Kidney disorder

This expanded access program lets doctors in Texas give banked, partially matched virus-specific T cells to children under 18 who have persistent or recurring EBV, CMV, adenovirus, or BK virus infections after an allogeneic stem cell transplant or CAR T therapy. The cells come fr…

This study tests the shingles vaccine (SHINGRIX) in 160 people: transplant recipients on different immunosuppressant drugs and their healthy housemates. Researchers will measure immune responses at five time points over a year to see if the vaccine works well in these groups. The…

This trial tests a two-part approach for advanced clear cell kidney cancer that has stopped responding to standard treatments. First, an imaging injection (PD-32766D) lights up cancer cells that have a specific marker (CA9). If the scan shows the marker is present, participants t…

This study tests whether using a hemostatic agent (a substance that stops bleeding) during kidney stone surgery can reduce blood loss compared to standard care. About 92 adults with kidney stones will be randomly assigned to receive either a hemostatic agent or no agent during th…

This study tests whether giving extra caffeine to very premature babies (born before 30 weeks) can improve kidney oxygen levels and reduce kidney injury. About 114 babies already receiving standard caffeine will get either an extra dose or a placebo. Researchers will monitor kidn…

This large trial is testing whether a blood test that looks for tumor DNA can help decide who needs immunotherapy after surgery for muscle-invasive urothelial cancer. About 992 participants will be assigned to different treatment plans based on their blood test results. The goal …

This study tests a drug called sacituzumab tirumotecan in 20 people with a rare and aggressive kidney cancer (SMARCB1-deficient renal medullary carcinoma) that has worsened after at least one prior treatment. The goal is to see if the drug can shrink or control the cancer. Resear…

This phase 2 trial is testing whether a combination of three drugs—nivolumab, ipilimumab, and cabozantinib—can help people with kidney cancer that has spread to the brain. The study will enroll 20 participants who have not had prior treatment for their brain metastases. The main …

This Phase 2 trial tests whether adding belimumab to standard rituximab treatment helps more people with primary membranous nephropathy achieve remission. The study enrolls 58 adults with confirmed disease. Belimumab targets new immune cells, while rituximab depletes existing one…

This study tests a new drug called AU-007 in people with advanced solid tumors that have spread or cannot be removed by surgery. The drug is designed to help the immune system fight cancer. About 159 participants will receive AU-007 alone or with other medicines to find the safes…

This study tests a drug called veverimer in 150 adults with moderate-to-severe chronic kidney disease (CKD) and a condition called metabolic acidosis, where acid builds up in the blood. The goal is to see if the drug can raise blood bicarbonate levels and improve physical functio…

This phase 2 trial tests an oral drug called ManNAc in 30 adults with primary focal segmental glomerulosclerosis (FSGS), a kidney disease that causes scarring and protein loss. Participants take ManNAc powder dissolved in water twice daily for 14 weeks. The study aims to see if t…

Researchers at the University of South Carolina are testing a program that pairs nurses with community health workers to coach adults who have chronic conditions like diabetes, high blood pressure, heart disease, kidney disease, or a prior stroke. Each patient joins with a carepa…

This phase II trial tests whether adding precise, high-dose radiation (SABR) to the main kidney tumor improves outcomes for people with metastatic kidney cancer that cannot be surgically removed. Participants receive standard immunotherapy drugs (avelumab, axitinib, or cabozantin…

This early-phase trial tests giving radiation therapy before surgery to people whose adrenal cancer has come back. The goal is to find a safe radiation dose and see if it helps shrink tumors before removal. About 32 adults with resectable recurrent ACC will receive daily radiatio…

This Phase 3 trial tests the drug benralizumab (Fasenra) in children aged 6 to 17 with two rare eosinophilic diseases: EGPA and HES. The study aims to see if the drug is safe, how it works in the body, and whether it can help control the disease. Fourteen children will receive in…

This phase II trial tests whether adding the immunotherapy cemiplimab to the targeted drug cabozantinib works better than cabozantinib alone for advanced adrenocortical cancer. About 48 adolescents and adults whose cancer has spread or cannot be removed will take part. The study …

Researchers compare empagliflozin and dapagliflozin, two similar diabetes drugs, to see which works better at preventing death, heart problems, and kidney damage in adults with type 2 diabetes, heart failure, or chronic kidney disease. The trial uses electronic health records to …

This study tests a new drug, povetacicept, against a standard treatment (calcineurin inhibitor) in 176 adults with primary membranous nephropathy, a kidney disease that can lead to kidney failure. The goal is to see if the new drug can put the disease into remission more safely a…

This trial compares two common diuretics—furosemide and mannitol—given during kidney transplant surgery to see which better prevents delayed graft function, a condition where the new kidney does not work right away and requires dialysis. The study enrolls adults receiving a decea…

This early-phase study tests a new treatment called GCAR1, which uses a patient's own immune cells (T-cells) that have been modified to recognize and attack cancer cells carrying a specific marker (GPNMB). The study enrolls 30 adults in Canada with advanced alveolar soft part sar…

This study tests whether adding BI 690517 (Vicadrostat) to empagliflozin can slow kidney disease and prevent heart failure hospitalizations or cardiovascular death in people with chronic kidney disease. About 11,000 adults with or without type 2 diabetes will take either BI 69051…

This study tests an oral medication called BI 764198 for people with a kidney condition called focal segmental glomerulosclerosis (FSGS). About 286 adults and teens will take either the study drug or a placebo daily for up to 2 years, while continuing their usual FSGS treatments.…

This study tests a new medicine, PF-08634404, in adults with advanced kidney cancer that has spread. The goal is to see if the drug is safe and can shrink tumors when used alone or with other cancer drugs. About 224 participants who have not had prior treatment for their advanced…

This early-phase trial tests a combination of three drugs—enfortumab vedotin, pembrolizumab, and quemliclustat—in people with advanced bladder or urinary tract cancer that has spread or cannot be removed by surgery. The goal is to see if the combination is safe and effective. The…

This study tests a new drug called GI-108 in people with advanced or metastatic solid tumors, including lung, head and neck, pancreatic, and kidney cancers. The drug is designed to boost the immune system's ability to fight cancer. The trial will first find the safest dose, then …

This early-stage study tests a new drug called N-3C01, given alone or with an immunotherapy, in people with advanced solid tumors that have spread or cannot be removed. The main goals are to check safety, find the right dose, and see if the combination shrinks tumors. About 114 a…

This study tests an experimental drug called STL303 for people with IgA nephropathy, a kidney disease. About 15 adults will receive either STL303 or a placebo to see if the drug is safe and can reduce protein in the urine, a sign of kidney damage. Possible side effects include na…

This study tests experimental drug combinations for people with advanced kidney cancer (clear cell type) that came back during or within 2 years of finishing immunotherapy. About 140 participants will receive these combinations to see if they are safe and can shrink tumors. The g…

This early-phase trial tests a new type of cell therapy called BCMA-CD19-IL-15/IL15sushi compound CAR T cells in 20 people with severe lupus that hasn't improved with standard treatments. The therapy aims to reset the immune system by targeting and eliminating faulty immune cells…

When a kidney stone blocks urine flow and causes a dangerous infection called urosepsis, doctors must drain the kidney right away. They can use a stent placed through the urinary tract or a tube inserted through the skin. This study compares how each drainage method affects the l…

This study is testing the long-term safety and effectiveness of two experimental drugs, pozelimab and cemdisiran, taken together for paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder. About 202 participants who completed a prior study will continue treatment to see…

This Phase 3 trial is testing whether adding the drug zanzalintinib to belzutifan helps people with advanced kidney cancer live longer and keep the cancer from growing. About 758 participants who have already tried standard treatments will receive either the combination or belzut…

Researchers are testing whether giving lenvatinib and pembrolizumab before surgery can shrink advanced kidney cancer and the tumor clot that extends into the main vein from the kidney. The trial enrolls 30 adults with stage III or IV renal cell carcinoma and a level II to IV infe…

This study tests a device called PrismaLung+ that removes carbon dioxide from the blood of critically ill patients who are on breathing machines. The trial will include 99 adults with acute respiratory distress syndrome or kidney injury. Half will receive standard care plus the d…

This study tests whether adding a virus-based drug (pelareorep) to standard chemotherapy can help people with a specific type of advanced colorectal cancer that has stopped responding to initial treatment. About 60 adults whose cancer has spread and has certain genetic features (…

This Phase 3 trial tests whether mezagitamab, an injectable drug, can reduce protein in the urine and preserve kidney function in adults with IgA nephropathy, a condition where immune complexes damage the kidneys. About 347 participants will receive either mezagitamab or a placeb…

This study tests an experimental drug called VIB4920 in people with active lupus nephritis, a serious kidney complication of lupus. About 74 adults will receive either VIB4920 or a placebo, along with standard medications, to see if the drug helps improve kidney function. The goa…

This Phase 2 trial tests whether combining pembrolizumab (an immunotherapy) with aldesleukin (IL-2) can shrink tumors in people with advanced melanoma or kidney cancer that hasn't responded to prior treatments. About 78 adults will receive two cycles of the combo in the hospital,…

This study tests an experimental tablet, BI 764198, in adults and some teens with four types of kidney disease that cause protein in the urine. Participants take the drug or a placebo daily for 20 weeks while continuing their usual care. The main goal is to see if the drug lowers…

This study tests the long-term safety of finerenone, a drug that helps control a key system involved in kidney damage, in children aged 1 to 18 with chronic kidney disease and proteinuria. All 100 participants will take finerenone alongside their usual ACE inhibitor or ARB medica…

This phase II trial is testing whether a combination of three drugs—cabozantinib, nivolumab, and ipilimumab—can shrink or slow the growth of rare genitourinary cancers that have spread. About 314 adults with these uncommon tumors will receive the drugs. The goal is to see if the …

Researchers are testing whether the drug daratumumab can treat kidney diseases caused by monoclonal gammopathy of renal significance (MGRS), a group of conditions where abnormal antibody proteins damage the kidneys. The trial enrolls 30 adults with biopsy-confirmed MGRS. Particip…

This study tests a drug called felzartamab in people with IgA nephropathy, a kidney disease where abnormal antibodies build up and damage the kidneys. The goal is to see if felzartamab can reduce protein in the urine, a sign of kidney damage. About 454 adults will receive either …

Diabetic nephropathy is a common kidney complication of diabetes that current drugs can only slow, not reverse. Researchers are testing human umbilical cord mesenchymal stem cells, given by injection at increasing doses, to see if they are safe and can reduce inflammation and rep…

This study tests whether combining two immune-suppressing drugs, rituximab and cyclosporine, can safely reduce protein leakage in the urine of people with membranous nephropathy, a kidney disease where the immune system attacks the kidneys. About 30 adults with persistent high pr…

This study tests a new way to do stem cell transplants for people with severe aplastic anemia or other bone marrow failure diseases. Doctors give a smaller number of donor white blood cells along with the stem cells to try to reduce serious side effects. Up to 120 patients aged 4…

This study tests whether a combination of belatacept and sirolimus works better than the standard drugs tacrolimus and MMF in children aged 13-20 who receive a kidney transplant. The goal is to reduce the risk of organ rejection and protect kidney function. Participants are rando…

