Scientists probe mysterious IgA deposits in kidney disease
NCT ID NCT04092491
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at the IgA antibodies in 80 people — 40 with IgA nephropathy (a kidney disease) and 40 healthy volunteers. Researchers took one blood sample from each person to analyze the IgA repertoire. The goal was to understand why IgA deposits form in the kidneys, which could help explain the disease and guide future treatments.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help researchers understand why IgA builds up in the kidneys, potentially pointing toward new treatment targets for IgA nephropathy.
- What could go wrong
- This is a small, completed observational study that only analyzed blood samples. It does not test any treatment, so it may not lead directly to new therapies.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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80 people
The number who actually took part.
- Started
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Nov 2019
- Finished
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Nov 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
patients with IgA nephropathy whose diagnosis was confirmed by renal biopsy
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Control population: * person between the ages of 18 and 55 (persons matched to age and sex (75% male) (N-IgA is more common in humans) free from any pathology. oAbsence of proteinuria and hematuria on urine sample (search by strip). * Patients with N-IgA * 40 patients with N-IgA whose diagnosis was confirmed by renal biopsy. These may be previously known patients who have not received treatment with corticosteroids or immunosuppressants for 12 months or new patients. The incidence of N-IgA is 20 patients per Mh; the number of incident patients with N-IgA is 10-15 per year in the nephrology department. The recruitment of 40 patients over 1 year is feasible. * Participant's written consent Exclusion Criteria: * Secondary or associated N-IgA (infection, malignant disease, inflammatory bowel disease, * Rheumatic autoimmune disease or other; * treatment with corticosteroids or immunosuppressants for less than 12 months. * person on dialysis
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Service de Néphrologie
Limoges, 87042, France
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