Simple urine test may spot kidney trouble early in kids with cancer
NCT ID NCT02822404
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether a substance called cystatin C, measured in urine and blood, can detect kidney damage from chemotherapy drugs cisplatin and ifosfamide in children. Researchers followed 42 children and compared cystatin C levels to standard kidney tests. The goal was to find a simpler, less burdensome way to monitor kidney health during cancer treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If cystatin C proves reliable, it could offer a simpler, less invasive way to monitor kidney health in children undergoing chemotherapy.
- What could go wrong
- This is a small, completed observational study. The marker may not be accurate enough to replace current tests, and results may not apply to all children or treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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42 people
The number who actually took part.
- Started
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Feb 2012
- Finished
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May 2021
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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Up to 18 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Children of 0 to18 years treated with cisplatin and / or ifosfamide in the hematology-oncology unit of Toulouse University Hospital of children regardless to the pathology they have been treated for * Children with more than 4kg * Written informed consent given by both parents or legal representative * Patient covered by a social security agreement Exclusion Criteria: * Impossibility to monitor and follow up the patient until the foreseeable end of the treatment (geographic reasons, etc.) * Contraindication to EDTA clearance performing
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU Toulouse
Toulouse, 31059, France
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Other studies related to the condition(s) this trial covers.
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