Can the shingles vaccine protect transplant patients? new study aims to find out

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

1. Population - Group 1. Healthy co-habitants (n = 30) Inclusion criteria: * Household co-habitant of transplant recipient in trial * Aged \>50 years * Previous documented infection with VZV (known infection history or positive VZV IgG result) Exclusion criteria: * Aged \<50 years * Unable or unwilling to provide informed consent to participate in the trial * Known allergy to or intolerance of the contents of the RZV vaccine * No previous infection with VZV (chickenpox) * History of primary immunodeficiency, documented vaccine hypo-responsiveness, or active immunosuppressive therapy 2. Population - Groups 2-4. Transplant recipients (n = 90) Inclusion criteria: * Organ transplant recipients \-- Specific immunosuppression regimen * Tacrolimus, mycophenolate, prednisolone (n = 30, Group 2) * Tacrolimus, mTORi, prednisolone (n = 30, Group 3) * mTORi, mycophenolate, prednisolone (n = 30, Group 4) * Aged \>18 years * estimated GFR \> 15 mL/min/1.73m2 * Previous documented infection with VZV (known infection history or positive VZV IgG result) Exclusion criteria: * Aged \<18 years * Unable or unwilling to provide informed consent to participate in the trial * No previous infection with VZV (chickenpox) * Known allergy to or intolerance of the contents of the RZV vaccine * Current pregnancy 3. Population - Group 5. Other (n = 10) Inclusion criteria: * Immunosuppressed patient receiving single-agent rapamycin immunosuppression * Aged \>18 years * Previous documented infection with VZV (known infection history or positive VZV IgG result) Exclusion criteria: * Aged \<18 years * Unable or unwilling to provide informed consent to participate in the trial * Known allergy to or intolerance of the contents of the RZV vaccine * No previous infection with VZV (chickenpox) * Known allergy to or intolerance of the contents of the RZV vaccine * Current pregnancy * History of primary immunodeficiency, documented vaccine hypo-responsiveness, or active immunosuppressive therapy 4. Population - Group 6. Dialysis group (n = 30) Inclusion criteria: * Kidney failure receiving haemodialysis as kidney replacement therapy * Aged \>18 years * Previous documented infection with VZV (known infection history or positive VZV IgG result) Exclusion criteria: * Aged \<18 years * Unable or unwilling to provide informed consent to participate in the trial * Known allergy to or intolerance of the contents of the RZV vaccine * No previous infection with VZV (chickenpox) * Known allergy to or intolerance of the contents of the RZV vaccine * Current pregnancy * History of primary immunodeficiency or active immunosuppressive therapy