of kidney cancer called clear cell renal cell carcinoma. The goal was to see if it is safe and how it spreads in the body. Researchers measured radiation doses to organs and checked for sid…

This study tested whether a laser confocal microscope, used during a kidney-ureter scope procedure, can tell the difference between normal and cancerous tissue in the upper urinary tract. 29 adults with conditions like blood in urine, kidney stones, or urinary tract cancer took p…

This study tested whether infusing mannitol, a sugar alcohol, can help diagnose polyuria-polydipsia syndrome—a condition of excessive thirst and urination. Researchers measured copeptin levels in 42 healthy adults and patients after mannitol or placebo infusion. The goal was to s…

This study tested whether special ultrasound scans can detect kidney damage in people who have received a kidney transplant. 141 transplant recipients had ultrasound imaging at 15 days, 3 months, and 12 months after surgery. The goal was to see if these scans could measure kidney…

This trial tests whether a software tool called the hypotension prediction index (HPI) can help prevent acute kidney injury after robotic-assisted urologic surgery. The tool uses arterial pressure data to forecast drops in blood pressure during the operation, allowing doctors to …

This trial asks whether giving dialysis patients four doses of a double-strength hepatitis B vaccine offers better protection than the standard three doses. People with kidney failure on dialysis often respond weakly to vaccines, leaving many unprotected. The study will compare a…

This study tested whether giving intravenous immunoglobulins (IVIG) could prevent BK virus infection in kidney transplant recipients. The virus often causes graft problems. Researchers enrolled 359 patients with low antibody levels against their donor's virus strain and gave some…

This study tested a 60% ethanol (alcohol) lock solution to prevent serious catheter infections in 1,460 ICU patients with acute kidney failure needing dialysis. The ethanol lock is placed inside the catheter to kill germs. The goal was to see if it reduces major catheter-related …

This study tested a six-month home-based exercise program using elastic bands to prevent frailty in 120 adults aged 50-85 with type 2 diabetes and chronic kidney disease. The program aimed to improve muscle strength and daily functioning. Researchers measured changes in frailty s…

This study tested a drug called conestat alfa in 141 people undergoing a minimally invasive heart valve replacement (TAVI) for severe aortic stenosis. The goal was to see if the drug could reduce the risk of small strokes and kidney damage that can happen after the procedure. Par…

This study tested whether giving a bicarbonate solution (like baking soda) is better than standard saline for preventing kidney injury caused by contrast dye used in imaging. The trial involved 300 adults in intensive care who needed contrast dye. Researchers compared how many pa…

This study tested whether regular retraining on infection prevention can lower peritonitis rates in new peritoneal dialysis patients. Over 700 adults from eight European countries were randomly assigned to either standard care or extra testing and retraining on dialysis technique…

This study compared two common surgeries for kidney stones 20 mm or smaller: super-mini percutaneous nephrolithotomy (SMP) and flexible ureteroscopy (fURS). Researchers in Vietnam randomly assigned 72 adults to one of the two procedures and measured how well the stones were remov…

This study tests whether a set of breathing exercises, called breath booster training, can strengthen respiratory muscles and improve quality of life in people on hemodialysis. Fifty patients aged 50 to 60 will do the exercises three times a week during their dialysis sessions. R…

Doctors often place a ureteral stent after flexible surgery to remove kidney stones, but stents cause discomfort and may need a second procedure for removal. This study at Ain Shams University follows 140 adults with upper urinary tract stones up to 2.5 cm who have the surgery wi…

This study looked at whether mandala art therapy (a structured coloring activity) can lower anxiety and increase comfort in people who received a kidney transplant. Eighty adult first-time kidney transplant recipients took part. The goal was to see if this simple, non-drug approa…

Researchers are testing whether oral N-acetylcysteine (NAC) can reduce signs of kidney tubular injury, oxidative stress, and inflammation in adults with non-severe leptospirosis. The trial enrolls 64 adults who have had fever for three to five days and a confirmed Leptospira infe…

This study tested two non-drug methods—reflexology (foot massage) and sleep hygiene education—to improve sleep and comfort in 60 adults on hemodialysis. Both approaches helped, but reflexology was more effective. The results suggest a simple, drug-free option for better rest in d…

This study tests whether a 6-week aerobic exercise program (done on non-dialysis days) can lower serum uric acid levels, improve walking ability, and boost quality of life in 32 adults aged 40-60 who are on hemodialysis. Half will exercise 3 times a week; the other half will rece…

People on long-term hemodialysis often lose physical function and strength. This trial tests whether adding receptive music listening to a supervised lower-limb resistance exercise program during dialysis improves physical function more than exercise alone or usual care. Forty-se…

Researchers are testing whether a guided mindfulness program can help adults with end-stage kidney disease who receive hemodialysis. The program involves listening to audio recordings for 30 minutes, three times a week for five weeks, during regular dialysis sessions. The study m…

Researchers compare two ultrasound-guided nerve blocks to see which better controls pain after percutaneous nephrolithotomy, a surgery to remove kidney stones. Adults aged 18 to 65 scheduled for this operation receive either an external oblique intercostal block or an erector spi…

This study tests whether a guided internet-based education and support program can help people with severe kidney failure who are waiting for a kidney transplant. The program includes 9 weekly modules covering kidney disease, treatment, self-care, and coping strategies. Researche…

This pilot trial tests whether dialysis patients can follow a supervised exercise program at home using video calls. Participants will do 40 to 45 minute sessions three times a week for 12 weeks. The study focuses on whether this approach is practical and safe, and whether it mig…

This trial tests whether a structured patient education program can lower the risk of severe immune-related side effects in people receiving immunotherapy for certain cancers, including melanoma, lung, kidney, and head and neck cancers. Participants either attend five educational…

This early-phase study tests whether taking amino acid supplements during dialysis can reduce fatigue, frailty, and improve thinking in people with end-stage kidney disease. Researchers will compare a single amino acid (valine) with a mix of essential amino acids in 28 adults on …

This trial tests whether a physical therapy technique called Muscle Energy Technique (MET) can reduce restless legs syndrome in people with end-stage kidney disease who are on hemodialysis. Participants receive either routine dialysis care or the same care plus MET during their d…

This trial tests whether a guided exercise program done during hospital hemodialysis sessions can improve physical capacity and quality of life in adults with chronic kidney disease. Participants will perform strength and balance exercises for their arms and legs while receiving …

