SARCOMA

This study tests two drugs—nivolumab alone or with azacitidine—in people whose osteosarcoma (a type of bone cancer) has come back and can be surgically removed. The goal is to see if the treatment is safe and helps keep the cancer from returning after surgery. About 21 adults and…

This study tests a new treatment for people with advanced sarcoma, a type of cancer. Researchers take the patient's own immune cells (T cells) and add a new gene to help them recognize and attack cancer cells that have a protein called HER2. Before the cells are given back, some …

This study tests whether combining two drugs, NKTR-214 and nivolumab, can shrink or control advanced sarcoma that has spread. About 88 people aged 12 and older with locally advanced or metastatic sarcoma will receive the combination. The main goal is to see how many patients' tum…

This study tests whether combining T-VEC (a virus that attacks cancer cells) with pembrolizumab (an immunotherapy) can shrink tumors in people with advanced sarcoma that cannot be removed by surgery. About 41 adults with certain sarcoma types will receive both drugs. The main goa…

This early-phase study tested the safety and best dose of adding bevacizumab to standard chemotherapy and radiation for people with soft tissue sarcoma that can be removed by surgery. The goal is to see if this combination can reduce the chance of the cancer returning after surge…

This study tested a combination of two chemotherapy drugs, irinotecan and carboplatin, as the first treatment for children and adults newly diagnosed with intermediate- or high-risk rhabdomyosarcoma, a type of muscle cancer. The goal was to see if this drug pair could shrink tumo…

This study tests whether using heat (thermal ablation) followed by very precise radiation (stereotactic radiosurgery) can better control cancer that has spread to the spine and is pressing on the spinal cord. About 60 adults with various solid tumors (like lung, breast, or prosta…

This study tests a new drug called 9-ING-41, given alone or with chemotherapy, in adults with advanced cancers that have stopped responding to standard treatments. The goal is to see if the drug is safe and can help control the cancer. About 350 people with various cancer types, …

This early-stage study tests whether adding high-dose vitamin C to a standard chemotherapy drug (gemcitabine) can help control advanced soft tissue or bone sarcomas that cannot be removed by surgery or have spread. About 30 adults will receive the combination intravenously. The m…

This study tests a combination of two drugs, epacadostat and pembrolizumab, in people with advanced sarcoma that has spread or cannot be removed by surgery. The goal is to see if the combo can shrink tumors or stop them from growing. About 30 adults who have already tried at leas…

This pilot study looks at whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve wound healing in adults with soft tissue sarcoma who had radiation and surgery. About 20 participants will be randomly assigned to receive either the oxygen th…

This early-phase trial tests the safety and best dose of combining two drugs—ziv-aflibercept and pembrolizumab—in people with advanced solid tumors that have spread. Ziv-aflibercept cuts off the tumor's blood supply, while pembrolizumab helps the immune system fight cancer. The s…

This study follows 100 sarcoma patients who receive a permanent radiation implant called CivaSheet during surgery. The implant delivers targeted radiation to kill remaining cancer cells. Researchers track safety, side effects, and tumor recurrence over 5 years. Participants must …

This study tests an experimental drug called HFB200301, given alone or with another drug (tislelizumab), in adults with advanced solid tumors like stomach, kidney, or lung cancer. The goal is to find a safe dose and see how well people tolerate it. About 72 participants will take…

This study tests whether combining two drugs (etrumadenant and zimberelimab) can shrink tumors or slow the disease in people with advanced dedifferentiated liposarcoma that has returned, spread, or cannot be removed by surgery. About 16 adults with this rare soft-tissue cancer wi…

This study compares two common blood thinners—aspirin and low molecular weight heparin—to see which works better at preventing dangerous blood clots after surgery for bone or soft tissue cancer in the pelvis or leg. About 2,868 adults who have had or will have such surgery will b…

This study is for people aged 1 to 30 who are newly diagnosed with a rare cancer called desmoplastic small round cell tumor (DSRCT). Researchers are adding three drugs (irinotecan, temozolomide, and bevacizumab) to the usual chemotherapy to see if the combination is safe and tole…

This study tests an inhaled form of a protein called interleukin-2 (IL-2) to treat cancers that have spread to the lungs, such as melanoma, kidney cancer, and sarcoma. The goal is to find the safest dose and see if it can shrink tumors. About 70 adults with advanced cancer and lu…

This early-phase study tests a new type of proton therapy called ProGRID for people with large tumors (over 7 cm) that are hard to treat. The goal is to see if the treatment is safe and can be delivered successfully. About 11 adults with sarcoma or melanoma are taking part.

This study compares two ways of giving high-dose radiation to people whose cancer has spread to bones, spine, soft tissue, or lymph nodes. One group gets a single large dose in one day, the other gets a slightly higher total dose spread over three days. The goal is to see which s…

This study tests a radioactive antibody called 124I-Hu3F8 to see how it moves through the body and attaches to tumors in people with melanoma, neuroblastoma, or sarcoma. Seven participants received the antibody followed by PET/CT scans at several time points. The goal is to under…

This study looks for brand-new gene changes that appear in a child but not in their parents, which might raise the risk of certain cancers. Researchers will compare DNA from cancer patients and their healthy parents to spot these changes. The goal is to better understand cancer r…

This study creates a large registry to collect information from nearly 58,000 children diagnosed with cancer or similar conditions in the U.S. and Canada. The goal is to help researchers study patterns, causes, and characteristics of childhood cancer. Parents provide details abou…

This study explores whether a special type of radiation therapy can protect the ovaries of young women (ages 18-50) undergoing pelvic radiation for cancers like uterine, rectal, or cervical cancer. The goal is to see if doctors can consistently see the ovaries on daily scans and …

This study collects leftover tissue, blood, and other body fluids from up to 6,000 people with benign or malignant tumors of the soft tissue, gastrointestinal tract, or abdomen. Researchers will use these samples in future lab studies to learn more about what causes these cancers…

This study screens up to 1,150 adults with advanced solid tumors (like head and neck, cervical, or lung cancer) to check their genetic markers. Researchers look for specific HLA types and tumor antigens to see if patients might qualify for future cell therapy trials. No treatment…

This study looks at whether a special PET scan combined with MRI can measure low oxygen levels (hypoxia) in soft tissue sarcoma tumors. About 70 adults with high-risk sarcoma will receive an injection of a radioactive tracer called FAZA before their standard treatment. The goal i…

This study looks back at the medical records of 250 sarcoma patients who received immunotherapy at Memorial Sloan Kettering Cancer Center. The goal is to gather information and better understand how well these treatments work. No new treatments are given; the study simply collect…