New combo therapy aims to slow advanced kidney cancer

NCT ID NCT07011719

Recruiting now Disease control Sponsor: Arcus Biosciences, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 3 times

Summary

This study tests whether adding the experimental drug casdatifan to the standard drug cabozantinib can slow cancer growth better than cabozantinib alone in people with advanced clear cell kidney cancer. About 720 adults whose cancer worsened after prior immunotherapy will receive either the combination or a placebo plus cabozantinib. The main goal is to see how long the cancer stays under control.

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Conditions

The condition(s) this trial relates to.

clear cell renal carcinoma Clear-cell metastatic renal cell carcinoma kidney cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED CLEAR CELL RENAL CELL CARCINOMA METASTATIC CLEAR CELL RENAL CELL CARCINOMA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

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Gilbert, Arizona, 85234, United States
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Goodyear, Arizona, 85338, United States
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Phoenix, Arizona, 85054, United States
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Duarte, California, 91010, United States
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Irvine, California, 91304, United States
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La Jolla, California, 92103, United States
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Los Angeles, California, 90095, United States
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Sacramento, California, 95817, United States
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San Diego, California, 92103, United States
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New Haven, Connecticut, 06519, United States
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Washington D.C., District of Columbia, 20057, United States
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Jacksonville, Florida, 32224, United States
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Miami, Florida, 33136, United States
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Orlando, Florida, 32804, United States
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Atlanta, Georgia, 30318, United States
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Atlanta, Georgia, 30322, United States
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Newnan, Georgia, 30265, United States
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Zion, Illinois, 60099, United States
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Indianapolis, Indiana, 46202, United States
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Louisville, Kentucky, 40207, United States
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Jefferson, Louisiana, 70121, United States
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Baltimore, Maryland, 21287, United States
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Boston, Massachusetts, 02114, United States
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Boston, Massachusetts, 02215, United States
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Rochester, Minnesota, 55905, United States
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St Louis, Missouri, 63110, United States
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Omaha, Nebraska, 68198, United States
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New Brunswick, New Jersey, 08903, United States
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Buffalo, New York, 14263, United States
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New York, New York, 10461, United States
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Rochester, New York, 14642, United States
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Chapel Hill, North Carolina, 27514, United States
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Durham, North Carolina, 27710, United States
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Cleveland, Ohio, 44106, United States
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Portland, Oregon, 97212, United States
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Monroeville, Pennsylvania, 15146, United States
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Charleston, South Carolina, 29425, United States
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Nashville, Tennessee, 37203, United States
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Nashville, Tennessee, 37232, United States
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Dallas, Texas, 75390, United States
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Lubbock, Texas, 79430, United States
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Salt Lake City, Utah, 84112, United States
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Charlottesville, Virginia, 22903, United States
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Seattle, Washington, 98109, United States
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Buenos Aires, Argentina
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Box Hill, Australia
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Chermside, Australia
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Elizabeth Vale, Australia
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Frankston, Australia
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Frenchs Forest, Australia
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Heidelberg, Australia
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Hobart, Australia
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Kurralta Park, Australia
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Macquarie Park, Australia
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Saint Leonards, Australia
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Subiaco, Australia
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Westmead, Australia
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Calgary, Canada
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Edmonton, Canada
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Hamilton, Canada
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Montreal, Canada
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Sherbrooke, Canada
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Toronto, Canada
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Vancouver, Canada
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Brno, Czechia
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Brno-střed, Czechia
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Hradec, Czechia
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Prague, Czechia
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Angers, France
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Brest, France
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Caen, France
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Clermont-Ferrand, France
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Lille, France
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Poitiers, France
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Reims, France
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Rennes, France
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Strasbourg, France
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Toulouse, France
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Villejuif, France
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Berlin, Germany
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Dresden, Germany
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Essen, Germany
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Frankfurt, Germany
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Freiburg im Breisgau, Germany
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Halle, Germany
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Hanover, Germany
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Heidelberg, Germany
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Leipzig, Germany
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Lübeck, Germany
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Marburg, Germany
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Rostock, Germany
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Ulm, Germany
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Milan, Italy
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Naples, Italy
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Rome, Italy
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Terni, Italy
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Verona, Italy
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Akita, Japan
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Asahikawa, Japan
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Fukuoka, Japan
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Kobe, Japan
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Matsuyama, Japan
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Nankoku, Japan
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Osaka, Japan
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Sapporo, Japan
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Shinjuku, Japan
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Yokohama, Japan
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Amsterdam, Netherlands
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Maastricht, Netherlands
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Nijmegen, Netherlands
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Rotterdam, Netherlands
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Zwolle, Netherlands
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Auckland, New Zealand
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Christchurch, New Zealand
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Hamilton, New Zealand
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Rotorua, New Zealand
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Krakow, Poland
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Otwock, Poland
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Poznan, Poland
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Skorzewo, Poland
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Tomaszów Mazowiecki, Poland
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Wroclaw, Poland
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Bucharest, Romania
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Craiova, Romania
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Iași, Romania
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Suceava, Romania
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Timișoara, Romania
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Busan, South Korea
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Daejeon, South Korea
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Goyang, South Korea
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Seongnam, South Korea
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Seoul, South Korea
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Suwon, South Korea
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Barcelona, Spain
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Córdoba, Spain
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Madrid, Spain
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Málaga, Spain
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Santander, Spain
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Seville, Spain
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Vigo, Spain
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Cambridge, United Kingdom
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Cottingham, United Kingdom
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Exeter, United Kingdom
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Glasgow, United Kingdom
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Leeds, United Kingdom
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London, United Kingdom
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Manchester, United Kingdom
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Newcastle upon Tyne, United Kingdom
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Northwood, United Kingdom
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Preston, United Kingdom
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Southampton, United Kingdom
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Sutton, United Kingdom
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Truro, United Kingdom

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