This pilot study tested an optimized dialysis technique using a special membrane and biofeedback software to see if it helps kidney failure patients recover faster after treatment. 18 patients on standard dialysis who took at least 4 hours to recover were observed. The study meas…

This study investigates whether a 12-week program of tai chi and qigong (called Body Mind Training) can reduce fatigue in male cancer survivors aged 55 and older. Participants are randomly assigned to the mind-body training, a light exercise-only group, or a usual-care group. Res…

This study tested whether listening to music and applying acupressure before needle insertion can reduce pain in dialysis patients. 72 participants were split into four groups: music plus acupressure, acupressure alone, music alone, or standard care. Pain was measured during thre…

This study looked at two different strengths of the numbing medicine bupivacaine used in a nerve block for pain after kidney stone surgery. Sixty adults having the surgery received either a 0.25% or 0.375% concentration. Researchers measured their pain levels, how much extra pain…

This study tested whether briefly stopping a patient's breathing during kidney stone laser surgery could make stone removal more efficient by reducing kidney movement. 150 adults with kidney stones were randomly assigned to normal breathing, low-volume breathing, or a short breat…

This study tested whether a combined aerobic and resistance exercise program could improve physical function and muscle health in people receiving peritoneal dialysis. Thirty-six adults on dialysis for at least six months were split into an exercise group and a usual-care group. …

This study tested whether wearing virtual reality goggles during the needle stick for dialysis can lower pain and anxiety. Fifty adults on hemodialysis were randomly assigned to either watch VR content during the procedure or receive usual care. The results will show if a simple,…

This study tested a device that uses ultrasound to help guide needles into the blood vessels of people with end-stage kidney disease who need dialysis. Ten adults with an arteriovenous fistula or graft took part. The main goal was to see if the device could help place needles suc…

This study looked at 40 infants under 1 year old having kidney surgery. They received a pain block with either bupivacaine alone or bupivacaine plus ketamine. The goal was to see if adding ketamine reduces pain and the need for extra pain medicine after surgery.

This study looked at 52 adults with EGPA (a rare inflammatory disease) and severe chronic sinusitis with nasal polyps. They received mepolizumab 300 mg every 4 weeks. The goal was to see if the drug reduces polyp size and improves symptoms like nasal congestion and sense of smell…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested whether using a 3D model of a patient's kidney before surgery could shorten the time needed for robotic-assisted partial nephrectomy (removing a kidney tumor). 370 adults with small kidney tumors took part. The goal was to see if better planning with 3D imaging …

This study tested whether a 16-week program of cycling during dialysis sessions could improve heart function in 30 adults with kidney failure and early signs of heart stiffness. Participants first received standard care for 16 weeks, then added supervised cycling during dialysis …

This study tested a drug called nemolizumab to see if it can reduce severe itching in adults with chronic kidney disease who are on dialysis. 258 participants received either nemolizumab or a placebo as injections every 4 weeks for 12 weeks. The main goal was to see how many peop…

This study tested whether doing handgrip exercises before and after surgery can improve the size and function of dialysis fistulas in people with advanced kidney disease. 40 patients participated, and the main goal was to see if the fistula diameter increased. The approach is sim…

This study tested whether light exercise or a technique called remote ischaemic preconditioning (rIPC) — using a blood pressure cuff to briefly restrict blood flow to the arm — could protect the heart during dialysis. 33 adults on hemodialysis took part in three sessions: one wit…

This study tested a program led by nurses that combined personalized nutrition advice and supervised exercise for people on hemodialysis. The goal was to see if it could improve their overall quality of life. 120 adults on long-term dialysis took part, with half receiving the pro…

This study compared two ways of doing kidney stone surgery (PCNL). In the standard method, a tube is left in the kidney to drain urine, which can cause pain. In the tubeless method, no tube is placed. Researchers measured pain and painkiller use in 60 adults after surgery. The go…

This study tested whether adding empagliflozin (a diabetes drug) to standard diuretics helps hospitalized heart failure patients with moderate to advanced kidney disease urinate more fluid. 25 participants were given the combination, and researchers measured urine output. The goa…

This study tested whether nurse-led mindfulness sessions could help people on hemodialysis feel better and follow their treatment more closely. Eighty patients were split into two groups: one received six weekly mindfulness sessions, the other got usual care. After the program, t…

This study tested whether a 12-week nurse-led program could help people on hemodialysis feel better and function better. 220 patients were split into two groups: one got the extra program during dialysis sessions, and the other got standard care. The program included light exerci…

This study tested whether watching calming VR videos (nature, forest, seaside) during needle insertion could reduce pain, distress, and improve comfort in 52 hemodialysis patients. Patients used VR headsets starting three minutes before the procedure. The goal was to see if this …

This study tested a traditional Chinese medicine patch made from herbs like ginger and Artemisia on 21 dialysis patients who had pain from their fistula. The patch was placed on specific acupoints during dialysis sessions for 4 weeks. Researchers measured pain, depression, and qu…

This study tested whether a guided mindfulness meditation program, practiced during dialysis sessions, could reduce anxiety and improve spiritual well-being in people with chronic kidney disease. Fifty-eight adults on hemodialysis were randomly assigned to either the meditation g…

This study tested whether the medication PB can safely reduce excessive urination in people with certain kidney diseases, including inherited nephrogenic diabetes insipidus, lithium-induced diabetes insipidus, and polycystic kidney disease treated with tolvaptan. Researchers meas…

This study tested whether a low dose (4.5 mg) of naltrexone, a drug already used for alcoholism, can improve physical health and quality of life in people with vasculitis. Sixty participants took either the drug or a placebo daily for six weeks. The goal was to see if the drug le…

This study tested two simple, drug-free ways to reduce pain when inserting needles for dialysis. 75 patients were split into three groups: one listened to calming music, one looked at their healthy arm in a mirror, and one received standard care. Pain scores were compared right a…

This study tested whether ketorolac, a non-steroidal anti-inflammatory drug (NSAID), works as well as the opioid oxycodone for pain after kidney stone removal. 81 adults who had ureteroscopy and received a ureteral stent took part. For five days after surgery, they recorded their…

This study tested a fast-recovery program for people having minimally invasive kidney surgery (laparoscopic or robotic) to remove tumors. The goal was to see if the program could safely shorten hospital stays by at least one day. Sixty patients took part, and researchers tracked …

