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Anesthesia choice may boost kidney transplant success

NCT ID NCT00337051

Disease control Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether using sevoflurane gas for anesthesia during kidney transplant surgery helps the new kidney recover faster than standard propofol anesthesia. 120 adults receiving a kidney transplant were randomly assigned to one of the two anesthetics. Researchers tracked kidney function for a year after surgery to see if sevoflurane reduced damage from the blood flow interruption that occurs during transplant.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Sevoflurane (an inhaled anesthetic gas)
What this could lead to
If it works, this could show that choosing sevoflurane during surgery helps transplanted kidneys start working sooner, reducing the need for dialysis after transplant.
What could go wrong
This is a completed Phase 3 trial, but results are not yet widely confirmed. The benefit may be small or not apply to all transplant patients. Anesthesia risks like allergic reactions or rare malignant hyperthermia exist.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

120 people

The number who actually took part.

Start date

Jun 2006

Finished

Jun 2010

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * age \> 18 years * scheduled to undergo renal allograft transplantation * transplant : cold ischemia duration \> 20 hours or donor age \> 50 years or donor cardiac arrest * ASA 2-3 * social security affiliation * informed consent signed Exclusion Criteria: * halogenated anesthetic agent hypersensibility * medical history or familial history of malignant hyperthermia * porphyria * pregnancy or breast feeding * hyperimmunized patient * participation in an immunosuppressive drug trial

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Conditions

The condition(s) this trial relates to.

acute kidney injury chronic kidney disease end stage renal failure ischemic disease kidney failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

End-stage chronic renal disease Renal transplantation Severe acute kidney failure

Contacts and locations

Locations

  • Département d'anesthésie réanimation 1 - Hôpital Pellegrin - CHU de Bordeaux

    Bordeaux, 33076, France

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