Which dialysis dose saves more lives in the ICU? a trial seeks answers
NCT ID NCT06014801
First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time
Summary
This trial asks whether a lower or medium intensity of continuous kidney replacement therapy (dialysis) is better for critically ill patients with acute kidney injury. It will compare a low dose (12 mL/kg/hr) against a standard medium dose (25 mL/kg/hr) to see which is more effective and safer. The study includes 400 adults in intensive care units and will track outcomes like death and how long patients need dialysis.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Continuous kidney replacement therapy (dialysis/filtration) at low or medium intensity
- What this could lead to
- If successful, this could identify the optimal dialysis intensity for ICU patients with acute kidney injury, potentially improving survival and reducing time on dialysis.
- What could go wrong
- This is a mid-stage trial, and results may not apply to all ICU patients. There are inherent risks of dialysis, such as infection or blood pressure changes, and the optimal intensity may vary by patient.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2/3
Runs two stages together: whether the treatment works, then large-scale confirmation.
- Participants
-
About 400 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Oct 2023
- Expected to finish
-
Jun 2030
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Patient who meets all of the following criteria and who has given informed consent. 1. Adults (18 years of age or older, regardless of the time since ICU admission) currently admitted to an intensive care unit\*. \*Includes high care units, where continuous monitoring is conducted and intensive care physicians are in charge of medical care. 2. A diagnosis of acute kidney injury is made according to the Kidney Disease: Improving Global Outcomes (KDIGO) international diagnostic criteria (one of the following is met) * Serum creatinine increased by more than 0.3 mg/dL within 48 hours * Serum creatinine increased more than 1.5-fold from baseline and the increase is considered to have occurred within 7 days * Oliguria (\< 0.5 mL/kg/hr) lasting more than 6 hours 3. The treating intensivist believes that continuous kidney replacement therapy is necessary Exclusion Criteria: Patient who meets any of the following exclusion criteria will be excluded. 1. Receiving chronic dialysis or scheduled for initiation of chronic dialysis 2. Undergoing any kidney replacement therapy or blood purification therapy within 48 hours 3. When kidney replacement therapy using other dialysate or replacement fluids, such as citrate dialysis, is preferred due to coexisting bleeding disorders or allergy to acetate 4. Concomitant blood purification therapy other than hemofiltration/dialysis, such as plasma exchange 5. The patient is in a very critical condition and the treating physician believes that survival for more than 24 hours is unlikely 6. Previous participation in the study 7. After receiving a full explanation of the study and with full understanding, a patient do not consent to participate in the study of their own (or their substitute decision maker's) will. 8. The principal investigator (or an investigator) thinks it to be inappropriate to participate in this study.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Acute kidney injury requiring continuous renal replacement therapy are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
9 sites. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
Jichi Medical University Hospital
RECRUITINGTochigi, 329 0498, Japan
-
Jikei University Hospital
RECRUITINGTokyo, 105 8471, Japan
-
Keio University Hospital
RECRUITINGTokyo, 160 0016, Japan
-
Osaka Medical and Pharmaceutical University Hospital
RECRUITINGTakatsuki, Osaka, 569-8686, Japan
-
Osaka University Hospital
NOT_YET_RECRUITINGOsaka, 565 0871, Japan
-
Sendai Medical Center
RECRUITINGSendai, Miyagi, 983-8520, Japan
-
Tsuchiura Kyodo General Hospital
RECRUITINGIbaraki, 300 0028, Japan
-
University of Fukui Hospital
RECRUITINGFukui, 910 1193, Japan
-
Wakayama Medical University Hospital
RECRUITINGWakayama, 641 8509, Japan