This study tested whether cycling for 30 minutes during each dialysis session, three times a week for three months, could improve blood flow in the legs of people on chronic hemodialysis. The goal was to see if this simple exercise could help prevent serious complications like wo…

This study tested whether lidocaine or benzocaine sprays could reduce pain and improve satisfaction during needle insertion for hemodialysis. 60 patients were randomly assigned to receive one of the two numbing sprays or a placebo. The goal was to see if these sprays make the pro…

This completed study in 49 veterans with early chronic kidney disease (CKD) tested whether diuretics (water pills) can reduce fluid overload and improve heart health. Researchers measured changes in heart stress markers and symptoms like fatigue after 4 weeks of treatment. The go…

Children with growth hormone deficiency often need daily injections, which can be hard to keep up with. Researchers in Belgium and Luxembourg are asking families in the BELGROW registry to fill out a questionnaire about whether they would consider switching to long-acting growth …

This study looked at 516 patients who had surgery for a torn aorta (aortic dissection). Researchers checked if a high ankle-brachial index (a simple test of blood flow in the legs) before surgery was linked to kidney problems afterward. The goal was to see if this test could help…

This study is looking for new markers in blood and urine that could predict kidney injury after heart surgery in high-risk patients. Researchers will follow about 1,500 adults undergoing open-heart surgery and check for kidney problems within a week. The goal is to find better wa…

This study looked at how the drug remibrutinib behaves in people with severe kidney problems compared to healthy people. Researchers measured drug levels in blood and urine to understand how the kidneys process it. The goal is to help doctors decide the right dose for patients wi…

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

This completed study looked at why some people develop scarring in their kidneys, including rare diseases like FSGS and a mysterious form of chronic kidney disease affecting farm workers. Researchers collected blood, urine, and kidney tissue from 537 participants to better unders…

Researchers are testing two ways to train VA primary care clinicians to hold goals of care conversations with veterans who have serious illnesses such as cancer, heart failure, or dementia. One approach gives clinicians written materials and online training. The other adds team f…

Researchers at a large hospital in Seoul reviewed records from nearly 33,000 adults who had curative-intent surgery for one of seven cancers in the abdomen or pelvis: pancreatic, gastric, rectal, cervical, endometrial, kidney, or prostate. They grouped patients by whether they re…

This study searched for genetic factors that may cause focal segmental glomerulosclerosis (FSGS), a kidney disease that can lead to kidney failure. Researchers compared DNA from 616 people, including African-Americans with FSGS, African-Americans with HIV but no FSGS, and non-Afr…

This early-stage study is testing a single dose of the drug MK-2828 in 24 people with different levels of kidney function, including those with severe kidney failure or on dialysis. The goal is to measure how the drug moves through the body over time and compare it to healthy vol…

Researchers want to learn which molecules on cancer cells the immune system attacks when checkpoint inhibitor drugs work well. They collect tumor and blood samples from adults with solid tumors who respond to these drugs, either during treatment or after surgery. The team then se…

This study is testing whether a green dye called ICG can help surgeons see tumors more clearly during surgery in children and teens with solid tumors. The dye is injected before surgery and makes tumor tissue glow under a special camera. The goal is to see if this technique helps…

Researchers are examining the medical records of 12,000 people with type 2 diabetes who visited a large diabetes care center in Southern India during 2022 and 2023. The study aims to estimate how many of these patients have kidney insufficiency, a complication that past estimates…

Researchers are studying whether children born prematurely who had acute kidney failure as newborns show signs of reduced kidney function later in childhood. The study compares about 50 preterm children with a history of neonatal kidney failure to 25 preterm children without it. …

This study follows about 36 children weighing 2.5-10 kg who have acute kidney injury or fluid overload and are treated with the Carpediem continuous renal replacement therapy system. Researchers will track survival, kidney recovery, and hospital stay lengths to see how well the d…

This study uses computer simulations to compare two treatment strategies for people with chronic kidney disease and type 2 diabetes. Researchers will model whether adding empagliflozin to finerenone reduces heart failure, hospitalizations, and cardiovascular death more than finer…

This completed Phase 1 study looked at how the drug avacopan is processed in 13 people with normal kidney function and those with end-stage renal disease requiring hemodialysis. Researchers measured drug levels in the blood and dialysis fluid after a single dose. The goal was to …

Researchers at Mansoura Urology and Nephrology Center in Egypt are studying patients with kidney stones to learn how common calcium-based stones are and whether certain gene variants play a role. The study enrolls about 84 people, including patients who need stone removal and hea…

Researchers measure blood levels of zinc, copper, selenium, lead, mercury and other trace elements in older adults with advanced chronic kidney disease who receive hemodialysis. The study compares levels before and after a dialysis session in patients new to treatment and in thos…

This study looks at American Indians with type 2 diabetes who had early kidney disease and took a drug called losartan years ago. Researchers want to see if the benefits of that treatment still help protect their kidneys today. About 141 people who were in the earlier study or th…

This trial tests whether a shared decision making approach, where doctors and patients weigh options together, helps people with advanced chronic kidney disease choose their treatment. Participants are patients whose kidneys are failing and who may need dialysis or a transplant w…

This trial tests whether rituximab, a drug used for ANCA-associated vasculitis, leaves patients with a weakened immune system. Researchers give pneumococcal vaccines to patients treated with rituximab, patients with the disease but not on rituximab, and healthy volunteers. They c…

This study tests whether a software tool called Synapse Medicine can help hospital pharmacists who work with medical teams make better and faster medication recommendations. The tool analyzes each patient's health information to flag potential drug-related risks, such as harmful …

This study looks back at treatment records from 119 people with kidney failure who underwent haemodialysis using Genius SleddFlux filters, Ultraflux AV 600 S filters, and Genius 90 concentrates. The goal is to assess how well these devices performed in acute and chronic dialysis …

Researchers are using ultrasound to measure the thickness of ankle cartilage in people with type 2 diabetes who have nerve damage, and comparing it with healthy adults. Diabetic polyneuropathy may change how the lower limbs move, which could affect the ankle joint. The study incl…

This study tests a program that combines an AI chatbot and genetic counseling to help African American living kidney donor candidates understand APOL1 genetic testing. The goal is to reduce uncertainty and improve informed consent about donation. Researchers will enroll about 280…

