SARCOMA

This study is testing a new drug called PEEL-224, given alongside two existing cancer drugs, in adolescents and young adults whose sarcomas have returned or not responded to standard treatments. The goal is to find a safe dose and see if this three-drug combination can shrink tum…

This early-stage trial is testing a new type of targeted radiation therapy for people with advanced solid tumors that have stopped responding to standard treatments. The therapy uses a radioactive drug designed to seek out and deliver a powerful, short-range form of radiation dir…

This study is testing a minimally invasive procedure called transarterial chemoembolization (TACE) for patients with advanced lung cancer or lung metastases that have stopped responding to standard treatments. The procedure works by injecting chemotherapy directly into the artery…

This study is observing how well the drug T-DXd works for people with advanced HER2-positive cancers who have already tried other treatments and have no good options left. It will follow about 100 patients in real-world US clinics to see how their tumors respond and how long the …

This study is testing whether a cancer drug called atezolizumab works better when given to people whose tumor DNA analysis suggests they might respond to it. It will enroll about 200 adults with various advanced, incurable solid tumors. Participants will receive the drug every th…

This early-stage study is testing the safety of a two-part treatment for advanced sarcomas that have stopped responding to standard therapies. Doctors take a patient's own immune cells, genetically modify them to recognize and attack cancer cells, and then infuse them back. These…

This study is testing a new type of immune cell therapy called EBNK-001 for people with advanced solid tumors that have stopped responding to standard treatments. Participants receive 'off-the-shelf' natural killer (NK) cells from a donor after a short course of chemotherapy, wit…

This is an early-stage safety study testing a new type of personalized cell therapy for patients with advanced solid tumors. Doctors will collect a patient's own immune cells, genetically modify them to better recognize a specific cancer marker called NY-ESO-1, and then infuse th…

This Danish study is testing whether a fluorescent dye can help surgeons see sarcoma tumor edges better during surgery. The goal is to remove more of the cancerous tissue in the first operation, reducing the need for follow-up surgeries. About 90 adults with intermediate-to-high …

This study is testing the safety and effectiveness of a new investigational drug called GI-101 for people with advanced or metastatic solid tumors. The drug is designed to work in two ways to help the immune system fight cancer. Researchers will test it alone and in combination w…

This study is testing whether an existing cancer drug called zanidatamab can help treat several different types of advanced solid tumors that share a specific genetic alteration in the HER2 gene. The trial will enroll 105 adults with advanced endometrial, colorectal, head & neck,…

This early-stage trial is testing a new drug called CRD3874-SI in people with advanced cancers that have spread or returned after previous treatments. Researchers will first find the highest safe dose, then test that dose in patients with specific cancers like sarcoma and Merkel …

This study is testing whether adding an experimental immunotherapy drug called retifanlimab to standard chemotherapy (gemcitabine and docetaxel) is safe and more effective for treating advanced soft tissue sarcoma. The goal is to see if the combination can better control the canc…

This early-stage trial is testing the safety of a new combination treatment for children and young adults (up to age 21) whose bone or soft tissue cancers (sarcomas) have come back or haven't responded to standard treatments. The approach combines a short, intense course of radia…

This is the first study in people testing a new cancer drug called MGC026. It aims to find a safe dose and see if the drug can help shrink tumors in adults with advanced solid tumors that have not responded to other treatments. The study will also check how the drug moves through…

This study is testing a special radiation technique called GRID for people with soft tissue sarcoma in their arms or legs. The goal is to see if adding a single dose of GRID before standard radiation and surgery can better shrink the tumor without causing more serious wound heali…

This study is testing if a special single-use wound dressing can help prevent healing problems after surgery to remove limb sarcoma (a type of cancer). The dressing uses gentle suction to help the wound close. Researchers will compare this new dressing to standard gauze bandages …

This study is testing whether a special pre-surgery rehabilitation program helps patients with limb sarcoma recover better after their operation. The program involves a team of health professionals who work with patients before surgery to improve their strength and function. Rese…

This study is testing whether a new, precise radiation planning technique can protect the ovaries in young women (ages 18-50) receiving pelvic radiation for cancers like uterine or rectal cancer. The goal is to prevent radiation from causing early menopause, which can lead to ser…

This study is testing whether a drug called nivolumab can be safely given after a half-matched bone marrow transplant to help prevent cancer from coming back. It involves children and young adults up to age 50 who have high-risk, recurrent, or hard-to-treat sarcomas and have alre…

This early-stage study is testing the safety and early effectiveness of an experimental cancer treatment called T3011. The treatment is injected directly into tumors and is being tested both alone and combined with an existing immunotherapy drug (pembrolizumab) in people with adv…

