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Scientists launch massive tumor repository to unlock cancer secrets

NCT ID NCT01109394

Knowledge-focused Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 04, 2026 · Updated 12 times

Summary

This study collects extra blood, urine, and tumor samples from children and adults with certain cancers to build a large tissue repository. Researchers will analyze these samples to learn more about the genetic and molecular makeup of these tumors. The goal is to support future studies that could lead to better treatments or diagnostic tools. No new treatments are being tested in this study.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this repository could help researchers better understand childhood cancers and find new ways to diagnose or treat them in the future.
What could go wrong
This is an observational study that does not test any treatment. It only collects samples for future research, so there is no direct benefit to participants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 6,035 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2010

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Subjects with a diagnosis of any tumor or malignancy regardless of age, or without malignancy undergoing surgery, other treatment or normal well visit. Suspicion of a familial premalignant condition. Biological relatives of a subject with a pediatric or adult tumor or malignancy or with suspected familial cancer syndrome.

Ages

4 weeks and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* SUBJECT INCLUSION CRITERIA: Pediatric or adult subjects with one of the following: * Diagnosis of any tumor, malignancy, pre-malignant disorder, or suspected premalignant familial syndromes, regardless, of patient age; * Biological relatives of any patient with a tumor, malignancy, pre-malignant disorder, or suspected familial pre-malignant syndrome, regardless of patient age or the diagnosis of an adult malignancy or pre-malignant disorder; * Healthy Volunteer without history of malignancy nor a family member currently being treated for cancer who are undergoing surgery, treatment or during well visits; * Biospecimens can be collected with minimal additional risk to the subject during sampling or procedures required for routine patient care. * Human samples, specimens and data collected on IRB approved protocols that are now closed * Ability of subject, Legally Authorized Representative (LAR), or parent/legal guardian of children \<=18 to understand and be willing to sign an IRB-approved informed consent document that permits the use of the tumor and other samples for genomic-based molecular characterization projects. Inclusion Criteria for Social and Behavioral Outcome Interviews: * Parent/caregiver of a participating pediatric or adult patient who is being treated for, or who has previously been treated for any form of pediatric cancer. * Must be able to give consent and sign the informed consent document. * Able to understand the English language. EXCLUSION CRITERIA: None

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Conditions

The condition(s) this trial relates to.

cancer central nervous system cancer central nervous system neoplasm childhood malignant neoplasm endocrine gland neoplasm hereditary neoplastic syndrome kidney cancer leukemia neoplasm neuroblastoma neuroendocrine neoplasm precancerous condition renal carcinoma retinoblastoma sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endocrine tumors Neuroblastoma Renal cancer Retinoblastoma Sarcoma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Carolinas Medical Center/Levine Children's Hospital

    WITHDRAWN

    Charlotte, North Carolina, 28203, United States

  • Children's Hospital of Orange County (CHOC Children's)

    WITHDRAWN

    Orange, Florida, 92613, United States

  • Children's National Medical Center

    COMPLETED

    Washington D.C., District of Columbia, 20010, United States

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

  • Tisch Cancer Institute, Mount Sinai Medical Center

    WITHDRAWN

    New York, New York, 10029-0574, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.