This study looks back at the medical records of 150 adults in Brazil diagnosed with adrenocortical carcinoma, a rare cancer of the adrenal glands. Researchers will collect details on age, gender, location, tumor stage, hormone activity, and treatments received since the year 2000…

This study looks at how the body handles a new drug called S-892216 in people with mild, moderate, or severe kidney problems, including those on dialysis, compared to people with healthy kidneys. About 40 adults will take a single dose of the drug, and researchers will measure it…

This study looked at adrenal gland tumors to understand why they form, why some release extra hormones, and why some are cancerous. Researchers studied 690 people with known or suspected adrenal tumors. Participants underwent tests like blood draws, imaging scans, and urine colle…

This study is tracking over 1,200 adults in Kazakhstan who have high blood pressure to see how many also have signs of chronic kidney disease (CKD). Researchers will measure things like protein in urine and kidney function. The goal is to understand how often CKD goes undiagnosed…

This large observational study will follow 4,000 adults undergoing percutaneous nephrolithotomy (PCNL) for kidney stones across many international centers. Researchers will track which surgical techniques are used, how well they clear stones, and what complications occur. The goa…

This trial tests whether a 15-minute educational video and a list of suggested questions can improve understanding of immunotherapy among patients with advanced cancer and their caregivers. Participants are randomly assigned to receive the educational materials or usual care, and…

This study follows adolescents with youth-onset type 2 diabetes, along with obese and lean peers, into young adulthood to see how their kidneys change over time. Using advanced imaging and kidney function tests, researchers aim to understand early signs of diabetic kidney disease…

This study looked at 166 older adults (65+) on hemodialysis to compare three types of vascular access: fistulas, grafts, and catheters. The goal was to see which option leads to fewer complications and better quality of life. Researchers tracked how many procedures were needed to…

This study is investigating how often dangerous heart rhythm problems occur in people receiving hemodialysis for end-stage kidney disease. Researchers will implant a small device under the skin to continuously monitor heart rhythm for 18 months in 70 patients, half of whom have d…

This study looks at whether a protein in the blood, called soluble CD95 ligand, plays a role in ANCA-associated vasculitis, a rare group of diseases that cause inflammation of blood vessels. Researchers will collect blood and urine samples from 48 adults with the condition and tr…

This study is testing whether measuring residual blood volume and excess fluid during hemodialysis can predict the risk of intradialytic hypotension—a sudden drop in blood pressure that can cause dizziness, nausea, or fainting. Researchers will follow 60 adults with chronic kidne…

This study developed and tested HistoMX, an automated platform that analyzes gene activity in kidney transplant biopsy samples. Researchers used over 2,400 archived biopsies from adult kidney transplant recipients to see if the platform could accurately identify different types o…

This study aims to create and validate a questionnaire that measures how people with chronic kidney failure experience each hemodialysis session. Researchers want to capture physical, emotional, and relational factors that affect the quality of the session. The tool could help he…

This study follows 211 people with IgA nephropathy who previously took a 6-9 month course of the steroid methylprednisolone in the TESTING trial. Researchers want to see if the steroid helped prevent end-stage kidney disease (needing dialysis or a transplant) over the long term. …

This study looks at how often chronic kidney disease (CKD) is diagnosed in adults with high blood pressure who have early signs of kidney trouble but no prior CKD diagnosis. Researchers will review medical records and follow patients over time to see how many are formally diagnos…

This study is testing whether a simple urine test can detect signs of kidney transplant rejection in children. Researchers are looking for specific molecules in urine that signal the body is attacking the new kidney. If the test works, it could help doctors spot problems early wi…

This study tests a program designed to increase living donor kidney transplants among Hispanic patients with end-stage renal disease. The program provides Spanish-language education and outreach by bicultural health workers. Researchers will compare transplant rates between Hispa…

This study uses a dye called iohexol to measure how well the kidneys are working in patients leaving the intensive care unit after acute kidney failure. The goal is to find out how many patients still have reduced kidney function even though their standard blood tests look normal…

This study looks at whether eating a single dose of dark chocolate (70% cocoa) changes blood flow to the kidneys and blood pressure, compared to white chocolate. Researchers will use ultrasound to measure kidney blood flow two hours after eating. The study includes 32 people: hea…

This completed study looked at 40,000 people with metastatic cancer who received the drug nivolumab. Researchers compared the old way of dosing (based on body weight) with a newer, simpler fixed dose. They used national health data to see if the fixed dose was just as good and mo…

This study looked at whether a special ultrasound check (called VExUS) can help doctors set the ideal dry weight for people on hemodialysis. The idea is that by spotting hidden fluid buildup, doctors can safely remove more fluid during dialysis to better control blood pressure. T…

This study looked at the IgA antibodies in 80 people — 40 with IgA nephropathy (a kidney disease) and 40 healthy volunteers. Researchers took one blood sample from each person to analyze the IgA repertoire. The goal was to understand why IgA deposits form in the kidneys, which co…

This study looked at 287 patients with acute kidney injury caused by tubular necrosis. Researchers measured two substances in urine (PIIINP and NGAL) to see if they could predict whether kidney function would return or if chronic kidney disease would develop. The goal is to find …

This completed study examined whether a specific variation in the VEGF gene (rs699947) is linked to a higher risk of developing kidney cancer in people who have received a kidney transplant. Researchers analyzed DNA from 272 transplant patients, some of whom had kidney cancer. Th…

This completed observational study looked at 4500 patients admitted to internal medicine wards with heart failure, COPD, or chronic kidney disease. Researchers aimed to identify which other chronic conditions tend to cluster with these diseases, and how those clusters affect pati…

This completed study looked at red and white blood cells in people with a rare blood disorder called PNH who also have bone marrow failure. Over 5,500 participants aged 10 and older with aplastic anemia or related conditions provided blood samples. The goal was simply to learn mo…

This completed study looked at 378 kidney transplant patients to see if measuring antibodies against BK virus before transplant could predict whether the virus would reactivate after surgery. Researchers used a lab-made virus-like particle to test for five different BK virus type…

This study tested a prediction tool (nomogram) to see if it could forecast how patients with metastatic clear cell renal cell carcinoma respond to the targeted therapy sunitinib. Researchers looked at 45 patients who had their kidney removed and were treated with sunitinib as the…

