SARCOMA

This early-phase study tested whether combining the immunotherapy drug pembrolizumab with the chemotherapy gemcitabine is safe for people with two rare types of soft tissue sarcoma (leiomyosarcoma and undifferentiated pleomorphic sarcoma). 25 participants with advanced or inopera…

This study tested the drug regorafenib in 219 people with soft tissue sarcoma that had spread and was no longer responding to standard chemotherapy. The goal was to see if the drug could slow down the cancer's growth. Participants were randomly assigned to receive either regorafe…

This study tested a new drug called CBX-12 in 69 adults with advanced solid tumors (like ovarian, lung, breast, or colon cancer) that had stopped responding to standard treatments. The goal was to find a safe dose and see if the drug could shrink tumors. The study was completed, …

This study tested whether adding the immunotherapy drug durvalumab to standard chemotherapy (doxorubicin) could help people with advanced soft tissue sarcoma that has spread or come back. The trial included 44 adults with confirmed sarcoma. The main goal was to check safety and h…

This study tested a combination of two drugs, MK3475 and low-dose cyclophosphamide, in 129 people with advanced sarcomas that could not be removed by surgery or had spread. The goal was to see if the treatment could shrink tumors or stop them from growing for at least 6 months. T…

This early-phase trial tested a treatment that uses a patient's own immune cells (called TILs) to fight soft tissue sarcoma. Nine young adults received chemotherapy to prepare their bodies, then an infusion of these specially grown immune cells plus high-dose IL-2. The main goal …

This early-phase study tested whether immune cells called natural killer (NK) cells could be safely given to children and young adults with solid tumors that did not respond to standard treatments. Sixteen participants received their own activated NK cells, with or without a prot…

This study tested whether artificial intelligence (AI) can help doctors tell the difference between cancerous and non-cancerous soft tissue lumps using MRI scans. 186 patients with soft tissue masses had extra MRI images taken. The AI was trained to identify which lumps were sarc…

This study tested a mobile app called WeCanManage designed to help cancer survivors with disabilities manage long-term effects of their illness and treatment. Twenty adults who had breast cancer, head and neck cancer, or sarcoma participated. The goal was to see if the app was ea…

This study looked back at the medical records of over 2,100 adults with advanced soft tissue sarcoma to see what treatments they actually received and how long they lived. Researchers focused on how often patients got chemotherapy, surgery for their tumors, or drugs not officiall…

This study looked back at the electronic health records of 700 people diagnosed with osteosarcoma or Ewing's sarcoma between 2003 and 2012. Researchers used machine learning to find patterns in the data, focusing on how long patients survived. The goal was to learn more about the…

This study looked back at medical records of 207 adults who died from sarcoma to understand how they were cared for by palliative teams. Researchers tracked things like hospital stays in palliative care units, visits with palliative doctors, and use of chemotherapy in the final w…

This study looked at how inflammation changes in the blood of people receiving immunotherapy for cancer. Researchers measured inflammatory markers to understand and possibly predict side effects. 98 adults with cancers like melanoma or lung cancer took part. The goal was to gathe…

This study tested a program designed to help adolescent and young adult cancer survivors (ages 15-39) find healthcare resources, learn self-care skills, and get support. The goal was to see if the program could reduce cancer-related distress and help survivors follow recommended …

This study involved 654 adults with sarcoma to understand how to better measure their health-related quality of life. Researchers interviewed patients and healthcare professionals to identify the most important issues. The goal is to create a questionnaire that captures the uniqu…

This study looked at healthy skin tissue from 58 adults in two age groups (18-40 and 55+) to understand why cancer risk rises with age. Researchers checked for signs of cell aging and DNA damage that might make cells more likely to turn cancerous. The goal was to learn more about…

This study tested a simple checklist tool to help people with sarcoma think about and plan for their future mobility needs, like getting around the house or dressing. The study included 27 patients who had limb surgery or advanced sarcoma. The goal was to see if the checklist was…

This study tested a tool called an oncology dashboard that shows key information about a patient's cancer treatment to the patient, their doctor, and radiologist. The goal was to see if it helps patients understand their disease and helps the medical team work more efficiently. T…

This study analyzed tumor and blood samples from 84 patients with brain cancer, meningioma, or sarcoma to find biomarkers that predict how well proton beam therapy works. The goal is to identify genetic or immune markers linked to tumor shrinkage six months after treatment. This …