Researchers are testing whether regularly checking a marker called Gd-IgA1 can help doctors adjust treatment for IgA nephropathy, a kidney disease. Adults with biopsy-confirmed IgA nephropathy or IgA vasculitis-associated nephritis receive Nefecon or telitacicept. Half have Gd-Ig…

This study tests whether empagliflozin, a medicine already used for diabetes, can help children aged 2 to 17 with chronic kidney disease. About 120 kids will take either the drug or a placebo for 6 months, then everyone gets the drug for a year. Researchers will check kidney func…

This study tests an oral drug called NEO212 in people with specific brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it helps control tumor growth. About 134 adults will take NEO212 alone or with sta…

This early-stage trial tests an experimental drug called INCA036873 in about 280 adults with advanced solid tumors or certain blood cancers that have worsened after standard treatments. The main goal is to check safety and find the right dose. Participants receive the drug throug…

After a liver transplant, patients take tacrolimus to stop their immune system from rejecting the new organ, but the drug can cause kidney problems, high blood pressure, diabetes, and other side effects. Researchers at the University of Alberta are comparing a once-daily extended…

People with end-stage kidney disease need a reliable way to connect to a dialysis machine, and their own veins sometimes cannot handle it. This study follows about 100 adults who receive a decellularized human femoral artery graft, a donated blood vessel stripped of living cells,…

This named patient program gives doctors controlled, pre-approval access to a mitomycin gel called JELMYTO for specific patients with cancer of the renal pelvis or ureter. It is for people in select countries where the treatment is not yet approved and who have exhausted other op…

This study tests whether injecting sodium thiosulfate directly into abnormal calcium deposits can shrink them and reduce pain. It includes people with three rare conditions: systemic sclerosis, dermatomyositis, and a genetic disorder called iPPSD2. Participants receive up to 11 i…

This early-phase trial tests SL-28, a cell therapy made from donor immune cells, in 60 people with advanced solid tumors (like lung, pancreatic, or breast cancer) that haven't responded to standard treatments. The study aims to find a safe dose and see if the therapy can shrink t…

This phase 2 trial is testing whether a new drug called obinutuzumab beta, combined with a short course of steroids, can help people with newly diagnosed ANCA-associated glomerulonephritis—a rare autoimmune disease that causes kidney inflammation and damage. The study will enroll…

Researchers are testing two experimental oral drugs, TT-10 and TT-4, in adults with advanced solid tumors such as kidney, prostate, and lung cancers that have worsened after standard treatment or cannot receive it. The drugs block adenosine receptors, which tumors use to quiet th…

This phase 2 trial is testing a new treatment called FT819 for people with lupus nephritis, a serious kidney complication of lupus. FT819 is made from donor immune cells that are engineered to target and destroy faulty B cells. The study will enroll 53 participants and aims to se…

This early-stage trial is testing two experimental drugs, vonsetamig and odronextamab, in people with lupus nephritis that has not responded to standard treatments. The main goal is to check safety and side effects over the long term. Researchers will also see if the drugs can he…

This study is testing a new experimental drug called GI-101, given alone or with pembrolizumab or lenvatinib, in people with advanced or metastatic solid tumors (cancers that have spread). The goal is to see if the drug is safe and can shrink or control tumors. About 317 adults w…

This study tests a new drug called pumitamig, alone or combined with ipilimumab or cabozantinib, in 254 people with advanced kidney cancer that cannot be removed by surgery. The goal is to see if the drug is safe and can shrink tumors. Participants must have a confirmed diagnosis…

This pilot phase II trial tests whether giving two immunotherapy drugs, botensilimab and balstilimab, before surgery is safe and feasible for patients with high-risk clear cell kidney cancer that hasn't spread. Sixteen participants will receive the drugs and then undergo surgery …

This study compares two ways of dosing the drug mycophenolate mofetil (MMF) for children with lupus nephritis, a kidney disease caused by lupus. One method uses a standard dose based on body size, while the other adjusts the dose based on drug levels in the blood. The goal is to …

This Phase 2 trial tests two experimental drugs, ALN-ANG3 and evinacumab, in 270 people with diabetic kidney disease. The drugs block a protein called ANGPTL3 to lower blood fats. Researchers will measure changes in urine protein and kidney function over time to see if the drugs …

This early-stage study tests the safety of a new drug called AZD1613 in 40 adults with autosomal dominant polycystic kidney disease (ADPKD), a condition that causes kidney cysts. Participants receive either the drug or a placebo to check for side effects and how the drug moves th…

Researchers are studying how well benralizumab works in adults with eosinophilic granulomatosis with polyangiitis (EGPA), a rare disease that inflames blood vessels and can affect the lungs, nerves, and sinuses. The study follows about 100 patients at European referral centers wh…

This early-stage trial tests a new drug, REGN15505, alone or with other drugs, in adults with advanced prostate or kidney cancer that has spread. The goal is to help the immune system attack cancer cells. About 265 participants will be enrolled to check safety, side effects, and …

This study tests whether giving calcium before reaching the hospital and vasopressin early in the hospital can reduce deaths in people with severe bleeding from injury. About 1050 adults at risk of hemorrhagic shock will be randomly assigned to receive these treatments or placebo…

This Phase 3 trial is testing whether a combination of two drugs, balcinrenone and dapagliflozin, works better than dapagliflozin alone to prevent heart failure events and cardiovascular death. About 4,800 adults with heart failure and moderate-to-severe kidney impairment who rec…

This study tests a drug called surovatamig in 43 adults with primary membranous nephropathy, a kidney disease caused by antibodies attacking the kidneys. The drug is given as a shot under the skin. Researchers want to see if it is safe and can reduce protein in the urine, which i…

This study tests a home monitoring system called VIEWER for people with advanced chronic kidney disease (stage 5) or end-stage renal disease. The system includes a tablet, blood pressure cuff, scale, oxygen monitor, and motion tracker. Researchers want to see if using this platfo…

Researchers are testing whether pumping donated kidneys with a warm, oxygen-rich fluid before transplant helps them work better than the standard method of cold storage. The trial enrolls adults waiting for a first or second kidney transplant from donors who died after circulator…

This early-stage study tests a new treatment called ALLO-329 for people with lupus, myositis, or scleroderma. The therapy uses specially engineered immune cells from a donor to target and calm the overactive immune system. The main goals are to check safety and see if it can impr…

This study tests whether empagliflozin, a diabetes medicine, can reduce protein leakage in urine and help protect the kidneys in people with very advanced chronic kidney disease (eGFR between 10 and 20). About 34 adults with type 2 diabetes will take either empagliflozin or a pla…

This study tests a drug called DS-8201a (trastuzumab deruxtecan) in children, teens, and young adults whose osteosarcoma, Wilms tumor, or desmoplastic small round cell tumor has come back or not responded to treatment. The drug works like a smart bomb, attaching to cancer cells a…

This study tests a device called the Selective Cytopheretic Device (SCD) in 339 ICU patients with severe acute kidney injury who are already on continuous kidney replacement therapy. The device filters blood to reduce inflammation, and researchers want to see if it improves survi…

This study tests a new treatment called AZD0120 for people with severe lupus that hasn't improved with standard therapies. AZD0120 is a type of CAR T cell therapy that targets two proteins (CD19 and BCMA) on immune cells to calm the overactive immune system. The trial will enroll…

This study tests an experimental drug called VX-147 in adults and children with a genetic form of kidney disease linked to the APOL1 gene. The goal is to see if the drug can reduce protein in the urine and protect kidney function. About 466 participants will receive either VX-147…

This early-stage trial is testing a drug called orellanine, derived from a mushroom, in 75 people with advanced kidney cancer who are also on dialysis. The drug is given intravenously to see if it is safe and can shrink tumors. All participants have end-stage kidney disease and h…

This study tests a new gene therapy, PS-002, for adults with IgA nephropathy, a kidney disease that can lead to kidney failure. The therapy aims to control the disease in people who are at high risk of getting worse despite current treatments. Participants receive a single dose a…

This study is testing whether a kidney from a genetically modified pig can safely work in people with end-stage renal disease who cannot get a human kidney. Up to 50 participants will receive the pig kidney and be followed for at least 24 weeks to check survival, kidney function,…

Researchers are testing whether sodium zirconium cyclosilicate (Lokelma) controls high potassium better than the usual approach of reducing or stopping RAASi and MRA medicines in people with chronic kidney disease. The trial enrolls adults with potassium levels between 5.0 and 6.…

This study looks at how well the medication pegcetacoplan works and how safe it is for people with two rare kidney conditions: C3 glomerulopathy (C3G) and primary immune complex membranoproliferative glomerulonephritis (IC-MPGN). Researchers will follow about 150 patients who are…

This phase III trial is testing whether an experimental drug called elecoglipron can reduce the risk of serious kidney decline, kidney failure, or death in people with chronic kidney disease. About 7,000 adults with the condition, with or without type 2 diabetes, will receive eit…

This 2-year extension study looks at lupus nephritis patients who finished a previous trial of ianalumab. Some patients who responded well will stop treatment to see if their kidney disease stays under control. Others who did not respond or were already on open-label ianalumab wi…

This early-phase trial is testing a new experimental drug, BNT317, in 39 people with advanced solid tumors who have run out of standard treatment options. The main goal is to check the drug's safety, find the right dose, and see how the body handles it. It is too soon to know if …

This early-stage study is testing a new drug called M0324, a bispecific antibody designed to target cancer cells. The trial will look at M0324 alone, with the immunotherapy pembrolizumab, and with chemotherapy in about 77 people with advanced solid tumors that have not responded …

This study tests an experimental drug called iptacopan in 31 children aged 2 to under 18 with IgA nephropathy, a kidney disease that can lead to kidney failure. The goal is to see if the drug reduces protein in the urine, a sign of kidney damage, and to check its safety and how t…

This pilot trial tests whether restarting renin-angiotensin system inhibitors (RASi) — common blood pressure and kidney-protecting medications — early after acute kidney injury is feasible and well-tolerated. Hospitalized adults who were on RASi before admission and stopped due t…

This early-stage trial will test the safety and tolerability of a new drug, cevostamab, in 46 people with systemic lupus erythematosus, some of whom also have active lupus nephritis. The drug is given intravenously, and researchers will monitor side effects and how the drug moves…

This early-stage study tests a new drug called NPX372 in people with advanced solid tumors that have not responded to standard treatments. The drug is designed to help the body's immune cells recognize and attack cancer cells. The main goals are to check the drug's safety and fin…

This trial tests whether a special filter called oXiris, used during continuous blood purification, can lower endotoxin levels in adults with septic shock and acute kidney injury. Septic shock is a life-threatening condition where infection causes severe organ failure. The filter…

This study tests a stem cell transplant using blood stem cells from a half-matched family donor (haploidentical) for people with severe aplastic anemia, related MDS, or PNH. Participants receive chemotherapy and a single radiation dose before the transplant, plus a drug to preven…

This study tests a daily pill called orforglipron to see if it can prevent major heart problems (like heart attacks or strokes) and slow kidney disease in people who already have heart or kidney disease. About 7,140 adults will take either the drug or a placebo for up to 5 years.…

This study looks at whether SGLT2 inhibitors, a class of diabetes and kidney drugs, can improve blood flow through the heart's small arteries in women with HIV who also have diabetes or chronic kidney disease. Eighty women aged 45-75 will be randomly assigned to health education …