This study looked at 90 adults having kidney stone surgery to see if the type of anesthesia—spinal or general—affects the body's inflammation response. Researchers measured blood markers before and after surgery. The goal is to learn which method might lead to less inflammation a…

This study analyzed health records from over 450,000 adults with obesity and type 2 diabetes to see if adding a GLP-1 or SGLT2 drug early improves survival and kidney health. Researchers compared those who added the other drug class within 90 days to those who added a different d…

This study follows people over 75 with advanced chronic kidney disease to better understand their health and treatment paths. Researchers want to create a tool that predicts which patients are at high risk of dying soon after starting dialysis. The goal is to help patients, famil…

This study followed 623 adults in France with advanced kidney cancer who were starting treatment with the immunotherapy drugs nivolumab (with or without ipilimumab) for the first time. Unlike a clinical trial, this was an observational study that simply tracked what happened in e…

This study followed 400 intensive care patients receiving beta-lactam antibiotics to see how often these drugs cause brain-related side effects like confusion or agitation. Researchers measured antibiotic levels in the blood and checked patients' neurological status several times…

This study looked at 174 adults in the intensive care unit (ICU) to find out how often acute kidney injury happens and what factors make it more likely. Researchers tracked patients who stayed in the ICU for at least 48 hours, excluding those with kidney problems at the start. Th…

This completed study looked at 170 adults who needed emergency hemodialysis for acute kidney injury. Researchers measured three blood markers (Activin A, Nostrin, and Angiopoetin-2) before dialysis to see if they could predict whether the kidneys would recover or if the patient w…

This study looked at 49 kidney transplant patients to see how two different induction therapies—thymoglobulin and basiliximab—affect B cells, a type of immune cell. Researchers compared the B cell profiles between the two groups and with data from patients who had chronic antibod…

This study looked at two tools to help people with chronic kidney disease (CKD) stay healthier. One tool gave doctors a registry to track patients, and the other offered phone coaching from a health coach. The goal was to see if these approaches could lower blood pressure and imp…

This study looked at how two types of exercise affect bone health in people with chronic kidney disease. Sixty patients did either treadmill walking or resistance training for 6 months. Researchers measured bone turnover markers and bone density before and after the program to se…

This study followed more than 3,000 adults with moderate to advanced chronic kidney disease (CKD) for up to 5 years. Researchers collected health data and blood/urine samples to identify factors that lead to kidney failure, heart problems, and other complications. The goal was to…

This study tested a new way for doctors to discuss CPR with older, seriously ill patients and their families. Instead of the usual conversation, doctors followed a step-by-step guide that focused on the patient's values and explained why CPR might not help. The goal was to see if…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study looked at how lifestyle factors like obesity and muscle loss affect kidney cancer risk and survival after kidney removal. Researchers collected blood, tissue, and questionnaire data from 161 patients over up to 5 years. The goal was to understand how to personalize tre…

This study looked at whether getting an islet transplant after a kidney transplant helps people with type 1 diabetes avoid kidney failure or death. Researchers reviewed data from 327 people in France who had a kidney transplant between 2000 and 2017. They compared those who also …

This study tested whether an AI tool that predicts the risk of kidney transplant failure within one year can improve conversations between patients, their families, and doctors. 76 adults with a functioning kidney transplant but declining kidney function took part. The goal was t…

This study looked at 88 adults with chronic kidney disease to see how their oral health changes at different stages. Researchers checked teeth, gums, saliva, and breath to find links with nutrition and inflammation. The goal is to understand if dental problems can worsen kidney d…

This study looked at a new device called AE05ML that helps surgeons place clips on blood vessels and other tissues during keyhole surgery. The goal was to see if the device is safe and works well. A total of 161 adults took part in the study.

This study tested whether a program of videos and text messages (called KidneyTIME) helps people with kidney failure learn more about getting a kidney from a living donor. 422 adults who were already being evaluated for a kidney transplant took part. The study compared those who …

This study looked at 100 critically ill adults with severe kidney failure who were receiving continuous kidney replacement therapy. Researchers used a special ultrasound technique to check for fluid buildup in the body, which can harm organs. The goal was to see how common fluid …

This study looked at whether starting dialysis at a specific time, based on a new mathematical formula, could help people with end-stage kidney disease live longer. 388 patients were randomly assigned to start dialysis either at an 'optimal' or 'late' time. Researchers tracked de…

This completed study collected blood and urine samples from 240 people with ciliopathies—rare genetic disorders that often lead to kidney failure. Researchers analyzed these samples to find biological markers that could predict how the disease will progress. The goal is to develo…

This study looked at whether adjusting the amount of magnesium in the dialysis fluid could help keep blood magnesium levels in a healthy range for people with kidney failure on hemodialysis. Fifty-four adults took part in this pilot crossover trial. The goal was to gather informa…

This study looks at people who carry one copy of a mutated AGXT gene, which is linked to a rare kidney stone disease. Some carriers develop kidney stones, while others do not. Researchers will compare their urine oxalate levels and lifestyle factors to find out what triggers symp…

This study looked at whether adding hands-on simulation training to standard classroom teaching helps nurses cause fewer problems when inserting needles into the arm access (arteriovenous fistula) of dialysis patients. About 9600 adults on chronic hemodialysis took part. The goal…

This completed Phase 2 study investigated how the drugs dapagliflozin and balcinrenone, alone or together, affect the body's handling of water and salts in people over 50 with stage 3 chronic kidney disease. Over 28 days, 103 participants took daily pills to measure changes in ur…

This study looked at 2,500 kidney transplant patients to find out why some develop cancer. The main focus was on the immunosuppressive drugs that prevent organ rejection, which can also raise cancer risk. Researchers tracked patients from four regions in France over 10 years to i…

This study followed over 3,400 people with autosomal dominant polycystic kidney disease (ADPKD) to learn how the disease progresses. Researchers measured kidney size, symptoms, quality of life, and healthcare costs. The goal was to identify factors that predict faster disease pro…

This study looked at 172 kidney transplant recipients who were on stable anti-rejection medication for at least 3 months. Researchers measured levels of a common, harmless virus (Torque Teno Virus) in their blood to see if it could predict serious infections or organ rejection. T…

This study looked at 395 adults on long-term dialysis to find out how often their blood pressure drops dangerously during treatment and what makes it more likely. Researchers collected information on patients' health history, medications, and dialysis settings. The goal is to hel…

