Which dialysis dose saves more lives in the ICU? a trial seeks answers

NCT ID NCT06014801

Recruiting now Disease control Sponsor: Jikei University School of Medicine Source: ClinicalTrials.gov ↗

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This trial asks whether a lower or medium intensity of continuous kidney replacement therapy (dialysis) is better for critically ill patients with acute kidney injury. It will compare a low dose (12 mL/kg/hr) against a standard medium dose (25 mL/kg/hr) to see which is more effective and safer. The study includes 400 adults in intensive care units and will track outcomes like death and how long patients need dialysis.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Continuous kidney replacement therapy (dialysis/filtration) at low or medium intensity
What this could lead to: If successful, this could identify the optimal dialysis intensity for ICU patients with acute kidney injury, potentially improving survival and reducing time on dialysis.
What could go wrong: This is a mid-stage trial, and results may not apply to all ICU patients. There are inherent risks of dialysis, such as infection or blood pressure changes, and the optimal intensity may vary by patient.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute kidney injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE KIDNEY INJURY REQUIRING CONTINUOUS RENAL REPLACEMENT THERAPY

Contacts and locations

Locations

Jichi Medical University Hospital
RECRUITING

Tochigi, 329 0498, Japan
Jikei University Hospital
RECRUITING

Tokyo, 105 8471, Japan
Keio University Hospital
RECRUITING

Tokyo, 160 0016, Japan
Osaka Medical and Pharmaceutical University Hospital
RECRUITING

Takatsuki, Osaka, 569-8686, Japan
Osaka University Hospital
NOT_YET_RECRUITING

Osaka, 565 0871, Japan
Sendai Medical Center
RECRUITING

Sendai, Miyagi, 983-8520, Japan
Tsuchiura Kyodo General Hospital
RECRUITING

Ibaraki, 300 0028, Japan
University of Fukui Hospital
RECRUITING

Fukui, 910 1193, Japan
Wakayama Medical University Hospital
RECRUITING

Wakayama, 641 8509, Japan