This study tests whether a structured, goal-directed care plan can help people with diabetic kidney disease better manage their kidney and heart health. About 100 adults with type 2 diabetes and kidney disease will either receive this focused care or standard treatment. The goal …

This early-stage trial tests a new drug called LY4052031, which is designed to deliver a cancer-killing agent directly to tumor cells that have a protein called Nectin-4. The study includes 420 adults with advanced or metastatic solid tumors such as bladder, breast, lung, and oth…

This study tests whether specially grown donor immune cells (called cytotoxic T lymphocytes) can safely and effectively control BK and JC virus infections in people with weakened immune systems, such as those with cancer, HIV, or organ transplants. About 100 participants will rec…

This study tests whether specially grown donor immune cells (viral-specific T-cells) can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard antiviral drugs. The approach aims to boos…

This study tests whether the diabetes drug empagliflozin (Jardiance) can safely raise low sodium levels in people with certain conditions like SIADH, liver failure, or kidney failure. About 172 adults with chronic low sodium will receive either the drug or a placebo for up to 30 …

This study tests whether giving sodium bicarbonate (baking soda) intravenously can reduce major kidney problems or death in critically ill patients with metabolic acidosis and acute kidney injury. About 660 adults in intensive care will receive either sodium bicarbonate or a stan…

This phase 2 trial is testing a combination of two drugs, zanzalintinib and nivolumab, given before surgery to people with advanced kidney cancer that is hard to remove. The goal is to shrink the tumor enough so that surgery becomes possible. About 69 participants will receive th…

This study tests three different drug combinations in 120 people with advanced kidney cancer that has spread. The goal is to see which combination works best to shrink tumors. Participants will receive either a new two-drug or three-drug combination, or a standard two-drug therap…

This study tests whether specially grown immune cells from an unrelated donor can safely treat viral infections in people with weakened immune systems, such as after a stem cell transplant. About 750 participants will receive these cells and be monitored for side effects like inf…

This study tests a special dialysis machine, the MultiFiltratePRO, in children with acute kidney failure. The goal is to see if it can deliver at least 80% of the prescribed treatment within 72 hours while being safe. About 43 children weighing between 8 and 40 kilograms will be …

This trial tests whether personalized pharmacological counselling can help manage side effects of the kidney cancer drug cabozantinib. The approach combines blood level monitoring, genetic testing, and drug interaction checks to tailor dosing. Researchers will compare treatment i…

This extension study follows people with von Hippel-Lindau (VHL) disease or advanced solid tumors who are already taking belzutifan in another trial. The goal is to see how long they live and how safe the drug is over the long term. About 450 participants will take belzutifan by …

This Phase 2 study tests a new drug called ADX-038, alone or with another drug (telitacicept), in 30 Chinese adults with kidney diseases caused by an overactive complement system (IgA nephropathy, C3G, or IC-MPGN). The goal is to see if the treatment is safe and can help control …

This study tests if obinutuzumab can help teens and children with lupus nephritis, a serious kidney complication of lupus. About 40 participants aged 5 to 17 will receive either the drug or a placebo. The goal is to see if the drug improves kidney function and reduces protein in …

This early-stage study tests a new drug called MK-4884 in about 120 people with advanced or metastatic solid tumors (colorectal, kidney, lung, or bile duct cancer). The main goal is to check the drug's safety and find the right dose. Researchers will monitor side effects and how …

This study follows adults with chronic kidney disease who are on dialysis and starting the phosphate binder Nephoxil for high blood phosphorus. Researchers track patients for 48 weeks to see how many reach a target phosphorus level of 3.5 to 5.5 mg/dL, using either a low or stand…

This study tests a new drug called VEL-101 in 120 kidney transplant patients. The goal is to see if VEL-101 can safely replace the standard drug tacrolimus, which often causes side effects. Researchers will monitor for rejection, side effects, and how the drug behaves in the body…

This trial compares two approaches for people with small, symptom-free kidney stones: immediate surgery versus simply monitoring them over time. Researchers want to know which strategy leads to less disruption in daily life, fewer emergency visits, and better overall well-being. …

This Phase 2 study is testing a new drug called ADX-038 in 45 adults with complement-mediated kidney diseases, such as IgA nephropathy and C3G. The drug is an siRNA that targets the complement system, which is overactive in these conditions. Researchers are checking if it is safe…

This study tests whether adding an immune-boosting drug (PDS01ADC) to standard chemotherapy delivered directly to the liver can help people with colorectal, bile duct, or adrenal cancer that has spread to the liver. About 70 adults will receive the drug combination along with a s…

This study tests whether adding TAVNEOS to standard treatment helps control ear, nose, and throat symptoms in people with granulomatosis with polyangiitis (GPA). About 30 adults with active ENT disease will receive either TAVNEOS or a placebo for 52 weeks. The goal is to see if m…

This study tests if a new drug called siplizumab can safely prevent kidney transplant rejection better than the current standard treatment. About 120 adults receiving a kidney transplant will be split into three groups: two groups get different doses of siplizumab, and one gets t…

This study tests a new daily pill called elecoglipron in adults with type 2 diabetes and reduced kidney function. Participants also take dapagliflozin, a standard diabetes medicine. The goal is to see if elecoglipron improves blood sugar control, body weight, and blood pressure c…

This trial tests an investigational cell therapy called FT839 in people with active autoimmune diseases, including ANCA-associated vasculitis, inflammatory myositis, rheumatoid arthritis, lupus, and systemic sclerosis. Participants receive FT839 as two intravenous infusions, some…

This study tests whether adding the experimental drug casdatifan to the standard drug cabozantinib can slow cancer growth better than cabozantinib alone in people with advanced clear cell kidney cancer. About 720 adults whose cancer worsened after prior immunotherapy will receive…

This phase 2 trial is testing whether a combination of three drugs—bevacizumab, erlotinib, and atezolizumab—can safely shrink or stabilize advanced kidney cancer in people with hereditary leiomyomatosis and renal cell cancer (HLRCC) or sporadic papillary renal cell cancer. The dr…

This study tests an experimental drug called APL2 for people with a kidney disease called FSGS. The goal is to see if APL2 can reduce protein in the urine, a sign of kidney damage. The trial has two parts: first, adults will receive APL2 openly; then, both adults and adolescents …

This study tests an experimental drug called AZD4144 in 124 adults with sepsis who have also developed acute kidney injury. Participants receive either the drug or a placebo daily by IV while in the hospital. The main goal is to see if the drug helps maintain kidney function bett…

This study tests whether a 15-month course of Nefecon can prevent proteinuria relapse in 288 adults with IgA nephropathy who have already achieved remission. Participants must have completed prior Nefecon therapy and have stable kidney function. The goal is to see if maintenance …

This study tests whether adding tivozanib to the standard immunotherapy pembrolizumab works better than pembrolizumab alone to keep kidney cancer from returning after surgery. About 1040 adults with high-risk clear cell renal cell carcinoma will take part. The goal is to see if t…

This study tests a new device that creates a connection between an artery and a vein using a small needle puncture instead of open surgery. The goal is to provide a reliable access point for dialysis in people with kidney failure. About 126 adults will be enrolled and followed fo…

This study follows people with chronic kidney disease who previously received an experimental treatment called REACT, which uses a patient's own kidney cells to try to repair damaged kidneys. Researchers will track participants for years to see if the therapy causes any delayed s…

This early-phase trial is testing whether adding an experimental drug called HC-7366 to standard immunotherapy drugs (nivolumab and ipilimumab) can help control advanced clear cell kidney cancer. About 35 adults with stage IV disease will receive the combination. The main goal is…

This trial compares two surgical techniques for removing complex kidney stones: a single-tract approach using a flexible scope versus the traditional multi-tract method. The goal is to see if the less invasive single-tract procedure can achieve similar stone-free rates at three m…

This study tests an investigational drug called ABBV-CLS-628 in adults with autosomal dominant polycystic kidney disease (ADPKD), a genetic condition that causes fluid-filled cysts to grow in the kidneys. About 240 participants worldwide will receive either the drug or a placebo …

This trial investigates whether a 12-week supervised exercise program, done during regular hemodialysis sessions, can improve postural problems like hunched back and forward head posture in adults with end-stage renal disease. Participants will be randomly assigned to either the …

This study tests a new way to deliver radiation therapy for people with lung cancer, melanoma, or kidney cancer that has started to grow again in a few spots despite treatment. The approach uses a PET scan to find the most active parts of the tumor and delivers a higher radiation…

This trial tests whether having clinical dietitians take the lead on nutrition care—rather than waiting for referrals—can help adult medical inpatients at risk of malnutrition. Researchers will compare a dietitian-driven model with usual care on three hospital wards, measuring le…

This study tests whether taking cabozantinib in a pattern that skips some days can keep the same drug levels in the body as the standard daily dose. It involves 34 adults with advanced kidney cancer who are already on a stable dose. Participants will try both the standard and the…

This study tests whether giving the drug vasopressin earlier or later during septic shock leads to better outcomes. Researchers will use a computer alert system to randomly assign 300 ICU patients to early or standard timing. The goal is to see if the timing can be reliably contr…

This early-stage study tests a new drug called casdatifan (AB521) alone or combined with other cancer drugs in people with advanced clear cell kidney cancer or other solid tumors. The main goals are to check safety and find the right dose. About 362 participants will take part.

This study looks at whether irreversible electroporation (IRE) can safely and effectively treat recurrent pelvic tumors in people who cannot have surgery, radiation, or other local treatments. IRE uses electrical pulses to destroy cancer cells without cutting or heating tissue. R…

This trial tests whether a blood purification device called LIPOSORBER LA-15 can help people with focal segmental glomerulosclerosis (FSGS), a kidney disease that causes protein to leak into the urine. The study includes adults whose disease did not respond to standard treatments…

This pilot study tests whether Omnisol, a new preservation solution, can keep deceased donor kidneys in better condition during machine perfusion before transplantation. The goal is to reduce delayed graft function, where the kidney takes time to start working, and improve early …

This trial tests whether a blood purification device called the Liposorber LA-15 System can help children with focal segmental glomerulosclerosis (FSGS), a kidney disease that causes protein to leak into the urine and often resists standard treatments. The device filters the bloo…

This study explores whether adding high-intensity interval training (HIIT) to standard immunotherapy (nivolumab plus ipilimumab) helps patients with advanced kidney cancer. Thirty participants are randomly assigned to either a supervised exercise program or usual care. Researcher…

This trial tests whether combining an individualized exercise program, dietary advice, and anti-inflammatory fish oil supplements can help patients with kidney failure who are losing muscle and strength—a condition called kidney cachexia. Participants on hemodialysis at risk of c…

This trial asks whether aggressively lowering blood phosphate levels in people with end-stage kidney disease on dialysis can reduce heart attacks, strokes, and death. Participants are randomly assigned to either a liberal phosphate target or an intensive target aimed at normal le…

This study tests a one-time treatment called Obe-cel, made from a patient's own immune cells, for severe lupus nephritis that hasn't improved with standard care. About 35 people aged 12 to 65 will receive the infusion and be monitored for up to 24 months. The main goal is to see …

This trial is testing whether MRI-guided radiation therapy can treat early-stage kidney cancer with fewer side effects than standard CT-based radiation. The study enrolls adults with kidney cancer who are not candidates for surgery or who decline it. Participants receive a single…