This is a first-in-human study to test the safety and find the right dose of a new oral drug, OKN4395, for people with advanced solid tumors. The trial will give the drug alone and combined with an existing immunotherapy (pembrolizumab) to about 166 participants with cancers like…

This study is testing a new type of radiation therapy called lattice radiation (LRT) for people with large cancer tumors that have spread to soft tissues. It compares LRT to standard radiation to see which is better at shrinking tumors and attracting immune cells to fight the can…

This study is testing whether combining two drugs, ATRA and cemiplimab, can help control advanced leiomyosarcoma, a type of cancer, in patients whose disease has worsened despite standard treatments. It will enroll 16 adults to see if the combination can shrink tumors or stop the…

This program provides the investigational drug selinexor to patients with certain cancers who have run out of standard treatment options and don't qualify for ongoing clinical trials. It allows doctors to request the drug for eligible patients before it receives full regulatory a…

This study compares two shorter radiation schedules before surgery for soft tissue sarcoma. Patients will receive either 14 treatments over 3 weeks or just 5 treatments over 1 week before their operation. Researchers want to see if the much shorter 5-treatment approach works as w…

This program provides access to an experimental treatment called DNG64-CAR-V for patients with advanced pancreatic cancer, sarcoma, or breast cancer who have no other effective options left. The treatment uses a specially engineered virus designed to target and kill cancer cells …

This study is testing a new three-drug combination for people with advanced bone or soft tissue sarcomas that have worsened after initial treatment. It aims to see if this combination can better control tumor growth while possibly causing fewer side effects than current options. …

This study is testing whether giving a lower dose of the chemotherapy drug doxorubicin weekly, instead of the standard higher dose every few weeks, can help control advanced sarcoma in patients aged 65-100 while causing fewer side effects. Researchers will see if this gentler sch…

This first-in-human study is testing an experimental cancer treatment called IDOV-Immune, which uses a modified virus designed to infect and destroy cancer cells while boosting the immune system. The trial aims to find the safest dose and check for early signs that the treatment …

This is the first human study of an experimental drug called SLV-154 for people with advanced solid tumors that have spread. The main goal is to find the highest safe dose and understand how the body processes the drug. About 70 adults with one of ten specific advanced cancers wh…

This is the first study in people to test a new cancer drug called KIVU-107. The main goal is to find a safe dose and see how well the body handles it. It is for adults with advanced solid tumors that have spread or cannot be removed by surgery and have stopped responding to avai…

This early-stage study is testing a drug called TURALIO in children and young adults (ages 3-35) whose cancers have returned or not responded to standard treatments. The main goals are to find the highest safe dose of the drug and understand its side effects. Participants will ta…

This study is testing whether a new combination treatment can safely slow the growth of advanced sarcoma tumors in an arm or leg. It combines a targeted limb chemotherapy procedure with a drug that helps the immune system fight cancer. The goal is to see if this approach can keep…

This study is testing whether the immunotherapy drug pembrolizumab can help control five specific types of ultra-rare sarcomas that have few treatment options. It will enroll 32 adults whose cancer has returned or spread despite prior treatments. The drug works by releasing the i…

This study is testing an experimental oral drug, ABSK043, in about 20 adults with advanced forms of a rare cancer called angiogenic sarcoma. The drug works by blocking a protein that can hide cancer cells from the immune system, potentially helping the body fight the cancer. The …

This study is testing a new blood test to see if it can detect many different types of cancer early, before symptoms appear. It will involve 7,000 people, both with and without cancer, to see if the test can spot cancer signals and identify where in the body the cancer started. T…

This study is testing whether smartwatch technology and artificial intelligence can reliably monitor heart function in people who have survived lymphoma or sarcoma. Researchers want to see if these wearable devices can detect early signs of heart problems caused by cancer treatme…

This study aims to collect blood and tissue samples to help develop a single blood test that can detect many different cancers early. Researchers will enroll 2,000 people, including those with cancer and those without, to create a reference set for testing. The goal is to validat…

This study is testing if a safe, fluorescent dye can help surgeons better see if any cancer cells are left behind during sarcoma removal surgery. Currently, surgeons send small samples to a lab during surgery, which takes time and only checks specific spots. Researchers will inje…

This study is testing a new imaging substance called [18F]FAPI-74 to see if it can detect certain cancers better than current standard scans. It will involve 320 adults with one of 10 specific cancer types who are scheduled for treatment. Participants will receive both the new tr…

This study is testing a checklist tool designed to help people with sarcoma plan for their future mobility needs. Researchers want to see if using this planning tool is helpful and easy for patients and their caregivers to use. The goal is to improve quality of life by helping pe…

