IMMUNOSUPPRESSION

This study tests whether doing a genetic test before a kidney transplant can help doctors choose the best starting dose of tacrolimus, an anti-rejection drug. About 114 adults waiting for a kidney transplant will be randomly assigned to either standard care or the genetic-testing…

This study tests whether giving immunosuppressive drugs as a single daily dose after liver transplant works as well as the standard twice-daily regimen. About 162 liver transplant recipients will be randomly assigned to once-daily or twice-daily dosing. The goal is to see if once…

This study compares two treatments for children with Crohn's disease: a single drug (infliximab or an immunosuppressant) versus a combination of both. The goal is to see which approach better controls the disease and leads to remission. About 128 children aged 6 to 18 with active…

This study tests if hand transplantation can help people who have lost a limb below the elbow. Up to 50 participants aged 18-65 will receive a transplant and be followed for 18 months to see how well they can use the new hand in daily activities. The study involves regular check-…

This study tests whether a special ultrasound called fibroscan can help doctors safely lower the dose of anti-rejection drugs in liver transplant patients. These drugs are needed for life but can cause serious side effects like kidney damage, diabetes, and heart disease. The stud…

This early-stage trial tests whether a donated bladder can be transplanted using robotic surgery in 5 people with severe bladder damage. The goal is to see if the transplant works and is safe. Participants will need to take lifelong anti-rejection drugs.

This study looks at how transplant patients, who take different medicines to suppress their immune system, respond to the shingles vaccine compared to their healthy housemates. About 160 people will get two doses of the SHINGRIX vaccine, and their immune responses will be checked…

This study looks at how problems with the immune system can lead to gum disease and other mouth issues. Researchers will collect samples like saliva, plaque, and blood from 700 people, including those with genetic immune defects and healthy volunteers. The goal is to understand t…

This observational study looks at how severe trauma changes the body's blood and bone marrow, aiming to understand why some patients become immune-suppressed and develop infections like sepsis. Researchers will collect blood and bone marrow samples from 255 trauma patients and co…