This completed study analyzed electronic health records from over 6,500 patients in China who started taking finerenone for chronic kidney disease and type 2 diabetes. Researchers tracked kidney function, potassium levels, and side effects like high potassium. The goal was to see…

This study tracked 228 critically ill patients in China who needed continuous kidney dialysis. Doctors used pre-mixed solutions instead of custom-mixed ones to see how well they worked in everyday hospital care. The goal was to gather information on filter life, blood chemistry, …

This study looked at how the amount of salt in the diet changes the effects of the diabetes drug ertugliflozin on blood pressure and kidney function. Overweight adults with type 2 diabetes followed either a low-salt or high-salt diet while taking the drug or a placebo. The goal w…

This study looked at how a nerve condition called cardiovascular autonomic neuropathy (CAN) affects the risk of kidney injury in people having heart bypass surgery. Researchers tracked 912 adults before, during, and after surgery to see if those with CAN had worse kidney function…

This study looked at data from 348 people with type 2 diabetes in Germany who use the myTherapy app. Researchers wanted to see how many had high levels of a protein called albumin in their urine, which is a sign of kidney damage. They also tracked how these levels changed over a …

This study looked at how immune checkpoint inhibitors, a type of cancer drug, might affect blood vessels and increase heart risks. Researchers measured blood vessel function and checked for related markers in 39 cancer patients before and after starting treatment. The goal was to…

This completed study looked at whether levels of a protein called angiotensinogen in blood and urine can predict long-term kidney function in people who had acute kidney injury. Researchers followed 80 patients for three years to see if this biomarker could help identify those at…

This pilot study looked at whether giving extra oxygen during heart surgery (when a heart-lung machine is used) affects kidney function afterward. 104 adults having elective heart surgery were randomly assigned to receive either high or normal oxygen levels. The main goal was to …

This completed study looked at how the drug Advagraf (a form of tacrolimus) works in 45 adults who received a kidney transplant. The goal was to find better ways to dose the drug by measuring its levels in the blood right after transplant and three months later. Researchers compa…

This study looked at immune cells from 138 people with Wegener's granulomatosis, a rare disease causing inflammation of blood vessels. Researchers measured levels of a protein called DAP12 in different immune cells to understand how the disease works. No new treatment was tested;…

This study looked at whether a substance called cystatin C, measured in urine and blood, can detect kidney damage from chemotherapy drugs cisplatin and ifosfamide in children. Researchers followed 42 children and compared cystatin C levels to standard kidney tests. The goal was t…

This completed study looked at whether a protein called vasorin in the blood can help predict how severe kidney injury will be in people with septic shock. Researchers took blood samples from 50 intensive care patients on day 0 and day 3. The goal was to see if vasorin levels are…

This study tested whether home automation and remote monitoring can help elderly people (65+) with multiple chronic conditions live safely at home. Over 500 participants had their homes equipped with sensors that tracked health signs and sent alerts to doctors. The main goal was …

This study looks at how a single 5 mg dose of the blood thinner apixaban is processed in people with end-stage kidney disease who are on peritoneal dialysis, compared to people with normal kidney function. Researchers measured drug levels in the blood over time. The goal is to un…

This study looked at whether giving African American adults with high blood pressure early access to genetic testing for a kidney disease risk gene (APOL1) could improve their care. Over 6,700 participants were randomly assigned to get their genetic results right away or later. T…

This study looked at over 5,000 critically ill children from hospitals worldwide to learn more about acute kidney injury (AKI). The goal was to better understand how common AKI is, what puts children at risk, and how to predict it using a tool called 'renal angina.' The study did…

This completed lab study took blood samples from 20 adults with relapsed membranous nephropathy, a kidney condition. Researchers tested different immune-modulating drugs on the blood cells to see how they affect the balance of Th17 and Treg immune cells. The goal is to find which…

This study looks at a new blood test that measures specific antibodies in people with membranous nephropathy, an autoimmune kidney disease. The test aims to predict which patients are more likely to develop kidney failure. Researchers will follow 52 adults over time to see if the…

This study tested a program called DIAL-SDM that trains kidney doctors and coaches older patients (65+) with advanced kidney disease to have better conversations about dialysis. The goal was to see if the program was practical and acceptable. 102 patients, their caregivers, and 2…

This study looked at 60 adults on long-term dialysis to see if the schedule of dialysis sessions affects blood flow to the legs. Some patients did standard 4-hour sessions three times a week, while others did shorter 2-hour sessions six times a week. The goal was to find out whic…

This completed study looked at how kidney cancers are found—either because a patient had symptoms or by chance during a scan for something else. Researchers reviewed 1000 patients who had surgery for kidney lesions in the Czech Republic. The goal was to see which detection method…

This study reviewed medical records of 139 people with advanced chronic kidney disease who had a heart attack. Researchers wanted to see if getting a coronary angiogram (a special X-ray of the heart arteries) soon after the heart attack was linked to living longer and needing dia…

This study tested whether having dialysis patients regularly fill out questionnaires about their symptoms and well-being helps them communicate better with their doctors and nurses. Over 3,900 adults on dialysis in Alberta and Ontario took part. The goal was to see if sharing the…

This study looked at whether eating at different times during hemodialysis affects blood pressure stability and how well the treatment removes waste from the body. Researchers divided 40 adults with chronic kidney disease into groups that ate at set times or followed their usual …

This study looks at whether heparin or citrate locks used in dialysis catheters leak into the bloodstream. It involves 76 adults with acute kidney failure. Researchers measure blood clotting and calcium levels before and after injecting the lock to check for leakage and potential…

This study aimed to find out how often people in Reunion Island start dialysis as an emergency and what social or medical factors lead to that. Researchers followed 233 adult patients beginning dialysis at local centers. The goal was to gather information to improve care and redu…

This Phase 1 study tested how a single dose of ADV7103 affects stomach acid levels in 12 healthy adults, both with and without food. The goal was to understand how the drug behaves in the stomach. Results may help guide future dosing for people with distal renal tubular acidosis,…

This study looked at how patients with advanced kidney cancer fared when taking the drug axitinib after first trying sunitinib. Researchers did not give any new treatment—they simply observed 554 patients to see how long the drug worked and how long patients stayed on it. The goa…

This study explored whether small particles called exosomes, found in blood and urine, can help predict how well treatment works in people with advanced kidney cancer. Researchers followed 91 patients for 16 weeks, collecting samples and comparing them to imaging results. The goa…

