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New dialysis strategy aims to prevent fluid overload in critical care

NCT ID NCT04801784

Disease control Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a method to carefully remove extra fluid from critically ill patients with kidney failure who are on continuous dialysis. The goal was to keep their fluid levels balanced without causing dangerous drops in blood pressure. Researchers used advanced heart monitoring to guide the fluid removal rate. The trial involved 65 adults in the ICU who needed blood pressure support and had severe kidney injury.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Increased net ultrafiltration with advanced hemodynamic monitoring
What this could lead to
If successful, this approach could help doctors safely manage fluid levels in critically ill patients, potentially reducing complications from fluid overload.
What could go wrong
This is a small, early-stage study (65 participants) focused on safety and feasibility, so results may not apply broadly. The intervention carries risks of hemodynamic instability.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

65 people

The number who actually took part.

Started

Jun 2021

Finished

Jul 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient 18 yo or more, affiliated to a social security system * Treated with vasopressors for acute circulatory failure * With KDIGO stage 3 acute kidney injury * Treated with continuous renal replacement therapy for less than 24 jours * Monitored with a calibrated continuous cardiac output device Exclusion Criteria: * Treatment by ECMO (extracorporeal membrane oxygenation) * Active hemorrhage necessitating transfusion * Maintenance dialysis or renal graft recipient * Switch to intermittent hemodialysis is scheduled in the next 72 hours * Acute cerebral stroke complicated by coma and under mechanical ventilation * Acute fulminant hepatitis * Postural maneuver (passive leg raising or Trendelenburg) cannot be performed (amputation, inferior vena cava obstruction) * Pregnancy or lactating * Withdrawal or limitation of care * Moribund patient * Patient under protective measures/wardship * Inclusion in another trial whose main outcome is cumulative fluid balance, or whose intervention targets hemodynamic physiology, fluid balance or net ultrafiltration. * Patient previously enrolled in the same study

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Conditions

The condition(s) this trial relates to.

acute kidney injury Edema Shock

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fluid overload

Contacts and locations

Locations

  • Hospices Civils de Lyon - Hôpital de la Croix Rousse

    Lyon, 69004, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.