This trial tests whether empagliflozin, a drug already used for diabetes, can protect kidney cells in African American veterans who have chronic kidney disease but do not have diabetes. Participants will take either empagliflozin or a placebo daily for four months. Researchers wi…

This study tests a drug called mosunetuzumab in 30 people with lupus, a disease where the immune system attacks the body. The goal is to see if the drug can put lupus into remission so that participants can stop most lupus medications for at least 6 months. However, some people m…

This trial explores whether starting dialysis twice a week instead of the standard three times a week, with a gradual increase over a year, can improve quality of life and preserve remaining kidney function in veterans with advanced kidney disease. Participants are randomly assig…

This trial tests whether droxidopa, an oral medication that raises blood pressure, can improve kidney function in people hospitalized with cirrhosis and acute kidney injury. The study will compare droxidopa to a placebo in 75 participants, measuring changes in blood pressure and …

This study tests an experimental oral drug called VMD-102 in people with advanced solid tumors, including liver, lung, kidney, skin (uveal melanoma), and colorectal cancers that have not responded to standard treatments. The drug works by blocking a specific protein (PKC epsilon)…

This study compares two common antibiotic combinations—vancomycin with piperacillin/tazobactam versus vancomycin with meropenem—to see which is less harmful to the kidneys. About 852 hospitalized adults with serious infections will be randomly assigned to one of the two combos. T…

This trial tests a drug called imlifidase in highly sensitized children aged 1-17 who need a kidney transplant. The drug aims to quickly clear antibodies that would normally cause rejection, turning a positive crossmatch negative and allowing the transplant to happen. Researchers…

This trial tests whether a single intravenous dose of mesenchymal stem cells, derived from bone marrow, can safely help adults with active lupus nephritis achieve a complete or partial kidney response. Participants receive either the stem cells or a placebo (saline) in a double-b…

This phase IIa trial investigates whether obinutuzumab, a monoclonal antibody, can effectively treat adults with newly diagnosed minimal change disease, a kidney condition causing protein leakage and swelling. Participants receive either two doses of obinutuzumab or standard gluc…

This study follows people with end-stage kidney disease who need a vascular graft for hemodialysis. The GORE ACUSEAL graft is placed to create a reliable access point for dialysis. Researchers will track how often the graft becomes infected and how long it stays functional, aimin…

This study tests whether low-dose colchicine, an inexpensive anti-inflammatory drug, is safe and acceptable for people on hemodialysis. Researchers will give 100 dialysis patients colchicine for about 3 months, monitoring side effects and how many stick with it. The goal is to se…

This trial tests whether adding voclosporin to standard lupus nephritis treatment (mycophenolate mofetil and prednisolone) reduces kidney inflammation faster and more completely than standard treatment alone. Adults with active lupus nephritis will be randomly assigned to either …

This study tests whether people with advanced kidney cancer can safely pause their medication after one year of treatment. Doctors will use a special PET scan that targets CD70 to decide who qualifies for a treatment break. The goal is to see if patients can stop drugs without th…

This trial tests a new model of care called PEN-Plus, which brings specialized treatment for severe chronic diseases like diabetes, heart conditions, and sickle cell disease to first-level hospitals in Zambia. The goal is to train local health workers and set up clinics to manage…

This trial tests whether vericiguat, a drug that relaxes blood vessels, can protect the body during heart surgery. About 170 adults scheduled for open-heart surgery will receive either vericiguat or a placebo starting two days before the operation. Researchers will measure blood …

This trial asks whether a lower or medium intensity of continuous kidney replacement therapy (dialysis) is better for critically ill patients with acute kidney injury. It will compare a low dose (12 mL/kg/hr) against a standard medium dose (25 mL/kg/hr) to see which is more effec…

This trial tests whether the direction of the needle bevel (up or down) during fistula puncture affects the risk of complications in people on hemodialysis. About 240 adults with end-stage kidney disease who are starting dialysis with a new arteriovenous fistula will be randomly …

This study tests whether altering gut bacteria can restore the effectiveness of immunotherapy in people with advanced kidney cancer. About 33 adults will receive a bowel cleanse, a live bacterial supplement, and then a combination of immunotherapy drugs. The goal is to see if thi…

This study tests two approaches to prevent kidney stones from coming back in people who have had them before. One approach uses a daily pill called empagliflozin (a diabetes drug) and the other gives personalized diet advice based on urine tests. The trial will involve 400 adults…

This trial tests whether a set of five kidney-protecting measures — given early to severe trauma patients identified as high-risk by a urine test — can reduce the chance of acute kidney injury. About 500 adults with severe injuries will be randomly assigned to receive either the …

This trial tests whether eating 5 grams of wakame seaweed daily for three months can lower levels of harmful AGEs in the blood of people with stage III chronic kidney disease. AGEs are compounds that may speed up kidney damage. The study includes 30 adults who will add the seawee…

This phase 2 trial tests a new drug called zanzalintinib, taken as a pill, combined with a bone-strengthening agent for people with advanced kidney cancer that has spread to the bones. The study enrolls 20 participants whose cancer has worsened after 1–3 prior treatments, includi…

This pilot trial tests whether using an ultrasound score (VeXUS) to guide fluid removal with diuretics can help kidneys recover in patients who develop acute kidney injury after cardiac surgery. About 40 participants will be randomly assigned to either VeXUS-guided fluid manageme…

This study tests whether a community health worker program can help people with advanced kidney disease start treatment more smoothly. The program provides support, education, and help with social challenges. Researchers will compare this to standard care in 448 adults with chron…

This study tests whether adding a clinical decision support tool to the electronic medical record helps doctors use the furosemide stress test in critically ill children at high risk for acute kidney injury. The furosemide stress test measures how the kidneys respond to a diureti…

This trial compares two starting doses of the steroid prednisone for children with lupus-related kidney inflammation (lupus nephritis). The standard high dose can cause serious side effects like growth problems and bone thinning. The study asks whether a lower initial dose can co…

This study tests a web-based program called Web-SUCCEED that helps veterans with chronic illness and their informal caregivers work together to manage the condition. The program includes three weekly online modules and brief phone calls with staff, focusing on stress coping and c…

This study tests whether giving a diuretic (furosemide) to reduce fluid buildup can better protect the kidneys from contrast dye damage compared to standard IV fluids. It involves 190 adults hospitalized with acute heart failure and moderate kidney problems who need a CT scan. Re…

This study tests whether a personalized, high-rate fluid removal strategy guided by ultrasound is as safe and effective as the standard rate for patients with advanced kidney disease hospitalized due to severe fluid overload. Participants are randomly assigned to receive either a…

This trial compares two surgical techniques for removing large or complex kidney stones: a modified mini version using a smaller access sheath (20 Fr) versus the standard approach (24 Fr). The goal is to see if the mini procedure causes less bleeding and pain while still clearing…

This study tests whether a structured arm exercise program can help arteriovenous fistulas (AVFs) mature properly in people with chronic kidney disease who need hemodialysis. AVFs are surgically created connections between an artery and a vein that allow for dialysis, but up to h…

This trial compares a new aspiration-enabled access sheath to a conventional one during retrograde intrarenal surgery (RIRS) for kidney stones. The new sheath continuously removes irrigation fluid to control pressure inside the kidney, potentially reducing temporary kidney injury…

This trial investigates whether pioglitazone, a drug used for diabetes, can help protect the kidneys in people with ANCA-associated vasculitis—a rare autoimmune disease that causes inflammation of blood vessels, often damaging the kidneys. Participants receive either pioglitazone…

This study tests whether a carefully controlled low protein diet (about 0.6 grams of protein per kilogram of body weight each day) can help people with advanced chronic kidney disease delay the need for dialysis or a kidney transplant. The study enrolls adults with stage 4-5 or f…

This study tests whether adding targeted radiation or heat-based ablation to ongoing drug therapy can control genitourinary cancers (prostate, bladder, or kidney) that have started growing in only a few new areas. Participants continue their current systemic treatment while recei…

This trial investigates whether ursodeoxycholic acid (UDCA), a bile acid medication, can protect kidney function in adults undergoing partial nephrectomy for kidney cancer. During surgery, blood flow to the kidney is temporarily stopped, which can cause injury. Participants take …

This study tests whether semaglutide, a diabetes drug, is safe and tolerable for people with type 2 diabetes who are on dialysis. About 100 participants will either receive weekly semaglutide injections or standard care for 26 weeks. The goal is to see if patients can stick with …

This study tests whether a personalized care plan at hospital discharge helps people who survived acute kidney injury recover better. Depending on their risk level, patients get education, a primary care visit, or specialist monitoring. The goal is to see if this approach increas…

This study tests whether giving patients special donor immune cells (called CD45RA-depleted DLI) can treat viral infections that persist after a stem cell transplant. The trial involves 30 participants who have not improved with standard antiviral drugs. Researchers will measure …

This study tests a special cartridge (pHA130) added to regular dialysis to remove toxins that standard dialysis misses. One hundred adults with kidney failure on maintenance dialysis will be split into two groups: one gets the new cartridge once a week plus standard dialysis twic…

This study tests whether the antibiotic rifampin can safely lower high calcium levels in the blood and urine of people with a rare genetic mutation in the CYP24A1 gene. The condition can cause kidney stones and other problems. Sixty participants aged 6 months to 65 years will tak…

This trial tests whether a new robotic system that uses only one small incision (single port) can safely perform common abdominal surgeries in children. The study includes children aged 1 to 17 who need procedures like pyeloplasty or reflux treatment. The goal is to see if the si…

This phase 3 trial compares two induction therapies—rabbit anti-thymocyte globulin (rATG) and basiliximab—in 244 sensitized kidney transplant recipients who do not have pre-existing donor-specific antibodies. The goal is to see which drug better prevents biopsy-proven acute rejec…

This early-phase study tests whether specially trained immune cells from healthy donors can safely treat viral infections (EBV, CMV, adenovirus, BK virus) in patients who have had a stem cell transplant or certain CAR-T therapy. These infections can be life-threatening when the i…

This study tests whether giving oxybutynin syrup early (starting at 3-6 months old) can improve bladder function in boys born with posterior urethral valves, a condition that blocks urine flow. Fifty boys who had valve surgery will be randomly assigned to receive either oxybutyni…

This study tests whether specially grown immune cells (called cytotoxic T lymphocytes) can safely lower BK virus levels in 20 transplant patients with weakened immune systems. Participants have had a stem cell or kidney transplant and show signs of BK virus infection. The goal is…

This early-phase trial tests whether a powerful immune reset using a patient's own stem cells can clear the antibodies that block them from receiving a kidney transplant. Ten highly sensitized adults with end-stage kidney disease will undergo intense conditioning to wipe out thei…

This study tests a radioactive drug, 177Lu-PSMA-617, in people with advanced kidney cancer that has spread and worsened despite standard treatments like immunotherapy and targeted therapy. The drug targets a protein called PSMA found on kidney cancer cells, delivering radiation d…

This study tests whether hydroxychloroquine, a drug already used for lupus, can slow kidney function decline in people with IgA nephropathy (Berger's disease). About 334 adults with biopsy-confirmed IgA nephropathy and high protein in their urine will receive either hydroxychloro…