This completed study examined blood vessel function in 101 elderly patients (65 and older) with chronic kidney disease who were not on dialysis. Researchers used ultrasound and other non-invasive tests to measure blood vessel health and looked for links to certain blood markers. …

This study reviewed 575 adults admitted to intensive care for a severe kidney infection called acute obstructive pyelonephritis. Researchers aimed to identify factors that lead to poor outcomes such as death or lasting kidney damage. The goal is to better understand which patient…

This completed study looked at 50 non-diabetic people with chronic kidney disease to see if the drug dapagliflozin changes the types of bacteria in their gut. Researchers measured gut bacteria diversity and related waste products in the blood before and after 12 weeks of treatmen…

This study involved 91 adults with advanced kidney cancer. Researchers collected blood and urine samples over 16 weeks to see if changes in tiny particles called exosomal miRNAs could predict whether treatment was working. The goal was to find a simple, non-invasive way to monito…

This study tested a program called ImPart-Multi, where a trained helper (lay navigator) coached Black patients with chronic kidney disease and their care partners on how to work together when making health decisions. 22 patients and their care partners joined, and patients comple…

This study tested whether a personalized, home-based exercise program done via video calls could improve muscle function in people with moderate-to-severe chronic kidney disease (CKD) who are not on dialysis. Thirty-two sedentary adults aged 30-75 with CKD took part. They did com…

This study looked at how semaglutide, a diabetes medicine, affects the kidneys in people with type 2 diabetes and chronic kidney disease. 106 participants received either semaglutide or a placebo injection once a week for about a year. Researchers used MRI scans, blood and urine …

This study looked at whether it is safe to stop regularly checking blood flow in the arm veins used for dialysis. Instead, doctors would only treat problems when they cause symptoms during dialysis. The goal was to see if this approach reduces the number of procedures and medical…

This study looked back at 455 adults who had heart surgery with a heart-lung machine. Researchers wanted to see if routine blood tests and other factors before surgery could predict acute kidney injury, a serious complication. They found that certain markers of inflammation and k…

This study compares two blood-filtering techniques—plasma exchange and immunoadsorption—in 40 patients with severe kidney failure caused by ANCA vasculitis or Goodpasture disease. The goal is to see which method removes disease-causing antibodies more quickly. Results may help do…

This study looked at 76 ICU patients with severe pneumonia who were placed on a lung machine (ECMO) and given minimal ventilator support. Researchers wanted to see if this approach changed how well the kidneys worked. They reviewed medical records from 2019 to 2023, comparing uri…

This study tested a prediction tool that uses routine lab results to estimate a patient's risk of kidney injury after heart surgery. Researchers looked at data from 2,500 adults who had heart surgery to see how well the tool worked. The goal is to help doctors catch kidney proble…

This completed study looked back at the medical records of 200 patients with advanced clear cell kidney cancer who received Tivozanib as their first treatment. The goal was to see how long patients went without their cancer getting worse and how long they lived overall. The study…

This study looked at 100 kidney dialysis patients to understand why their blood vessels get damaged, raising heart risks. Researchers measured harmful substances called AGEs in the blood and skin, and checked for genetic factors. The goal was to learn how these substances interac…

This study looked at whether a specific antibody, called anti-GBM, could be a useful marker for lupus nephritis—a serious kidney complication of lupus. Researchers tested stored blood samples from 100 people with lupus (some with kidney issues, some without) and compared them to …

This study looked at whether training community health workers to focus on kidney disease care, and teaching doctors about trauma-informed care, could improve quality of life for Black and Hispanic patients with advanced chronic kidney disease. The study involved 153 patients fro…

This study tested whether teaching dialysis staff and providing support to patients could reduce episodes of dangerously low blood pressure during treatment. Over 1,400 patients across multiple clinics took part. The goal was to make dialysis sessions safer and more stable.

This study looked at whether a tailored program of protein supplements and exercise can increase muscle protein production in people with advanced chronic kidney disease (CKD) who are not yet on dialysis. Researchers compared these patients to healthy adults to see how their bodi…

This study tested a computer program that acts like a virtual doctor to teach people with advanced chronic kidney disease about kidney transplants. 148 patients took part. The goal was to see if talking with this virtual agent could increase their interest in considering a transp…

This study looked at 380 adults in the intensive care unit with suspected or confirmed COVID-19. Researchers tracked organ problems like kidney injury and lung failure, and measured survival rates at 30 days and one year. The goal was to learn how COVID-19 causes organ damage, no…

This study looked at whether continuous kidney replacement therapy can cause temporary heart muscle weakness (myocardial stunning) in critically ill patients with severe acute kidney injury. Researchers used echocardiograms to measure changes in heart wall motion in 42 adults. Th…

This study looked at how the antibiotic ceftriaxone moves through the blood and belly fluid in 20 people with severe liver disease and fluid buildup (ascites). Researchers collected leftover blood and fluid samples to measure drug levels. The goal was to better understand dosing …

This study followed 530 adults with autosomal dominant polycystic kidney disease (ADPKD) who were already taking the drug tolvaptan (JINARC™). Researchers wanted to see how the medication affected their quality of life, pain, and daily activities, as well as how long it took befo…

This study looked at 807 adults with adrenal tumors found by accident during scans for other reasons. Researchers compared the usual approach of repeat CT scans to a single urine steroid profile test to see which is more cost-effective for detecting cancer. The goal is to find a …

This study looked at nearly 6,000 ICU patients with severe kidney injury to see if a scoring tool called UNDERSCORE can predict when dialysis can be safely stopped. The goal was to avoid restarting dialysis or early death within 7 days. Researchers used existing hospital data to …

This study used advanced MRI scans to look at the hearts of 276 people with chronic kidney disease, including those on dialysis. The goal was to identify different types of heart damage and link them to patient outcomes. No new treatment was tested; instead, researchers aimed to …

This study looked at 44 couples where one or both partners have polycystic kidney disease (PKD). They used IVF combined with genetic testing to select embryos without the disease. The goal was to see how often these treatments led to a healthy pregnancy and live birth, and to tra…

This study measured how often teenagers develop chronic kidney disease after having heart surgery as young children. Researchers collected blood and urine samples from 120 teens aged 10 to 15 during their regular heart check-ups. The goal was to find out how common kidney damage …

