New combo therapy aims to stall advanced kidney cancer

NCT ID NCT07011719

Recruiting now Disease control Sponsor: Arcus Biosciences, Inc. Source: ClinicalTrials.gov ↗

First seen Sep 30, 2025 · Last updated May 24, 2026 · Updated 31 times

Summary

This study tests whether adding the experimental drug casdatifan to the standard drug cabozantinib helps people with advanced clear cell kidney cancer live longer without their disease getting worse. About 720 adults whose cancer progressed after prior immunotherapy will receive either casdatifan or a placebo, both combined with cabozantinib. The main goal is to see if the new combination delays cancer growth.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

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Gilbert, Arizona, 85234, United States
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Goodyear, Arizona, 85338, United States
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Phoenix, Arizona, 85054, United States
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Duarte, California, 91010, United States
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La Jolla, California, 92103, United States
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Los Angeles, California, 90095, United States
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Sacramento, California, 95817, United States
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San Diego, California, 92103, United States
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New Haven, Connecticut, 06519, United States
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Jacksonville, Florida, 32224, United States
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Miami, Florida, 33136, United States
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Orlando, Florida, 32804, United States
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Atlanta, Georgia, 30318, United States
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Atlanta, Georgia, 30322, United States
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Newnan, Georgia, 30265, United States
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Zion, Illinois, 60099, United States
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Indianapolis, Indiana, 46202, United States
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Louisville, Kentucky, 40207, United States
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Jefferson, Louisiana, 70121, United States
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Baltimore, Maryland, 21287, United States
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Boston, Massachusetts, 02114, United States
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Boston, Massachusetts, 02215, United States
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Rochester, Minnesota, 55905, United States
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St Louis, Missouri, 63110, United States
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Omaha, Nebraska, 68198, United States
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New Brunswick, New Jersey, 08903, United States
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Buffalo, New York, 14263, United States
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Rochester, New York, 14642, United States
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Chapel Hill, North Carolina, 27514, United States
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Cleveland, Ohio, 44106, United States
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Portland, Oregon, 97212, United States
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Monroeville, Pennsylvania, 15146, United States
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Charleston, South Carolina, 29425, United States
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Nashville, Tennessee, 37203, United States
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Nashville, Tennessee, 37232, United States
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Dallas, Texas, 75390, United States
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Lubbock, Texas, 79430, United States
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Salt Lake City, Utah, 84112, United States
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Charlottesville, Virginia, 22903, United States
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Seattle, Washington, 98109, United States
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Chermside, Australia
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Hobart, Australia
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Kurralta Park, Australia
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Subiaco, Australia
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Montreal, Canada
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Toronto, Canada
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Prague, Czechia
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Angers, France
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Brest, France
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Montpellier, France
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Paris, France
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Poitiers, France
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Rennes, France
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Strasbourg, France
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Villejuif, France
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Berlin, Germany
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Dresden, Germany
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Frankfurt, Germany
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Halle, Germany
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Rostock, Germany
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Terni, Italy
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Nijmegen, Netherlands
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Rotterdam, Netherlands
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Zwolle, Netherlands
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Auckland, New Zealand
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Christchurch, New Zealand
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Krakow, Poland
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Otwock, Poland
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Poznan, Poland
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Rzeszów, Poland
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Skorzewo, Poland
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Tomaszów Mazowiecki, Poland
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Craiova, Romania
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Suceava, Romania
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Timișoara, Romania
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Busan, South Korea
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Daejeon, South Korea
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Goyang, South Korea
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Seongnam, South Korea
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Seoul, South Korea
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Suwon, South Korea
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Barcelona, Spain
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Córdoba, Spain
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Madrid, Spain
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Santander, Spain
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Seville, Spain
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Vigo, Spain
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Cambridge, United Kingdom
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Exeter, United Kingdom
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Glasgow, United Kingdom
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Leeds, United Kingdom
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London, United Kingdom
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Manchester, United Kingdom
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Preston, United Kingdom
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Southampton, United Kingdom
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Sutton, United Kingdom
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Truro, United Kingdom

Conditions

Explore the condition pages connected to this study.

ADVANCED CLEAR CELL RENAL CELL CARCINOMA METASTATIC CLEAR CELL RENAL CELL CARCINOMA