This study tests a drug called sparsentan in 24 adults with IgA nephropathy, a kidney disease. Some participants are newly diagnosed, others have the disease return after a kidney transplant. The goal is to see if sparsentan can reduce protein in the urine, a sign of kidney damag…

This study is testing whether semaglutide, a drug already used for type 2 diabetes, can reduce kidney damage in people with type 1 diabetes and diabetic kidney disease. About 60 adults will receive either semaglutide or a placebo for 26 weeks. Researchers will measure changes in …

This trial tests a special cannula that captures debris during high-risk heart valve surgery. The goal is to see if it reduces the chance of stroke, kidney injury, and delirium. About 842 patients aged 60 and older will be randomly assigned to receive either the new device or a s…

This study looks at whether the blood thinner warfarin can safely reduce stroke risk in people with end-stage kidney disease on dialysis who also have atrial fibrillation (an irregular heartbeat). About 718 adults will be randomly assigned to take warfarin or not, and researchers…

This study compares two types of continuous dialysis used in the ICU for patients with sudden kidney failure. One method uses a citrate-based blood thinner, the other uses heparin. The goal is to see if the citrate method is just as effective at removing waste from the blood. 80 …

This study tests whether giving children with a severe E. coli infection extra fluids through an IV can prevent kidney failure. About 1,040 children aged 9 months to 21 years will take part. The goal is to see if this simple approach reduces the need for dialysis or long-term kid…

This large trial in New Taipei City will test whether a mobile digital health platform with interactive modules helps people better control high blood pressure, high blood sugar, and high cholesterol. It will also compare taking blood pressure medication at night versus in the mo…

This study tests whether a virtual home hospital program with remote monitoring can help people recover from acute kidney injury without needing to stay in the hospital. Researchers will enroll 354 adults who are at high risk of readmission. Participants will receive digital tool…

This pilot study tests whether time-restricted eating (eating all meals within an 8-hour window each day) can reduce protein in the urine and slow kidney function decline in people with moderate chronic kidney disease. Fifty adults with stage 2-3 CKD and elevated albuminuria will…

This phase 2 trial is testing whether giving two drugs—toripalimab and lenvatinib—before and after surgery can improve outcomes for people with clear cell renal cell carcinoma. The study enrolls 75 patients with different stages of kidney cancer. Participants receive the drugs fo…

This study tests whether taking sodium bicarbonate (baking soda) daily can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will receive either sodium bicarbonate or a…

This study looks at whether removing the kidney tumor after starting immunotherapy helps people with advanced kidney cancer live longer. About 400 participants will be randomly assigned to have surgery or not. The goal is to see if delayed surgery improves overall survival compar…

This study tests whether a daily 25 mg dose of empagliflozin (a diabetes drug) is safe and helps preserve remaining kidney function in 20 adults on peritoneal dialysis. Participants must still produce at least 250 mL of urine daily. The trial measures changes in kidney filtration…

This early-stage trial tests a new cell therapy called Eight Treg in 9 people receiving a kidney from a living donor. The therapy uses the patient's own immune cells, grown in a lab, to help the body accept the new kidney without strong anti-rejection drugs. The main goal is to c…

This study is testing a precise type of radiation, called SBRT, for people with kidney cancer that cannot be removed with surgery. The treatment aims to control the tumor while limiting damage to healthy tissue. Researchers will track tumor control and quality of life in 70 parti…

This early-phase trial tests a one-time infusion of specially engineered immune cells (CAR-NK cells) that target two proteins, CD70 and CAIX, found on kidney cancer cells. The study includes 36 adults with advanced clear cell renal cell carcinoma that has worsened after standard …

This study is testing whether empagliflozin (Jardiance), a drug used for diabetes and chronic kidney disease, is safe for people who have received a kidney transplant. Researchers will enroll 264 veterans and monitor for side effects like infections and changes in kidney function…

This study tests whether combining a special PET scan (CAIX PET/CT) with standard therapy can better control advanced kidney cancer. About 70 adults with recurrent or metastatic clear cell renal cell carcinoma will receive targeted therapy and immunotherapy, plus precise radiatio…

This study tests a noninvasive device that gently stimulates a nerve in the ear to help children with steroid-resistant nephrotic syndrome, a kidney condition that doesn't respond to standard steroids. The goal is to see if this approach is feasible and tolerable, and if it can r…

This study tests whether a drug called ferric citrate can lower a harmful protein (FGF23) in children aged 6–18 with moderate chronic kidney disease. About 160 kids will take either the drug or a placebo for 12 months. The goal is to see if the drug is safe and helps control kidn…

This study tests the drug nivolumab in people with advanced rare cancers that have a specific marker (PD-L1). The goal is to see if the drug can shrink or control the tumors when other treatments have stopped working. Up to 28 adults will receive treatment for up to 12 months, an…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can help control nephrotic syndrome in children aged 3-17. The goal is to reduce relapses and the need for steroids or other immune-suppressing drugs. Thirty children will be randomly as…

This study tests whether giving two drugs (pembrolizumab and axitinib) before surgery can shrink a tumor-related blood clot in the main vein of the abdomen in people with kidney cancer. The goal is to make surgery safer and improve long-term outcomes. About 17 adults with clear c…

This study tests a new treatment for adults with severe lupus that hasn't improved with standard therapies. Doctors will use a person's own immune cells, modified to target specific lupus-driving cells (CD19 or BCMA), and give them back as a one-time infusion. The goal is to cont…

This early-stage trial is testing a new treatment called VET3-TGI, a virus designed to infect and destroy cancer cells. It is being given alone or with the immunotherapy drug atezolizumab to 60 people with advanced solid tumors that have not responded to standard treatments. The …

This study tests a daily pill called olaparib in 20 adults with advanced kidney cancer that has spread. To join, your cancer must have a specific gene change (like BAP-1 or BRCA) and you must have already tried at least one other treatment. The goal is to see if olaparib can shri…

This study tests whether two infusions of AION-301 are safe and can reduce symptoms or slow the worsening of Stage 3 chronic kidney disease. About 36 adults will receive either AION-301 or a placebo, along with oral vitamins, and be followed for up to 24 months. The main goal is …

This study tests a drug called obinutuzumab in 33 adults with a relapsing form of granulomatosis with polyangiitis (GPA, formerly Wegener's). The goal is to see if the drug can stop disease activity and turn off the related antibody. Participants will be followed for 6 months to …

Researchers are testing whether a drug called 5-aminolevulinic acid (5-ALA) can make kidney tumors glow under blue light during surgery. Adults with suspected kidney cancer take the drug by mouth before a partial nephrectomy, a procedure that removes part of the kidney. Surgeons …

This study tests whether a medication called 5-ALA, already used in brain surgery, can make upper urinary tract tumors glow under blue light during surgery. About 10 adults with known or suspected tumors will take 5-ALA before their procedure. The goal is to see if this technique…

Researchers are testing a radioactive tracer called 18F-NY104 to see how well it detects kidney cancer and other tumors that carry a protein called CAIX. About 120 people with known or suspected kidney cancer, or other CAIX-positive cancers, will receive an injection of the trace…

People with lupus can develop kidney inflammation called lupus nephritis, which is easier to treat when caught early. This study enrolls adults with lupus who are at higher risk for kidney problems and assigns them by chance to either standard care alone or standard care plus wee…

IgA nephropathy is a kidney disease where immune proteins build up in the kidney's filtering units. Researchers in China are collecting samples from 600 people aged 16 and older, including those with biopsy-confirmed IgA nephropathy, to study the bacteria living in their mouths, …

The ORACLE study watches people who have finished treatment for early-stage solid tumors, such as lung, breast, colon, and pancreatic cancers. Researchers want to see if a blood test called Guardant Reveal can find tiny traces of tumor DNA that might signal the cancer is coming b…

Researchers are studying whether biomarkers in blood, urine, and stool can predict acute kidney injury in adults scheduled for cardiovascular surgery. The trial follows about 1,500 patients, collecting samples and clinical data before and after contrast dye exposure and surgery. …

This early-phase trial is testing whether a single dose of a hormone pill can help diagnose oxytocin deficiency in young people with hypopituitarism. Researchers will give the pill to 20 participants and measure oxytocin-related substances in blood and saliva. The goal is to deve…

This observational study is testing whether a combination of non-invasive measurements—including blood pressure monitoring, ultrasound, blood and urine tests, and a light-based technique called photoplethysmography—can detect early damage to blood vessels and organs in adults at …

This study is testing whether a protein called NMAP, measured in a blood sample, can help tell apart people with newly diagnosed kidney cancer from those without cancer. Researchers will compare NMAP levels in about 400 adults — half with kidney cancer and half without — to see h…

This study compares a new diagnostic test using mannitol infusion to the standard hypertonic saline test for diagnosing the cause of polyuria-polydipsia syndrome (excessive urination and thirst). Researchers will enroll 144 adults to see if the mannitol test is as accurate and mo…

This study investigates whether a urine test called Nephrocheck can predict which patients with septic shock will develop severe acute kidney injury. The test measures two markers of kidney damage (TIMP2 and IGFBP7). Researchers will analyze data from previous studies involving a…

This study tests a special PET/CT scan using a radioactive tracer called 68Ga-NYM096 to see if it can accurately detect clear cell kidney cancer in people with complex kidney cysts who are scheduled for surgery. About 70 participants will receive the tracer and undergo imaging be…

This study is testing a new blood test that looks at RNA (genetic material) to quickly tell if a person with belly pain has an infection inside the abdomen, like appendicitis or diverticulitis. About 1,000 adults and children over age 7 with abdominal pain will give a blood sampl…

This study is testing a new, non-invasive urine test to detect clear cell renal cell carcinoma, a common type of kidney cancer. Currently, diagnosis often requires expensive imaging or a painful biopsy. Researchers are looking for tiny particles called exosomes in urine that are …

This study aims to confirm if a test using a sample of amniotic fluid can accurately predict how well a baby's kidneys will work after birth. Researchers will analyze 78 fetuses with kidney and urinary tract malformations from hospitals across France. The goal is to see if this t…

This study tests whether a device that measures brain waves (called BIS) can detect dialysis disequilibrium syndrome, a complication that can occur during first-time dialysis. Twenty new dialysis patients will be monitored during their first three sessions. The goal is to see if …

This study tests whether special MRI and CT scans can accurately measure the stiffness of kidney tumors. Researchers will compare these scans to standard methods in 50 adults scheduled for kidney tumor surgery. The goal is to improve 3D-printed models that help surgeons plan oper…

Researchers in Pakistan are testing whether a mobile app that uses artificial intelligence to send personalized heat-risk alerts can reduce heat-related illness symptoms in adults with chronic conditions such as hypertension, diabetes, kidney disease, heart disease, or obesity. T…

Researchers are testing whether adding dapagliflozin to a lifestyle program can normalize blood sugar in people with prediabetes and protect their kidneys. The trial enrolls 170 adults aged 35 to 75 with prediabetes. Participants receive either dapagliflozin or a placebo for six …

This study tests a non-invasive ear stimulation technique (taVNS) to prevent acute kidney injury in 152 adults having heart surgery with a heart-lung machine. Half receive real stimulation before and after surgery; the other half get a sham. The main goal is to see if fewer peopl…

