Sarcoma

This trial tests whether a coordinated care pathway, involving oncologists, geriatricians, pharmacists, and pharmacologists, can reduce severe side effects in adults over 70 with certain cancers who are starting oral therapy. Participants receive extra monitoring, including blood…

This early-stage trial is testing a combination of specially engineered immune cells (CAR T cells) and a vaccine for people with sarcoma that has come back or spread. The goal is to see if the treatment is safe and can help shrink tumors. About 20 participants will receive the th…

This trial tests a 4th-generation safety-engineered CAR T cell therapy for people with relapsed or late-stage sarcomas, including osteosarcoma and Ewing sarcoma. Participants receive a single infusion of these immune cells designed to target and attack sarcoma cells. The study ai…

This phase 2 trial is testing whether lifileucel, a therapy made from a patient's own tumor-infiltrating lymphocytes (immune cells), can shrink tumors in adults with advanced soft tissue sarcoma. Participants will have their tumor removed to create the personalized therapy, then …

This study tests whether leaving the needle biopsy track in place during sarcoma surgery is as safe as removing it. The goal is to see if avoiding extra tissue removal can lower complications without increasing the chance of the cancer coming back. About 3,300 people with sarcoma…

This phase 2 trial tests whether adding a drug called liposomal transcrocetin (L-TC) to short-course radiation before surgery can kill more cancer cells in people with soft-tissue sarcoma. About 42 adults with localized or locally advanced sarcoma will be randomly assigned to rec…

This early-phase trial tests a new drug called BOLD-100 combined with standard chemotherapy (doxorubicin) in 32 people with advanced soft tissue sarcomas that cannot be removed by surgery or have spread. The goal is to find the safest dose and see if the combination can shrink tu…

This study tests whether a green dye called indocyanine green (ICG) can help surgeons find sentinel lymph nodes—the first nodes where cancer might spread—in children with solid tumors. Ten children under 18 will get the dye injected during surgery, and doctors will check if it li…

This study tests whether a special MRI sequence, called 'pseudo-scanner,' can accurately map bone tumors and guide surgery, potentially replacing CT scans. About 122 people with bone sarcoma who need surgery will participate. If successful, this approach could reduce patients' ex…

This trial tests whether doing light-to-moderate aerobic exercise during chemotherapy infusions is safe and practical for people with sarcoma (a type of cancer). Participants will exercise in 15-minute intervals during each infusion, and researchers will also check if exercise te…

This study tests whether a single hypnosis session during chemotherapy can reduce anxiety and other side effects like nausea in young people with cancer. It includes 70 participants aged 15-49 with sarcoma, germ cell tumors, or breast cancer. Researchers will compare anxiety leve…

This study tests whether adding acupuncture to standard care can lower the risk of hospital stays for a serious chemo side effect called febrile neutropenia (fever with low white blood cells). About 60 adults with sarcoma receiving doxorubicin chemotherapy will be randomly assign…

This study is testing a new AI chatbot designed to answer questions from people with sarcoma, a type of cancer. The chatbot will be available 24/7 by voice or text for one month. Researchers want to see if using the chatbot helps patients feel more satisfied with the information …

This study will test whether immunotherapy drugs (immune checkpoint inhibitors) change how the liver processes other medications. About 80 adults with various cancers who are starting immunotherapy will take a low-dose cocktail of 7 common drugs. Researchers will measure drug lev…

This study is testing a mobile app called my.naviGATE for teens and young adults (ages 15-24) who have finished cancer treatment. The app provides personalized education, peer support, and tracks how patients are doing. Researchers want to see if the app helps patients feel more …

This very small study will test whether it is practical to add three extra MRI scans during standard radiation treatment for soft tissue sarcoma. Only 5 adults will take part. The goal is simply to see if the extra scans can be completed, not to change treatment or improve outcom…