Gut microbes may hold key to Post-Transplant pain

NCT ID NCT06206486

Knowledge-focused Sponsor: University of Illinois at Chicago Source: ClinicalTrials.gov ↗

First seen Aug 17, 2026 · Last updated Aug 18, 2026 · Updated 1 time

Summary

This study investigates whether the gut microbiome and its byproducts influence chronic pain in people who have received a kidney transplant. Many transplant recipients experience persistent pain, which can affect their quality of life and treatment adherence. Researchers will track participants before and after transplant, analyzing stool and blood samples alongside pain reports, diet, and stress levels. The goal is to uncover biological mechanisms that could lead to better pain management strategies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to: If successful, this research could identify gut microbiome patterns linked to pain, paving the way for future microbiome-based pain interventions in kidney transplant recipients.
What could go wrong: This is an observational study, so it cannot prove cause and effect. Results may not lead directly to treatments, and the findings might not apply to all transplant patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 133 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2023

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Kidney Transplant Recipients

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Receiving a kidney transplant at the University of Illinois Hospital \& Health Sciences System (UI Health) Transplant Center at the University of Illinois Chicago (UIC), * Planning to receive a kidney transplant at the UI Health Transplant Center * 18 years of age or older (adult), and * Understand the study process and provide written informed consent to participate. Exclusion Criteria: * Having a history of colon cancer or an inflammatory bowel disease * Planning to receive a multiorgan transplant (e.g., simultaneous pancreas and kidney transplant). * Having a history of Clostridium difficile infection in the preceding 8 weeks.

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Conditions

The condition(s) this trial relates to.

end stage renal failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gut microbiome Kidney transplant symptoms

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Gut microbes may hold key to Post-Transplant pain

What the study statuses mean