People with end-stage kidney disease who start hemodialysis often use a central venous catheter for access. These catheters raise the risk of bloodstream infections. Researchers are testing whether a daily antibiotic, amoxicillin-clavulanic acid, can prevent these infections comp…

This study tests whether empagliflozin, a drug used for diabetes and heart conditions, can help prevent calcium-based kidney stones. Researchers will give the drug daily for 4 weeks to 32 adults who have had calcium oxalate or calcium phosphate stones. They will measure changes i…

This study is testing whether a home-based screening kit can identify hidden heart risks better than standard doctor visits. 45,000 adults in Sweden aged 50-75 will either receive a home blood pressure monitor, a finger-prick blood test, and a health questionnaire, or continue wi…

This study tests whether the drug R2R01 can prevent acute kidney injury in people at high risk who are having heart surgery with a heart-lung machine. Participants receive either R2R01 or a placebo before and after surgery. The goal is to see if the drug reduces kidney damage and…

This study tests whether giving a concentrated saltwater solution (hypertonic saline) right after a heart transplant can prevent or lessen acute kidney injury. About 74 adults who are hospitalized for a heart transplant will take part. The goal is to see if this simple approach c…

This study compares two long-acting drugs, indapamide and chlorthalidone, to the standard short-acting drug hydrochlorothiazide for preventing calcium kidney stones. About 99 adults who have had at least two kidney stones in the past 10 years will participate. The goal is to see …

Researchers are testing whether two kinds of exercise done during hemodialysis are safe and helpful for adults with kidney failure. Participants are assigned to cycle on a stationary bike, use elastic bands for resistance training, or receive standard dialysis care. The study mea…

Researchers compare two ultrasound-guided nerve block combinations to numb the arm during surgery for a dialysis fistula. Adults with end-stage kidney disease receive either an intercostobrachial nerve block or an erector spinae block, each added to a standard supraclavicular blo…

This study tests whether a specific physical activity program, called the GH Method, can improve physical abilities in people who are frail and on dialysis or have advanced kidney disease. Participants attend two one-hour muscle therapy sessions per week for 12 months. Researcher…

This trial tests a communication tool called 'CKD Jumpstart-Tips' for older adults with advanced chronic kidney disease (stages 4 and 5). Before a clinic visit, patients answer questions about their understanding of their illness, treatment options, and personal goals. During the…

This study looks at whether a simple home-based walking program can boost memory, thinking skills, and brain structure in older adults (over 55) who have both chronic kidney disease and mild cognitive impairment. Over 6 months, participants will either walk regularly or receive h…

Researchers in Singapore are testing a mobile app that helps people with chronic kidney disease (CKD) choose suitable foods when dining out. The app, called RENDOFOMAP, lets users photograph their meals and provides guidance based on a map of kidney-friendly options. In this pilo…

This study tests whether a program that combines gentle walking with progressive muscle relaxation can help reduce the extreme tiredness (fatigue) that many people with end-stage kidney disease feel while on dialysis. Researchers will enroll 40 adults who are on hemodialysis and …

This study compares a new radiation technique called lattice radiation therapy (LRT) to standard stereotactic body radiation therapy (SBRT) for people with solid tumors that have spread to soft tissues. The goal is to see if LRT shrinks tumors better and helps the immune system f…

This study tests a medicine called difelikefalin in teenagers aged 12 to 17 who are on hemodialysis and have moderate to severe itching. The goal is to see if the drug is safe and how much gets into the blood. About 18 teens will receive the medicine up to 4 times a week for 12 w…

This pilot study tests a care model called Patient Priorities Care (PPC) for older African Americans with heart disease plus other chronic conditions like diabetes or COPD. The approach shifts focus from treating each disease separately to aligning care with what matters most to …

This study tests whether watching a virtual reality (VR) video before kidney stone surgery can lower anxiety, boost knowledge, and improve self-care. About 90 adults scheduled for surgery will be split into three groups: standard education, standard VR, or a special VR with built…

This study tests a wearable suit called AquaPass that removes excess fluid through sweat in people with chronic heart failure and fluid overload. Participants wear the suit for up to 5 hours in a hospital or clinic, alongside their usual medications. The goal is to see if the sui…

This study compares a combination of anesthesia methods (multimodal) to standard anesthesia for people having robotic kidney surgery for cancer. The goal is to see if the special approach helps patients recover more quickly, have less pain, and go home sooner. About 80 adults wil…

This study tests if taking tamsulosin before surgery or using aminophylline during surgery helps doctors place a tube needed for kidney stone removal. About 322 adults with small kidney stones will be randomly assigned to receive one or both medications or placebos. The goal is t…

This study tests whether a 4-week mindfulness meditation program can improve sleep quality, reduce stress, and ease symptoms in people receiving hemodialysis. Fifty adults on dialysis will either get meditation plus usual care or usual care alone. Researchers will measure changes…

This study tests whether a high-protein nutrition plan combined with resistance exercises, started weeks before surgery and continued for 24 weeks after, can help older adults with cancer preserve their physical function. The trial enrolls Veterans aged 55 and older with certain …

This study tests a new type of ureteric stent designed to cause fewer blockages, infections, and less pain than standard stents. About 50 adults who have had stents before for kidney stones or cancer will try the new stent. The goal is to see if it reduces complications and the n…

This study tests whether folic acid supplements can reduce mucositis (painful sores in the mouth, nose, throat, or other areas) in people with advanced kidney cancer who are on targeted therapy or immunotherapy. About 100 participants will receive either folic acid or a placebo, …

This study tests whether a 15-20 minute session in a specially designed sensory modulation room before kidney transplant surgery can reduce pain, anxiety, and sleep problems afterward. The room has dim lights, nature videos, calming music, and tactile objects like stress balls. R…

This study tests a new biodegradable stent (Hydrustent) that dissolves on its own after being placed in the ureter following kidney stone removal. The goal is to see if it keeps urine flowing safely and reduces the need for a second procedure to remove the stent. About 134 adults…

This study looks at whether adding a blood-filtering step called hemoadsorption to regular dialysis can help people with kidney failure who still have bothersome symptoms like itching, tiredness, and trouble sleeping. Researchers will follow 120 adults for 6 months, tracking how …

This study is a registry that collects information on the safety and effectiveness of Medtronic medical devices already on the market. It will include up to 100,000 people who have or will receive a Medtronic product for conditions like heart, nerve, or digestive disorders. The g…

This study examines how the body processes nemtabrutinib in people with severe kidney impairment compared to healthy volunteers. By measuring drug levels in the blood after a single dose, researchers aim to understand whether kidney function changes how the drug is handled. The r…

This study follows up to 3,000 people who have, are at risk for, or are related to someone with a parathyroid disorder. Researchers will collect medical records, questionnaires, and samples like blood and saliva to learn what causes these conditions and how they change over time.…

This study looks at 50 adults with AL amyloidosis who achieved complete remission after initial chemotherapy. It checks if tiny amounts of remaining disease (called minimal residual disease, or MRD) affect organ recovery and survival. Researchers also test whether a stem cell tra…

This study tests how a single injection of HRS-4729 behaves in people with mild, moderate, or severe kidney impairment compared with healthy people. Researchers measure drug levels in the blood over time to see if kidney function affects how the body processes the drug. The trial…

This study aims to learn more about how lupus (SLE) develops and changes over time by observing patients and their relatives. Up to 2000 people aged 3 and older with known or suspected lupus, along with their family members, will provide medical history, blood and urine samples, …

This study will follow 1000 adults with advanced chronic kidney disease (stage 4-5) to learn why they face higher risks of bone fractures and heart disease. Researchers will track bone turnover markers, calcium and phosphate levels, and kidney function over time. No new treatment…

This study follows people with a rare genetic condition called DICER1 syndrome, which raises the risk of certain childhood cancers like pleuropulmonary blastoma. Researchers will collect medical histories, genetic samples, and tissue from up to 1,500 participants and their relati…

This study will look at 54,000 adults having surgery with general anesthesia to see how different oxygen levels affect their recovery. Patients will receive lower, intermediate, or higher oxygen during their operation. The goal is to find which oxygen level reduces the risk of or…

This study aims to uncover the genetic causes of hereditary leiomyomatosis renal cell cancer (HLRCC), a condition that can lead to painful skin bumps, uterine fibroids, and kidney tumors. Researchers will study people with known or suspected HLRCC and their family members to iden…

This study will survey 400 adults with moderate to severe chronic kidney disease in Réunion Island to find out how many use herbal medicines and whether those herbs affect how fast their kidney disease gets worse over one year. Participants will fill out questionnaires about thei…

This study looks at a rare inherited condition called Birt-Hogg-Dube (BHD) syndrome, which raises the risk of kidney cancer. Researchers will collect blood, saliva, and tissue samples from up to 950 participants to find the genes involved and understand how kidney tumors grow. Th…

Researchers in China are building a registry of people diagnosed with lupus nephritis, a kidney complication of lupus. The study plans to enroll 5,000 patients from participating hospitals and follow them with yearly check-ins. By collecting baseline and follow-up information, th…

This natural history study will look at how metabolism relates to body size and composition in 2,000 people aged 2 and older, including healthy volunteers and those with conditions like diabetes, obesity, or cancer. Participants will stay in the hospital for two days to undergo v…

Researchers at Sun Yat-sen University are building a registry of people with nephrotic syndrome across hospitals in China. The study aims to enroll 5,000 patients regardless of the underlying cause. By recording baseline and follow-up information, the team will track kidney funct…

Researchers in China are enrolling people with biopsy-confirmed primary IgA nephropathy into a long-term registry. Participants are followed once a year, with baseline and follow-up details recorded in a database. The study tracks deaths from any cause and heart-related deaths, p…

Researchers at Sun Yat-sen University are building a registry of people receiving hemodialysis at hospitals across China. The study plans to enroll about 30,000 adults with end-stage renal disease and follow them every three months. By comparing survival, dialysis access patency,…

Researchers at University Hospital, Strasbourg, are developing 3D tumor models grown from patient tissue to study kidney, bladder, and prostate cancers. The study collects tumor samples and a small blood sample from about 100 adults with these cancers. Scientists use the blood to…

This observational study will follow 2000 adults with type 2 diabetes to see how their eating habits, body composition, and grip strength change over time. Researchers hope to identify patterns that could help improve care. Participants must be 18 or older and able to complete ba…

Researchers at Sun Yat-sen University are building a registry of peritoneal dialysis patients across hospitals in China. The study plans to enroll about 10,000 people and follow them every three months. The team will collect baseline and follow-up information to compare patient s…

Calciphylaxis is a rare disorder where calcium builds up in small blood vessels in the skin, causing painful lesions. Researchers at Massachusetts General Hospital are building a biobank and patient registry to collect samples and health information from up to 300 adults with the…

This study is testing whether smartwatches and blood tests can measure how well children recover after surgery to remove a solid tumor. About 40 children and their caregivers will wear smartwatches and answer questionnaires before surgery and for up to a year after. Researchers w…

Researchers are following 10,000 registered nurses in Xiamen, China, to see how genes, lifestyle, and environment relate to common chronic diseases like high blood pressure, heart disease, stroke, diabetes, kidney disease, and some cancers. The study collects health and lifestyle…

This study looks at how different levels of kidney function affect the way the body handles an experimental drug called RO7795081. Researchers will give a single oral dose to people with various degrees of kidney impairment and compare them to people with normal kidney function. …

