SARCOMA

This study tests a new medicine called Risvutatug Rezetecan (Ris-Rez) in adolescents and adults with advanced bone or soft tissue sarcomas that have returned or spread and cannot be removed by surgery. The goal is to see if the drug can shrink tumors or slow cancer growth, and to…

This study tests a combination of three drugs (selumetinib, ZEN-3694, and durvalumab) in people with advanced sarcomas, including a type called MPNST. The goal is to see if the combination is safe and can shrink tumors or stop them from growing. About 41 adults with sarcomas that…

This early-phase trial tests a new radioactive drug (177Lu-INN805) in 10 adults with advanced solid tumors like head & neck, thyroid, lung, breast, or sarcoma cancer who have not responded to standard treatments. The drug is given every 6 weeks for up to 4 cycles to find the safe…

This early-phase study tests a new type of cell therapy for people with certain cancers (lymphoma, myeloma, and solid tumors like kidney cancer and sarcoma) that have returned or not responded to standard treatments. The therapy uses the patient's own T cells, which are modified …

This early-phase trial tests a new drug called BOLD-100 combined with standard chemotherapy (doxorubicin) in people with advanced soft tissue sarcoma that cannot be removed by surgery. The main goals are to find the safest dose and see how well the combination controls the cancer…

This study tests whether leaving the needle biopsy tract in place during sarcoma surgery is as safe as removing it. About 3,300 people with extremity sarcoma will be randomly assigned to have the tract removed or not. The goal is to see if skipping removal lowers the chance of ca…

This study tests whether a special MRI technique, called 'pseudo-scanner,' can accurately show bone tumor edges and help plan surgery, just like a CT scan but without radiation. About 122 people with bone sarcoma who need surgery will take part. If successful, this could reduce p…

This study looks at whether adding acupuncture to standard care can lower the chance and length of hospital stays for a serious side effect of chemotherapy called febrile neutropenia (fever with low white blood cells). The study will include 60 adults with sarcoma who are getting…

This study is testing a new AI chatbot designed with help from patients to answer questions about sarcoma. About 78 people with soft tissue sarcoma will use the chatbot for one month to see if it helps them feel more informed and less stressed. The goal is to see if the chatbot i…

This study is testing whether it's possible to do extra MRI scans during standard radiation treatment for soft tissue sarcoma. Five adults will get three additional MRIs (at weeks 1, 3, and 5 of radiation) to see if the extra scans can be completed. The goal is to learn more abou…

This study looks at whether immunotherapy drugs (immune checkpoint inhibitors) change how the liver processes other medications. About 80 adults with certain cancers who are starting immunotherapy will take a mix of 7 common drugs to measure these effects. The goal is to understa…

This study is for young adults (ages 21-45) who had certain cancers as teens or young adults. Researchers are adapting a program that helps patients manage follow-up care and feel more in control of their health. The goal is to see if the program is helpful and practical for use …

This study is testing a mobile app called my.naviGATE for teens and young adults (ages 15-24) who have finished cancer treatment. The app provides personalized education, peer support, and tracks how patients are doing. Researchers want to see if using the app helps patients feel…