SARCOMA

This study tested the safety of combining two drugs, pembrolizumab and gemcitabine, in patients with advanced forms of sarcoma called leiomyosarcoma and undifferentiated pleomorphic sarcoma. The main goal was to find the highest dose of gemcitabine that could be safely given with…

This study tested whether combining an immunotherapy drug (MK3475) with a low-dose chemotherapy (cyclophosphamide) could help control advanced sarcomas. It involved 129 adults whose cancer had progressed despite prior treatments. The main goal was to see if the combination could …

This early-stage trial tested whether a personalized immune cell therapy is safe for young adults with advanced soft tissue sarcoma. Doctors collected each patient's own tumor-fighting immune cells, grew them in a lab, and then infused them back after a brief chemotherapy treatme…

This early-stage study tested a new immune therapy for children and young adults whose solid tumors did not respond to standard treatments. Doctors collected and grew a patient's own 'natural killer' (NK) immune cells, then gave them back to the patient to fight the cancer. The m…

This study tested a smartphone app called WeCanManage, designed to help cancer survivors manage long-term disabilities and symptoms after treatment. Twenty survivors of breast, head/neck, or sarcoma cancers tried the app to see if it was easy to use and helpful. The main goal was…

This study tested a mobile app program designed to help young adult cancer survivors manage their health after treatment. It aimed to reduce cancer-related distress and improve how well survivors follow recommended health check-ups. Researchers compared the app to standard online…

This study used computer programs to analyze old medical records from 700 patients with two rare and aggressive bone cancers, osteosarcoma and Ewing's sarcoma. The goal was to look for patterns in the data that could help predict a patient's chances of survival. No new treatments…

This study tested whether a digital dashboard that shows patients and doctors how a sarcoma tumor changes on scans over time helps patients understand their disease better and makes clinic visits more efficient. 92 adults with sarcoma were randomly assigned to either use the dash…

This study aimed to understand when and how the body's inflammatory chemicals change during a common cancer treatment called immune checkpoint inhibitor therapy. Researchers followed 98 adults with cancers like melanoma and lung cancer, taking their blood at specific times after …

This study aimed to understand why older people are more likely to get certain cancers. Researchers collected small samples of healthy skin from 58 people in two age groups (18-40 and 55+) who were having surgery for a different condition. They analyzed these samples in a lab to …

This study looked back at the medical records of over 2,000 adults with advanced soft tissue sarcoma to understand what treatments they received in real-world clinics and how long they lived. Researchers analyzed patterns of care, including chemotherapy and off-label drug use, to…