This trial tests five different dialysis approaches in people with end-stage kidney disease to see how each affects salt stored in tissues and the health of small blood vessels. Participants receive each method in random order over four weeks. Researchers use MRI scans and skin p…

This study will check if a simple ultrasound of the neck vein, done before and right after anesthesia, can predict low blood pressure during surgery and kidney injury afterward. Researchers will observe 150 adults having major abdominal surgery. The goal is to see if changes in t…

This study tests whether a 12-week nutrition and kidney health program, called THINK-Well, works well for adults with chronic kidney disease. The program includes group nutrition classes, cooking practice, and food bucks to buy healthy foods. Researchers want to see how many peop…

This registry is collecting information from 35,000 adults with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease. Researchers want to see how these conditions are managed in everyday medical practice, what treatments people receive, and how often…

This observational study follows 350 adults with pulmonary hypertension to see if certain biomarkers in urine and blood are linked to worsening kidney function. Participants undergo standard tests but receive no experimental treatment. The goal is to better understand how kidney …

This study will follow 300 adults and children with kidney failure who use a specific type of catheter for peritoneal dialysis. Researchers will track infections, complications, and how well the catheter works over time. The goal is to see if these catheters are safe and effectiv…

This early-stage trial is testing whether hemodialysis—a treatment that filters waste from the blood when kidneys fail—changes how the body processes a combination drug called balcinrenone/dapagliflozin. The study will give a single dose of the drug to about 10 people with kidney…

This study tests whether a bedside ultrasound tool called the VExUS score can predict acute kidney injury after open-heart surgery. The score measures fluid buildup in the veins, which may stress the kidneys. Researchers will follow 135 adults undergoing heart surgery with a hear…

This study looks at whether people who carry one copy of the cystic fibrosis gene (CF carriers) have early signs of kidney or pancreas problems. Researchers will compare 1250 CF carriers and non-carriers using blood tests, urine and stool samples, and surveys. The goal is to see …

This study collects extra blood, urine, and tumor samples from children and adults with certain cancers to build a large tissue repository. Researchers will analyze these samples to learn more about the genetic and molecular makeup of these tumors. The goal is to support future s…

This study tracks 230 adults having planned heart surgery to see if unstable blood pressure during the operation raises the risk of serious problems like confusion, kidney injury, stroke, or death within 30 days. Researchers will monitor blood pressure dips and use of pressure-ra…

This observational study collects tumor tissue and blood cells from 200 people with advanced solid tumors like colorectal, lung, and pancreatic cancers. The goal is to understand how often tumors lose a specific marker (HLA) and to store participants' own T cells for potential fu…

Researchers are testing whether hyperspectral imaging, a camera technique that captures hundreds of light bands invisible to the eye, can map blood flow and identify tumor types during robot-assisted partial nephrectomy. The study will enroll 60 adults with kidney tumors up to 7 …

This study is observing 223 people with active lupus (including kidney inflammation) who haven't gotten better with steroids and at least two immunosuppressants. Researchers want to see how well today's standard treatments work for these tough cases. The goal is to measure how ma…

This early-stage study is testing a new oral drug called SK-09 in 72 healthy adults to see if it is safe and how the body processes it. The study is split into two parts: one where participants get a single dose, and another where they get multiple doses. No one knows who gets th…

This study compares two levels of patient navigation—high-intensity versus low-intensity—to see which helps more people with prostate or kidney cancer enroll in clinical trials. About 90 participants will be randomly assigned to receive either extra support from a patient navigat…

This study tests whether a device called FIZE kUO®, which tracks urine output every minute, can help doctors manage fluids and diuretics in patients recovering from heart surgery. Researchers will monitor 45 adults in the intensive care unit and compare urine output before and af…

This study collects blood and tissue samples from 2000 people—some with cancer and some without—to create a blinded reference set. Researchers will use these samples to evaluate how well new blood tests can detect many types of cancer early. The goal is to improve the accuracy of…

This study will collect data from 2,000 patients in the Netherlands and France who are receiving standard, minimally invasive cancer treatments like tumor ablation or catheter-based therapies for liver, lung, kidney, or bone cancers. During these procedures, a special CT scanner …

This early-stage trial is testing an experimental oral drug called TUL321 in healthy adults to see if it is safe and tolerable. The study will also measure how the drug moves through the body and whether food affects its absorption. TUL321 is being developed as a potential treatm…

This study aims to find out why people with diabetes often have lower vitamin C levels in their blood. Researchers will measure vitamin C in blood, urine, and cells from 5,000 adults with and without diabetes. They will also look at genes that control vitamin C transport. The goa…

This study follows up to 2000 people with immune-related kidney diseases, such as nephrotic syndrome and lupus nephritis. Researchers will collect medical history, lab tests, and blood or urine samples to better understand these conditions. The goal is to learn more about causes …

This study creates a biorepository of blood and urine samples from adults of African ancestry, including those with end-stage kidney disease and healthy controls. The goal is to support research on APOL1 gene mutations, which are linked to kidney disease and are only found in peo…

This study explores whether a special type of MRI, called multiparametric MRI, can detect kidney scarring (fibrosis) without the need for an invasive biopsy. Researchers will follow living kidney donors, transplant recipients, and healthy volunteers over two years, comparing MRI …

This study looks at women who had surgery for deep endometriosis affecting the ureters, the tubes that carry urine from the kidneys to the bladder. The goal is to see how their kidney function and blood pressure fare years after the operation, and whether the type of surgery matt…

This study investigates whether signs of complement activation in the blood can serve as a biomarker for the severity and progression of IgA nephropathy, a kidney disease. Researchers will follow 400 adults with biopsy-proven IgA nephropathy, including those with or without a kid…

This study investigates whether the gut microbiome and its byproducts influence chronic pain in people who have received a kidney transplant. Many transplant recipients experience persistent pain, which can affect their quality of life and treatment adherence. Researchers will tr…

This study investigates why arteries stiffen and harden faster in children and young people with chronic kidney disease (CKD) and high blood pressure. Researchers will use non-invasive tests to compare arterial stiffness between those with CKD and matched controls, including heal…

This study follows people with rare inherited forms of kidney stones and chronic kidney disease, such as primary hyperoxaluria, cystinuria, and Dent disease, to learn how these conditions develop over time. Researchers will measure markers of inflammation in blood and urine and t…

This study analyzes data from over 6,000 French patients with non-metastatic kidney cancer to understand how the disease progresses after surgery. The goal is to identify which patients are at high risk of recurrence and might benefit from adjuvant immunotherapy, while avoiding u…

This study aims to understand the quality of life of school-aged children who were treated for posterior urethral valves (PUV) in their first year of life. PUV is a rare birth defect that can affect kidney and bladder function. Researchers will use a standard questionnaire called…

This study follows people with SPLIS, a rare inherited metabolic condition, to map its natural history—how the disease unfolds over time. Researchers will track growth, organ function, quality of life, and survival in about 28 participants. The goal is to understand the full rang…

This trial asks whether five advanced AI models can match the treatment recommendations of expert tumor boards for cancer patients. Using 100 standardized synthetic cases across breast, lung, urological, digestive, and gynecological cancers, each AI and two independent tumor boar…

This study looks at whether levels of a molecule called inorganic pyrophosphate (PPi) in the blood are linked to blood vessel damage in children with chronic kidney disease (CKD). Researchers will compare PPi levels in children with CKD (including those on dialysis or with a kidn…

This study tests whether nurses can accurately identify depression in people on hemodialysis. About 450 patients will have their depression symptoms assessed both by a nurse and by themselves using a standard questionnaire. The goal is to see if nurse assessments can be a reliabl…

This study explores the personal experiences of young women with chronic kidney disease (CKD) who are not yet on dialysis or transplant. Researchers aim to understand how the disease impacts daily life, fertility, and life plans, and whether the cause (genetic vs. non-genetic) ma…

This study collects medical information from people around the world who have one of four rare hereditary kidney stone diseases: primary hyperoxaluria, Dent disease, cystinuria, or APRT deficiency. By gathering data from many patients, researchers hope to better understand how th…

This study will observe 128 critically ill patients with acute kidney injury who need dialysis to remove excess fluid. Researchers want to understand why some patients become unstable during fluid removal. They will monitor heart function, blood flow, and other signs before and d…

This study will look at how people with chronic kidney disease use a digital app called MyRenalCare. Researchers want to see if the app helps improve health, lowers hospital visits, and reduces costs and environmental impact. About 1,000 adults under kidney care will be included.

This study investigates how changes in kidney cell metabolism relate to the rate of kidney function decline in people with ANCA vasculitis and other kidney diseases. Researchers will analyze kidney biopsy samples and blood/urine tests from 146 participants over one year. The goal…

This study will follow 500 adults with chronic kidney disease and type 2 diabetes who are taking finerenone, a drug that helps protect the kidneys and heart. Researchers want to see if a tool called the Klinrisk score, which estimates the risk of kidney disease getting worse, imp…

This research study follows 500 adolescents with type 2 diabetes to understand why some develop kidney problems. Researchers are looking at biological factors like blood sugar and blood pressure, as well as psychological and social factors such as stress, mental health, and pover…

This study follows 500 adults with lupus to see if blood and urine tests can reliably detect kidney inflammation (lupus nephritis). Participants give samples during routine visits, and doctors track their kidney health over time. The goal is to find simple, non-invasive markers t…

This study looks at gum disease in people with rare kidney disorders like Alport syndrome, Fabry disease, and tuberous sclerosis, as well as lupus. Researchers will compare 100 participants to those with chronic kidney disease and healthy controls. They aim to understand how comm…

This observational study will compare blood fat (lipid) levels in 200 adults with chronic kidney disease—half with diabetes and half without. Researchers want to find out if having diabetes leads to worse fat problems in these patients. Participants will fast for 10 hours before …

This study is collecting blood, urine, and fecal samples from 100 people with ANCA-associated vasculitis, a rare autoimmune disease. Researchers will follow participants for up to 5 years, tracking relapses and complications. The goal is to identify factors that predict disease f…

This study is observing 40 adults with multiple sclerosis to see how clinical tests of balance and walking relate to detailed motion-capture measurements. Participants will attend one session where they walk on force plates and perform balance tasks while cameras track their move…

This observational study will follow 800 adults with IgA nephropathy, a common kidney disease, to see how well current treatments control protein in the urine and preserve kidney function over 12 months. Researchers want to understand why some patients do not respond to standard …

This study is collecting blood, urine, and kidney tissue samples from 144 children and adults with a kidney condition called nephrotic syndrome. The goal is to build a large database and sample collection to study how the immune system and kidney cells interact. Researchers hope …

This study looks at a type of immune cell called memory B cells in people waiting for a kidney transplant who have certain antibodies. Researchers want to understand why some of these cells cause rejection while others don't. They will analyze blood samples from 51 patients to fi…

This study looks at how a 12-week lifestyle change affects inflammation and stress markers in 60 overweight adults with type 2 diabetes and moderate chronic kidney disease. Participants will follow a modified diet and exercise plan. The goal is to see if these changes can reduce …

This study is testing three different low doses of the blood thinner rivaroxaban in 10 adults on chronic hemodialysis. The goal is to see how the drug behaves in the body and how much it thins the blood, to find a dose that might lower bleeding risks. Participants will take each …

This study follows 100 obese patients starting dialysis to understand why they are less likely to receive a kidney transplant. Researchers will track health changes over two years and compare them to non-obese patients. The goal is to identify barriers and improve access to trans…

This study is looking for certain cells in the blood of people with 9 types of advanced cancers that have spread. Researchers will take one blood sample from each of 450 participants before they start a new treatment. They will use two different lab methods to see if they can fin…

This study creates a registry to collect health information from people with Autosomal Dominant Polycystic Kidney Disease (ADPKD), the most common genetic cause of kidney failure. While ADPKD was once thought to only affect adults, researchers now know it begins in childhood, but…

This study is creating a central database and tissue bank for rare diseases affecting the kidneys and liver, such as ARPKD and Joubert syndrome. Researchers will collect medical information, genetic samples, and tissues from 200 participants to help doctors and scientists better …

This study is gathering information from 400 adults in France diagnosed with membranous nephropathy, a rare kidney condition. Researchers will track how the disease progresses over one year, looking at remission rates and possible environmental or genetic risk factors. The goal i…

This study is for people with rare kidney diseases like Minimal Change Disease, Focal Segmental Glomerulosclerosis, and Membranous Nephropathy. Researchers will collect health information and biological samples from 1,200 participants over many years. The goal is to better unders…

This study measures hip muscle strength in 50 adults on hemodialysis using a handheld device. The goal is to create reference values for lower-limb strength in this group. Researchers will also check how strength relates to handgrip, walking speed, and quality of life.