This study is testing a digital health program called AYA STEPS, designed to help young adult cancer survivors manage common symptoms like pain, fatigue, and emotional distress after their main cancer treatment is over. The program teaches skills to help survivors feel more confi…

This study is testing whether a supervised exercise program helps children and young adults with sarcoma better tolerate their chemotherapy treatments. Researchers will enroll 40 participants aged 12-39 who are starting chemotherapy and haven't been regularly active. The goal is …

This study is testing whether a drug called riluzole can help prevent the memory and thinking problems often called 'chemo brain' in people receiving chemotherapy for various cancers. About 24 adult patients will be randomly assigned to receive either riluzole or a placebo pill w…

This study aims to understand how personalized chemotherapy given before surgery works for patients with high-risk soft tissue sarcoma. Researchers will collect and analyze tissue samples from 800 patients, comparing those who receive chemotherapy before surgery to those who have…

This study aims to understand how sarcoma patients recover after surgery by using a smartphone app. The app will ask patients questions about their health and quality of life, and it will also track their daily movement, like step count. Researchers want to see if this app gives …

This study aims to collect and store tumor tissue and blood samples from patients with several types of cancer. The goal is to create a biobank, or a library of samples, to help researchers better understand how cancer cells, their surrounding environment, and the body's immune s…

This study is creating a large national database to collect information about sarcoma patients in France. It aims to understand how patients are treated and what factors affect their survival and time between treatments. The study does not test new treatments; it only gathers exi…

This study aims to create tiny, lab-grown models called 'immune organoids' from the cells of children and young adults with cancer. Researchers will use these models to study how the immune system interacts with tumors like brain cancer, kidney cancer, neuroblastoma, and sarcoma.…

This study is creating a large registry to track children and young adults receiving radiation therapy for sarcoma or brain tumors. It aims to collect detailed treatment and health data to understand long-term survival and side effects. The goal is to compare outcomes between dif…

This study aims to understand the long-term quality of life, medical care experiences, and unmet needs of people who have survived sarcoma (a rare cancer) for five years or more. Researchers will survey 1,600 survivors in Germany and conduct in-depth interviews to gather detailed…

This study aims to understand how young people who have survived sarcoma experience chronic pain and use opioid medications. Researchers will ask 40 participants to complete brief daily surveys on their smartphones for three months to track their pain levels, opioid use, and rela…

This study is testing a blood test that looks for tiny pieces of tumor DNA to see if it can detect cancer recurrence earlier than standard scans. It aims to enroll 100 adults, including people with various solid tumors and healthy volunteers. The goal is to gather information tha…

This study aims to learn how a sarcoma diagnosis and its treatments affect people's health and quality of life over many years. It will follow 2,100 survivors of all ages, collecting health data, activity information from wearable devices, and survey answers. The goal is to ident…

This study is testing whether a simple blood test can detect sarcoma DNA, which could help doctors diagnose and monitor the disease without needing repeated tumor biopsies. Researchers will collect blood samples from 50 sarcoma patients at different stages of treatment to look fo…

This study is testing a new blood test to find tiny pieces of cancer DNA from sarcoma, a type of bone or soft tissue cancer. It will enroll 300 patients of all ages, including children, who have or are suspected of having sarcoma. The goal is to see if this 'liquid biopsy' can he…

This study analyzes cancer patients' tumor tissue and blood samples to identify specific genetic changes in their cancer. The goal is to create a detailed database of cancer mutations and use that information to match patients with the most relevant treatment options and clinical…

This study aims to understand how children and their families recover from the stress of major cancer surgery. Researchers will have children and a caregiver wear smartwatches, answer questionnaires, and provide extra blood samples during routine draws to look for patterns linked…

This study is testing whether a short educational video can be a good alternative to standard genetic counseling for patients with certain cancers. Researchers want to see if the video helps people understand their risk for hereditary cancers and makes genetic testing information…

This study is building a large, long-term database of health information and biological samples from people with cancer, people at risk for cancer, and healthy volunteers. The goal is to collect this data to help researchers better understand what causes cancer and how to prevent…

This study is creating a large national registry to collect information about sarcoma, a rare type of cancer, and related tumors in Germany. It aims to enroll up to 9,000 adult patients to better understand how these cancers are currently treated and what outcomes patients experi…

This study is testing whether educational videos can help sarcoma patients and their caregivers better understand their disease and treatment options before their first oncology appointment. Participants will watch four videos about sarcoma and complete surveys before and after t…

This study aims to collect and store blood, tumor, and tissue samples from children and adults with cancer to create a large research repository. The goal is to help scientists better understand cancer biology by studying these samples in the lab. Participants provide samples onl…