This study looked at whether a simple urine test could predict scarring in kidney transplants, instead of using a needle biopsy. Researchers measured certain genetic markers in urine cells from 300 kidney transplant recipients over the first year after transplant. The goal was to…

This completed study in Greece observed 125 patients with chronic kidney disease (on or off dialysis) or heart failure who were taking sodium zirconium cyclosilicate for high potassium levels. Researchers collected data on patient characteristics and treatment patterns over six m…

This study looked at 70 adults having kidney stone surgery to see if the amount of air given by the breathing machine (tidal volume) affects how the surgery goes. Researchers compared low versus standard tidal volume settings to see if they changed surgery time, stone removal rat…

This study tested a computer system that alerts pharmacists about potential kidney failure or high potassium risks in older hospital patients. Researchers wanted to see if these alerts, combined with pharmacist reviews, could reduce serious side effects from medications. The stud…

This study tested a program called the Live Donor Champion Program, which trains a friend or family member to help a kidney patient find a live donor. The program was offered to 111 patients on the kidney transplant waitlist. Researchers wanted to see if the program could be succ…

This study looked at whether analyzing the fluid used to preserve kidneys on a LifePort® machine could help predict how well the kidney will work after transplant. Researchers measured chemicals in the fluid and compared them to early kidney function in 40 recipients. The goal is…

This study looked at how gut bacteria in people with chronic kidney disease (CKD) produce harmful toxins that build up in the body. Researchers collected stool samples from 20 patients with advanced CKD and placed them into an artificial intestine to test whether probiotics could…

This study looks at how pancreas-kidney transplantation changes bile acids and gut-related metabolism in people with type 1 diabetes and kidney disease. Researchers will measure bile acid levels and glucose responses in 50 transplant patients, comparing them to kidney-only transp…

This study tested an electronic alert system that reminds doctors to screen, monitor, and refer patients with chronic kidney disease (CKD). It involved 66 primary care centers in Stockholm, covering about 780,000 people. The goal was to see if the system improves detection and ma…

This study looked at whether a heart ultrasound (echocardiography) can help doctors better manage liver cirrhosis patients who also develop sudden kidney injury. Researchers examined 28 patients to see how their heart function related to their kidney problem. The goal was to impr…

This study used a special MRI technique to measure phosphate and ATP (energy) levels inside muscle cells of 11 kidney dialysis patients during a 4-hour session. The goal was to find out whether phosphate removed during dialysis comes from inside cells. If it does, it might explai…

This study looked at 80 adults on heart-lung support (ECMO) who also needed kidney dialysis (CRRT). Researchers compared two methods of connecting the machines to see which made the dialysis circuit last longer. The goal was to find a better approach for managing these complex tr…

This completed study of 88 heart attack patients looked at why some develop kidney injury after receiving contrast dye during a procedure to open blocked arteries. Researchers analyzed medical records to find which factors—like age, lab results, or procedure details—were linked t…

This study looked at whether certain gene variants (APOL1) are linked to advanced chronic kidney disease (stage 4) in Afro-Caribbean adults living in Guadeloupe. Researchers analyzed blood samples from 88 participants to find how common these gene variants are. The goal was to be…

This study looked at whether a simple blood test score, called the CALLY index, can help predict how well adult sepsis patients will do in the intensive care unit (ICU). Researchers reviewed medical records of 276 patients to see if the CALLY index was linked to the risk of death…

This study asked 167 people with cancer (and their caregivers) what they value most during pharmacy consultations for oral cancer drugs. Using a survey method, researchers identified key preferences to help hospitals design better support services. The goal was to improve patient…

This study looked at whether using dialysis less often helps people recover from acute kidney injury that requires dialysis. 220 hospitalized adults were assigned to either a conservative (less frequent) dialysis plan or the usual thrice-weekly schedule. The goal was to see if th…

This study surveyed 1,500 Chinese heart and kidney specialists to understand their awareness and perceptions of systemic inflammation in patients with both atherosclerotic cardiovascular disease and chronic kidney disease. The goal was to learn how doctors currently identify and …

This completed study from University Hospital Freiburg looked back at 490 patients with liver cirrhosis and signs of chronic kidney disease who were treated for hepatorenal syndrome. Researchers compared how well patients with and without pre-existing kidney disease responded to …

This study tested whether a special type of MRI can detect early changes in the kidneys of people with medullary sponge kidney, a rare condition that can cause kidney stones. Researchers compared MRI scans from 33 adults with the disease to scans from healthy controls. The goal w…

This completed Phase 1 study looked at how the drug AZD5462 behaves in people with reduced kidney function compared to healthy volunteers. Sixteen participants received a single oral dose, and researchers measured drug levels in the blood and monitored for side effects. The goal …

This completed study enrolled 43 people with kidney cancer who were starting sunitinib (Sutent). Researchers measured the drug's level in the blood and checked for genetic differences that might affect how the body processes it. The goal was to understand why sunitinib levels var…

This study reviewed medical records of 345 adults to see if primary care doctors referred patients with chronic kidney disease to a kidney specialist at the right time and with the right treatment. The goal was to understand how well current referral practices work, not to test a…

This study tested a new way to measure blood pressure in 90 people with severe kidney disease. The new method uses a different part of the blood pressure wave, and researchers wanted to see if it works as well as the standard arm cuff method. The goal was to find a more accurate …

This study looked at 225 adults with a rare, inherited form of kidney disease to find the genetic causes. Participants had chronic kidney failure and often had a family history of gout. Researchers tested for known gene mutations and searched for new ones in families without a cl…

This study tested whether having a clinical pharmacist work alongside doctors in a hospital ward could reduce medication errors in patients with kidney disease. Researchers followed 160 adults with reduced kidney function, comparing usual care, doctor education, and active pharma…

This study tested a new surgical approach for removing kidney tumors using a robot. It compared the new method to the standard one in 40 adults. The goal was to see if the new method saves time and feels better for the surgeon.

This study created a registry of 655 people and families with Alport syndrome to collect health information over time. The goal is to better understand how the disease progresses and to provide a foundation for testing new treatments. Participants simply share their medical histo…

This study looked at how often kidney hypodysplasia (a condition where one or both kidneys are small and underdeveloped) runs in families. Researchers collected DNA from 342 children aged 3 months to 18 years to try to find genes that may cause the condition. The goal was to bett…