This study is collecting detailed genetic and health information from 500 people with various cancers, including breast, lung, and leukemia. The goal is to create a shared database that helps researchers develop more personalized treatments. Participants provide samples and data,…

This study is testing whether a blood test that looks at tiny genetic molecules called microRNAs can accurately detect bone problems in people with chronic kidney disease. Currently, doctors rely on a bone biopsy, which is invasive and not practical for most patients. The researc…

This study watches how blood flows to the kidneys in 51 adults having elective minimally invasive abdominal surgery. Researchers use two non-invasive tools—ultrasound and light sensors—to measure kidney function at key times during and after surgery. The goal is to see if these t…

This study observes 1000 people with severe aortic stenosis and kidney disease who are getting a TAVI procedure. Researchers want to see how removing the blocked valve affects the kidneys' response to contrast dye used during the procedure. The goal is to understand if TAVI lower…

This study aims to learn how well heart scans (MRI, ultrasound, PET) can detect and predict outcomes in people with suspected or known inflammatory heart diseases. Researchers will follow 5,000 adults for one year to see how often heart involvement is confirmed and how it affects…

This pilot study is looking at whether levels of a common virus called TTV can help predict how well immunotherapy works in people with advanced kidney cancer. Researchers will measure TTV levels in 20 patients before and during their first immunotherapy treatment. The goal is to…

This study follows 100 adults with end-stage kidney disease who need long-term dialysis but have no working access sites left. Researchers are watching how well the HeRO and Super HeRO grafts perform over two years, checking for infections, blockages, and overall safety. The goal…

This study looks at whether a special ultrasound technique, called shear wave elastography, can predict how well a child's kidney will recover after surgery to fix a blockage. Researchers will measure kidney stiffness before and after surgery in 84 children aged 6 months to 18 ye…

This study is checking how accurate the Dexcom G7 continuous glucose monitor is for patients in the intensive care unit after major abdominal surgery or organ transplant. Researchers will place two sensors on each patient—one that is calibrated and used to guide insulin dosing, a…

This study follows 60 kidney transplant recipients in Denmark to find out how often blood vessel problems cause poor kidney function or hard-to-treat high blood pressure. Participants will get special imaging tests, and if a narrowed artery is found, they may receive balloon trea…

This study tests a new, non-invasive method using calcium isotope ratios in blood to see if the drug cinacalcet improves bone calcium balance in children aged 3-17 who are on dialysis and have secondary hyperparathyroidism. Researchers will measure these ratios before and three m…

This study is creating a large database of health information from 743 adults with HIV/AIDS across Brazil. Researchers will look at how common chronic diseases like heart disease, kidney disease, and cancer are in this group. The goal is to gather data to help improve health poli…

This study is looking at 1,000 liver transplant recipients to see if testing their blood, urine, and tissue samples can detect early signs of chronic kidney disease, acute rejection, or hepatitis C. The goal is to find simple biomarkers that could lead to earlier treatment and fe…

This study is developing an AI system that tracks tumors and organs during radiation therapy without needing physical markers. Researchers will use existing patient data to train and test the AI. If it works, it could help doctors target radiation more accurately. The study invol…

This study follows 500 American Indian adults with early kidney disease to learn how their condition progresses and what factors affect heart health. Researchers will measure kidney function and track heart events like heart attacks and strokes. The goal is to fill knowledge gaps…

This study collects anonymous symptom descriptions from 1,000 adults through an online platform. An AI tool then searches medical literature to see if it can find reliable biological signals in the free-text descriptions. The goal is to test how accurate and consistent the AI's f…

This study looks at why people with chronic kidney disease (CKD) have trouble exercising and often experience high blood pressure during physical activity. Researchers will test whether regular cycling exercise, a drug called Kuvan, or supplements like histidine and beta-alanine …

This study will compare kidney function in 3,000 adults with Crohn's disease or ulcerative colitis to 3,000 adults without these conditions. Participants will provide blood and urine samples and have a kidney ultrasound. The goal is to learn how common kidney problems are in IBD …

This study looks at why people with chronic kidney disease (CKD) have trouble exercising and why their blood pressure rises during activity. Researchers will measure muscle oxygen and acid levels in 110 veterans with and without CKD. The goal is to understand the body's response,…

Many people with chronic kidney disease also have heart disease, but heart procedures like angiograms and surgery can raise the risk of kidney complications. This study tests an online decision aid called 'My Heart and CKD' that helps patients and doctors weigh the benefits and r…

This study is not testing a new treatment. Instead, it aims to collect health information from 40 people with LCAT deficiency, a rare genetic disorder that affects cholesterol and kidney function. Researchers will review medical records, perform blood and urine tests, and track h…

This study is collecting health information, lifestyle data, and biological samples from up to 100,000 adults to help researchers better understand diseases like lupus, celiac disease, and kidney disease. Participants provide data and samples through a direct-to-patient platform.…

This study looks at better ways to check kidney function after acute kidney injury (AKI). Researchers will compare two blood tests (creatinine and cystatin C) to see which is more reliable. They will also interview patients about their recovery experiences and hold workshops to d…

This study looks for better ways to monitor kidney transplant recipients for signs of rejection or long-term damage. Researchers will collect blood, urine, and tissue samples from 1000 patients during routine biopsies to find early warning markers. The goal is to replace less sen…

This study looks at how long a person has been on dialysis and how much urine they still make affects bladder size and flexibility. Researchers will measure bladder function in 87 adults with kidney failure who are waiting for a transplant. The goal is to find bladder problems ea…

This study is testing a new ureteroscope that shows surgeons the pressure inside the kidney in real time during stone removal. Researchers want to see if having this information changes how surgeons operate and leads to better outcomes. The study will enroll 80 adults with large …

This study tests two programs to help people aged 75 and older with advanced kidney disease decide on their treatment. One program provides standard information and support, while the other adds a video decision aid and coaching from a specialist. Researchers will compare which a…

This study tests whether community health workers and special training for doctors can help more kidney patients get on the transplant waitlist. Five patients will be assigned to either usual care or extra support from a community health worker who addresses social needs like hou…

This study looks at whether a new type of dialysis filter (medium cut-off dialyzer) helps kidney patients live longer and have fewer complications compared to standard filters. Researchers will review medical records from 1,000 adults on maintenance dialysis. The study is observa…

This study looks at whether special diets—like a fasting-mimicking diet, a ketogenic diet, or a low-sulfur diet—can change the molecular makeup of kidney tissue before living donation. Researchers will analyze proteins, fats, and genetic material in kidney biopsies from 80 donors…

This study is tracking up to 2,000 people with autosomal dominant polycystic kidney disease (ADPKD) who are taking or considering tolvaptan. Researchers will collect real-world data on dosing, side effects, and kidney function over time. The goal is to understand how the drug is …

This study is collecting medical information and biological samples (like blood, urine, and kidney tissue) from 300 people with FSGS or MCD who have had or will have a kidney transplant. The goal is to build a research biobank called RESOLVE to help scientists study why these dis…

This observational study is collecting blood and urine samples from 250 people with early-stage polycystic kidney disease (PKD), their unaffected family members, and healthy volunteers. The goal is to create a biobank that researchers can use to find biological markers of disease…

This study will track 1,200 adults in semi-rural Tanzania to find out how common chronic kidney disease (CKD) is and what factors increase the risk. Participants will have blood and urine tests at the start, after 90 days, and again after one year. The goal is to create better wa…

This study is creating a large database of 8,000 adults with heart, kidney, or metabolic diseases to track their health over up to 5 years. Researchers will collect medical records, imaging, and lab data to understand how these conditions interact and affect long-term outcomes. T…

This study follows children with chronic kidney disease to track how their condition changes over time and what factors affect their health. Researchers will monitor kidney function, heart health, and other outcomes in about 1,300 participants. The goal is to better understand th…

This study asks 500 adults with advanced kidney disease to complete a questionnaire that presents different dialysis options. Patients choose between home dialysis (with a financial allowance) and in-center dialysis (without the allowance) 13 times, each with varying features lik…

This study uses data from 4,700 kidney cancer patients treated at a single hospital over 12 years. The goal is to create a new model that better predicts how the disease will progress, especially for patients with a tumor thrombus. Researchers will also test whether using this mo…

This study aims to better understand acute kidney injury and chronic kidney disease by analyzing kidney tissue from 1000 volunteers. Researchers will use advanced technology to identify different disease types and find new targets for therapies. The goal is to pave the way for pe…

This study is building a special collection of blood and urine samples from 800 adults with sickle cell disease or sickle cell trait, along with some healthy volunteers. Researchers will use these samples and medical records to learn how kidney disease starts and gets worse in pe…

This study follows 2000 Chinese patients with IgA nephropathy who still have relatively good kidney function. Researchers will test their blood and urine for biomarkers that might predict if and when their kidney disease gets worse. No new treatment is being tested; the goal is t…

This study tests a modified blood-thinning protocol using citrate during continuous kidney replacement therapy in 43 ICU patients with acute kidney injury. The goal is to see if the new method reduces loss of important minerals like potassium and magnesium, cutting down on the ne…

This study follows 50 adults with localized kidney cancer who have laparoscopic nephrectomy as an outpatient (no overnight stay). Researchers will record any complications that happen within the first month after surgery, such as pain, infection, or bleeding. The goal is to bette…

This study looks at whether kidney failure changes how well the flu vaccine works in people on dialysis. Researchers will compare the immune response of 146 dialysis patients and healthy volunteers after they get the flu shot. Participants will give blood samples over several mon…

This study follows 350 adults with major injuries admitted to intensive care. Doctors will use a non-invasive bedside ultrasound to check blood flow in the kidneys and liver at several time points. The goal is to see if certain ultrasound patterns are linked to acute kidney injur…